Published in PLoS Genet on February 01, 2008
Analysis of microRNA knockouts in mice. Hum Mol Genet (2010) 1.59
A brief review on the mechanisms of miRNA regulation. Genomics Proteomics Bioinformatics (2009) 1.56
Mirtrons: microRNA biogenesis via splicing. Biochimie (2011) 1.24
Targeting microRNAs in obesity. Expert Opin Ther Targets (2009) 1.14
Epigenetic modifications in rheumatoid arthritis. Arthritis Res Ther (2008) 1.13
Genomics and genetics in the biology of adaptation to exercise. Compr Physiol (2011) 1.02
Neuronal activity regulates hippocampal miRNA expression. PLoS One (2011) 0.98
Identification and characterization of Dlc1 isoforms in the mouse and study of the biological function of a single gene trapped isoform. BMC Biol (2010) 0.94
miR-142 orchestrates a network of actin cytoskeleton regulators during megakaryopoiesis. Elife (2014) 0.94
MicroRNAs in mouse development and disease. Semin Cell Dev Biol (2010) 0.89
Analysis of Gga null mice demonstrates a non-redundant role for mammalian GGA2 during development. PLoS One (2012) 0.86
Vivo-morpholinos induced transient knockdown of physical activity related proteins. PLoS One (2013) 0.84
MicroRNAs: history, biogenesis, and their evolving role in animal development and disease. Vet Pathol (2013) 0.84
Overexpression of wild-type murine tau results in progressive tauopathy and neurodegeneration. Am J Pathol (2009) 0.83
Low levels of human HIP14 are sufficient to rescue neuropathological, behavioural, and enzymatic defects due to loss of murine HIP14 in Hip14-/- mice. PLoS One (2012) 0.83
Mechanisms of fertilization elucidated by gene-manipulated animals. Asian J Androl (2015) 0.81
Mechanism of fertilization: a modern view. Exp Anim (2014) 0.79
Effects of Aromatase Inhibition on the Physical Activity Levels of Male Mice. J Steroids Horm Sci (2011) 0.78
A conditional system to specifically link disruption of protein-coding function with reporter expression in mice. Cell Rep (2014) 0.77
Transcriptome Analysis of Targeted Mouse Mutations Reveals the Topography of Local Changes in Gene Expression. PLoS Genet (2016) 0.75
Hitting two birds with one stone: The unforeseen consequences of nested gene knockouts in Caenorhabditis elegans. Worm (2016) 0.75
miRBase: microRNA sequences, targets and gene nomenclature. Nucleic Acids Res (2006) 39.25
Identification of mammalian microRNA host genes and transcription units. Genome Res (2004) 14.63
Phylogenetic shadowing and computational identification of human microRNA genes. Cell (2005) 13.24
The Mouse Genome Database (MGD): from genes to mice--a community resource for mouse biology. Nucleic Acids Res (2005) 8.19
The International Gene Trap Consortium Website: a portal to all publicly available gene trap cell lines in mouse. Nucleic Acids Res (2006) 3.40
Congenital diaphragmatic hernia, kidney agenesis and cardiac defects associated with Slit3-deficiency in mice. Mech Dev (2003) 1.55
Dysregulation of cardiogenesis, cardiac conduction, and cell cycle in mice lacking miRNA-1-2. Cell (2007) 12.72
A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference. Nat Genet (2003) 12.16
The RNaseIII enzyme Dicer is required for morphogenesis but not patterning of the vertebrate limb. Proc Natl Acad Sci U S A (2005) 8.33
MicroRNA-responsive 'sensor' transgenes uncover Hox-like and other developmentally regulated patterns of vertebrate microRNA expression. Nat Genet (2004) 6.11
TAZ, a transcriptional modulator of mesenchymal stem cell differentiation. Science (2005) 5.56
Foxp3-dependent microRNA155 confers competitive fitness to regulatory T cells by targeting SOCS1 protein. Immunity (2009) 5.10
Dicer function is essential for lung epithelium morphogenesis. Proc Natl Acad Sci U S A (2006) 4.87
Selective miRNA disruption in T reg cells leads to uncontrolled autoimmunity. J Exp Med (2008) 4.68
Chd1 regulates open chromatin and pluripotency of embryonic stem cells. Nature (2009) 4.13
Genome-wide profiling of salt fractions maps physical properties of chromatin. Genome Res (2008) 4.03
The microRNA miR-196 acts upstream of Hoxb8 and Shh in limb development. Nature (2005) 3.78
Altered brain microRNA biogenesis contributes to phenotypic deficits in a 22q11-deletion mouse model. Nat Genet (2008) 3.76
A systematic mammalian genetic interaction map reveals pathways underlying ricin susceptibility. Cell (2013) 3.53
RNA interference of influenza virus production by directly targeting mRNA for degradation and indirectly inhibiting all viral RNA transcription. Proc Natl Acad Sci U S A (2003) 3.48
Dicer1 and miR-219 Are required for normal oligodendrocyte differentiation and myelination. Neuron (2010) 3.37
Conditional loss of Dicer disrupts cellular and tissue morphogenesis in the cortex and hippocampus. J Neurosci (2008) 3.33
A neuronal isoform of CPEB regulates local protein synthesis and stabilizes synapse-specific long-term facilitation in aplysia. Cell (2003) 3.15
MicroRNA expression is required for pancreatic islet cell genesis in the mouse. Diabetes (2007) 2.80
Essential role for Dicer during skeletal muscle development. Dev Biol (2007) 2.76
Podocyte-specific deletion of dicer alters cytoskeletal dynamics and causes glomerular disease. J Am Soc Nephrol (2008) 2.69
Pervasive transcription of the human genome produces thousands of previously unidentified long intergenic noncoding RNAs. PLoS Genet (2013) 2.46
Dicer loss in striatal neurons produces behavioral and neuroanatomical phenotypes in the absence of neurodegeneration. Proc Natl Acad Sci U S A (2008) 2.32
IRE1α cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2. Science (2012) 2.25
LPS induces KH-type splicing regulatory protein-dependent processing of microRNA-155 precursors in macrophages. FASEB J (2009) 1.99
Rapid creation and quantitative monitoring of high coverage shRNA libraries. Nat Methods (2009) 1.98
Expanded RNA-binding activities of mammalian Argonaute 2. Nucleic Acids Res (2009) 1.94
Disruption of Dicer1 induces dysregulated fetal gene expression and promotes hepatocarcinogenesis. Gastroenterology (2009) 1.86
Precursor microRNA-programmed silencing complex assembly pathways in mammals. Mol Cell (2012) 1.81
A resource for the conditional ablation of microRNAs in the mouse. Cell Rep (2012) 1.66
Mouse let-7 miRNA populations exhibit RNA editing that is constrained in the 5'-seed/ cleavage/anchor regions and stabilize predicted mmu-let-7a:mRNA duplexes. Genome Res (2008) 1.66
Dicer ablation in oligodendrocytes provokes neuronal impairment in mice. Ann Neurol (2009) 1.62
Analysis of microRNA knockouts in mice. Hum Mol Genet (2010) 1.59
Residual microRNA expression dictates the extent of inner ear development in conditional Dicer knockout mice. Dev Biol (2009) 1.55
Up-regulation of miR-21 by HER2/neu signaling promotes cell invasion. J Biol Chem (2009) 1.53
Dicer1 is required for differentiation of the mouse male germline. Biol Reprod (2008) 1.52
MicroRNAs and endocrine biology. J Endocrinol (2005) 1.47
T cell activation induces proteasomal degradation of Argonaute and rapid remodeling of the microRNA repertoire. J Exp Med (2013) 1.42
Sertoli cell Dicer is essential for spermatogenesis in mice. Dev Biol (2008) 1.37
Genetic analyses reveal a requirement for Dicer1 in the mouse urogenital tract. Mamm Genome (2009) 1.31
Next-generation NAMPT inhibitors identified by sequential high-throughput phenotypic chemical and functional genomic screens. Chem Biol (2013) 1.17
Research resource: RNA-Seq reveals unique features of the pancreatic β-cell transcriptome. Mol Endocrinol (2012) 1.16
Monoallelic deletion of the microRNA biogenesis gene Dgcr8 produces deficits in the development of excitatory synaptic transmission in the prefrontal cortex. Neural Dev (2011) 1.16
Stage-specific regulation of natural killer cell homeostasis and response against viral infection by microRNA-155. Proc Natl Acad Sci U S A (2013) 1.12
Right- and left-loop short shRNAs have distinct and unusual mechanisms of gene silencing. Nucleic Acids Res (2012) 1.07
Posttranscriptional silencing of effector cytokine mRNA underlies the anergic phenotype of self-reactive T cells. Immunity (2011) 1.07
The Pitx2:miR-200c/141:noggin pathway regulates Bmp signaling and ameloblast differentiation. Development (2013) 1.04
Widespread RNA 3'-end oligouridylation in mammals. RNA (2012) 1.04
A screen in mice uncovers repression of lipoprotein lipase by microRNA-29a as a mechanism for lipid distribution away from the liver. Hepatology (2014) 0.94
Slowing down the Ras lane: miRNAs as tumor suppressors? Sci STKE (2005) 0.93
Behind the scenes of a small RNA gene-silencing pathway. Hum Gene Ther (2008) 0.90
Let-7b/c enhance the stability of a tissue-specific mRNA during mammalian organogenesis as part of a feedback loop involving KSRP. PLoS Genet (2012) 0.89
The microRNA-processing enzyme Dicer is dispensable for somite segmentation but essential for limb bud positioning. Dev Biol (2011) 0.89
A prospective manikin-based observational study of telephone-directed cardiopulmonary resuscitation. Resuscitation (2007) 0.88
An siRNA screen in pancreatic beta cells reveals a role for Gpr27 in insulin production. PLoS Genet (2012) 0.86
Partially penetrant postnatal lethality of an epithelial specific MicroRNA in a mouse knockout. PLoS One (2013) 0.84
Polymerase II promoter strength determines efficacy of microRNA adapted shRNAs. PLoS One (2011) 0.84
The proteomics of senescence in leaves of white clover, Trifolium repens (L.). Proteomics (2002) 0.81
Changes in 1-aminocyclopropane-1-carboxlate (ACC) oxidase expression and enzyme activity in response to excess manganese in white clover (Trifolium repens L.). Plant Physiol Biochem (2011) 0.81
Lentiviral strategies for RNAi knockdown of neuronal genes. Curr Protoc Neurosci (2007) 0.80
Complex formation between recombinant ATP sulfurylase and APS reductase of Allium cepa (L.). FEBS Lett (2007) 0.80
Expression of 1-aminocyclopropane-1-carboxylate (ACC) oxidase genes during the development of vegetative tissues in white clover (Trifolium repens L.) is regulated by ontological cues. Plant Mol Biol (2006) 0.78
Renewable RNAi. Nat Biotechnol (2013) 0.78
Characterization of the 1-aminocyclopropane-1-carboxylic acid (ACC) oxidase multigene family of Malus domestica Borkh. Phytochemistry (2009) 0.78
Identification and characterisation of proteinase inhibitors and their genes from seeds of apple (Malus domestica). J Biochem (2003) 0.76
The X-ray crystal structure of APR-B, an atypical adenosine 5'-phosphosulfate reductase from Physcomitrella patens. FEBS Lett (2013) 0.76
Discovering the complexity of the metazoan transcriptome. Genome Biol (2014) 0.75
Removal of the N-linked glycan structure from the peanut peroxidase prxPNC2: influence on protein stability and activity. Phytochemistry (2005) 0.75
Emergency medicine in South Africa - time to catch up. S Afr Med J (2012) 0.75
ACC oxidase (ACO) genes in Trifolium occidentale (L.) and their relationship to ACO genes in white clover (T. repens L.) and T. pallescens (L.). Plant Physiol Biochem (2011) 0.75