Published in Semin Cell Dev Biol on February 10, 2010
Ablation of Dicer from murine Schwann cells increases their proliferation while blocking myelination. PLoS One (2010) 1.07
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MicroRNA-directed cleavage of HOXB8 mRNA. Science (2004) 18.33
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The role of microRNA-1 and microRNA-133 in skeletal muscle proliferation and differentiation. Nat Genet (2005) 17.07
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Dicer is essential for mouse development. Nat Genet (2003) 15.87
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Control of stress-dependent cardiac growth and gene expression by a microRNA. Science (2007) 12.08
MicroRNA-133 controls cardiac hypertrophy. Nat Med (2007) 11.68
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Regulation of progenitor cell proliferation and granulocyte function by microRNA-223. Nature (2008) 8.69
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The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis. Dev Cell (2008) 7.26
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MicroRNA-responsive 'sensor' transgenes uncover Hox-like and other developmentally regulated patterns of vertebrate microRNA expression. Nat Genet (2004) 6.11
Prestin is required for electromotility of the outer hair cell and for the cochlear amplifier. Nature (2002) 5.54
Dicer ablation affects antibody diversity and cell survival in the B lymphocyte lineage. Cell (2008) 5.53
microRNA-133a regulates cardiomyocyte proliferation and suppresses smooth muscle gene expression in the heart. Genes Dev (2008) 5.39
miRNAs control gene expression in the single-cell alga Chlamydomonas reinhardtii. Nature (2007) 4.72
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MicroRNAs miR-143 and miR-145 modulate cytoskeletal dynamics and responsiveness of smooth muscle cells to injury. Genes Dev (2009) 4.62
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MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice. J Clin Invest (2009) 4.39
Critical roles for Dicer in the female germline. Genes Dev (2007) 4.23
Maternal microRNAs are essential for mouse zygotic development. Genes Dev (2007) 4.16
Acquisition of the contractile phenotype by murine arterial smooth muscle cells depends on the Mir143/145 gene cluster. J Clin Invest (2009) 4.12
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miR-375 maintains normal pancreatic alpha- and beta-cell mass. Proc Natl Acad Sci U S A (2009) 3.89
Mutations in the seed region of human miR-96 are responsible for nonsyndromic progressive hearing loss. Nat Genet (2009) 3.72
The miRNA-processing enzyme dicer is essential for the morphogenesis and maintenance of hair follicles. Curr Biol (2006) 3.64
The knockout of miR-143 and -145 alters smooth muscle cell maintenance and vascular homeostasis in mice: correlates with human disease. Cell Death Differ (2009) 3.43
Detecting microRNA binding and siRNA off-target effects from expression data. Nat Methods (2008) 3.41
Conditional loss of Dicer disrupts cellular and tissue morphogenesis in the cortex and hippocampus. J Neurosci (2008) 3.33
An ENU-induced mutation of miR-96 associated with progressive hearing loss in mice. Nat Genet (2009) 3.05
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Prestin-based outer hair cell motility is necessary for mammalian cochlear amplification. Neuron (2008) 2.98
MicroRNA expression is required for pancreatic islet cell genesis in the mouse. Diabetes (2007) 2.80
Attribution of vascular phenotypes of the murine Egfl7 locus to the microRNA miR-126. Development (2008) 2.71
Podocyte-specific deletion of dicer alters cytoskeletal dynamics and causes glomerular disease. J Am Soc Nephrol (2008) 2.69
MicroRNA-1 and microRNA-133a expression are decreased during skeletal muscle hypertrophy. J Appl Physiol (1985) (2006) 2.63
Dicer inactivation leads to progressive functional and structural degeneration of the mouse retina. J Neurosci (2008) 2.50
DGCR8-dependent microRNA biogenesis is essential for skin development. Proc Natl Acad Sci U S A (2008) 2.49
Loss of cardiac microRNA-mediated regulation leads to dilated cardiomyopathy and heart failure. Circ Res (2009) 2.44
Generation of Pax2-Cre mice by modification of a Pax2 bacterial artificial chromosome. Genesis (2004) 2.43
The zinc finger transcription factor Gfi1, implicated in lymphomagenesis, is required for inner ear hair cell differentiation and survival. Development (2003) 2.38
Polymorphisms in human pre-miRNAs. Biochem Biophys Res Commun (2005) 2.29
MicroRNA gene expression in the mouse inner ear. Brain Res (2006) 2.13
Deletion of Dicer in somatic cells of the female reproductive tract causes sterility. Mol Endocrinol (2008) 1.91
MicroRNA genes are frequently located near mouse cancer susceptibility loci. Proc Natl Acad Sci U S A (2007) 1.90
Essential role of POU-domain factor Brn-3c in auditory and vestibular hair cell development. Proc Natl Acad Sci U S A (1997) 1.88
Disruption of Dicer1 induces dysregulated fetal gene expression and promotes hepatocarcinogenesis. Gastroenterology (2009) 1.86
Altered retinal microRNA expression profile in a mouse model of retinitis pigmentosa. Genome Biol (2007) 1.67
MicroRNAs are essential for development and function of inner ear hair cells in vertebrates. Proc Natl Acad Sci U S A (2009) 1.67
A receptor-like inositol lipid phosphatase is required for the maturation of developing cochlear hair bundles. J Neurosci (2003) 1.63
MicroRNA-206 is overexpressed in the diaphragm but not the hindlimb muscle of mdx mouse. Am J Physiol Cell Physiol (2007) 1.57
Residual microRNA expression dictates the extent of inner ear development in conditional Dicer knockout mice. Dev Biol (2009) 1.55
Fibroblast growth factor signaling regulates pillar cell development in the organ of corti. J Neurosci (2002) 1.54
Dnm3os, a non-coding RNA, is required for normal growth and skeletal development in mice. Dev Dyn (2008) 1.45
miR-17 family miRNAs are expressed during early mammalian development and regulate stem cell differentiation. Dev Biol (2008) 1.43
Unintentional miRNA ablation is a risk factor in gene knockout studies: a short report. PLoS Genet (2008) 1.03
MicroRNA expression in preimplantation mouse embryos from Ped gene positive compared to Ped gene negative mice. J Assist Reprod Genet (2008) 0.86
Mutations in the seed region of human miR-96 are responsible for nonsyndromic progressive hearing loss. Nat Genet (2009) 3.72
Sox2 is required for sensory organ development in the mammalian inner ear. Nature (2005) 3.58
Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes. Cell (2013) 3.47
Mutation of Celsr1 disrupts planar polarity of inner ear hair cells and causes severe neural tube defects in the mouse. Curr Biol (2003) 3.31
An ENU-induced mutation of miR-96 associated with progressive hearing loss in mice. Nat Genet (2009) 3.05
Defects in whirlin, a PDZ domain molecule involved in stereocilia elongation, cause deafness in the whirler mouse and families with DFNB31. Nat Genet (2003) 2.98
Wnt5a functions in planar cell polarity regulation in mice. Dev Biol (2007) 2.85
Beethoven, a mouse model for dominant, progressive hearing loss DFNA36. Nat Genet (2002) 2.31
Mouse large-scale phenotyping initiatives: overview of the European Mouse Disease Clinic (EUMODIC) and of the Wellcome Trust Sanger Institute Mouse Genetics Project. Mamm Genome (2012) 2.12
A comparative phenotypic and genomic analysis of C57BL/6J and C57BL/6N mouse strains. Genome Biol (2013) 2.04
Loss of myosin VI reduces secretion and the size of the Golgi in fibroblasts from Snell's waltzer mice. EMBO J (2003) 1.74
Multiple mutations in mouse Chd7 provide models for CHARGE syndrome. Hum Mol Genet (2005) 1.71
Mosaic complementation demonstrates a regulatory role for myosin VIIa in actin dynamics of stereocilia. Mol Cell Biol (2007) 1.66
Tmc1 is necessary for normal functional maturation and survival of inner and outer hair cells in the mouse cochlea. J Physiol (2006) 1.65
Lack of pendrin expression leads to deafness and expansion of the endolymphatic compartment in inner ears of Foxi1 null mutant mice. Development (2003) 1.59
Comprehensive sequence analysis of nine Usher syndrome genes in the UK National Collaborative Usher Study. J Med Genet (2011) 1.54
Role of myosin VIIa and Rab27a in the motility and localization of RPE melanosomes. J Cell Sci (2004) 1.53
Great vessel development requires biallelic expression of Chd7 and Tbx1 in pharyngeal ectoderm in mice. J Clin Invest (2009) 1.40
Usher syndromes due to MYO7A, PCDH15, USH2A or GPR98 mutations share retinal disease mechanism. Hum Mol Genet (2008) 1.36
miR-96 regulates the progression of differentiation in mammalian cochlear inner and outer hair cells. Proc Natl Acad Sci U S A (2011) 1.32
Elongation of hair cell stereocilia is defective in the mouse mutant whirler. J Comp Neurol (2002) 1.31
A Sall4 mutant mouse model useful for studying the role of Sall4 in early embryonic development and organogenesis. Genesis (2007) 1.22
The role of sphingosine-1-phosphate transporter Spns2 in immune system function. J Immunol (2012) 1.20
The deaf mouse mutant whirler suggests a role for whirlin in actin filament dynamics and stereocilia development. Cell Motil Cytoskeleton (2007) 1.13
Deficiency for the ubiquitin ligase UBE3B in a blepharophimosis-ptosis-intellectual-disability syndrome. Am J Hum Genet (2012) 1.13
Stereocilia defects in waltzer (Cdh23), shaker1 (Myo7a) and double waltzer/shaker1 mutant mice. Hear Res (2002) 1.13
The deaf mouse mutant Jeff (Jf) is a single gene model of otitis media. J Assoc Res Otolaryngol (2003) 1.08
Progressive hearing loss and increased susceptibility to noise-induced hearing loss in mice carrying a Cdh23 but not a Myo7a mutation. J Assoc Res Otolaryngol (2003) 1.08
MyosinVIIa interacts with Twinfilin-2 at the tips of mechanosensory stereocilia in the inner ear. PLoS One (2009) 1.08
The novel mouse mutation Oblivion inactivates the PMCA2 pump and causes progressive hearing loss. PLoS Genet (2008) 1.08
The human deafness-associated connexin 30 T5M mutation causes mild hearing loss and reduces biochemical coupling among cochlear non-sensory cells in knock-in mice. Hum Mol Genet (2010) 1.07
A Myo6 mutation destroys coordination between the myosin heads, revealing new functions of myosin VI in the stereocilia of mammalian inner ear hair cells. PLoS Genet (2008) 1.07
A Myo7a mutation cosegregates with stereocilia defects and low-frequency hearing impairment. Mamm Genome (2004) 1.07
Two quantitative trait loci affecting progressive hearing loss in 101/H mice. Mamm Genome (2006) 1.03
ENU mutagenesis reveals a highly mutable locus on mouse Chromosome 4 that affects ear morphogenesis. Mamm Genome (2002) 1.03
Exome sequencing identifies a missense mutation in Isl1 associated with low penetrance otitis media in dearisch mice. Genome Biol (2011) 1.03
Myosin Va is required for normal photoreceptor synaptic activity. J Cell Sci (2004) 1.01
Study of smell and reproductive organs in a mouse model for CHARGE syndrome. Eur J Hum Genet (2009) 1.01
Ectopic expression of activated notch or SOX2 reveals similar and unique roles in the development of the sensory cell progenitors in the mammalian inner ear. J Neurosci (2013) 0.99
The Usher 1B protein, MYO7A, is required for normal localization and function of the visual retinoid cycle enzyme, RPE65. Hum Mol Genet (2011) 0.99
Mouse models for Usher syndrome 1B. Adv Exp Med Biol (2003) 0.97
Cdh23 mutations in the mouse are associated with retinal dysfunction but not retinal degeneration. Exp Eye Res (2003) 0.96
Presynaptic maturation in auditory hair cells requires a critical period of sensory-independent spiking activity. Proc Natl Acad Sci U S A (2013) 0.95
Atp6v0a4 knockout mouse is a model of distal renal tubular acidosis with hearing loss, with additional extrarenal phenotype. Proc Natl Acad Sci U S A (2012) 0.92
An ENU-induced mutation in AP-2alpha leads to middle ear and ocular defects in Doarad mice. Mamm Genome (2004) 0.92
Catweasel mice: a novel role for Six1 in sensory patch development and a model for branchio-oto-renal syndrome. Dev Biol (2009) 0.91
The homeobox gene Emx2 underlies middle ear and inner ear defects in the deaf mouse mutant pardon. J Neurocytol (2003) 0.91
Mcph1-deficient mice reveal a role for MCPH1 in otitis media. PLoS One (2013) 0.90
Circling, deafness, and yellow coat displayed by yellow submarine (ysb) and light coat and circling (lcc) mice with mutations on chromosome 3. Genomics (2002) 0.90
Two new mouse mutants with vestibular defects that map to the highly mutable locus on chromosome 4. Int J Audiol (2005) 0.90
Characterization of a new mouse mutant, flouncer, with a balance defect and inner ear malformation. Otol Neurotol (2004) 0.88
A novel stereocilia defect in sensory hair cells of the deaf mouse mutant Tasmanian devil. Eur J Neurosci (2002) 0.87
Emx2 and early hair cell development in the mouse inner ear. Dev Biol (2010) 0.85
Mutations in the USH1C gene associated with sector retinitis pigmentosa and hearing loss. Retina (2011) 0.85
Linkage study and exome sequencing identify a BDP1 mutation associated with hereditary hearing loss. PLoS One (2013) 0.85
The future role of genetic screening to detect newborns at risk of childhood-onset hearing loss. Int J Audiol (2012) 0.83
Myosin VI is required for normal retinal function. Exp Eye Res (2005) 0.83
A missense mutation in Fgfr1 causes ear and skull defects in hush puppy mice. Mamm Genome (2011) 0.82
A reduction in Ptprq associated with specific features of the deafness phenotype of the miR-96 mutant mouse diminuendo. Eur J Neurosci (2014) 0.81
Auditory function in the Tc1 mouse model of down syndrome suggests a limited region of human chromosome 21 involved in otitis media. PLoS One (2012) 0.80
Mice deficient in H+-ATPase a4 subunit have severe hearing impairment associated with enlarged endolymphatic compartments within the inner ear. Dis Model Mech (2012) 0.80
Genetics, gene expression and bioinformatics of the pituitary gland. Horm Res (2009) 0.80
Hush puppy: a new mouse mutant with pinna, ossicle, and inner ear defects. Laryngoscope (2005) 0.79
Towards a mutant map of the mouse--new models of neurological, behavioural, deafness, bone, renal and blood disorders. Genetica (2004) 0.79
Specific expression of Kcna10, Pxn and Odf2 in the organ of Corti. Gene Expr Patterns (2012) 0.78
Early development and degeneration of vestibular hair cells in bronx waltzer mutant mice. Hear Res (2002) 0.77
Use of mouse genetics for studying inner ear development. Curr Top Dev Biol (2003) 0.77
Mutanlallemand (mtl) and Belly Spot and Deafness (bsd) are two new mutations of Lmx1a causing severe cochlear and vestibular defects. PLoS One (2012) 0.76
Headbobber: a combined morphogenetic and cochleosaccular mouse model to study 10qter deletions in human deafness. PLoS One (2013) 0.76
Omi, a recessive mutation on chromosome 10, is a novel allele of Ostm1. Mamm Genome (2012) 0.75
A cornucopia of candidates for deafness. Cell (2012) 0.75