PubRank

Donald E Ingber

Author PubWeight™ 218.41‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells. Nat Genet 2003 13.33
2 Transcriptome-wide noise controls lineage choice in mammalian progenitor cells. Nature 2008 7.60
3 Reconstituting organ-level lung functions on a chip. Science 2010 5.75
4 Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus. Nat Rev Mol Cell Biol 2009 5.41
5 Viscoelastic retraction of single living stress fibers and its impact on cell shape, cytoskeletal organization, and extracellular matrix mechanics. Biophys J 2006 4.06
6 Cell fates as high-dimensional attractor states of a complex gene regulatory network. Phys Rev Lett 2005 3.90
7 Microtubules can bear enhanced compressive loads in living cells because of lateral reinforcement. J Cell Biol 2006 3.63
8 Directional control of lamellipodia extension by constraining cell shape and orienting cell tractional forces. FASEB J 2002 3.45
9 A mechanosensitive transcriptional mechanism that controls angiogenesis. Nature 2009 3.44
10 Shear-activated nanotherapeutics for drug targeting to obstructed blood vessels. Science 2012 3.33
11 Endothelial cilia are fluid shear sensors that regulate calcium signaling and nitric oxide production through polycystin-1. Circulation 2008 3.33
12 Mechanical control of tissue and organ development. Development 2010 3.18
13 Cellular adaptation to mechanical stress: role of integrins, Rho, cytoskeletal tension and mechanosensitive ion channels. J Cell Sci 2006 2.98
14 Gene Expression Dynamics Inspector (GEDI): for integrative analysis of expression profiles. Bioinformatics 2003 2.92
15 From 3D cell culture to organs-on-chips. Trends Cell Biol 2011 2.83
16 Cell shape provides global control of focal adhesion assembly. Biochem Biophys Res Commun 2003 2.71
17 Mechanical forces alter zyxin unbinding kinetics within focal adhesions of living cells. J Cell Physiol 2006 2.62
18 A human disease model of drug toxicity-induced pulmonary edema in a lung-on-a-chip microdevice. Sci Transl Med 2012 2.52
19 Micropatterning tractional forces in living cells. Cell Motil Cytoskeleton 2002 2.45
20 High-betweenness proteins in the yeast protein interaction network. J Biomed Biotechnol 2005 2.44
21 Cell tension, matrix mechanics, and cancer development. Cancer Cell 2005 2.42
22 Mechanotransduction: all signals point to cytoskeleton, matrix, and integrins. Sci STKE 2002 2.36
23 Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow. Lab Chip 2012 2.36
24 Nanomagnetic actuation of receptor-mediated signal transduction. Nat Nanotechnol 2007 2.22
25 Microengineered physiological biomimicry: organs-on-chips. Lab Chip 2012 2.21
26 Control of basement membrane remodeling and epithelial branching morphogenesis in embryonic lung by Rho and cytoskeletal tension. Dev Dyn 2005 2.13
27 Intracellular stress tomography reveals stress focusing and structural anisotropy in cytoskeleton of living cells. Am J Physiol Cell Physiol 2003 2.09
28 Low urine vascular endothelial growth factor levels are associated with mechanical ventilation, bronchopulmonary dysplasia and retinopathy of prematurity. Neonatology 2013 2.06
29 Role of RhoA, mDia, and ROCK in cell shape-dependent control of the Skp2-p27kip1 pathway and the G1/S transition. J Biol Chem 2004 1.98
30 Combined microfluidic-micromagnetic separation of living cells in continuous flow. Biomed Microdevices 2006 1.96
31 Loss of polycystin-1 in human cyst-lining epithelia leads to ciliary dysfunction. J Am Soc Nephrol 2006 1.95
32 Self-assembly of three-dimensional prestressed tensegrity structures from DNA. Nat Nanotechnol 2010 1.95
33 Micromagnetic-microfluidic blood cleansing device. Lab Chip 2009 1.95
34 Geometric determinants of directional cell motility revealed using microcontact printing. Langmuir 2003 1.85
35 TRPV4 channels mediate cyclic strain-induced endothelial cell reorientation through integrin-to-integrin signaling. Circ Res 2009 1.84
36 Mechanochemical control of mesenchymal condensation and embryonic tooth organ formation. Dev Cell 2011 1.82
37 Angiopoietin-1 requires p190 RhoGAP to protect against vascular leakage in vivo. J Biol Chem 2007 1.81
38 Mechanosensitive mechanisms in transcriptional regulation. J Cell Sci 2012 1.76
39 Epoxyeicosanoids stimulate multiorgan metastasis and tumor dormancy escape in mice. J Clin Invest 2011 1.74
40 Selective chemical treatment of cellular microdomains using multiple laminar streams. Chem Biol 2003 1.74
41 Estrogen-receptor-alpha exchange and chromatin dynamics are ligand- and domain-dependent. J Cell Sci 2006 1.72
42 Directional control of cell motility through focal adhesion positioning and spatial control of Rac activation. FASEB J 2008 1.71
43 Extracellular matrix controls myosin light chain phosphorylation and cell contractility through modulation of cell shape and cytoskeletal prestress. Am J Physiol Cell Physiol 2004 1.68
44 Paper-supported 3D cell culture for tissue-based bioassays. Proc Natl Acad Sci U S A 2009 1.60
45 Tumor-derived endothelial cells exhibit aberrant Rho-mediated mechanosensing and abnormal angiogenesis in vitro. Proc Natl Acad Sci U S A 2008 1.60
46 Inhibition of endothelial cell migration by thrombospondin-1 type-1 repeats is mediated by beta1 integrins. J Cell Biol 2005 1.59
47 Alpha-actinin-4 is required for normal podocyte adhesion. J Biol Chem 2006 1.58
48 Multistable and multistep dynamics in neutrophil differentiation. BMC Cell Biol 2006 1.56
49 Gut-on-a-Chip microenvironment induces human intestinal cells to undergo villus differentiation. Integr Biol (Camb) 2013 1.54
50 Noise-driven stem cell and progenitor population dynamics. PLoS One 2008 1.52
51 Human kidney proximal tubule-on-a-chip for drug transport and nephrotoxicity assessment. Integr Biol (Camb) 2013 1.52
52 Forty-year journey of angiogenesis translational research. Sci Transl Med 2011 1.51
53 Filamin links cell shape and cytoskeletal structure to Rho regulation by controlling accumulation of p190RhoGAP in lipid rafts. J Cell Sci 2007 1.51
54 A non-genetic basis for cancer progression and metastasis: self-organizing attractors in cell regulatory networks. Breast Dis 2007 1.49
55 Mechanobiology and developmental control. Annu Rev Cell Dev Biol 2013 1.48
56 Cytoskeletal control of growth and cell fate switching. Curr Opin Cell Biol 2009 1.45
57 Microfabrication of human organs-on-chips. Nat Protoc 2013 1.44
58 Filamin A regulates focal adhesion disassembly and suppresses breast cancer cell migration and invasion. J Exp Med 2010 1.43
59 Global cytoskeletal control of mechanotransduction in kidney epithelial cells. Exp Cell Res 2004 1.43
60 Sequential involvement of Cdk1, mTOR and p53 in apoptosis induced by the HIV-1 envelope. EMBO J 2002 1.42
61 Ablation of cytoskeletal filaments and mitochondria in live cells using a femtosecond laser nanoscissor. Mech Chem Biosyst 2005 1.40
62 Micromechanical control of cell and tissue development: implications for tissue engineering. Adv Drug Deliv Rev 2007 1.36
63 A combined micromagnetic-microfluidic device for rapid capture and culture of rare circulating tumor cells. Lab Chip 2012 1.35
64 ABL2/ARG tyrosine kinase mediates SEMA3F-induced RhoA inactivation and cytoskeleton collapse in human glioma cells. J Biol Chem 2008 1.34
65 Mechanical properties of individual focal adhesions probed with a magnetic microneedle. Biochem Biophys Res Commun 2004 1.29
66 Rheological behavior of living cells is timescale-dependent. Biophys J 2007 1.29
67 Evidence by molecular profiling for a placental origin of infantile hemangioma. Proc Natl Acad Sci U S A 2005 1.28
68 Carbon metabolism-mediated myogenic differentiation. Nat Chem Biol 2010 1.25
69 Extracellular matrix, mechanotransduction and structural hierarchies in heart tissue engineering. Philos Trans R Soc Lond B Biol Sci 2007 1.24
70 Ultra-rapid activation of TRPV4 ion channels by mechanical forces applied to cell surface beta1 integrins. Integr Biol (Camb) 2010 1.23
71 Towards a holistic, yet gene-centered analysis of gene expression profiles: a case study of human lung cancers. J Biomed Biotechnol 2006 1.22
72 Alpha4beta1-dependent adhesion strengthening under mechanical strain is regulated by paxillin association with the alpha4-cytoplasmic domain. J Cell Biol 2005 1.17
73 Rho signaling and mechanical control of vascular development. Curr Opin Hematol 2008 1.17
74 Engineered in vitro disease models. Annu Rev Pathol 2015 1.16
75 Magnetically-guided self-assembly of fibrin matrices with ordered nano-scale structure for tissue engineering. Tissue Eng 2006 1.13
76 Investigating complexity of protein-protein interactions in focal adhesions. Biochem Biophys Res Commun 2008 1.11
77 Fibronectin unfolding revisited: modeling cell traction-mediated unfolding of the tenth type-III repeat. PLoS One 2008 1.10
78 Caldesmon-dependent switching between capillary endothelial cell growth and apoptosis through modulation of cell shape and contractility. Angiogenesis 2003 1.10
79 A computational tensegrity model predicts dynamic rheological behaviors in living cells. Ann Biomed Eng 2004 1.09
80 A Wnt-bmp feedback circuit controls intertissue signaling dynamics in tooth organogenesis. Sci Signal 2012 1.09
81 Multizone paper platform for 3D cell cultures. PLoS One 2011 1.09
82 A discrete cell cycle checkpoint in late G(1) that is cytoskeleton-dependent and MAP kinase (Erk)-independent. Exp Cell Res 2002 1.08
83 Epoxyeicosanoids promote organ and tissue regeneration. Proc Natl Acad Sci U S A 2013 1.08
84 Tensegrity, cellular biophysics, and the mechanics of living systems. Rep Prog Phys 2014 1.06
85 Tumor growth and angiogenesis are dependent on the presence of immature dendritic cells. FASEB J 2009 1.06
86 Discovery of potent and practical antiangiogenic agents inspired by cortistatin A. J Am Chem Soc 2009 1.06
87 Paxillin mediates sensing of physical cues and regulates directional cell motility by controlling lamellipodia positioning. PLoS One 2011 1.06
88 Intact vinculin protein is required for control of cell shape, cell mechanics, and rac-dependent lamellipodia formation. Biochem Biophys Res Commun 2002 1.05
89 Absence of cyclooxygenase-2 exacerbates hypoxia-induced pulmonary hypertension and enhances contractility of vascular smooth muscle cells. Circulation 2008 1.05
90 Force meets chemistry: analysis of mechanochemical conversion in focal adhesions using fluorescence recovery after photobleaching. J Cell Biochem 2006 1.04
91 Novel dynamic rheological behavior of individual focal adhesions measured within single cells using electromagnetic pulling cytometry. Acta Biomater 2005 1.04
92 Integrins beta1, alpha6, and alpha3 contribute to mechanical strain-induced differentiation of fetal lung type II epithelial cells via distinct mechanisms. Am J Physiol Lung Cell Mol Physiol 2005 1.03
93 Silencing HoxA1 by intraductal injection of siRNA lipidoid nanoparticles prevents mammary tumor progression in mice. Sci Transl Med 2014 1.03
94 A multi-modular tensegrity model of an actin stress fiber. J Biomech 2008 1.03
95 Mechanotransduction of fluid stresses governs 3D cell migration. Proc Natl Acad Sci U S A 2014 1.02
96 Nogo-A is a negative regulator of CNS angiogenesis. Proc Natl Acad Sci U S A 2013 1.02
97 A mathematical model to determine molecular kinetic rate constants under non-steady state conditions using fluorescence recovery after photobleaching (FRAP). Biophys Chem 2005 1.01
98 Tools to study cell mechanics and mechanotransduction. Methods Cell Biol 2007 1.01
99 Methods for measuring rates of protein binding to insoluble scaffolds in living cells: histone H1-chromatin interactions. J Cell Biochem 2006 1.00
100 Control of embryonic lung branching morphogenesis by the Rho activator, cytotoxic necrotizing factor 1. J Surg Res 2002 1.00
101 Synaptic reorganization in scaled networks of controlled size. J Neurosci 2007 0.97
102 Control of lung vascular permeability and endotoxin-induced pulmonary oedema by changes in extracellular matrix mechanics. Nat Commun 2013 0.94
103 A mini-microscope for in situ monitoring of cells. Lab Chip 2012 0.93
104 Mechanical control of cAMP signaling through integrins is mediated by the heterotrimeric Galphas protein. J Cell Biochem 2009 0.93
105 Tensile forces stimulate vascular remodeling and epidermal cell proliferation in living skin. Ann Surg 2007 0.92
106 Platform for high-throughput testing of the effect of soluble compounds on 3D cell cultures. Anal Chem 2013 0.92
107 An improved mathematical approach for determination of molecular kinetics in living cells with FRAP. Mech Chem Biosyst 2004 0.91
108 l-Caldesmon regulates proliferation and migration of vascular smooth muscle cells and inhibits neointimal formation after angioplasty. Arterioscler Thromb Vasc Biol 2006 0.89
109 Paxillin controls endothelial cell migration and tumor angiogenesis by altering neuropilin 2 expression. J Cell Sci 2014 0.87
110 Developmentally-inspired shrink-wrap polymers for mechanical induction of tissue differentiation. Adv Mater 2014 0.87
111 Inhibition of mammary tumor growth using lysyl oxidase-targeting nanoparticles to modify extracellular matrix. Nano Lett 2012 0.86
112 A microdevice for rapid optical detection of magnetically captured rare blood pathogens. Lab Chip 2014 0.86
113 How changes in extracellular matrix mechanics and gene expression variability might combine to drive cancer progression. PLoS One 2013 0.86
114 Intraductal injection for localized drug delivery to the mouse mammary gland. J Vis Exp 2013 0.85
115 SLLISWD sequence in the 10FNIII domain initiates fibronectin fibrillogenesis. J Biol Chem 2013 0.84
116 Clear castable polyurethane elastomer for fabrication of microfluidic devices. Lab Chip 2013 0.84
117 Breast cancer normalization induced by embryonic mesenchyme is mediated by extracellular matrix biglycan. Integr Biol (Camb) 2013 0.82
118 Developing microphysiological systems for use as regulatory tools--challenges and opportunities. ALTEX 2014 0.82
119 Organs on Chips 2013. Lab Chip 2013 0.81
120 Nanostructured magnetizable materials that switch cells between life and death. Biomaterials 2007 0.81
121 Paxillin controls directional cell motility in response to physical cues. Cell Adh Migr 2012 0.81
122 LRP5 regulates development of lung microvessels and alveoli through the angiopoietin-Tie2 pathway. PLoS One 2012 0.81
123 Polymeric nanomaterials for islet targeting and immunotherapeutic delivery. Nano Lett 2011 0.80
124 Magnetic Cellular Switches. IEEE Trans Magn 2004 0.80
125 Measuring direct current trans-epithelial electrical resistance in organ-on-a-chip microsystems. Lab Chip 2015 0.80
126 Unexpected strength and toughness in chitosan-fibroin laminates inspired by insect cuticle. Adv Mater 2011 0.79
127 Methods for studying mechanical control of angiogenesis by the cytoskeleton and extracellular matrix. Methods Enzymol 2008 0.76
128 Using self-assembled monolayers to pattern ECM proteins and cells on substrates. Methods Mol Biol 2009 0.76
129 Lab on a chip: United States of America. Lab Chip 2012 0.76
130 Identification of a distinct class of cytoskeleton-associated mRNAs using microarray technology. BMC Cell Biol 2003 0.76
131 Reply: To PMID 23711562. Neonatology 2013 0.75
132 Mononuclear cells from dedifferentiation of mouse myotubes display remarkable regenerative capability. Stem Cells 2014 0.75
133 Organs-on-chips with integrated electrodes for trans-epithelial electrical resistance (TEER) measurements of human epithelial barrier function. Lab Chip 2017 0.75
134 Interview with Donald E Ingber. Nanomedicine (Lond) 2014 0.75