Published in J Mol Biol on February 07, 2003
Human telomere, oncogenic promoter and 5'-UTR G-quadruplexes: diverse higher order DNA and RNA targets for cancer therapeutics. Nucleic Acids Res (2007) 3.49
Structure of the human telomere in K+ solution: an intramolecular (3 + 1) G-quadruplex scaffold. J Am Chem Soc (2006) 3.26
Two-repeat human telomeric d(TAGGGTTAGGGT) sequence forms interconverting parallel and antiparallel G-quadruplexes in solution: distinct topologies, thermodynamic properties, and folding/unfolding kinetics. J Am Chem Soc (2003) 2.52
DNA architecture: from G to Z. Curr Opin Struct Biol (2006) 1.97
G-quadruplex nucleic acids as therapeutic targets. Curr Opin Chem Biol (2009) 1.74
Detection of G-quadruplex DNA in mammalian cells. Nucleic Acids Res (2013) 1.53
Biophysical studies of the c-MYC NHE III1 promoter: model quadruplex interactions with a cationic porphyrin. Biophys J (2006) 1.20
Two-repeat Tetrahymena telomeric d(TGGGGTTGGGGT) Sequence interconverts between asymmetric dimeric G-quadruplexes in solution. J Mol Biol (2004) 1.19
Solution structure of a 2:1 quindoline-c-MYC G-quadruplex: insights into G-quadruplex-interactive small molecule drug design. J Am Chem Soc (2011) 1.17
A crystallographic and modelling study of a human telomeric RNA (TERRA) quadruplex. Nucleic Acids Res (2010) 1.16
Molecular dynamics and principal components analysis of human telomeric quadruplex multimers. Biophys J (2008) 1.16
Genome-wide analysis of a G-quadruplex-specific single-chain antibody that regulates gene expression. Nucleic Acids Res (2009) 1.15
A thymine tetrad in d(TGGGGT) quadruplexes stabilized with Tl+/Na+ ions. Nucleic Acids Res (2004) 1.14
Crystal structure of a c-kit promoter quadruplex reveals the structural role of metal ions and water molecules in maintaining loop conformation. Nucleic Acids Res (2012) 1.01
Guanine base stacking in G-quadruplex nucleic acids. Nucleic Acids Res (2012) 0.92
Templated ligand assembly by using G-quadruplex DNA and dynamic covalent chemistry. Angew Chem Int Ed Engl (2004) 0.92
Automatic workflow for the classification of local DNA conformations. BMC Bioinformatics (2013) 0.89
New approaches of PARP-1 inhibitors in human lung cancer cells and cancer stem-like cells by some selected anthraquinone-derived small molecules. PLoS One (2013) 0.89
Synthesis and G-quadruplex binding studies of new 4-N-methylpyridinium porphyrins. Org Biomol Chem (2006) 0.87
Sequence, stability, and structure of G-quadruplexes and their interactions with drugs. Curr Protoc Nucleic Acid Chem (2012) 0.85
N-methylmesoporphyrin IX fluorescence as a reporter of strand orientation in guanine quadruplexes. FEBS J (2014) 0.84
Structure-based DNA-targeting strategies with small molecule ligands for drug discovery. Med Res Rev (2013) 0.84
End-stacking of copper cationic porphyrins on parallel-stranded guanine quadruplexes. J Biol Inorg Chem (2007) 0.84
Studies on the site and mode of TMPyP4 interactions with Bcl-2 promoter sequence G-Quadruplexes. Biophys J (2010) 0.83
RNautophagy/DNautophagy possesses selectivity for RNA/DNA substrates. Nucleic Acids Res (2015) 0.83
Rational design of substituted diarylureas: a scaffold for binding to G-quadruplex motifs. J Med Chem (2008) 0.82
Synthesis of unimolecularly circular G-quadruplexes as prospective molecular probes. Nucleic Acids Res (2004) 0.82
Recognition and discrimination of DNA quadruplexes by acridine-peptide conjugates. Org Biomol Chem (2008) 0.81
DSC deconvolution of the structural complexity of c-MYC P1 promoter G-quadruplexes. Biophys J (2011) 0.81
The high-resolution crystal structure of a parallel intermolecular DNA G-4 quadruplex/drug complex employing syn glycosyl linkages. Nucleic Acids Res (2012) 0.80
Targeting human telomerase for cancer therapeutics. Cytotechnology (2004) 0.79
Structural studies on dinuclear ruthenium(II) complexes that bind diastereoselectively to an antiparallel folded human telomere sequence. J Med Chem (2013) 0.78
Refinement of Generalized Born Implicit Solvation Parameters for Nucleic Acids and Their Complexes with Proteins. J Chem Theory Comput (2015) 0.78
Molecular dynamics studies of the 3D structure and planar ligand binding of a quadruplex dimer. J Mol Model (2010) 0.78
Gaining insights into the small molecule targeting of the G-quadruplex in the c-MYC promoter using NMR and an allele-specific transcriptional assay. Top Curr Chem (2013) 0.77
Classification of g-quadruplex DNA on the basis of the quadruplex twist angle and planarity of g-quartets. Acta Naturae (2010) 0.76
New insights from molecular dynamic simulation studies of the multiple binding modes of a ligand with G-quadruplex DNA. J Comput Aided Mol Des (2012) 0.76
Synthesis and g-quadruplex-binding properties of defined acridine oligomers. J Nucleic Acids (2010) 0.76
The MOD-QM/MM Method: Applications to Studies of Photosystem II and DNA G-Quadruplexes. Methods Enzymol (2016) 0.75
Distance measurements between paramagnetic ligands bound to parallel stranded guanine quadruplexes. Phys Chem Chem Phys (2016) 0.75
Bcl-2 promoter sequence G-quadruplex interactions with three planar and non-planar cationic porphyrins: TMPyP4, TMPyP3, and TMPyP2. PLoS One (2013) 0.75
Crystal structure of parallel quadruplexes from human telomeric DNA. Nature (2002) 8.90
Quadruplex DNA: sequence, topology and structure. Nucleic Acids Res (2006) 6.42
Highly prevalent putative quadruplex sequence motifs in human DNA. Nucleic Acids Res (2005) 5.34
Targeting G-quadruplexes in gene promoters: a novel anticancer strategy? Nat Rev Drug Discov (2011) 3.54
Putative DNA quadruplex formation within the human c-kit oncogene. J Am Chem Soc (2005) 3.28
Loop-length-dependent folding of G-quadruplexes. J Am Chem Soc (2004) 3.16
A conserved quadruplex motif located in a transcription activation site of the human c-kit oncogene. Biochemistry (2006) 2.62
The structure of telomeric DNA. Curr Opin Struct Biol (2003) 2.32
Crystal structure of the potassium form of an Oxytricha nova G-quadruplex. J Mol Biol (2002) 2.29
Structure of an unprecedented G-quadruplex scaffold in the human c-kit promoter. J Am Chem Soc (2007) 2.26
The G-quadruplex-interactive molecule BRACO-19 inhibits tumor growth, consistent with telomere targeting and interference with telomerase function. Cancer Res (2005) 1.84
G-quadruplex nucleic acids as therapeutic targets. Curr Opin Chem Biol (2009) 1.74
The application of DNA and RNA G-quadruplexes to therapeutic medicines. Chem Soc Rev (2011) 1.54
A G-rich sequence within the c-kit oncogene promoter forms a parallel G-quadruplex having asymmetric G-tetrad dynamics. J Am Chem Soc (2009) 1.40
Structural basis for binding of porphyrin to human telomeres. Biochemistry (2007) 1.37
A G-quadruplex-interactive potent small-molecule inhibitor of telomerase exhibiting in vitro and in vivo antitumor activity. Mol Pharmacol (2002) 1.33
Structure-specific recognition of quadruplex DNA by organic cations: influence of shape, substituents and charge. Biophys Chem (2006) 1.32
H-NS forms a superhelical protein scaffold for DNA condensation. Proc Natl Acad Sci U S A (2010) 1.30
Structure of the first parallel DNA quadruplex-drug complex. J Am Chem Soc (2003) 1.26
Structural basis of DNA quadruplex recognition by an acridine drug. J Am Chem Soc (2008) 1.25
Sequence occurrence and structural uniqueness of a G-quadruplex in the human c-kit promoter. Nucleic Acids Res (2007) 1.24
Thiophene-based diamidine forms a "super" at binding minor groove agent. J Am Chem Soc (2004) 1.18
A crystallographic and modelling study of a human telomeric RNA (TERRA) quadruplex. Nucleic Acids Res (2010) 1.16
Molecular dynamics and principal components analysis of human telomeric quadruplex multimers. Biophys J (2008) 1.16
Stabilization of G-quadruplex DNA and inhibition of telomerase activity by square-planar nickel(II) complexes. J Am Chem Soc (2006) 1.15
Quadruplex DNA crystal structures and drug design. Biochimie (2008) 1.15
Targeting human gastrointestinal stromal tumor cells with a quadruplex-binding small molecule. J Med Chem (2009) 1.15
Out-of-shape DNA minor groove binders: induced fit interactions of heterocyclic dications with the DNA minor groove. Biochemistry (2005) 1.12
Trisubstituted acridines as G-quadruplex telomere targeting agents. Effects of extensions of the 3,6- and 9-side chains on quadruplex binding, telomerase activity, and cell proliferation. J Med Chem (2006) 1.11
A G-quadruplex telomere targeting agent produces p16-associated senescence and chromosomal fusions in human prostate cancer cells. Mol Cancer Ther (2004) 1.11
A role for water molecules in DNA-ligand minor groove recognition. Acc Chem Res (2009) 1.10
Aminoacyl-anthraquinone conjugates as telomerase inhibitors: synthesis, biophysical and biological evaluation. J Med Chem (2008) 1.10
Synthesis and evaluation of analogues of 10H-indolo[3,2-b]quinoline as G-quadruplex stabilising ligands and potential inhibitors of the enzyme telomerase. Org Biomol Chem (2004) 1.09
Effects of metal coordination geometry on stabilization of human telomeric quadruplex DNA by square-planar and square-pyramidal metal complexes. Inorg Chem (2008) 1.09
The design of G-quadruplex ligands as telomerase inhibitors. Mini Rev Med Chem (2003) 1.08
Topology conservation and loop flexibility in quadruplex-drug recognition: crystal structures of inter- and intramolecular telomeric DNA quadruplex-drug complexes. J Mol Biol (2008) 1.08
Electrospray mass spectrometry of telomeric RNA (TERRA) reveals the formation of stable multimeric G-quadruplex structures. J Am Chem Soc (2010) 1.07
Strong binding in the DNA minor groove by an aromatic diamidine with a shape that does not match the curvature of the groove. J Am Chem Soc (2002) 1.06
The relationship of potential G-quadruplex sequences in cis-upstream regions of the human genome to SP1-binding elements. Nucleic Acids Res (2008) 1.06
Studies on the nitroreductase prodrug-activating system. Crystal structures of complexes with the inhibitor dicoumarol and dinitrobenzamide prodrugs and of the enzyme active form. J Med Chem (2003) 1.05
Characterization of a novel DNA minor-groove complex. Biophys J (2004) 1.04
Structural basis of telomeric RNA quadruplex--acridine ligand recognition. J Am Chem Soc (2011) 1.03
Predictive modelling of topology and loop variations in dimeric DNA quadruplex structures. Nucleic Acids Res (2006) 1.02
Exploring the recognition of quadruplex DNA by an engineered Cys2-His2 zinc finger protein. Biochemistry (2006) 1.02
Crystal structure of a c-kit promoter quadruplex reveals the structural role of metal ions and water molecules in maintaining loop conformation. Nucleic Acids Res (2012) 1.01
Structural basis for telomeric G-quadruplex targeting by naphthalene diimide ligands. J Am Chem Soc (2012) 1.01
Trisubstituted acridine derivatives as potent and selective telomerase inhibitors. J Med Chem (2003) 0.99
Observation of unphosphorylated STAT3 core protein binding to target dsDNA by PEMSA and X-ray crystallography. FEBS Lett (2013) 0.98
On the function of the internal cavity of histone deacetylase protein 8: R37 is a crucial residue for catalysis. Bioorg Med Chem Lett (2011) 0.97
Mechanism of acridine-based telomerase inhibition and telomere shortening. Biochem Pharmacol (2007) 0.96
Natural and synthetic G-quadruplex interactive berberine derivatives. Bioorg Med Chem Lett (2006) 0.96
Evaluation of by disubstituted acridone derivatives as telomerase inhibitors: the importance of G-quadruplex binding. Bioorg Med Chem Lett (2004) 0.95
Shedding light on the interaction between TMPyP4 and human telomeric quadruplexes. J Phys Chem B (2009) 0.95
Water-mediated binding of agents that target the DNA minor groove. J Am Chem Soc (2011) 0.94
Selectivity in ligand recognition of G-quadruplex loops. Biochemistry (2009) 0.94
Topology variation and loop structural homology in crystal and simulated structures of a bimolecular DNA quadruplex. J Am Chem Soc (2006) 0.93
Stabilization of G-quadruplex DNA by highly selective ligands via click chemistry. J Am Chem Soc (2006) 0.93
Molecular modeling and simulation of G-quadruplexes and quadruplex-ligand complexes. Methods Mol Biol (2010) 0.93
A structural analysis of G-quadruplex/ligand interactions. Biochimie (2011) 0.92
Protein and drug interactions in the minor groove of DNA. Nucleic Acids Res (2002) 0.92
Induced fit conformational changes of a "reversed amidine" heterocycle: optimized interactions in a DNA minor groove complex. J Am Chem Soc (2007) 0.92
Structure-activity relationships of monomeric C2-aryl pyrrolo[2,1-c][1,4]benzodiazepine (PBD) antitumor agents. J Med Chem (2010) 0.92
Selectivity in small molecule binding to human telomeric RNA and DNA quadruplexes. Chem Commun (Camb) (2009) 0.91
Small-molecule binding to the DNA minor groove is mediated by a conserved water cluster. J Am Chem Soc (2013) 0.89
Molecular basis of structure-activity relationships between salphen metal complexes and human telomeric DNA quadruplexes. J Med Chem (2011) 0.88
Xanthene and xanthone derivatives as G-quadruplex stabilizing ligands. Molecules (2013) 0.88
Tetrasubstituted naphthalene diimide ligands with selectivity for telomeric G-quadruplexes and cancer cells. Bioorg Med Chem Lett (2010) 0.88
Tri- and tetra-substituted naphthalene diimides as potent G-quadruplex ligands. Bioorg Med Chem Lett (2008) 0.88
TRAP-LIG, a modified telomere repeat amplification protocol assay to quantitate telomerase inhibition by small molecules. Anal Biochem (2008) 0.87
Defining the mechanism of action and enzymatic selectivity of psammaplin A against its epigenetic targets. J Med Chem (2012) 0.87
G-quadruplexes and metal ions. Met Ions Life Sci (2012) 0.87
Bioactive pyridine-N-oxide disulfides from Allium stipitatum. J Nat Prod (2009) 0.87
Molecular modeling on inhibitor complexes and active-site dynamics of cytochrome P450 C17, a target for prostate cancer therapy. J Mol Biol (2010) 0.87
Amide bond direction modulates G-quadruplex recognition and telomerase inhibition by 2,6 and 2,7 bis-substituted anthracenedione derivatives. Bioorg Med Chem (2007) 0.86
Conformational dynamics of the human propeller telomeric DNA quadruplex on a microsecond time scale. Nucleic Acids Res (2013) 0.86
Observation of the coexistence of sodium and calcium ions in a DNA G-quadruplex ion channel. J Am Chem Soc (2007) 0.86
Stabilisation of human telomeric quadruplex DNA and inhibition of telomerase by a platinum-phenanthroline complex. Chem Commun (Camb) (2007) 0.86
Structure-based design of selective high-affinity telomeric quadruplex-binding ligands. Chem Commun (Camb) (2010) 0.85