Published in Nucleic Acids Res on May 24, 2005
Prevalence of quadruplexes in the human genome. Nucleic Acids Res (2005) 7.79
Quadruplex DNA: sequence, topology and structure. Nucleic Acids Res (2006) 6.42
G-quadruplexes in promoters throughout the human genome. Nucleic Acids Res (2006) 5.84
Quantitative visualization of DNA G-quadruplex structures in human cells. Nat Chem (2013) 4.61
Targeting G-quadruplexes in gene promoters: a novel anticancer strategy? Nat Rev Drug Discov (2011) 3.54
Human telomere, oncogenic promoter and 5'-UTR G-quadruplexes: diverse higher order DNA and RNA targets for cancer therapeutics. Nucleic Acids Res (2007) 3.49
Putative DNA quadruplex formation within the human c-kit oncogene. J Am Chem Soc (2005) 3.28
Circular dichroism and conformational polymorphism of DNA. Nucleic Acids Res (2009) 3.20
DNA secondary structures: stability and function of G-quadruplex structures. Nat Rev Genet (2012) 3.15
Gene function correlates with potential for G4 DNA formation in the human genome. Nucleic Acids Res (2006) 3.13
QGRS Mapper: a web-based server for predicting G-quadruplexes in nucleotide sequences. Nucleic Acids Res (2006) 2.62
A conserved quadruplex motif located in a transcription activation site of the human c-kit oncogene. Biochemistry (2006) 2.62
Not so crystal clear: the structure of the human telomere G-quadruplex in solution differs from that present in a crystal. Nucleic Acids Res (2005) 2.57
Small-molecule-induced DNA damage identifies alternative DNA structures in human genes. Nat Chem Biol (2012) 2.41
Structures, folding patterns, and functions of intramolecular DNA G-quadruplexes found in eukaryotic promoter regions. Biochimie (2008) 2.38
Non-B DNA structure-induced genetic instability and evolution. Cell Mol Life Sci (2009) 2.37
5'-UTR RNA G-quadruplexes: translation regulation and targeting. Nucleic Acids Res (2012) 2.36
The yeast Pif1 helicase prevents genomic instability caused by G-quadruplex-forming CEB1 sequences in vivo. PLoS Genet (2009) 2.32
Conserved elements with potential to form polymorphic G-quadruplex structures in the first intron of human genes. Nucleic Acids Res (2008) 2.27
Structure of an unprecedented G-quadruplex scaffold in the human c-kit promoter. J Am Chem Soc (2007) 2.26
G-quadruplexes: the beginning and end of UTRs. Nucleic Acids Res (2008) 2.18
Genome-wide prediction of G4 DNA as regulatory motifs: role in Escherichia coli global regulation. Genome Res (2006) 2.12
Genomic distribution and functional analyses of potential G-quadruplex-forming sequences in Saccharomyces cerevisiae. Nucleic Acids Res (2007) 1.98
DNA architecture: from G to Z. Curr Opin Struct Biol (2006) 1.97
Deconvoluting the structural and drug-recognition complexity of the G-quadruplex-forming region upstream of the bcl-2 P1 promoter. J Am Chem Soc (2006) 1.93
Trisubstituted isoalloxazines as a new class of G-quadruplex binding ligands: small molecule regulation of c-kit oncogene expression. J Am Chem Soc (2007) 1.87
A sequence-independent study of the influence of short loop lengths on the stability and topology of intramolecular DNA G-quadruplexes. Biochemistry (2007) 1.75
G-quadruplex nucleic acids as therapeutic targets. Curr Opin Chem Biol (2009) 1.74
G-quadruplex structures are stable and detectable in human genomic DNA. Nat Commun (2013) 1.72
GRSDB: a database of quadruplex forming G-rich sequences in alternatively processed mammalian pre-mRNA sequences. Nucleic Acids Res (2006) 1.54
Discrimination of common and unique RNA-binding activities among Fragile X mental retardation protein paralogs. Hum Mol Genet (2009) 1.53
Detection of G-quadruplex DNA in mammalian cells. Nucleic Acids Res (2013) 1.53
Formation of the G-quadruplex and i-motif structures in retinoblastoma susceptibility genes (Rb). Nucleic Acids Res (2006) 1.49
5'-UTR G-quadruplex structures acting as translational repressors. Nucleic Acids Res (2010) 1.49
G-quadruplex DNA sequences are evolutionarily conserved and associated with distinct genomic features in Saccharomyces cerevisiae. PLoS Comput Biol (2010) 1.47
Homologous recombination is required for genome stability in the absence of DOG-1 in Caenorhabditis elegans. Genetics (2006) 1.47
Altered gene expression in the Werner and Bloom syndromes is associated with sequences having G-quadruplex forming potential. Nucleic Acids Res (2009) 1.44
A G-rich sequence within the c-kit oncogene promoter forms a parallel G-quadruplex having asymmetric G-tetrad dynamics. J Am Chem Soc (2009) 1.40
Genome-wide analysis reveals regulatory role of G4 DNA in gene transcription. Genome Res (2007) 1.39
Structure-function studies of FMRP RGG peptide recognition of an RNA duplex-quadruplex junction. Nat Struct Mol Biol (2011) 1.38
QuadBase: genome-wide database of G4 DNA--occurrence and conservation in human, chimpanzee, mouse and rat promoters and 146 microbes. Nucleic Acids Res (2007) 1.35
Inhibition of translation in living eukaryotic cells by an RNA G-quadruplex motif. RNA (2008) 1.34
G4 resolvase 1 binds both DNA and RNA tetramolecular quadruplex with high affinity and is the major source of tetramolecular quadruplex G4-DNA and G4-RNA resolving activity in HeLa cell lysates. J Biol Chem (2008) 1.32
Intramolecular DNA quadruplexes with different arrangements of short and long loops. Nucleic Acids Res (2007) 1.30
Formation of a G-quadruplex at the BCL2 major breakpoint region of the t(14;18) translocation in follicular lymphoma. Nucleic Acids Res (2010) 1.30
Evidence of genome-wide G4 DNA-mediated gene expression in human cancer cells. Nucleic Acids Res (2009) 1.28
Quadfinder: server for identification and analysis of quadruplex-forming motifs in nucleotide sequences. Nucleic Acids Res (2006) 1.26
Sequence occurrence and structural uniqueness of a G-quadruplex in the human c-kit promoter. Nucleic Acids Res (2007) 1.24
GRSDB2 and GRS_UTRdb: databases of quadruplex forming G-rich sequences in pre-mRNAs and mRNAs. Nucleic Acids Res (2007) 1.24
Predicting and understanding the stability of G-quadruplexes. Bioinformatics (2009) 1.23
Single-molecule investigation of G-quadruplex folds of the human telomere sequence in a protein nanocavity. Proc Natl Acad Sci U S A (2014) 1.21
G-quadruplex structures in RNA stimulate mitochondrial transcription termination and primer formation. Proc Natl Acad Sci U S A (2010) 1.21
Biophysical studies of the c-MYC NHE III1 promoter: model quadruplex interactions with a cationic porphyrin. Biophys J (2006) 1.20
Oxazole-based peptide macrocycles: a new class of G-quadruplex binding ligands. J Am Chem Soc (2006) 1.20
Genome-wide analyses of recombination prone regions predict role of DNA structural motif in recombination. PLoS One (2009) 1.14
A G-quadruplex structure within the 5'-UTR of TRF2 mRNA represses translation in human cells. Nucleic Acids Res (2010) 1.13
A non-canonical DNA structure is a binding motif for the transcription factor SP1 in vitro. Nucleic Acids Res (2011) 1.12
Predictable suppression of gene expression by 5'-UTR-based RNA quadruplexes. Nucleic Acids Res (2009) 1.11
Quartets in G-major. The First International Meeting on Quadruplex DNA. EMBO Rep (2007) 1.11
Interaction of human telomeric DNA with N-methyl mesoporphyrin IX. Nucleic Acids Res (2012) 1.11
Macrocyclic and helical oligoamides as a new class of G-quadruplex ligands. J Am Chem Soc (2007) 1.10
G4 resolvase 1 tightly binds and unwinds unimolecular G4-DNA. Nucleic Acids Res (2011) 1.09
Exploring mRNA 3'-UTR G-quadruplexes: evidence of roles in both alternative polyadenylation and mRNA shortening. Nucleic Acids Res (2013) 1.07
Greglist: a database listing potential G-quadruplex regulated genes. Nucleic Acids Res (2007) 1.07
The relationship of potential G-quadruplex sequences in cis-upstream regions of the human genome to SP1-binding elements. Nucleic Acids Res (2008) 1.06
Neil3 and NEIL1 DNA glycosylases remove oxidative damages from quadruplex DNA and exhibit preferences for lesions in the telomeric sequence context. J Biol Chem (2013) 1.05
The effect of osmolytes and small molecule on Quadruplex-WC duplex equilibrium: a fluorescence resonance energy transfer study. Nucleic Acids Res (2005) 1.04
The disruptive positions in human G-quadruplex motifs are less polymorphic and more conserved than their neutral counterparts. Nucleic Acids Res (2009) 1.04
Solution structures of all parallel-stranded monomeric and dimeric G-quadruplex scaffolds of the human c-kit2 promoter. Nucleic Acids Res (2010) 1.04
A chromatin structure-based model accurately predicts DNA replication timing in human cells. Mol Syst Biol (2014) 1.04
Determinants of G quadruplex-induced epigenetic instability in REV1-deficient cells. EMBO J (2014) 1.04
A sequence-independent analysis of the loop length dependence of intramolecular RNA G-quadruplex stability and topology. Biochemistry (2011) 1.04
The DEAH-box RNA helicase RHAU binds an intramolecular RNA G-quadruplex in TERC and associates with telomerase holoenzyme. Nucleic Acids Res (2011) 1.04
Exploring the differential recognition of DNA G-quadruplex targets by small molecules using dynamic combinatorial chemistry. Angew Chem Int Ed Engl (2008) 1.03
The KRAS promoter responds to Myc-associated zinc finger and poly(ADP-ribose) polymerase 1 proteins, which recognize a critical quadruplex-forming GA-element. J Biol Chem (2010) 1.03
Replication protein A unfolds G-quadruplex structures with varying degrees of efficiency. J Phys Chem B (2012) 1.02
A thermodynamic overview of naturally occurring intramolecular DNA quadruplexes. Nucleic Acids Res (2008) 1.02
Predictive modelling of topology and loop variations in dimeric DNA quadruplex structures. Nucleic Acids Res (2006) 1.02
Selective recognition of a DNA G-quadruplex by an engineered antibody. Biochemistry (2008) 1.02
Crystal structure of a c-kit promoter quadruplex reveals the structural role of metal ions and water molecules in maintaining loop conformation. Nucleic Acids Res (2012) 1.01
G-quadruplex folds of the human telomere sequence alter the site reactivity and reaction pathway of guanine oxidation compared to duplex DNA. Chem Res Toxicol (2013) 1.01
Effect of loop length variation on quadruplex-Watson Crick duplex competition. Nucleic Acids Res (2008) 1.00
COPI transport complexes bind to specific RNAs in neuronal cells. Hum Mol Genet (2012) 0.99
Specialization among iron-sulfur cluster helicases to resolve G-quadruplex DNA structures that threaten genomic stability. J Biol Chem (2013) 0.99
Position and stability are determining factors for translation repression by an RNA G-quadruplex-forming sequence within the 5' UTR of the NRAS proto-oncogene. Biochemistry (2008) 0.98
G-quadruplex DNA as a molecular target for induced synthetic lethality in cancer cells. J Am Chem Soc (2013) 0.98
QGRS-H Predictor: a web server for predicting homologous quadruplex forming G-rich sequence motifs in nucleotide sequences. Nucleic Acids Res (2012) 0.97
The NEIL glycosylases remove oxidized guanine lesions from telomeric and promoter quadruplex DNA structures. Nucleic Acids Res (2015) 0.97
Stability of intramolecular quadruplexes: sequence effects in the central loop. Nucleic Acids Res (2009) 0.97
The porphyrin TmPyP4 unfolds the extremely stable G-quadruplex in MT3-MMP mRNA and alleviates its repressive effect to enhance translation in eukaryotic cells. Nucleic Acids Res (2012) 0.97
Triarylpyridines: a versatile small molecule scaffold for G-quadruplex recognition. Chem Commun (Camb) (2008) 0.97
Genome-wide colonization of gene regulatory elements by G4 DNA motifs. Nucleic Acids Res (2009) 0.97
In vivo veritas: using yeast to probe the biological functions of G-quadruplexes. Biochimie (2008) 0.97
Mechanistic insight into the interaction of BLM helicase with intra-strand G-quadruplex structures. Nat Commun (2014) 0.97
Loop and backbone modifications of peptide nucleic acid improve g-quadruplex binding selectivity. J Am Chem Soc (2009) 0.96
Short loop length and high thermal stability determine genomic instability induced by G-quadruplex-forming minisatellites. EMBO J (2015) 0.94
Diarylethynyl amides that recognize the parallel conformation of genomic promoter DNA G-quadruplexes. J Am Chem Soc (2008) 0.94
MAZ-binding G4-decoy with locked nucleic acid and twisted intercalating nucleic acid modifications suppresses KRAS in pancreatic cancer cells and delays tumor growth in mice. Nucleic Acids Res (2013) 0.94
Arginine methylation of RNA-binding proteins regulates cell function and differentiation. Mol Reprod Dev (2012) 0.94
A toolbox for predicting g-quadruplex formation and stability. J Nucleic Acids (2010) 0.94
CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res (1994) 392.47
Sequence logos: a new way to display consensus sequences. Nucleic Acids Res (1990) 36.74
An overview of Ensembl. Genome Res (2004) 10.35
Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcription. Proc Natl Acad Sci U S A (2002) 9.60
Crystal structure of parallel quadruplexes from human telomeric DNA. Nature (2002) 8.90
Prevalence of quadruplexes in the human genome. Nucleic Acids Res (2005) 7.79
G-quartets 40 years later: from 5'-GMP to molecular biology and supramolecular chemistry. Angew Chem Int Ed Engl (2004) 4.20
DNA tetraplex formation in the control region of c-myc. Nucleic Acids Res (1998) 4.09
Propeller-type parallel-stranded G-quadruplexes in the human c-myc promoter. J Am Chem Soc (2004) 3.74
G-quadruplex DNA structures--variations on a theme. Biol Chem (2001) 3.36
Telomere maintenance as a target for anticancer drug discovery. Nat Rev Drug Discov (2002) 3.32
The dynamic character of the G-quadruplex element in the c-MYC promoter and modification by TMPyP4. J Am Chem Soc (2004) 3.19
Loop-length-dependent folding of G-quadruplexes. J Am Chem Soc (2004) 3.16
Studies on the structure and dynamics of the human telomeric G quadruplex by single-molecule fluorescence resonance energy transfer. Proc Natl Acad Sci U S A (2003) 2.82
Two-repeat human telomeric d(TAGGGTTAGGGT) sequence forms interconverting parallel and antiparallel G-quadruplexes in solution: distinct topologies, thermodynamic properties, and folding/unfolding kinetics. J Am Chem Soc (2003) 2.52
Human telomeric DNA: G-quadruplex, i-motif and Watson-Crick double helix. Nucleic Acids Res (2002) 2.35
Biophysical and biological properties of quadruplex oligodeoxyribonucleotides. Nucleic Acids Res (2003) 2.34
The structure of telomeric DNA. Curr Opin Struct Biol (2003) 2.32
Crystal structure of the potassium form of an Oxytricha nova G-quadruplex. J Mol Biol (2002) 2.29
Influence of loop size on the stability of intramolecular DNA quadruplexes. Nucleic Acids Res (2004) 1.99
Cell senescence and telomere shortening induced by a new series of specific G-quadruplex DNA ligands. Proc Natl Acad Sci U S A (2002) 1.75
An interlocked dimeric parallel-stranded DNA quadruplex: a potent inhibitor of HIV-1 integrase. Proc Natl Acad Sci U S A (2005) 1.71
Structure-based design of selective and potent G quadruplex-mediated telomerase inhibitors. Proc Natl Acad Sci U S A (2001) 1.69
Stability of intramolecular DNA quadruplexes: comparison with DNA duplexes. Biochemistry (2003) 1.66
Small change in a G-rich sequence, a dramatic change in topology: new dimeric G-quadruplex folding motif with unique loop orientations. J Am Chem Soc (2003) 1.60
Induction of duplex to G-quadruplex transition in the c-myc promoter region by a small molecule. J Biol Chem (2000) 1.54
Stabilization of the c-myc gene promoter quadruplex by specific ligands' inhibitors of telomerase. Biochem Biophys Res Commun (2004) 1.52
G-Quadruplex DNA as a target for drug design. Curr Pharm Des (2000) 1.45
Biological activity of the G-quadruplex ligand RHPS4 (3,11-difluoro-6,8,13-trimethyl-8H-quino[4,3,2-kl]acridinium methosulfate) is associated with telomere capping alteration. Mol Pharmacol (2004) 1.37
Formation of an interlocked quadruplex dimer by d(GGGT). J Am Chem Soc (2004) 1.37
Telomerase inhibition and cell growth arrest by G-quadruplex interactive agent in multiple myeloma. Mol Cancer Ther (2003) 1.26
Unusual DNA conformations: implications for telomeres. Curr Med Chem Anticancer Agents (2002) 1.10
Crystal structure of parallel quadruplexes from human telomeric DNA. Nature (2002) 8.90
Quadruplex DNA: sequence, topology and structure. Nucleic Acids Res (2006) 6.42
Targeting G-quadruplexes in gene promoters: a novel anticancer strategy? Nat Rev Drug Discov (2011) 3.54
Putative DNA quadruplex formation within the human c-kit oncogene. J Am Chem Soc (2005) 3.28
Loop-length-dependent folding of G-quadruplexes. J Am Chem Soc (2004) 3.16
A conserved quadruplex motif located in a transcription activation site of the human c-kit oncogene. Biochemistry (2006) 2.62
Crystal structure of the potassium form of an Oxytricha nova G-quadruplex. J Mol Biol (2002) 2.29
Structure of an unprecedented G-quadruplex scaffold in the human c-kit promoter. J Am Chem Soc (2007) 2.26
The G-quadruplex-interactive molecule BRACO-19 inhibits tumor growth, consistent with telomere targeting and interference with telomerase function. Cancer Res (2005) 1.84
G-quadruplex nucleic acids as therapeutic targets. Curr Opin Chem Biol (2009) 1.74
The meaning and measurement of implementation climate. Implement Sci (2011) 1.64
Structure of a G-quadruplex-ligand complex. J Mol Biol (2003) 1.49
A G-rich sequence within the c-kit oncogene promoter forms a parallel G-quadruplex having asymmetric G-tetrad dynamics. J Am Chem Soc (2009) 1.40
Structural basis for binding of porphyrin to human telomeres. Biochemistry (2007) 1.37
A G-quadruplex-interactive potent small-molecule inhibitor of telomerase exhibiting in vitro and in vivo antitumor activity. Mol Pharmacol (2002) 1.33
Structure-specific recognition of quadruplex DNA by organic cations: influence of shape, substituents and charge. Biophys Chem (2006) 1.32
Structure of the first parallel DNA quadruplex-drug complex. J Am Chem Soc (2003) 1.26
Structural basis of DNA quadruplex recognition by an acridine drug. J Am Chem Soc (2008) 1.25
Sequence occurrence and structural uniqueness of a G-quadruplex in the human c-kit promoter. Nucleic Acids Res (2007) 1.24
Thiophene-based diamidine forms a "super" at binding minor groove agent. J Am Chem Soc (2004) 1.18
A crystallographic and modelling study of a human telomeric RNA (TERRA) quadruplex. Nucleic Acids Res (2010) 1.16
Molecular dynamics and principal components analysis of human telomeric quadruplex multimers. Biophys J (2008) 1.16
Stabilization of G-quadruplex DNA and inhibition of telomerase activity by square-planar nickel(II) complexes. J Am Chem Soc (2006) 1.15
Targeting human gastrointestinal stromal tumor cells with a quadruplex-binding small molecule. J Med Chem (2009) 1.15
Out-of-shape DNA minor groove binders: induced fit interactions of heterocyclic dications with the DNA minor groove. Biochemistry (2005) 1.12
Trisubstituted acridines as G-quadruplex telomere targeting agents. Effects of extensions of the 3,6- and 9-side chains on quadruplex binding, telomerase activity, and cell proliferation. J Med Chem (2006) 1.11
A G-quadruplex telomere targeting agent produces p16-associated senescence and chromosomal fusions in human prostate cancer cells. Mol Cancer Ther (2004) 1.11
Aminoacyl-anthraquinone conjugates as telomerase inhibitors: synthesis, biophysical and biological evaluation. J Med Chem (2008) 1.10
A role for water molecules in DNA-ligand minor groove recognition. Acc Chem Res (2009) 1.10
Synthesis and evaluation of analogues of 10H-indolo[3,2-b]quinoline as G-quadruplex stabilising ligands and potential inhibitors of the enzyme telomerase. Org Biomol Chem (2004) 1.09
Effects of metal coordination geometry on stabilization of human telomeric quadruplex DNA by square-planar and square-pyramidal metal complexes. Inorg Chem (2008) 1.09
The design of G-quadruplex ligands as telomerase inhibitors. Mini Rev Med Chem (2003) 1.08
Topology conservation and loop flexibility in quadruplex-drug recognition: crystal structures of inter- and intramolecular telomeric DNA quadruplex-drug complexes. J Mol Biol (2008) 1.08
Electrospray mass spectrometry of telomeric RNA (TERRA) reveals the formation of stable multimeric G-quadruplex structures. J Am Chem Soc (2010) 1.07
Strong binding in the DNA minor groove by an aromatic diamidine with a shape that does not match the curvature of the groove. J Am Chem Soc (2002) 1.06
The relationship of potential G-quadruplex sequences in cis-upstream regions of the human genome to SP1-binding elements. Nucleic Acids Res (2008) 1.06
Studies on the nitroreductase prodrug-activating system. Crystal structures of complexes with the inhibitor dicoumarol and dinitrobenzamide prodrugs and of the enzyme active form. J Med Chem (2003) 1.05
Characterization of a novel DNA minor-groove complex. Biophys J (2004) 1.04
Structural basis of telomeric RNA quadruplex--acridine ligand recognition. J Am Chem Soc (2011) 1.03
Debye screening in single-molecule carbon nanotube field-effect sensors. Nano Lett (2011) 1.02
Predictive modelling of topology and loop variations in dimeric DNA quadruplex structures. Nucleic Acids Res (2006) 1.02
Exploring the recognition of quadruplex DNA by an engineered Cys2-His2 zinc finger protein. Biochemistry (2006) 1.02
Implementing community-based provider participation in research: an empirical study. Implement Sci (2012) 1.01
Crystal structure of a c-kit promoter quadruplex reveals the structural role of metal ions and water molecules in maintaining loop conformation. Nucleic Acids Res (2012) 1.01
Structural basis for telomeric G-quadruplex targeting by naphthalene diimide ligands. J Am Chem Soc (2012) 1.01
The Global Invertebrate Genomics Alliance (GIGA): developing community resources to study diverse invertebrate genomes. J Hered (2013) 1.00
Trisubstituted acridine derivatives as potent and selective telomerase inhibitors. J Med Chem (2003) 0.99
Observation of unphosphorylated STAT3 core protein binding to target dsDNA by PEMSA and X-ray crystallography. FEBS Lett (2013) 0.98
On the function of the internal cavity of histone deacetylase protein 8: R37 is a crucial residue for catalysis. Bioorg Med Chem Lett (2011) 0.97
Natural and synthetic G-quadruplex interactive berberine derivatives. Bioorg Med Chem Lett (2006) 0.96
Mechanism of acridine-based telomerase inhibition and telomere shortening. Biochem Pharmacol (2007) 0.96
Evaluation of by disubstituted acridone derivatives as telomerase inhibitors: the importance of G-quadruplex binding. Bioorg Med Chem Lett (2004) 0.95
Shedding light on the interaction between TMPyP4 and human telomeric quadruplexes. J Phys Chem B (2009) 0.95
Selectivity in ligand recognition of G-quadruplex loops. Biochemistry (2009) 0.94
Water-mediated binding of agents that target the DNA minor groove. J Am Chem Soc (2011) 0.94
Topology variation and loop structural homology in crystal and simulated structures of a bimolecular DNA quadruplex. J Am Chem Soc (2006) 0.93
Molecular modeling and simulation of G-quadruplexes and quadruplex-ligand complexes. Methods Mol Biol (2010) 0.93
Stabilization of G-quadruplex DNA by highly selective ligands via click chemistry. J Am Chem Soc (2006) 0.93
A structural analysis of G-quadruplex/ligand interactions. Biochimie (2011) 0.92
Protein and drug interactions in the minor groove of DNA. Nucleic Acids Res (2002) 0.92
Induced fit conformational changes of a "reversed amidine" heterocycle: optimized interactions in a DNA minor groove complex. J Am Chem Soc (2007) 0.92
Structure-activity relationships of monomeric C2-aryl pyrrolo[2,1-c][1,4]benzodiazepine (PBD) antitumor agents. J Med Chem (2010) 0.92
Selectivity in small molecule binding to human telomeric RNA and DNA quadruplexes. Chem Commun (Camb) (2009) 0.91
Small-molecule binding to the DNA minor groove is mediated by a conserved water cluster. J Am Chem Soc (2013) 0.89
Molecular basis of structure-activity relationships between salphen metal complexes and human telomeric DNA quadruplexes. J Med Chem (2011) 0.88
Xanthene and xanthone derivatives as G-quadruplex stabilizing ligands. Molecules (2013) 0.88
Tri- and tetra-substituted naphthalene diimides as potent G-quadruplex ligands. Bioorg Med Chem Lett (2008) 0.88
Tetrasubstituted naphthalene diimide ligands with selectivity for telomeric G-quadruplexes and cancer cells. Bioorg Med Chem Lett (2010) 0.88
Defining the mechanism of action and enzymatic selectivity of psammaplin A against its epigenetic targets. J Med Chem (2012) 0.87
G-quadruplexes and metal ions. Met Ions Life Sci (2012) 0.87
TRAP-LIG, a modified telomere repeat amplification protocol assay to quantitate telomerase inhibition by small molecules. Anal Biochem (2008) 0.87
Bioactive pyridine-N-oxide disulfides from Allium stipitatum. J Nat Prod (2009) 0.87
Molecular modeling on inhibitor complexes and active-site dynamics of cytochrome P450 C17, a target for prostate cancer therapy. J Mol Biol (2010) 0.87
Amide bond direction modulates G-quadruplex recognition and telomerase inhibition by 2,6 and 2,7 bis-substituted anthracenedione derivatives. Bioorg Med Chem (2007) 0.86
Observation of the coexistence of sodium and calcium ions in a DNA G-quadruplex ion channel. J Am Chem Soc (2007) 0.86
Conformational dynamics of the human propeller telomeric DNA quadruplex on a microsecond time scale. Nucleic Acids Res (2013) 0.86
Stabilisation of human telomeric quadruplex DNA and inhibition of telomerase by a platinum-phenanthroline complex. Chem Commun (Camb) (2007) 0.86
Targeting pancreatic cancer with a G-quadruplex ligand. Bioorg Med Chem (2011) 0.85
Targeting telomerase and telomeres: a click chemistry approach towards highly selective G-quadruplex ligands. Mol Biosyst (2008) 0.85
Fluorine in medicinal chemistry: β-fluorination of peripheral pyrrolidines attached to acridine ligands affects their interactions with G-quadruplex DNA. Org Biomol Chem (2011) 0.85
Structure-based design of selective high-affinity telomeric quadruplex-binding ligands. Chem Commun (Camb) (2010) 0.85
Inhibition of the hypoxia-inducible factor pathway by a G-quadruplex binding small molecule. Sci Rep (2013) 0.85
Synthesis of distamycin A polyamides targeting G-quadruplex DNA. Org Biomol Chem (2006) 0.84
N-cyclic bay-substituted perylene G-quadruplex ligands have selective antiproliferative effects on cancer cells and induce telomere damage. J Med Chem (2011) 0.84
A molecular model for drug binding to tandem repeats of telomeric G-quadruplexes. Biochem Soc Trans (2009) 0.84
Synthesis of Sequence-Selective C8-Linked Pyrrolo[2,1-c][1,4]benzodiazepine DNA Interstrand Cross-Linking Agents. J Org Chem (1996) 0.84
Structure-based design and evaluation of naphthalene diimide G-quadruplex ligands as telomere targeting agents in pancreatic cancer cells. J Med Chem (2013) 0.84
Interactions with DNA: Into the minor groove. Nat Chem (2012) 0.84
Mapping the sequences of potential guanine quadruplex motifs. Nucleic Acids Res (2011) 0.84
Identification of novel telomeric G-quadruplex-targeting chemical scaffolds through screening of three NCI libraries. Bioorg Med Chem Lett (2012) 0.83
Structure-based design of benzylamino-acridine compounds as G-quadruplex DNA telomere targeting agents. Bioorg Med Chem Lett (2007) 0.83
Rational design of acridine-based ligands with selectivity for human telomeric quadruplexes. J Am Chem Soc (2010) 0.83
Sequence-specific minor groove binding by bis-benzimidazoles: water molecules in ligand recognition. Nucleic Acids Res (2003) 0.83
Rational design of substituted diarylureas: a scaffold for binding to G-quadruplex motifs. J Med Chem (2008) 0.82
Tetrapeptides induce selective recognition for G-quadruplexes when conjugated to a DNA-binding platform. Org Biomol Chem (2004) 0.82
Truncated azinomycin analogues intercalate into DNA. Bioorg Med Chem Lett (2005) 0.81
Crystallography of DNA and RNA G-quadruplex nucleic acids and their ligand complexes. Curr Protoc Nucleic Acid Chem (2012) 0.81
Targeting a c-MYC G-quadruplex DNA with a fragment library. Chem Commun (Camb) (2014) 0.81
Recognition and discrimination of DNA quadruplexes by acridine-peptide conjugates. Org Biomol Chem (2008) 0.81
Small-molecule G-quadruplex interactions: Systematic exploration of conformational space using multiple molecular dynamics. Biopolymers (2013) 0.81