Published in Am J Respir Crit Care Med on September 11, 2008
Integrating mechanisms of pulmonary fibrosis. J Exp Med (2011) 3.57
Disruption of microRNA expression in human airway cells by diesel exhaust particles is linked to tumorigenesis-associated pathways. Environ Health Perspect (2009) 1.98
Circulating microRNAs in patients with active pulmonary tuberculosis. J Clin Microbiol (2011) 1.70
Epigenetic mechanisms and the development of asthma. J Allergy Clin Immunol (2012) 1.67
Systems biology of interstitial lung diseases: integration of mRNA and microRNA expression changes. BMC Med Genomics (2011) 1.51
Environmental epigenetics: prospects for studying epigenetic mediation of exposure-response relationships. Hum Genet (2012) 1.47
Methodological challenges in utilizing miRNAs as circulating biomarkers. J Cell Mol Med (2014) 1.34
Reduced miR-146a increases prostaglandin E₂in chronic obstructive pulmonary disease fibroblasts. Am J Respir Crit Care Med (2010) 1.33
Comprehensive microRNA analysis in bleomycin-induced pulmonary fibrosis identifies multiple sites of molecular regulation. Physiol Genomics (2011) 1.32
MicroRNAs profiling in murine models of acute and chronic asthma: a relationship with mRNAs targets. PLoS One (2011) 1.31
MicroRNAs in inflammatory lung disease--master regulators or target practice? Respir Res (2010) 1.24
Epigenetic control of gene expression in the lung. Am J Respir Crit Care Med (2011) 1.24
Involvement of microRNAs in physiological and pathological processes in the lung. Respir Res (2010) 1.17
MicroRNAs as potential signatures of environmental exposure or effect: a systematic review. Environ Health Perspect (2015) 1.13
Radiation-induced micro-RNA expression changes in peripheral blood cells of radiotherapy patients. Int J Radiat Oncol Biol Phys (2011) 1.11
Role of MicroRNAs in lung disease. Arch Bronconeumol (2012) 0.96
Human SP-A1 (SFTPA1) variant-specific 3' UTRs and poly(A) tail differentially affect the in vitro translation of a reporter gene. Am J Physiol Lung Cell Mol Physiol (2010) 0.91
mRNA and miRNA regulatory networks reflective of multi-walled carbon nanotube-induced lung inflammatory and fibrotic pathologies in mice. Toxicol Sci (2014) 0.84
Persistence of smoking-induced dysregulation of miRNA expression in the small airway epithelium despite smoking cessation. PLoS One (2015) 0.83
Comparative evaluation of miRNA expression between in vitro and in vivo airway epithelium demonstrates widespread differences. Am J Pathol (2013) 0.83
Key role of microRNA in the regulation of granulocyte macrophage colony-stimulating factor expression in murine alveolar epithelial cells during oxidative stress. J Biol Chem (2013) 0.82
IL-4 induces differentiation of human embryonic stem cells into fibrogenic fibroblast-like cells. J Allergy Clin Immunol (2011) 0.81
Beyond the genome: epigenetic mechanisms in lung remodeling. Physiology (Bethesda) (2014) 0.81
An 11-nt sequence polymorphism at the 3'UTR of human SFTPA1 and SFTPA2 gene variants differentially affect gene expression levels and miRNA regulation in cell culture. Am J Physiol Lung Cell Mol Physiol (2014) 0.80
Proton radiation-induced miRNA signatures in mouse blood: characterization and comparison with 56Fe-ion and gamma radiation. Int J Radiat Biol (2012) 0.80
Integrating omics technologies to study pulmonary physiology and pathology at the systems level. Cell Physiol Biochem (2014) 0.76
Peroxisome Proliferator-Activated Receptor γ Regulates Chronic Alcohol-Induced Alveolar Macrophage Dysfunction. Am J Respir Cell Mol Biol (2016) 0.76
Acute cellular rejection elicits distinct microRNA signatures in airway epithelium of lung transplant patients. Transplant Direct (2015) 0.76
Reduced microRNA-503 expression augments lung fibroblast VEGF production in chronic obstructive pulmonary disease. PLoS One (2017) 0.75
The sequence of the human genome. Science (2001) 101.55
Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell (2005) 96.87
MicroRNA expression profiles classify human cancers. Nature (2005) 69.12
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell (1993) 64.62
Prediction of mammalian microRNA targets. Cell (2003) 53.70
An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans. Science (2001) 44.16
Finishing the euchromatic sequence of the human genome. Nature (2004) 41.40
MicroRNA targeting specificity in mammals: determinants beyond seed pairing. Mol Cell (2007) 38.42
RAS is regulated by the let-7 microRNA family. Cell (2005) 30.24
Real-time quantification of microRNAs by stem-loop RT-PCR. Nucleic Acids Res (2005) 29.17
Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers. Proc Natl Acad Sci U S A (2004) 28.29
MicroRNA gene expression deregulation in human breast cancer. Cancer Res (2005) 27.56
Unique microRNA molecular profiles in lung cancer diagnosis and prognosis. Cancer Cell (2006) 23.59
NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses. Proc Natl Acad Sci U S A (2006) 21.58
Reduced expression of the let-7 microRNAs in human lung cancers in association with shortened postoperative survival. Cancer Res (2004) 18.86
MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells. Cancer Res (2005) 18.58
Switching from repression to activation: microRNAs can up-regulate translation. Science (2007) 17.00
Modulation of hepatitis C virus RNA abundance by a liver-specific MicroRNA. Science (2005) 16.84
Requirement of bic/microRNA-155 for normal immune function. Science (2007) 16.24
Impaired microRNA processing enhances cellular transformation and tumorigenesis. Nat Genet (2007) 15.46
A pancreatic islet-specific microRNA regulates insulin secretion. Nature (2004) 15.02
An oligonucleotide microchip for genome-wide microRNA profiling in human and mouse tissues. Proc Natl Acad Sci U S A (2004) 13.66
Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters. Cell (2008) 12.29
MicroRNA-133 controls cardiac hypertrophy. Nat Med (2007) 11.68
LNA-mediated microRNA silencing in non-human primates. Nature (2008) 11.45
MicroRNA-155 is induced during the macrophage inflammatory response. Proc Natl Acad Sci U S A (2007) 11.42
MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer. Oncogene (2007) 10.79
A polycistronic microRNA cluster, miR-17-92, is overexpressed in human lung cancers and enhances cell proliferation. Cancer Res (2005) 10.46
MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B. Proc Natl Acad Sci U S A (2007) 9.82
The let-7 microRNA represses cell proliferation pathways in human cells. Cancer Res (2007) 9.32
microPrimer: the biogenesis and function of microRNA. Development (2005) 8.19
Characterization of microRNA expression profiles in normal human tissues. BMC Genomics (2007) 8.01
Target mRNAs are repressed as efficiently by microRNA-binding sites in the 5' UTR as in the 3' UTR. Proc Natl Acad Sci U S A (2007) 7.93
Genomics of microRNA. Trends Genet (2006) 7.75
MicroRNA-21 targets tumor suppressor genes in invasion and metastasis. Cell Res (2008) 7.53
A microRNA signature of hypoxia. Mol Cell Biol (2006) 7.24
Cell-type-specific signatures of microRNAs on target mRNA expression. Proc Natl Acad Sci U S A (2006) 7.11
Suppression of non-small cell lung tumor development by the let-7 microRNA family. Proc Natl Acad Sci U S A (2008) 6.89
microRNA-155 regulates the generation of immunoglobulin class-switched plasma cells. Immunity (2007) 6.72
Retracted A genomic strategy to refine prognosis in early-stage non-small-cell lung cancer. N Engl J Med (2006) 6.69
Comprehensive analysis of microRNA expression patterns in hepatocellular carcinoma and non-tumorous tissues. Oncogene (2006) 6.61
MicroRNA signature predicts survival and relapse in lung cancer. Cancer Cell (2008) 5.34
A high-throughput method to monitor the expression of microRNA precursors. Nucleic Acids Res (2004) 5.21
A viral microRNA functions as an orthologue of cellular miR-155. Nature (2007) 5.09
miR-221 and miR-222 expression affects the proliferation potential of human prostate carcinoma cell lines by targeting p27Kip1. J Biol Chem (2007) 5.02
Dicer function is essential for lung epithelium morphogenesis. Proc Natl Acad Sci U S A (2006) 4.87
MicroRNA-21 promotes cell transformation by targeting the programmed cell death 4 gene. Oncogene (2008) 4.43
Transgenic over-expression of the microRNA miR-17-92 cluster promotes proliferation and inhibits differentiation of lung epithelial progenitor cells. Dev Biol (2007) 4.16
Quantitative analysis of Argonaute protein reveals microRNA-dependent localization to stress granules. Proc Natl Acad Sci U S A (2006) 4.02
The oncogenic microRNA-27a targets genes that regulate specificity protein transcription factors and the G2-M checkpoint in MDA-MB-231 breast cancer cells. Cancer Res (2007) 3.40
MicroRNA expression profiling of single whole embryonic stem cells. Nucleic Acids Res (2006) 3.36
MicroRNAs and immunity: novel players in the regulation of normal immune function and inflammation. Semin Cancer Biol (2008) 3.32
Direct and sensitive miRNA profiling from low-input total RNA. RNA (2006) 3.17
Apoptosis induction by antisense oligonucleotides against miR-17-5p and miR-20a in lung cancers overexpressing miR-17-92. Oncogene (2007) 3.11
Epstein-Barr virus latent membrane protein 1 induces cellular MicroRNA miR-146a, a modulator of lymphocyte signaling pathways. J Virol (2007) 2.88
Allele-specific targeting of microRNAs to HLA-G and risk of asthma. Am J Hum Genet (2007) 2.58
Experimental validation of miRNA targets. Methods (2008) 2.57
Expression profiling in vivo demonstrates rapid changes in lung microRNA levels following lipopolysaccharide-induced inflammation but not in the anti-inflammatory action of glucocorticoids. BMC Genomics (2007) 2.49
MicroRNA signatures of TRAIL resistance in human non-small cell lung cancer. Oncogene (2008) 2.44
EGFR regulation by microRNA in lung cancer: correlation with clinical response and survival to gefitinib and EGFR expression in cell lines. Ann Oncol (2008) 2.29
Epigenetic activation of tumor suppressor microRNAs in human cancer cells. Cell Cycle (2006) 1.98
Liver-specific microRNA miR-122 enhances the replication of hepatitis C virus in nonhepatic cells. J Virol (2008) 1.96
Small RNAs: regulators and guardians of the genome. J Cell Physiol (2007) 1.86
MicroRNA function in neuronal development, plasticity and disease. Biochim Biophys Acta (2008) 1.84
Profiling microRNA expression with microarrays. Trends Biotechnol (2008) 1.48
microRNA expression in the aging mouse lung. BMC Genomics (2007) 1.37
Proteomic patterns of preinvasive bronchial lesions. Am J Respir Crit Care Med (2005) 1.32
Expression and function of micro-RNAs in immune cells during normal or disease state. Int J Med Sci (2008) 1.30
Two molecular features contribute to the Argonaute specificity for the microRNA and RNAi pathways in C. elegans. RNA (2008) 1.22
MicroRNAs: fundamental facts and involvement in human diseases. Birth Defects Res C Embryo Today (2006) 1.17
A novel method to detect functional microRNA targets. J Mol Biol (2006) 1.11
Detection of microRNAs by Northern blot analyses using LNA probes. Methods (2007) 1.05
Detection of microRNA expression in human peripheral blood microvesicles. PLoS One (2008) 8.04
Involvement of human micro-RNA in growth and response to chemotherapy in human cholangiocarcinoma cell lines. Gastroenterology (2006) 7.06
Expression profiling identifies microRNA signature in pancreatic cancer. Int J Cancer (2007) 6.57
Real-time expression profiling of microRNA precursors in human cancer cell lines. Nucleic Acids Res (2005) 5.44
Ultraconserved regions encoding ncRNAs are altered in human leukemias and carcinomas. Cancer Cell (2007) 5.40
MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response. Proc Natl Acad Sci U S A (2012) 5.07
MicroRNA expression in response to murine myocardial infarction: miR-21 regulates fibroblast metalloprotease-2 via phosphatase and tensin homologue. Cardiovasc Res (2009) 4.88
Systematic evaluation of microRNA processing patterns in tissues, cell lines, and tumors. RNA (2007) 3.91
Association of MicroRNA expression in hepatocellular carcinomas with hepatitis infection, cirrhosis, and patient survival. Clin Cancer Res (2008) 3.67
Acquired weakness, handgrip strength, and mortality in critically ill patients. Am J Respir Crit Care Med (2008) 3.59
MicroRNA-34a inhibits glioblastoma growth by targeting multiple oncogenes. Cancer Res (2009) 3.57
Body mass index is independently associated with hospital mortality in mechanically ventilated adults with acute lung injury. Crit Care Med (2006) 3.38
Methylation mediated silencing of MicroRNA-1 gene and its role in hepatocellular carcinogenesis. Cancer Res (2008) 3.16
A human CD34(+) subset resides in lymph nodes and differentiates into CD56bright natural killer cells. Immunity (2005) 3.14
Oral plasmablastic lymphomas in AIDS patients are associated with human herpesvirus 8. Am J Surg Pathol (2004) 3.09
MicroRNAs modulate the chemosensitivity of tumor cells. Mol Cancer Ther (2008) 3.06
Glucose variability and mortality in patients with sepsis. Crit Care Med (2008) 3.00
Retracted MicroRNA-155 regulates human angiotensin II type 1 receptor expression in fibroblasts. J Biol Chem (2006) 2.62
Retracted The human angiotensin II type 1 receptor +1166 A/C polymorphism attenuates microRNA-155 binding. J Biol Chem (2007) 2.60
Experimental validation of miRNA targets. Methods (2008) 2.57
Extracellular microRNA: a new source of biomarkers. Mutat Res (2011) 2.55
miRNA signatures associate with pathogenesis and progression of osteosarcoma. Cancer Res (2012) 2.52
Alcohol dependence is independently associated with sepsis, septic shock, and hospital mortality among adult intensive care unit patients. Crit Care Med (2007) 2.42
Complexity of the microRNA repertoire revealed by next-generation sequencing. RNA (2010) 2.38
Norepinephrine up-regulates the expression of vascular endothelial growth factor, matrix metalloproteinase (MMP)-2, and MMP-9 in nasopharyngeal carcinoma tumor cells. Cancer Res (2006) 2.32
Role of microRNA-155 at early stages of hepatocarcinogenesis induced by choline-deficient and amino acid-defined diet in C57BL/6 mice. Hepatology (2009) 2.29
Increased expression of microRNA-155 in Epstein-Barr virus transformed lymphoblastoid cell lines. Genes Chromosomes Cancer (2006) 2.29
MicroRNA regulation of a cancer network: consequences of the feedback loops involving miR-17-92, E2F, and Myc. Proc Natl Acad Sci U S A (2008) 2.24
A 52-kb deletion in the SOST-MEOX1 intergenic region on 17q12-q21 is associated with van Buchem disease in the Dutch population. Am J Med Genet (2002) 2.21
Epigenetic regulation of miR-17~92 contributes to the pathogenesis of pulmonary fibrosis. Am J Respir Crit Care Med (2013) 2.16
MicroRNAs and cancer: profile, profile, profile. Int J Cancer (2008) 2.10
Antisense inhibition of microRNA-21 or -221 arrests cell cycle, induces apoptosis, and sensitizes the effects of gemcitabine in pancreatic adenocarcinoma. Pancreas (2009) 2.09
Modulation of mismatch repair and genomic stability by miR-155. Proc Natl Acad Sci U S A (2010) 2.05
Methylation of p16(INK4a) promoters occurs in vivo in histologically normal human mammary epithelia. Cancer Res (2003) 2.03
MicroRNA-21 induces resistance to 5-fluorouracil by down-regulating human DNA MutS homolog 2 (hMSH2). Proc Natl Acad Sci U S A (2010) 1.99
Caspase-7 activation by the Nlrc4/Ipaf inflammasome restricts Legionella pneumophila infection. PLoS Pathog (2009) 1.99
Retracted Human chromosome 21-derived miRNAs are overexpressed in down syndrome brains and hearts. Biochem Biophys Res Commun (2008) 1.91
Expression and functional role of a transcribed noncoding RNA with an ultraconserved element in hepatocellular carcinoma. Proc Natl Acad Sci U S A (2010) 1.87
A methodology for the combined in situ analyses of the precursor and mature forms of microRNAs and correlation with their putative targets. Nat Protoc (2009) 1.85
MiR-34a/c-Dependent PDGFR-α/β Downregulation Inhibits Tumorigenesis and Enhances TRAIL-Induced Apoptosis in Lung Cancer. PLoS One (2013) 1.82
Macrophage microvesicles induce macrophage differentiation and miR-223 transfer. Blood (2012) 1.80
Systems medicine and integrated care to combat chronic noncommunicable diseases. Genome Med (2011) 1.78
Giant breast tumors: surgical management of phyllodes tumors, potential for reconstructive surgery and a review of literature. World J Surg Oncol (2008) 1.73
The digital code of DNA. Nature (2003) 1.70
The complex exogenous RNA spectra in human plasma: an interface with human gut biota? PLoS One (2012) 1.68
Microarray analysis of human monocytes infected with Francisella tularensis identifies new targets of host response subversion. PLoS One (2008) 1.67
Activation of estrogen receptor-alpha reduces aortic smooth muscle differentiation. Circ Res (2006) 1.63
Gene expression networks in COPD: microRNA and mRNA regulation. Thorax (2011) 1.62
Depletion of peripheral macrophages and brain microglia increases brain tumor titers of oncolytic viruses. Cancer Res (2007) 1.60
The role of inflammation in the pathogenesis of idiopathic pulmonary fibrosis. Antioxid Redox Signal (2008) 1.60
The association between body mass index, processes of care, and outcomes from mechanical ventilation: a prospective cohort study. Crit Care Med (2012) 1.60
Thy-1 promoter hypermethylation: a novel epigenetic pathogenic mechanism in pulmonary fibrosis. Am J Respir Cell Mol Biol (2008) 1.58
MicroRNA 133B targets pro-survival molecules MCL-1 and BCL2L2 in lung cancer. Biochem Biophys Res Commun (2009) 1.58
A comparison of clinically utilized human papillomavirus detection methods in head and neck cancer. Mod Pathol (2011) 1.58
Human papillomavirus 16 and 18 expression in conjunctival intraepithelial neoplasia. Ophthalmology (2002) 1.57
Granulocyte macrophage colony-stimulating factor inhibits breast cancer growth and metastasis by invoking an anti-angiogenic program in tumor-educated macrophages. Cancer Res (2009) 1.57
MiR-155 induction by F. novicida but not the virulent F. tularensis results in SHIP down-regulation and enhanced pro-inflammatory cytokine response. PLoS One (2009) 1.55
Future directions in idiopathic pulmonary fibrosis research. An NHLBI workshop report. Am J Respir Crit Care Med (2014) 1.54
Retracted Chromosome 21-derived microRNAs provide an etiological basis for aberrant protein expression in human Down syndrome brains. J Biol Chem (2009) 1.53
The role of the NADPH oxidase complex, p38 MAPK, and Akt in regulating human monocyte/macrophage survival. Am J Respir Cell Mol Biol (2006) 1.52
Systems biology of interstitial lung diseases: integration of mRNA and microRNA expression changes. BMC Med Genomics (2011) 1.51
miR-221 silencing blocks hepatocellular carcinoma and promotes survival. Cancer Res (2011) 1.51
M-CSF induces vascular endothelial growth factor production and angiogenic activity from human monocytes. J Immunol (2003) 1.50
Epigenetic modification of CCAAT/enhancer binding protein alpha expression in acute myeloid leukemia. Cancer Res (2008) 1.49
Important roles for macrophage colony-stimulating factor, CC chemokine ligand 2, and mononuclear phagocytes in the pathogenesis of pulmonary fibrosis. Am J Respir Crit Care Med (2007) 1.46
Cell carriage, delivery, and selective replication of an oncolytic virus in tumor in patients. Sci Transl Med (2012) 1.46
miR-132 and miR-212 are increased in pancreatic cancer and target the retinoblastoma tumor suppressor. Biochem Biophys Res Commun (2011) 1.42
Diagnostic microRNA markers for screening sporadic human colon cancer and active ulcerative colitis in stool and tissue. Cancer Genomics Proteomics (2009) 1.41
Benign metastasizing leiomyoma of the lung: clinicopathologic, immunohistochemical, and micro-RNA analyses. Diagn Mol Pathol (2008) 1.41
Squamous intraepithelial lesions arising in benign endocervical polyps: a report of 9 cases with correlation to the Pap smears, HPV analysis, and immunoprofile. Int J Gynecol Pathol (2008) 1.40
Cancer as robust intrinsic state of endogenous molecular-cellular network shaped by evolution. Med Hypotheses (2007) 1.39
Characterization of a preclinical model of chronic ischemic wound. Physiol Genomics (2009) 1.38
Regulation of acute graft-versus-host disease by microRNA-155. Blood (2012) 1.35
Methodological challenges in utilizing miRNAs as circulating biomarkers. J Cell Mol Med (2014) 1.34
In vivo monitoring of pH, redox status, and glutathione using L-band EPR for assessment of therapeutic effectiveness in solid tumors. Magn Reson Med (2011) 1.33
Surface plasmon resonance biosensor for rapid label-free detection of microribonucleic acid at subfemtomole level. Anal Chem (2010) 1.32
Insulin growth factor signaling is regulated by microRNA-486, an underexpressed microRNA in lung cancer. Proc Natl Acad Sci U S A (2013) 1.32
Natural killer cells produce T cell-recruiting chemokines in response to antibody-coated tumor cells. Cancer Res (2006) 1.32
The inositol 3-phosphatase PTEN negatively regulates Fc gamma receptor signaling, but supports Toll-like receptor 4 signaling in murine peritoneal macrophages. J Immunol (2004) 1.31
miR-199a-3p targets CD44 and reduces proliferation of CD44 positive hepatocellular carcinoma cell lines. Biochem Biophys Res Commun (2010) 1.30
The acute respiratory distress syndrome: a role for transforming growth factor-beta 1. Am J Respir Cell Mol Biol (2003) 1.28
Epm2a suppresses tumor growth in an immunocompromised host by inhibiting Wnt signaling. Cancer Cell (2006) 1.28
Diseases as network perturbations. Curr Opin Biotechnol (2010) 1.23
GM-CSF induces expression of soluble VEGF receptor-1 from human monocytes and inhibits angiogenesis in mice. Immunity (2004) 1.23