Published in J Am Coll Cardiol on October 07, 2008
Proinflammatory phenotype of perivascular adipocytes: influence of high-fat feeding. Circ Res (2009) 2.56
Measuring adiposity in patients: the utility of body mass index (BMI), percent body fat, and leptin. PLoS One (2012) 2.12
Obesity, subclinical myocardial injury, and incident heart failure. JACC Heart Fail (2014) 1.54
Molecular pathways: adiponectin and leptin signaling in cancer. Clin Cancer Res (2013) 1.37
Cardiovascular effects of leptin. Nat Rev Cardiol (2009) 1.26
Leptin upregulates caveolin-1 expression: implications for development of atherosclerosis. Atherosclerosis (2010) 1.19
Leptin, resistin and visfatin: the missing link between endocrine metabolic disorders and immunity. Eur J Med Res (2013) 1.19
P wave indices, obesity, and the metabolic syndrome: the atherosclerosis risk in communities study. Obesity (Silver Spring) (2011) 1.14
Human obesity and endothelium-dependent responsiveness. Br J Pharmacol (2012) 1.14
Phenotypic and genetic variation in leptin as determinants of weight regain. Int J Obes (Lond) (2010) 1.14
A high-fat diet increases adiposity but maintains mitochondrial oxidative enzymes without affecting development of heart failure with pressure overload. Am J Physiol Heart Circ Physiol (2009) 1.10
Obstructive sleep apnea, immuno-inflammation, and atherosclerosis. Semin Immunopathol (2009) 1.06
Association of coffee consumption with serum adiponectin, leptin, inflammation and metabolic markers in Japanese workers: a cross-sectional study. Nutr Diabetes (2012) 1.01
Latent associations of low serum amylase with decreased plasma insulin levels and insulin resistance in asymptomatic middle-aged adults. Cardiovasc Diabetol (2012) 0.99
Effects of body fat on the associations of high-molecular-weight adiponectin, leptin and soluble leptin receptor with metabolic syndrome in Chinese. PLoS One (2011) 0.98
Impact of treating the metabolic syndrome on chronic kidney disease. Nat Rev Nephrol (2009) 0.96
Adipocytokines, insulin resistance, and coronary atherosclerosis in rheumatoid arthritis. Arthritis Rheum (2010) 0.96
Obesity, Oxidative Stress, Adipose Tissue Dysfunction, and the Associated Health Risks: Causes and Therapeutic Strategies. Metab Syndr Relat Disord (2015) 0.94
Central obesity, type 2 diabetes and insulin: exploring a pathway full of thorns. Arch Med Sci (2015) 0.93
The effects of obesity on skeletal muscle regeneration. Front Physiol (2013) 0.93
Role of C reactive protein (CRP) in leptin resistance. Curr Pharm Des (2014) 0.93
The obesity of bone. Ther Adv Endocrinol Metab (2015) 0.92
A multifaceted analysis of immune-endocrine-metabolic alterations in patients with pulmonary tuberculosis. PLoS One (2011) 0.91
Adipocytokines in atherothrombosis: focus on platelets and vascular smooth muscle cells. Mediators Inflamm (2010) 0.90
Polycystic ovary syndrome, insulin resistance, and obesity: navigating the pathophysiologic labyrinth. Int J Reprod Med (2014) 0.90
Association of adipokines, leptin/adiponectin ratio and C-reactive protein with obesity and type 2 diabetes mellitus. Diabetol Metab Syndr (2014) 0.90
Pollock oil supplementation modulates hyperlipidemia and ameliorates hepatic steatosis in mice fed a high-fat diet. Lipids Health Dis (2011) 0.89
Leptin is associated with vascular endothelial function in overweight patients with type 2 diabetes. Cardiovasc Diabetol (2014) 0.88
Metabolic dysfunction in diabetic cardiomyopathy. Heart Fail Rev (2014) 0.88
Endothelial function and weight loss: comparison of low-carbohydrate and low-fat diets. Obesity (Silver Spring) (2013) 0.88
Leptin upregulates the expression of plasminogen activator inhibitor-1 in human vascular endothelial cells. Biochem Biophys Res Commun (2010) 0.86
Fat-mass-related hormone, plasma leptin, predicts brain volumes in the elderly. Neuroreport (2013) 0.86
Effect of fructooligosaccharides fraction from Psacalium decompositum on inflammation and dyslipidemia in rats with fructose-induced obesity. Nutrients (2014) 0.85
Inflammation and oxidative stress in obesity-related glomerulopathy. Int J Nephrol (2012) 0.85
Effect of thiamine administration on metabolic profile, cytokines and inflammatory markers in drug-naïve patients with type 2 diabetes. Eur J Nutr (2010) 0.85
Leptin signaling in adipose tissue: role in lipid accumulation and weight gain. Circ Res (2012) 0.84
The macrophage at the intersection of immunity and metabolism in obesity. Diabetol Metab Syndr (2011) 0.84
Leptin-based adjuvants: an innovative approach to improve vaccine response. Vaccine (2013) 0.84
Maternal Body Weight and Gestational Diabetes Differentially Influence Placental and Pregnancy Outcomes. J Clin Endocrinol Metab (2015) 0.83
Leptin in sarcopenic visceral obesity: possible link between adipocytes and myocytes. PLoS One (2011) 0.83
C-reactive protein modifies the association of plasma leptin with coronary calcium in asymptomatic overweight individuals. Obesity (Silver Spring) (2011) 0.83
Association of Serum Phosphate and Related Factors in ESRD-Related Vascular Calcification. Int J Nephrol (2011) 0.82
Increased soluble leptin receptor levels in morbidly obese patients with insulin resistance and nonalcoholic fatty liver disease. Obesity (Silver Spring) (2010) 0.82
Leptin and incident cardiovascular disease: the Multi-ethnic Study of Atherosclerosis (MESA). Atherosclerosis (2014) 0.82
Leptin and its cardiovascular effects: Focus on angiogenesis. Adv Biomed Res (2015) 0.81
Differential effects of leptin on adiponectin expression with weight gain versus obesity. Int J Obes (Lond) (2015) 0.81
Alterations in brain leptin signalling in spite of unchanged CSF leptin levels in Alzheimer's disease. Aging Cell (2014) 0.81
Prostaglandin E Receptor Subtype 4 Signaling in the Heart: Role in Ischemia/Reperfusion Injury and Cardiac Hypertrophy. J Diabetes Res (2016) 0.80
Leptin, insulin and thyroid hormones in a cohort of Egyptian obese Down syndrome children: a comparative study. BMC Endocr Disord (2012) 0.80
How to estimate fat mass in overweight and obese subjects. Int J Endocrinol (2013) 0.80
Anti-inflammatory nutrition as a pharmacological approach to treat obesity. J Obes (2010) 0.80
Childhood adiposity: being male is a potential cardiovascular risk factor. Eur J Pediatr (2015) 0.79
Serum leptin levels are independently related to the incidence of ischemic heart disease in a prospective study of patients with type 2 diabetes. Cardiovasc Diabetol (2015) 0.79
Diet-induced swine model with obesity/leptin resistance for the study of metabolic syndrome and type 2 diabetes. ScientificWorldJournal (2012) 0.79
Leptin deficiency recapitulates the histological features of pulmonary arterial hypertension in mice. Int J Clin Exp Pathol (2014) 0.79
Cytokine Profile in Chronic Periodontitis Patients with and without Obesity: A Systematic Review and Meta-Analysis. Dis Markers (2016) 0.79
Short duration of sleep is associated with hyperleptinemia in Taiwanese adults. J Clin Sleep Med (2013) 0.78
Prevalence, clinical characteristics, and predictors of obesity hypoventilation syndrome in a large sample of Saudi patients with obstructive sleep apnea. Saudi Med J (2015) 0.78
Hyperleptinemia: implications on the inflammatory state and vascular protection in obese adolescents submitted to an interdisciplinary therapy. Inflammation (2014) 0.78
Rheumatic diseases and obesity: adipocytokines as potential comorbidity biomarkers for cardiovascular diseases. Mediators Inflamm (2013) 0.78
Sulforaphane improves dysregulated metabolic profile and inhibits leptin-induced VSMC proliferation: Implications toward suppression of neointima formation after arterial injury in western diet-fed obese mice. J Nutr Biochem (2016) 0.77
The cellular specificity of leptin-mediated actions in the infarcted heart. Cardiovasc Res (2010) 0.77
Immunotherapy of genitourinary malignancies. J Oncol (2012) 0.77
INFLUENCE OF DIABETES ON AMBULATION AND INFLAMMATION IN MEN AND WOMEN WITH SYMPTOMATIC PERIPHERAL ARTERY DISEASE. J Clin Transl Endocrinol (2015) 0.77
Does the sympathetic nervous system contribute to the pathophysiology of metabolic syndrome? Front Physiol (2015) 0.76
Insulin and leptin levels in overweight and normal-weight Iranian adolescents: The CASPIAN-III study. J Res Med Sci (2014) 0.76
Serum Leptin Levels and the Risk of Stroke: The Framingham Study. Stroke (2015) 0.76
The relationship between leptin and ventilatory control in heart failure. J Card Fail (2013) 0.76
Voluntary exercise under a food restriction condition decreases blood branched-chain amino acid levels, in addition to improvement of glucose and lipid metabolism, in db mice, animal model of type 2 diabetes. Environ Health Prev Med (2014) 0.76
Activation of innate immunity modulates insulin sensitivity, glucose effectiveness and pancreatic β-cell function in both African ancestry and European ancestry healthy humans. Metabolism (2014) 0.76
Impact of child obesity on adipose tissue physiology: assessment of adipocytokines and inflammatory cytokines as biomarkers of obesity. Pediatr Rep (2010) 0.76
Short Hypoxia Does not Affect Plasma Leptin in Healthy Men under Euglycemic Clamp Conditions. Int J Endocrinol (2009) 0.76
Benefits of resistance exercise in lean women with fibromyalgia: involvement of IGF-1 and leptin. BMC Musculoskelet Disord (2017) 0.75
The Intricate Network of Adipokines and Stroke. Int J Endocrinol (2015) 0.75
ADIPOQ and IL6 variants are associated with a pro-inflammatory status in obeses with cardiometabolic dysfunction. Diabetol Metab Syndr (2015) 0.75
Role of leptin on the expression of low density lipoprotein receptor. Indian J Med Res (2014) 0.75
Leptin, Leptin Soluble Receptor, and the Free Leptin Index following a Diet and Physical Activity Lifestyle Intervention in Obese Males and Females. J Obes (2016) 0.75
Association of polymorphism in adiponectin (+45 T/G) and leptin (-2548 G/A) genes with type 2 diabetes mellitus in male Egyptians. Arch Med Sci (2015) 0.75
Early Effects of Treatment Low-Dose Atorvastatin on Markers of Insulin Resistance and Inflammation in Patients with Myocardial Infarction. Front Pharmacol (2016) 0.75
Leptin Resistance and the Neuro-Adipose Connection. Front Endocrinol (Lausanne) (2017) 0.75
Leptin Resistance: A Possible Interface Between Obesity and Pulmonary-Related Disorders. Int J Endocrinol Metab (2016) 0.75
Leptin and uric acid as predictors of metabolic syndrome in jordanian adults. Nutr Res Pract (2016) 0.75
Increased arterial stiffness in patients with end-stage osteoarthritis: a case-control study. BMC Musculoskelet Disord (2016) 0.75
Oxytocin and cardioprotection in diabetes and obesity. BMC Endocr Disord (2016) 0.75
Stress during Adolescence Alters Palatable Food Consumption in a Context-Dependent Manner. PLoS One (2016) 0.75
Low Plasma Hdl Cholesterol and Elevated C Reactive Protein further Increase Cardiovascular Disease Risk in Latinos with Type 2 Diabetes. J Diabetes Metab (2010) 0.75
Vitamin D, leptin and impact on immune response to seasonal influenza A/H1N1 vaccine in older persons. Hum Vaccin Immunother (2016) 0.75
Xanthohumol improves dysfunctional glucose and lipid metabolism in diet-induced obese C57BL/6J mice. Arch Biochem Biophys (2016) 0.75
The Associations of Novel Vitamin D3 Metabolic Gene CYP27A1 Polymorphism, Adiponectin/Leptin Ratio, and Metabolic Syndrome in Middle-Aged Taiwanese Males. Int J Endocrinol (2015) 0.75
Cardio-oncology Related to Heart Failure: Common Risk Factors Between Cancer and Cardiovascular Disease. Heart Fail Clin (2017) 0.75
Leptin independently predicts development of sepsis and its outcome. J Inflamm (Lond) (2017) 0.75
The Role of Supplemental Complex Dietary Carbohydrates and Gut Microbiota in Promoting Cardiometabolic and Immunological Health in Obesity: Lessons from Healthy Non-Obese Individuals. Front Nutr (2017) 0.75
Endurance exercise training decreased serum levels of surfactant protein D and improved aerobic fitness of obese women with type-2 diabetes. Diabetol Metab Syndr (2017) 0.75
Prevalence of overweight and obesity in the United States, 1999-2004. JAMA (2006) 72.59
Positional cloning of the mouse obese gene and its human homologue. Nature (1994) 38.85
Inflammation, atherosclerosis, and coronary artery disease. N Engl J Med (2005) 28.21
Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med (1996) 16.98
C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus. JAMA (2001) 15.85
Leptin and the regulation of body weight in mammals. Nature (1998) 14.84
Effects of the obese gene product on body weight regulation in ob/ob mice. Science (1995) 13.57
Adipocytokines: mediators linking adipose tissue, inflammation and immunity. Nat Rev Immunol (2006) 10.05
Identification and expression cloning of a leptin receptor, OB-R. Cell (1995) 9.74
A family of cytokine-inducible inhibitors of signalling. Nature (1997) 9.22
Plasma concentration of interleukin-6 and the risk of future myocardial infarction among apparently healthy men. Circulation (2000) 8.17
Leptin-replacement therapy for lipodystrophy. N Engl J Med (2002) 7.78
Abnormal splicing of the leptin receptor in diabetic mice. Nature (1996) 7.71
Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice. Cell (1996) 7.45
Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression. Nature (1998) 7.36
Effects of recombinant leptin therapy in a child with congenital leptin deficiency. N Engl J Med (1999) 6.94
A new protein containing an SH2 domain that inhibits JAK kinases. Nature (1997) 6.28
Structure and function of a new STAT-induced STAT inhibitor. Nature (1997) 6.02
Inflammatory markers and the risk of coronary heart disease in men and women. N Engl J Med (2004) 5.86
Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency. J Clin Invest (2002) 5.83
Obese, a new mutation in the house mouse. J Hered (1950) 5.33
Leptin. Annu Rev Physiol (2000) 4.78
Recombinant leptin for weight loss in obese and lean adults: a randomized, controlled, dose-escalation trial. JAMA (1999) 4.71
Induction of leptin resistance through direct interaction of C-reactive protein with leptin. Nat Med (2006) 4.35
Region-specific leptin resistance within the hypothalamus of diet-induced obese mice. Endocrinology (2004) 4.10
Leptin enters the brain by a saturable system independent of insulin. Peptides (1996) 3.97
Identification of SOCS-3 as a potential mediator of central leptin resistance. Mol Cell (1998) 3.84
Elevation of tumor necrosis factor-alpha and increased risk of recurrent coronary events after myocardial infarction. Circulation (2000) 3.66
Plasma leptin and the risk of cardiovascular disease in the west of Scotland coronary prevention study (WOSCOPS). Circulation (2001) 3.57
Diet-induced obese mice develop peripheral, but not central, resistance to leptin. J Clin Invest (1997) 3.56
Human leptin deficiency caused by a missense mutation: multiple endocrine defects, decreased sympathetic tone, and immune system dysfunction indicate new targets for leptin action, greater central than peripheral resistance to the effects of leptin, and spontaneous correction of leptin-mediated defects. J Clin Endocrinol Metab (1999) 3.26
The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors. Proc Natl Acad Sci U S A (1996) 3.21
Cerebrospinal fluid leptin levels: relationship to plasma levels and to adiposity in humans. Nat Med (1996) 3.20
Expression of ob mRNA and its encoded protein in rodents. Impact of nutrition and obesity. J Clin Invest (1995) 3.18
Effects of parabiosis of obese with diabetes and normal mice. Diabetologia (1973) 3.16
Acute stimulation of glucose metabolism in mice by leptin treatment. Nature (1997) 3.12
Leptin: a review of its peripheral actions and interactions. Int J Obes Relat Metab Disord (2002) 3.09
Divergent signaling capacities of the long and short isoforms of the leptin receptor. J Biol Chem (1997) 3.01
Prospective study of C-reactive protein in relation to the development of diabetes and metabolic syndrome in the Mexico City Diabetes Study. Diabetes Care (2002) 3.00
Attenuation of leptin action and regulation of obesity by protein tyrosine phosphatase 1B. Dev Cell (2002) 2.99
Obesity-induced inflammation: a metabolic dialogue in the language of inflammation. J Intern Med (2007) 2.72
Endotoxin and cytokines induce expression of leptin, the ob gene product, in hamsters. J Clin Invest (1996) 2.68
The role of SOCS-3 in leptin signaling and leptin resistance. J Biol Chem (1999) 2.63
Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults. Proc Natl Acad Sci U S A (2004) 2.41
Leptin induces mitochondrial superoxide production and monocyte chemoattractant protein-1 expression in aortic endothelial cells by increasing fatty acid oxidation via protein kinase A. J Biol Chem (2001) 2.30
Inflammatory cytokines stimulated C-reactive protein production by human coronary artery smooth muscle cells. Circulation (2003) 2.28
Role of selective leptin resistance in diet-induced obesity hypertension. Diabetes (2005) 2.24
Crystal structure of the obese protein leptin-E100. Nature (1997) 2.22
Independent association between plasma leptin and C-reactive protein in healthy humans. Circulation (2004) 2.21
Evidence against either a premature stop codon or the absence of obese gene mRNA in human obesity. J Clin Invest (1995) 2.20
A prospective study of inflammatory cytokines and diabetes mellitus in a multiethnic cohort of postmenopausal women. Arch Intern Med (2007) 2.05
Leptin and atherosclerosis. Atherosclerosis (2006) 1.95
Leptin signaling and obesity: cardiovascular consequences. Circ Res (2007) 1.95
Effect of leptin on arterial thrombosis following vascular injury in mice. JAMA (2002) 1.83
The metabolic significance of leptin in humans: gender-based differences in relationship to adiposity, insulin sensitivity, and energy expenditure. J Clin Endocrinol Metab (1997) 1.82
Plasma leptin levels are increased in survivors of acute sepsis: associated loss of diurnal rhythm, in cortisol and leptin secretion. J Clin Endocrinol Metab (1998) 1.80
Role of leptin in immunity. Cell Mol Immunol (2007) 1.67
Liporegulation in diet-induced obesity. The antisteatotic role of hyperleptinemia. J Biol Chem (2000) 1.65
Plasma leptin and prognosis in patients with established coronary atherosclerosis. J Am Coll Cardiol (2004) 1.64
Association of insulin resistance, hyperleptinemia, and impaired nitric oxide release with in-stent restenosis in patients undergoing coronary stenting. Circulation (2003) 1.63
Short term effects of leptin on hepatic gluconeogenesis and in vivo insulin action. J Biol Chem (1997) 1.61
Hypothalamic leptin resistance is associated with impaired leptin signal transduction in aged obese rats. Neuroscience (2001) 1.60
Caloric restriction reverses the deficits in leptin receptor protein and leptin signaling capacity associated with diet-induced obesity: role of leptin in the regulation of hypothalamic long-form leptin receptor expression. J Endocrinol (2004) 1.58
Plasma leptin levels are associated with coronary atherosclerosis in type 2 diabetes. J Clin Endocrinol Metab (2004) 1.55
Relationship of plasma leptin to plasma insulin and adiposity in normal weight and overweight women: effects of dietary fat content and sustained weight loss. J Clin Endocrinol Metab (1996) 1.53
Adipokines, insulin resistance, and coronary artery calcification. J Am Coll Cardiol (2008) 1.53
Glucose-dependent regulation of cholesterol ester metabolism in macrophages by insulin and leptin. J Biol Chem (2002) 1.53
Leptin is associated with increased risk of myocardial infarction. J Intern Med (1999) 1.52
Selective leptin resistance: a new concept in leptin physiology with cardiovascular implications. J Hypertens (2002) 1.45
The role of leptin in leptin resistance and obesity. Physiol Behav (2006) 1.41
Leptin-dependent platelet aggregation and arterial thrombosis suggests a mechanism for atherothrombotic disease in obesity. J Clin Invest (2001) 1.41
The concept of selective leptin resistance: evidence from agouti yellow obese mice. Diabetes (2002) 1.37
Leptin suppression of insulin secretion and gene expression in human pancreatic islets: implications for the development of adipogenic diabetes mellitus. J Clin Endocrinol Metab (1999) 1.37
Expression of leptin receptor isoforms in rat brain microvessels. Endocrinology (1998) 1.36
Soluble leptin receptor represents the main leptin binding activity in human blood. Biochem Biophys Res Commun (2001) 1.36
Role of leptin in blood pressure regulation and arterial hypertension. J Hypertens (2006) 1.33
Leptin, but not adiponectin, predicts stroke in males. J Intern Med (2004) 1.31
Fasting plasma leptin, tumor necrosis factor-alpha receptor 2, and monocyte chemoattracting protein 1 concentration in a population of glucose-tolerant and glucose-intolerant women: impact on cardiovascular mortality. Diabetes Care (2003) 1.27
Endogenous hormones and carotid atherosclerosis in elderly men. Am J Epidemiol (2003) 1.17
Effects of prolonged hyperinsulinemia on serum leptin in normal human subjects. J Clin Invest (1997) 1.17
Leptin and the proinflammatory state associated with human obesity. J Clin Endocrinol Metab (2004) 1.17
Leptin resistance exacerbates diet-induced obesity and is associated with diminished maximal leptin signalling capacity in rats. Diabetologia (2005) 1.16
Leptin promotes aggregation of human platelets via the long form of its receptor. Diabetes (1999) 1.15
Leptin induces C-reactive protein expression in vascular endothelial cells. Arterioscler Thromb Vasc Biol (2007) 1.14
Plasma leptin level is associated with myocardial wall thickness in hypertensive insulin-resistant men. Hypertension (1999) 1.14
Low grade inflammation in juvenile obesity and type 1 diabetes associated with early signs of atherosclerosis. Exp Clin Endocrinol Diabetes (2004) 1.14
Role of leptin in obesity-related hypertension. Exp Physiol (2005) 1.12
Plasma insulin, leptin, and soluble TNF receptors levels in relation to obesity-related atherogenic and thrombogenic cardiovascular disease risk factors among men. Atherosclerosis (2001) 1.11
High plasma immunoreactive leptin level in essential hypertension. Am J Hypertens (1997) 1.10
Leptinemia is not a risk factor for ischemic heart disease in men. Prospective results from the Quebec Cardiovascular Study. Diabetes Care (1998) 1.10
C-reactive protein in young, apparently healthy men: associations with serum leptin, QTc interval, and high-density lipoprotein-cholesterol. Metabolism (2003) 1.10
Central leptin gene delivery evokes persistent leptin signal transduction in young and aged-obese rats but physiological responses become attenuated over time in aged-obese rats. Neuropharmacology (2002) 1.06
Determination of endothelial function and early atherosclerotic changes in healthy obese women. Diabetes Nutr Metab (2003) 1.05
The effects of leptin administration in non-obese human subjects. Obes Res (2001) 1.04
Plasma leptin is independently associated with the intima-media thickness of the common carotid artery. Int J Obes Relat Metab Disord (2001) 1.04
Detection and quantification of the leptin receptor splice variants Ob-Ra, b, and, e in different mouse tissues. Biochem Biophys Res Commun (1997) 1.03
Leptin is a risk marker for first-ever hemorrhagic stroke in a population-based cohort. Stroke (1999) 1.03
Circulating insulin concentrations, smoking, and alcohol intake are important independent predictors of leptin in young healthy men. Obes Res (1998) 1.03
The soluble leptin receptor is crucial for leptin action: evidence from clinical and experimental data. Int J Obes Relat Metab Disord (2003) 1.02
Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21
Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat Genet (2006) 19.03
A common variant on chromosome 9p21 affects the risk of myocardial infarction. Science (2007) 18.96
A variant in CDKAL1 influences insulin response and risk of type 2 diabetes. Nat Genet (2007) 13.28
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat Genet (2011) 13.25
Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes. Nat Genet (2007) 12.65
Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. Nat Genet (2009) 12.19
Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study. Lancet (2012) 12.10
Meta-analysis and imputation refines the association of 15q25 with smoking quantity. Nat Genet (2010) 8.55
Large-scale association analysis identifies new risk loci for coronary artery disease. Nat Genet (2012) 7.59
Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction. Nat Genet (2009) 6.83
The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm. Nat Genet (2008) 6.72
A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium. Nat Genet (2009) 6.31
Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution. Nat Genet (2007) 5.88
Triglyceride-mediated pathways and coronary disease: collaborative analysis of 101 studies. Lancet (2010) 5.31
Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies. Lancet (2012) 4.63
Genetic variants influencing circulating lipid levels and risk of coronary artery disease. Arterioscler Thromb Vasc Biol (2010) 4.08
Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways. Diabetes (2010) 4.07
Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease. N Engl J Med (2016) 3.88
Identification of seven loci affecting mean telomere length and their association with disease. Nat Genet (2013) 3.87
Pharmacological activation of liver X receptors promotes reverse cholesterol transport in vivo. Circulation (2005) 3.25
Overexpression of apolipoprotein A-I promotes reverse transport of cholesterol from macrophages to feces in vivo. Circulation (2003) 3.24
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet (2012) 3.21
Design of the Coronary ARtery DIsease Genome-Wide Replication And Meta-Analysis (CARDIoGRAM) Study: A Genome-wide association meta-analysis involving more than 22 000 cases and 60 000 controls. Circ Cardiovasc Genet (2010) 3.15
Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project. PLoS Genet (2011) 3.07
Common variants associated with plasma triglycerides and risk for coronary artery disease. Nat Genet (2013) 2.92
Inflammation impairs reverse cholesterol transport in vivo. Circulation (2009) 2.86
Common variation in KITLG and at 5q31.3 predisposes to testicular germ cell cancer. Nat Genet (2009) 2.85
Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci. Am J Hum Genet (2012) 2.53
An inflammatory cascade leading to hyperresistinemia in humans. PLoS Med (2004) 2.51
Innate immunity modulates adipokines in humans. J Clin Endocrinol Metab (2007) 2.48
Experimental endotoxemia induces adipose inflammation and insulin resistance in humans. Diabetes (2009) 2.27
Relationship of estimated GFR and coronary artery calcification in the CRIC (Chronic Renal Insufficiency Cohort) Study. Am J Kidney Dis (2011) 2.25
Genetically determined height and coronary artery disease. N Engl J Med (2015) 2.24
Lack of association between the Trp719Arg polymorphism in kinesin-like protein-6 and coronary artery disease in 19 case-control studies. J Am Coll Cardiol (2010) 2.17
Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease. Nat Genet (2012) 2.17
Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height. Am J Hum Genet (2010) 2.15
A genome-wide association study reveals variants in ARL15 that influence adiponectin levels. PLoS Genet (2009) 2.09
Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. Am J Hum Genet (2012) 1.96
Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque. Nat Genet (2011) 1.92
CXCL16 is a marker of inflammation, atherosclerosis, and acute coronary syndromes in humans. J Am Coll Cardiol (2007) 1.87
Strong synaptic transmission impact by copy number variations in schizophrenia. Proc Natl Acad Sci U S A (2010) 1.85
Endomyocardial biopsy plays a role in diagnosing patients with unexplained cardiomyopathy. Am Heart J (2004) 1.84
Loss-of-function variants in endothelial lipase are a cause of elevated HDL cholesterol in humans. J Clin Invest (2009) 1.83
Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm. Nat Genet (2010) 1.79
Association of lower plasma fetuin-a levels with peripheral arterial disease in type 2 diabetes. Diabetes Care (2009) 1.75
Association of the vitamin D metabolism gene CYP24A1 with coronary artery calcification. Arterioscler Thromb Vasc Biol (2010) 1.69
Fibroblast growth factor 23 is not associated with and does not induce arterial calcification. Kidney Int (2013) 1.66
A genome-wide association study identifies LIPA as a susceptibility gene for coronary artery disease. Circ Cardiovasc Genet (2011) 1.63
Genetic association for renal traits among participants of African ancestry reveals new loci for renal function. PLoS Genet (2011) 1.60
Interferon gamma attenuates insulin signaling, lipid storage, and differentiation in human adipocytes via activation of the JAK/STAT pathway. J Biol Chem (2009) 1.60
A human model of inflammatory cardio-metabolic dysfunction; a double blind placebo-controlled crossover trial. J Transl Med (2012) 1.59
Utility and barriers to performance of the ankle-brachial index in primary care practice. Vasc Med (2004) 1.57
A functional synonymous coding variant in the IL1RN gene is associated with survival in septic shock. Am J Respir Crit Care Med (2014) 1.53
Adipokines, insulin resistance, and coronary artery calcification. J Am Coll Cardiol (2008) 1.53
Endothelial lipase concentrations are increased in metabolic syndrome and associated with coronary atherosclerosis. PLoS Med (2005) 1.52
Overlap between common genetic polymorphisms underpinning kidney traits and cardiovascular disease phenotypes: the CKDGen consortium. Am J Kidney Dis (2013) 1.52
Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants. Stroke (2013) 1.51
Genome-wide association study for circulating tissue plasminogen activator levels and functional follow-up implicates endothelial STXBP5 and STX2. Arterioscler Thromb Vasc Biol (2014) 1.45
Fractalkine is a novel human adipochemokine associated with type 2 diabetes. Diabetes (2011) 1.44
Computed tomography-defined abdominal adiposity is associated with acute kidney injury in critically ill trauma patients*. Crit Care Med (2014) 1.41
Associations among race/ethnicity, ApoC-III genotypes, and lipids in HIV-1-infected individuals on antiretroviral therapy. PLoS Med (2006) 1.40
Effects of pioglitazone on lipoproteins, inflammatory markers, and adipokines in nondiabetic patients with metabolic syndrome. Arterioscler Thromb Vasc Biol (2005) 1.35
A genome-wide association study for coronary artery disease identifies a novel susceptibility locus in the major histocompatibility complex. Circ Cardiovasc Genet (2012) 1.35
Gene profiling of human adipose tissue during evoked inflammation in vivo. Diabetes (2009) 1.34
A second independent locus within DMRT1 is associated with testicular germ cell tumor susceptibility. Hum Mol Genet (2011) 1.34
Loss-of-function DNA sequence variant in the CLCNKA chloride channel implicates the cardio-renal axis in interindividual heart failure risk variation. Proc Natl Acad Sci U S A (2011) 1.33
Abnormal lipoprotein particles and cholesterol efflux capacity in patients with psoriasis. Atherosclerosis (2012) 1.29
Loci influencing blood pressure identified using a cardiovascular gene-centric array. Hum Mol Genet (2013) 1.27
Dense genotyping of candidate gene loci identifies variants associated with high-density lipoprotein cholesterol. Circ Cardiovasc Genet (2011) 1.27
Endothelial lipase is increased in vivo by inflammation in humans. Circulation (2008) 1.27
Genome-wide association study for circulating levels of PAI-1 provides novel insights into its regulation. Blood (2012) 1.26
Adipose inflammation, insulin resistance, and cardiovascular disease. JPEN J Parenter Enteral Nutr (2008) 1.25
Adipocyte modulation of high-density lipoprotein cholesterol. Circulation (2010) 1.21
Inflammation modulates human HDL composition and function in vivo. Atherosclerosis (2012) 1.18
Higher serum testosterone concentration in older women is associated with insulin resistance, metabolic syndrome, and cardiovascular disease. J Clin Endocrinol Metab (2009) 1.16
Genetic basis of atherosclerosis: insights from mice and humans. Circ Res (2012) 1.14
Evaluating the impact of sequencing depth on transcriptome profiling in human adipose. PLoS One (2013) 1.11
Cardiac signaling genes exhibit unexpected sequence diversity in sporadic cardiomyopathy, revealing HSPB7 polymorphisms associated with disease. J Clin Invest (2009) 1.10
Race and gender variation in response to evoked inflammation. J Transl Med (2013) 1.10
Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease. Am J Clin Nutr (2013) 1.08
Correcting population stratification in genetic association studies using a phylogenetic approach. Bioinformatics (2010) 1.08
The novel atherosclerosis locus at 10q11 regulates plasma CXCL12 levels. Eur Heart J (2011) 1.07
Selective PKC beta inhibition with ruboxistaurin and endothelial function in type-2 diabetes mellitus. Cardiovasc Drugs Ther (2008) 1.07
The addition of niacin to statin therapy improves high-density lipoprotein cholesterol levels but not metrics of functionality. J Am Coll Cardiol (2013) 1.07
Relation of plasma fatty acid binding proteins 4 and 5 with the metabolic syndrome, inflammation and coronary calcium in patients with type-2 diabetes mellitus. Am J Cardiol (2010) 1.05
Metabolic syndrome, components, and cardiovascular disease prevalence in chronic kidney disease: findings from the Chronic Renal Insufficiency Cohort (CRIC) Study. Am J Nephrol (2011) 1.05
Exome sequencing and directed clinical phenotyping diagnose cholesterol ester storage disease presenting as autosomal recessive hypercholesterolemia. Arterioscler Thromb Vasc Biol (2013) 1.03
Comparison of matrix metalloproteinase 9 and brain natriuretic peptide as clinical biomarkers in chronic heart failure. Am Heart J (2008) 1.03
Association between the chromosome 9p21 locus and angiographic coronary artery disease burden: a collaborative meta-analysis. J Am Coll Cardiol (2013) 1.02
Apolipoprotein B but not LDL cholesterol is associated with coronary artery calcification in type 2 diabetic whites. Diabetes (2009) 1.02
Genetics of coronary artery calcification among African Americans, a meta-analysis. BMC Med Genet (2013) 0.99
A naturally occurring variant of endothelial lipase associated with elevated HDL exhibits impaired synthesis. J Lipid Res (2009) 0.97
Novel eicosapentaenoic acid-derived F3-isoprostanes as biomarkers of lipid peroxidation. J Biol Chem (2009) 0.97
PennSeq: accurate isoform-specific gene expression quantification in RNA-Seq by modeling non-uniform read distribution. Nucleic Acids Res (2013) 0.97
Importance of evaluating cell cholesterol influx with efflux in determining the impact of human serum on cholesterol metabolism and atherosclerosis. Arterioscler Thromb Vasc Biol (2013) 0.96