Published in EMBO J on February 01, 1991
Differential effect of zinc finger deletions on the binding of CTCF to the promoter of the amyloid precursor protein gene. Nucleic Acids Res (2000) 1.59
Review and hypothesis: Alzheimer disease and Down syndrome--chromosome 21 nondisjunction may underlie both disorders. Am J Hum Genet (1991) 1.43
Neuropathology and apolipoprotein E profile of aged chimpanzees: implications for Alzheimer disease. Proc Natl Acad Sci U S A (1994) 1.22
Dysregulation of gene expression in mouse trisomy 16, an animal model of Down syndrome. EMBO J (1992) 1.08
Expression of the human beta-amyloid precursor protein gene from a yeast artificial chromosome in transgenic mice. Proc Natl Acad Sci U S A (1993) 0.89
Beta/A4 proteinlike immunoreactive granular structures in the brain of senescence-accelerated mouse. Am J Pathol (1993) 0.88
Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem Biophys Res Commun (1984) 20.07
The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature (1987) 17.08
Amyloid plaque core protein in Alzheimer disease and Down syndrome. Proc Natl Acad Sci U S A (1985) 16.10
Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus. Science (1987) 8.29
Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease. Science (1987) 6.89
Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease. Proc Natl Acad Sci U S A (1986) 6.56
Neuronal origin of a cerebral amyloid: neurofibrillary tangles of Alzheimer's disease contain the same protein as the amyloid of plaque cores and blood vessels. EMBO J (1985) 6.24
Ubiquitin is a component of paired helical filaments in Alzheimer's disease. Science (1987) 5.06
Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type. Science (1990) 4.71
Paired helical filaments in electron microscopy of Alzheimer's disease. Nature (1963) 4.62
Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease. Proc Natl Acad Sci U S A (1988) 4.45
ALZHEIMER'S DISEASE--AN ELECTRON MICROSCOPICAL STUDY. Brain (1964) 3.82
Neuritic plaques and cerebrovascular amyloid in Alzheimer disease are antigenically related. Proc Natl Acad Sci U S A (1985) 3.54
Isolation of low-molecular-weight proteins from amyloid plaque fibers in Alzheimer's disease. J Neurochem (1986) 3.31
A4 amyloid protein deposition and the diagnosis of Alzheimer's disease: prevalence in aged brains determined by immunocytochemistry compared with conventional neuropathologic techniques. Neurology (1988) 3.28
Amyloid A4 protein and its precursor in Down's syndrome and Alzheimer's disease. N Engl J Med (1989) 3.24
THE FINE STRUCTURE OF NEUROFIBRILLARY TANGLES IN ALZHEIMER'S DISEASE. J Neuropathol Exp Neurol (1963) 3.14
Immunochemical identification of the serine protease inhibitor alpha 1-antichymotrypsin in the brain amyloid deposits of Alzheimer's disease. Cell (1988) 3.11
Neurofibrillary tangles of paired helical filaments. J Neurol Sci (1976) 2.80
Senile dementia of the Alzheimer type. Ann Neurol (1983) 2.47
Human amyloidosis, Alzheimer disease and related disorders. Lab Invest (1988) 2.44
The development of the pathologic changes of Alzheimer's disease and senile dementia in patients with Down's syndrome. Am J Pathol (1973) 2.02
Amyloid beta protein precursor gene and hereditary cerebral hemorrhage with amyloidosis (Dutch). Science (1990) 1.92
Neurofibrillary tangles of Alzheimer's disease: an immunohistochemical study. J Submicrosc Cytol (1985) 1.69
Failure of familial Alzheimer's disease to segregate with the A4-amyloid gene in several European families. Nature (1987) 1.68
Beta amyloid gene duplication in Alzheimer's disease and karyotypically normal Down syndrome. Science (1987) 1.67
Dementia of the Alzheimer type. Clinical genetics, natural history, and associated conditions. Arch Gen Psychiatry (1981) 1.67
The amyloid precursor protein is concentrated in neuronal lysosomes in normal and Alzheimer disease subjects. Exp Neurol (1989) 1.45
Systematic approach to the study of trisomy in the mouse. II. Cytogenet Cell Genet (1975) 1.40
Amyloid protein and neurofibrillary tangles coexist in the same neuron in Alzheimer disease. Proc Natl Acad Sci U S A (1989) 1.40
Immunocytochemical properties of Alzheimer straight filaments. J Neurosci (1987) 1.32
Down's syndrome and Alzheimer's disease: a review. Psychol Med (1986) 1.31
Alpha 1-antichymotrypsin is associated solely with amyloid deposits containing the beta-protein. Amyloid and cell localization of alpha 1-antichymotrypsin. Neurobiol Aging (1990) 1.19
Down syndrome, Alzheimer's disease and the trisomy 16 mouse. Trends Neurosci (1988) 1.04
Purification, ultrastructure, and chemical analysis of Alzheimer disease amyloid plaque core protein. Proc Natl Acad Sci U S A (1986) 1.04
Alzheimer's disease and Down's syndrome. Ann N Y Acad Sci (1982) 1.01
Autosomal aneuploidy in mice: generation and developmental consequences. Brain Res Bull (1986) 0.93
Genetic linkage in the mouse of genes involved in Down syndrome and Alzheimer's disease in man. Brain Res (1987) 0.92
The mouse homolog of the human amyloid beta protein (AD-AP) gene is located on the distal end of mouse chromosome 16: further extension of the homology between human chromosome 21 and mouse chromosome 16. Biochem Biophys Res Commun (1987) 0.86
The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature (1987) 17.08
Amyloid plaque core protein in Alzheimer disease and Down syndrome. Proc Natl Acad Sci U S A (1985) 16.10
Imaging beta-amyloid burden in aging and dementia. Neurology (2007) 7.70
Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease. Ann Neurol (1999) 7.69
Neuronal origin of a cerebral amyloid: neurofibrillary tangles of Alzheimer's disease contain the same protein as the amyloid of plaque cores and blood vessels. EMBO J (1985) 6.24
Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease. Proc Natl Acad Sci U S A (1989) 5.97
Gene structure and extracellular secretion of Neisseria gonorrhoeae IgA protease. Nature (1987) 5.88
Creutzfeldt-Jakob disease: patterns of worldwide occurrence and the significance of familial and sporadic clustering. Ann Neurol (1979) 5.53
Rapid induction of Alzheimer A beta amyloid formation by zinc. Science (1994) 5.34
Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein. Cell (1989) 4.99
Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau. Proc Natl Acad Sci U S A (1988) 4.68
Characterization of progressive motor deficits in mice transgenic for the human Huntington's disease mutation. J Neurosci (1999) 4.56
Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons. Proc Natl Acad Sci U S A (1998) 4.49
Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice. Neuron (2001) 4.42
The strychnine-binding subunit of the glycine receptor shows homology with nicotinic acetylcholine receptors. Nature (1987) 4.15
Central nervous system damage produced by expression of the HIV-1 coat protein gp120 in transgenic mice. Nature (1994) 3.87
How lac repressor binds to DNA. Nature (1972) 3.72
Simvastatin strongly reduces levels of Alzheimer's disease beta -amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo. Proc Natl Acad Sci U S A (2001) 3.50
The amino-acid sequence of lac repressor. Proc Natl Acad Sci U S A (1973) 3.36
Aggregation and secondary structure of synthetic amyloid beta A4 peptides of Alzheimer's disease. J Mol Biol (1991) 3.33
Isolation of low-molecular-weight proteins from amyloid plaque fibers in Alzheimer's disease. J Neurochem (1986) 3.31
A4 amyloid protein deposition and the diagnosis of Alzheimer's disease: prevalence in aged brains determined by immunocytochemistry compared with conventional neuropathologic techniques. Neurology (1988) 3.28
Amyloid A4 protein and its precursor in Down's syndrome and Alzheimer's disease. N Engl J Med (1989) 3.24
Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport. Proc Natl Acad Sci U S A (1990) 3.13
Analysis of heterogeneous A4 peptides in human cerebrospinal fluid and blood by a newly developed sensitive Western blot assay. J Biol Chem (1996) 3.10
Evidence that beta-amyloid protein in Alzheimer's disease is not derived by normal processing. Science (1990) 3.10
Distinct sites of intracellular production for Alzheimer's disease A beta40/42 amyloid peptides. Nat Med (1997) 2.95
The mechanism of chromosomal translocation t(11;14) involving the T-cell receptor C delta locus on human chromosome 14q11 and a transcribed region of chromosome 11p15. EMBO J (1988) 2.81
Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6. Proc Natl Acad Sci U S A (1993) 2.79
Alzheimer's-disease-like changes in tau protein processing: association with aluminium accumulation in brains of renal dialysis patients. Lancet (1994) 2.74
The role of cortical connectivity in Alzheimer's disease pathogenesis: a review and model system. Neurobiol Aging (1993) 2.65
Abeta deposits in older non-demented individuals with cognitive decline are indicative of preclinical Alzheimer's disease. Neuropsychologia (2008) 2.58
[Virus proteins. IV. Constitution of the coat protein of the fd phage]. Hoppe Seylers Z Physiol Chem (1969) 2.56
Determinants of diagnostic investigation sensitivities across the clinical spectrum of sporadic Creutzfeldt-Jakob disease. Brain (2006) 2.54
Subacute spongiform encephalopathy (Creutzfeldt-Jakob disease). The nature and progression of spongiform change. Brain (1978) 2.49
Most cases of dementia with hippocampal sclerosis may represent frontotemporal dementia. Neurology (2004) 2.42
Large amounts of neocortical beta A4 deposits without neuritic plaques nor tangles in a psychometrically assessed, non-demented person. Neurosci Lett (1990) 2.40
Immunoglobulin V region variants in hybridoma cells. II. Recombination between V genes. EMBO J (1982) 2.31
Packaging of prions into exosomes is associated with a novel pathway of PrP processing. J Pathol (2007) 2.31
Cu(II) potentiation of alzheimer abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction. J Biol Chem (1999) 2.30
The amyloid precursor protein of Alzheimer's disease in the reduction of copper(II) to copper(I) Science (1996) 2.29
Alzheimer's disease amyloidogenic glycoprotein: expression pattern in rat brain suggests a role in cell contact. EMBO J (1988) 2.26
Chicken NFI/TGGCA proteins are encoded by at least three independent genes: NFI-A, NFI-B and NFI-C with homologues in mammalian genomes. Nucleic Acids Res (1990) 2.24
Ultrastructural morphology of amyloid fibrils from neuritic and amyloid plaques. Acta Neuropathol (1983) 2.23
Identification, transmembrane orientation and biogenesis of the amyloid A4 precursor of Alzheimer's disease. EMBO J (1988) 2.23
A heparin-binding domain in the amyloid protein precursor of Alzheimer's disease is involved in the regulation of neurite outgrowth. J Neurosci (1994) 2.19
In vitro and in vivo products of E. coli lactose permease gene are identical. Nature (1980) 2.18
Receptor-stimulated death pathway is opened by antigen in mature T cells. Proc Natl Acad Sci U S A (1991) 2.13
Amyloid load in Parkinson's disease dementia and Lewy body dementia measured with [11C]PIB positron emission tomography. J Neurol Neurosurg Psychiatry (2008) 2.12
Amyloid, aluminium and the aetiology of Alzheimer's disease. Med J Aust (1995) 2.09
Basal forebrain neurons in the dementia of Parkinson disease. Ann Neurol (1983) 2.06
Subunit structure of paired helical filaments in Alzheimer's disease. J Cell Biol (1985) 2.06
The cDNA clone for strictosidine synthase from Rauvolfia serpentina. DNA sequence determination and expression in Escherichia coli. FEBS Lett (1988) 2.05
Beta-amyloid burden in the temporal neocortex is related to hippocampal atrophy in elderly subjects without dementia. Neurology (2010) 1.99
Minor salivary gland involvement in Sjögren's syndrome. Oral Surg Oral Med Oral Pathol (1974) 1.99
Long-term survival of human central nervous system progenitor cells transplanted into a rat model of Parkinson's disease. Exp Neurol (1997) 1.98
Oral transmission of kuru, Creutzfeldt-Jakob disease, and scrapie to nonhuman primates. J Infect Dis (1980) 1.96
Homodimerization of amyloid precursor protein and its implication in the amyloidogenic pathway of Alzheimer's disease. J Biol Chem (2001) 1.96
Mammalian single-stranded DNA binding protein UP I is derived from the hnRNP core protein A1. EMBO J (1986) 1.94
The "staircase test": a measure of independent forelimb reaching and grasping abilities in rats. J Neurosci Methods (1991) 1.93
TMEM106B regulates progranulin levels and the penetrance of FTLD in GRN mutation carriers. Neurology (2010) 1.93
The promoter of Alzheimer's disease amyloid A4 precursor gene. EMBO J (1988) 1.92
Molecular characterization of the minimal protease resistant tau unit of the Alzheimer's disease paired helical filament. EMBO J (1993) 1.91
Substitutions of hydrophobic amino acids reduce the amyloidogenicity of Alzheimer's disease beta A4 peptides. J Mol Biol (1992) 1.90
Selective discrimination learning impairments in mice expressing the human Huntington's disease mutation. J Neurosci (1999) 1.86
A viral member of the ERV1/ALR protein family participates in a cytoplasmic pathway of disulfide bond formation. Proc Natl Acad Sci U S A (2000) 1.86
A comparative analysis of leucine-rich repeat kinase 2 (Lrrk2) expression in mouse brain and Lewy body disease. Neuroscience (2007) 1.86
Two alleles of a neural protein gene linked to scrapie in sheep. Proc Natl Acad Sci U S A (1990) 1.84
Image reconstruction of the Alzheimer paired helical filament. EMBO J (1985) 1.82
Intraneuronal Abeta accumulation precedes plaque formation in beta-amyloid precursor protein and presenilin-1 double-transgenic mice. Neurosci Lett (2001) 1.82
The familial occurrence of Creutzfeldt-Jakob disease and Alzheimer's disease. Brain (1981) 1.80
Structure of amyloid A4-(1-40)-peptide of Alzheimer's disease. Eur J Biochem (1995) 1.80
Unilateral transplantation of human primary fetal tissue in four patients with Huntington's disease: NEST-UK safety report ISRCTN no 36485475. J Neurol Neurosurg Psychiatry (2002) 1.76
The protein component of scrapie-associated fibrils is a glycosylated low molecular weight protein. EMBO J (1985) 1.76
Differential expression of immediate early genes in the hippocampus and spinal cord. Neuron (1990) 1.76
The LPS receptor (CD14) links innate immunity with Alzheimer's disease. FASEB J (2003) 1.75
Abnormal synaptic plasticity and impaired spatial cognition in mice transgenic for exon 1 of the human Huntington's disease mutation. J Neurosci (2000) 1.75
Surgical treatment and risk of sporadic Creutzfeldt-Jakob disease: a case-control study. Lancet (1999) 1.74
The amyloid protein precursor of Alzheimer's disease is a mediator of the effects of nerve growth factor on neurite outgrowth. Neuron (1992) 1.72