Published in J Leukoc Biol on December 30, 2008
IL-7 promotes T cell viability, trafficking, and functionality and improves survival in sepsis. J Immunol (2010) 2.29
IL-15 prevents apoptosis, reverses innate and adaptive immune dysfunction, and improves survival in sepsis. J Immunol (2009) 1.91
Epigenetic regulation of immune cell functions during post-septic immunosuppression. Epigenetics (2011) 1.38
The neutrophil-lymphocyte count ratio in patients with community-acquired pneumonia. PLoS One (2012) 1.24
Interleukin-7 ameliorates immune dysfunction and improves survival in a 2-hit model of fungal sepsis. J Infect Dis (2012) 1.10
Immune unresponsiveness to secondary heterologous bacterial infection after sepsis induction is TRAIL dependent. J Immunol (2011) 1.03
Chronic alcohol ingestion increases mortality and organ injury in a murine model of septic peritonitis. PLoS One (2013) 0.96
Sustained and incomplete recovery of naive CD8+ T cell precursors after sepsis contributes to impaired CD8+ T cell responses to infection. J Immunol (2013) 0.95
Impact of sepsis on CD4 T cell immunity. J Leukoc Biol (2014) 0.94
T-cell-mediated immunity and the role of TRAIL in sepsis-induced immunosuppression. Crit Rev Immunol (2013) 0.91
Differential alterations of tissue T-cell subsets after sepsis. Immunol Lett (2015) 0.82
Alterations in antigen-specific naive CD4 T cell precursors after sepsis impairs their responsiveness to pathogen challenge. J Immunol (2015) 0.80
Dynamics of peripheral blood lymphocyte subpopulations in the acute and subacute phase of Legionnaires' disease. PLoS One (2013) 0.80
Toll-like receptor 4 stimulation before or after Streptococcus pneumoniae induced sepsis improves survival and is dependent on T-cells. PLoS One (2014) 0.77
Clinical and Experimental Sepsis Impairs CD8 T-Cell-Mediated Immunity. Crit Rev Immunol (2016) 0.76
Heterogeneity among septic shock patients in a set of immunoregulatory markers. Eur J Clin Microbiol Infect Dis (2013) 0.76
Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med (2001) 46.58
The pathophysiology and treatment of sepsis. N Engl J Med (2003) 21.67
Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo. Nat Immunol (2000) 12.81
Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction. Crit Care Med (1999) 7.24
Maintaining the norm: T-cell homeostasis. Nat Rev Immunol (2002) 5.63
MyD88-dependent expansion of an immature GR-1(+)CD11b(+) population induces T cell suppression and Th2 polarization in sepsis. J Exp Med (2007) 5.48
Low-affinity ligands for the TCR drive proliferation of mature CD8+ T cells in lymphopenic hosts. Immunity (1999) 4.61
Interleukin 7 and T cell receptor signals regulate homeostasis of CD4 memory cells. Nat Immunol (2003) 3.82
Deaths: final data for 1998. Natl Vital Stat Rep (2000) 3.44
Prevention of lymphocyte cell death in sepsis improves survival in mice. Proc Natl Acad Sci U S A (1999) 3.35
Overexpression of Bcl-2 in transgenic mice decreases apoptosis and improves survival in sepsis. J Immunol (1999) 2.92
Leukocyte apoptosis and its significance in sepsis and shock. J Leukoc Biol (2005) 2.38
Depletion of dendritic cells, but not macrophages, in patients with sepsis. J Immunol (2002) 2.25
Prolonged lymphopenia, lymphoid depletion, and hypoprolactinemia in children with nosocomial sepsis and multiple organ failure. J Immunol (2005) 2.17
Gut flora antigens are not important in the maintenance of regulatory T cell heterogeneity and homeostasis. Eur J Immunol (2007) 2.12
Spontaneous and homeostatic proliferation of CD4 T cells are regulated by different mechanisms. J Immunol (2005) 2.06
Naïve cytotoxic T lymphocytes spontaneously acquire effector function in lymphocytopenic recipients: A pitfall for T cell memory studies? Eur J Immunol (1999) 2.03
Increased natural CD4+CD25+ regulatory T cells and their suppressor activity do not contribute to mortality in murine polymicrobial sepsis. J Immunol (2006) 1.86
Uptake of apoptotic antigen-coupled cells by lymphoid dendritic cells and cross-priming of CD8(+) T cells produce active immune unresponsiveness. J Immunol (2002) 1.79
The contribution of CD4+ CD25+ T-regulatory-cells to immune suppression in sepsis. Shock (2007) 1.71
Lymphopenic mice reconstituted with limited repertoire T cells develop severe, multiorgan, Th2-associated inflammatory disease. Proc Natl Acad Sci U S A (2007) 1.64
Cutting edge: homeostatic proliferation of peripheral T lymphocytes is regulated by clonal competition. J Immunol (2003) 1.55
T cell homeostasis in tolerance and immunity. J Leukoc Biol (2005) 1.50
Competition for self ligands restrains homeostatic proliferation of naive CD4 T cells. Proc Natl Acad Sci U S A (2003) 1.47
CD11chigh dendritic cell ablation impairs lymphopenia-driven proliferation of naive and memory CD8+ T cells. J Immunol (2005) 1.44
Adoptive transfer of in vitro-stimulated CD4+CD25+ regulatory T cells increases bacterial clearance and improves survival in polymicrobial sepsis. J Immunol (2005) 1.42
IL-15 is required for sustained lymphopenia-driven proliferation and accumulation of CD8 T cells. J Immunol (2007) 1.30
Homeostasis and T cell regulation. Curr Opin Immunol (2004) 1.26
The role of TCR engagement and activation-induced cell death in sepsis-induced T cell apoptosis. J Immunol (2006) 1.22
Peripheral T cell expansion in lymphopenic mice results in a restricted T cell repertoire. Eur J Immunol (2000) 1.19
A major role for memory CD4 T cells in the control of lymphopenia-induced proliferation of naive CD4 T cells. J Immunol (2005) 1.17
IL-10 mediation of activation-induced TH1 cell apoptosis and lymphoid dysfunction in polymicrobial sepsis. Cytokine (2001) 1.11
Self-recognition is crucial for maintaining the peripheral CD4+ T-cell pool in a nonlymphopenic environment. Blood (2006) 1.11
Spleen depletion in neonatal sepsis and chorioamnionitis. Am J Clin Pathol (2004) 1.08
On the role of MHC class II molecules in the survival and lymphopenia-induced proliferation of peripheral CD4+ T cells. Proc Natl Acad Sci U S A (2003) 1.08
Injury primes the immune system for an enhanced and lethal T-cell response against bacterial superantigen. Shock (1999) 0.81
Lymphopenia-induced homeostatic proliferation of CD8+ T cells is a mechanism for effective allogeneic skin graft rejection following burn injury. J Immunol (2006) 0.81
Cell death and the immune response: a lesson from the privileged. J Clin Immunol (1997) 0.76
Immunosuppression in patients who die of sepsis and multiple organ failure. JAMA (2011) 7.10
Induction of immunological tolerance by apoptotic cells requires caspase-dependent oxidation of high-mobility group box-1 protein. Immunity (2008) 4.37
The Rd8 mutation of the Crb1 gene is present in vendor lines of C57BL/6N mice and embryonic stem cells, and confounds ocular induced mutant phenotypes. Invest Ophthalmol Vis Sci (2012) 4.11
The sepsis seesaw: tilting toward immunosuppression. Nat Med (2009) 3.95
Mechanisms of cardiac and renal dysfunction in patients dying of sepsis. Am J Respir Crit Care Med (2013) 3.25
Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms. Nature (2004) 2.98
Delayed administration of anti-PD-1 antibody reverses immune dysfunction and improves survival during sepsis. J Leukoc Biol (2010) 2.81
The presence of hypothermia within 24 hours of sepsis diagnosis predicts persistent lymphopenia. Crit Care Med (2015) 2.81
Abandon the mouse research ship? Not just yet! Shock (2014) 2.60
Inducer-stimulated Fas targets activated endothelium for destruction by anti-angiogenic thrombospondin-1 and pigment epithelium-derived factor. Nat Med (2002) 2.34
IL-7 promotes T cell viability, trafficking, and functionality and improves survival in sepsis. J Immunol (2010) 2.29
Sepsis-induced human lymphocyte apoptosis and cytokine production in "humanized" mice. J Leukoc Biol (2009) 2.27
Inhibition of intestinal epithelial apoptosis and survival in a murine model of pneumonia-induced sepsis. JAMA (2002) 2.20
Overexpression of Bcl-2 in the intestinal epithelium improves survival in septic mice. Crit Care Med (2002) 2.20
Macrophages inhibit neovascularization in a murine model of age-related macular degeneration. PLoS Med (2006) 2.18
IL-15 prevents apoptosis, reverses innate and adaptive immune dysfunction, and improves survival in sepsis. J Immunol (2009) 1.91
Identification of the PGRMC1 protein complex as the putative sigma-2 receptor binding site. Nat Commun (2011) 1.86
Isolated lymphoid follicle formation is inducible and dependent upon lymphotoxin-sufficient B lymphocytes, lymphotoxin beta receptor, and TNF receptor I function. J Immunol (2003) 1.84
Sepsis from Pseudomonas aeruginosa pneumonia decreases intestinal proliferation and induces gut epithelial cell cycle arrest. Crit Care Med (2003) 1.83
Sepsis induces apoptosis and profound depletion of splenic interdigitating and follicular dendritic cells. J Immunol (2003) 1.76
Characterization and modulation of the immunosuppressive phase of sepsis. Infect Immun (2010) 1.76
Noncanonical autophagy promotes the visual cycle. Cell (2013) 1.74
Multiple triggers of cell death in sepsis: death receptor and mitochondrial-mediated apoptosis. FASEB J (2007) 1.73
Effects of age on mortality and antibiotic efficacy in cecal ligation and puncture. Shock (2003) 1.73
Senescence regulates macrophage activation and angiogenic fate at sites of tissue injury in mice. J Clin Invest (2007) 1.72
Effects of aging on the immunopathologic response to sepsis. Crit Care Med (2009) 1.72
Antibiotics improve survival in sepsis independent of injury severity but do not change mortality in mice with markedly elevated interleukin 6 levels. Shock (2004) 1.68
Cancer causes increased mortality and is associated with altered apoptosis in murine sepsis. Crit Care Med (2010) 1.68
Interaction of ICP34.5 with Beclin 1 modulates herpes simplex virus type 1 pathogenesis through control of CD4+ T-cell responses. J Virol (2009) 1.67
High-dose exogenous iron following cecal ligation and puncture increases mortality rate in mice and is associated with an increase in gut epithelial and splenic apoptosis. Crit Care Med (2004) 1.54
Deletion of MyD88 markedly attenuates sepsis-induced T and B lymphocyte apoptosis but worsens survival. J Leukoc Biol (2008) 1.54
Akt decreases lymphocyte apoptosis and improves survival in sepsis. J Immunol (2004) 1.54
A genetically encoded multifunctional TRAIL trimer facilitates cell-specific targeting and tumor cell killing. Mol Cancer Ther (2010) 1.53
Mechanisms of decreased intestinal epithelial proliferation and increased apoptosis in murine acute lung injury. Crit Care Med (2005) 1.49
Age-dependent changes in FasL (CD95L) modulate macrophage function in a model of age-related macular degeneration. Invest Ophthalmol Vis Sci (2013) 1.48
Selective sigma-2 ligands preferentially bind to pancreatic adenocarcinomas: applications in diagnostic imaging and therapy. Mol Cancer (2007) 1.46
Subcellular localization of sigma-2 receptors in breast cancer cells using two-photon and confocal microscopy. Cancer Res (2007) 1.44
Development of an immunoassay for the kidney-specific protein myo-inositol oxygenase, a potential biomarker of acute kidney injury. Clin Chem (2014) 1.43
Sepsis induces extensive autophagic vacuolization in hepatocytes: a clinical and laboratory-based study. Lab Invest (2009) 1.41
A prospective analysis of lymphocyte phenotype and function over the course of acute sepsis. Crit Care (2012) 1.41
Agonistic monoclonal antibody against CD40 receptor decreases lymphocyte apoptosis and improves survival in sepsis. J Immunol (2006) 1.40
Blockade of the negative co-stimulatory molecules PD-1 and CTLA-4 improves survival in primary and secondary fungal sepsis. Crit Care (2013) 1.37
Myeloperoxidase produces nitrating oxidants in vivo. J Clin Invest (2002) 1.35
Apoptotic cells induce tolerance by generating helpless CD8+ T cells that produce TRAIL. J Immunol (2007) 1.33
Persistent lymphopenia after diagnosis of sepsis predicts mortality. Shock (2014) 1.30
Neutrophil depletion causes a fatal defect in murine pulmonary Staphylococcus aureus clearance. J Surg Res (2008) 1.30
Dose-dependent effect of anti-CTLA-4 on survival in sepsis. Shock (2011) 1.26
Pneumonia after cecal ligation and puncture: a clinically relevant "two-hit" model of sepsis. Shock (2006) 1.26
Interleukin-7 (IL-7) treatment accelerates neutrophil recruitment through gamma delta T-cell IL-17 production in a murine model of sepsis. Infect Immun (2010) 1.25
Early antibiotic administration but not antibody therapy directed against IL-6 improves survival in septic mice predicted to die on basis of high IL-6 levels. Am J Physiol Regul Integr Comp Physiol (2005) 1.24
The role of TCR engagement and activation-induced cell death in sepsis-induced T cell apoptosis. J Immunol (2006) 1.22
CC chemokine receptor 6 expression by B lymphocytes is essential for the development of isolated lymphoid follicles. Am J Pathol (2007) 1.21
Advances in the management of sepsis and the understanding of key immunologic defects. Anesthesiology (2011) 1.21
Bim siRNA decreases lymphocyte apoptosis and improves survival in sepsis. Shock (2008) 1.19
Epidermal growth factor treatment decreases mortality and is associated with improved gut integrity in sepsis. Shock (2008) 1.16
Parallels between cancer and infectious disease. N Engl J Med (2014) 1.16
CD4+ lymphocytes control gut epithelial apoptosis and mediate survival in sepsis. FASEB J (2009) 1.14
Identification of an IFN-gamma-producing neutrophil early in the response to Listeria monocytogenes. J Immunol (2009) 1.14
Streptococcus pneumoniae and Pseudomonas aeruginosa pneumonia induce distinct host responses. Crit Care Med (2010) 1.14
Cell death in the maintenance and abrogation of tolerance: the five Ws of dying cells. Immunity (2011) 1.13
Sepsis-induced apoptosis leads to active suppression of delayed-type hypersensitivity by CD8+ regulatory T cells through a TRAIL-dependent mechanism. J Immunol (2010) 1.13
Targeted delivery of siRNA to cell death proteins in sepsis. Shock (2009) 1.12
Adaptive immune responses are dispensable for isolated lymphoid follicle formation: antigen-naive, lymphotoxin-sufficient B lymphocytes drive the formation of mature isolated lymphoid follicles. J Immunol (2005) 1.11
Interleukin-7 ameliorates immune dysfunction and improves survival in a 2-hit model of fungal sepsis. J Infect Dis (2012) 1.10
TRAIL: a mechanism of tumor surveillance in an immune privileged site. J Immunol (2002) 1.09
Age disproportionately increases sepsis-induced apoptosis in the spleen and gut epithelium. Shock (2004) 1.07
Stimulation of neovascularization by the anti-angiogenic factor PEDF. Invest Ophthalmol Vis Sci (2004) 1.06
Dendritic cells produce CXCL13 and participate in the development of murine small intestine lymphoid tissues. Am J Pathol (2010) 1.06
Peripheral deletion of antigen-specific T cells leads to long-term tolerance mediated by CD8+ cytotoxic cells. J Immunol (2005) 1.05
The plasticity of regulatory T cell function. J Immunol (2011) 1.03
Sigma-2 receptor ligands potentiate conventional chemotherapies and improve survival in models of pancreatic adenocarcinoma. J Transl Med (2009) 1.03
Molecular diagnostics in sepsis: from bedside to bench. J Am Coll Surg (2006) 1.02
Postgestational lymphotoxin/lymphotoxin beta receptor interactions are essential for the presence of intestinal B lymphocytes. J Immunol (2002) 1.02
FasL-Fas interactions regulate neovascularization in the cornea. Invest Ophthalmol Vis Sci (2003) 1.01
Modulation of the Bcl-2 family blocks sepsis-induced depletion of dendritic cells and macrophages. Shock (2009) 1.00
Antibiotics improve survival and alter the inflammatory profile in a murine model of sepsis from Pseudomonas aeruginosa pneumonia. Shock (2003) 1.00
Leukocyte phenotyping to stratify septic shock patients. Crit Care (2009) 0.99
Splenic CD4+ T cells have a distinct transcriptional response six hours after the onset of sepsis. J Am Coll Surg (2006) 0.99
Intravital microscopy comparing T lymphocyte trafficking to the spleen and the mesenteric lymph node. Am J Physiol Heart Circ Physiol (2003) 0.98
TAT-Bim induces extensive apoptosis in cancer cells. Ann Surg Oncol (2007) 0.97
Mechanisms and consequences of ebolavirus-induced lymphocyte apoptosis. J Immunol (2010) 0.97
Interleukin-7 and anti-programmed cell death 1 antibody have differing effects to reverse sepsis-induced immunosuppression. Shock (2015) 0.97
Bim-Bcl-2 homology 3 mimetic therapy is effective at suppressing inflammatory arthritis through the activation of myeloid cell apoptosis. Arthritis Rheum (2010) 0.95
Isatin sulfonamide analogs containing a Michael addition acceptor: a new class of caspase 3/7 inhibitors. J Med Chem (2007) 0.94
Prevention of immune cell apoptosis as potential therapeutic strategy for severe infections. Emerg Infect Dis (2007) 0.93
Probiotics for preventing ventilator-associated pneumonia. Cochrane Database Syst Rev (2014) 0.93