Published in Endocrinology on January 29, 2009
Adipose Tissue and Polycystic Ovary Syndrome (PCOS)(EIFFEL) (EIFFEL) | NCT01745471
Obesity is associated with inflammation and elevated aromatase expression in the mouse mammary gland. Cancer Prev Res (Phila) (2011) 2.97
Distinct hypothalamic neurons mediate estrogenic effects on energy homeostasis and reproduction. Cell Metab (2011) 2.61
The role of estrogens in control of energy balance and glucose homeostasis. Endocr Rev (2013) 1.93
Estradiol regulates brown adipose tissue thermogenesis via hypothalamic AMPK. Cell Metab (2014) 1.30
Interferon-gamma-inducible kynurenines/pteridines inflammation cascade: implications for aging and aging-associated psychiatric and medical disorders. J Neural Transm (Vienna) (2010) 1.25
Oestrogen alters adipocyte biology and protects female mice from adipocyte inflammation and insulin resistance. Diabetes Obes Metab (2011) 1.20
Sex differences in the physiology of eating. Am J Physiol Regul Integr Comp Physiol (2013) 1.18
The sexually dimorphic role of adipose and adipocyte estrogen receptors in modulating adipose tissue expansion, inflammation, and fibrosis. Mol Metab (2013) 1.17
Cellular mechanism by which estradiol protects female ovariectomized mice from high-fat diet-induced hepatic and muscle insulin resistance. Endocrinology (2013) 1.15
Obesity promotes breast cancer by CCL2-mediated macrophage recruitment and angiogenesis. Cancer Res (2013) 1.14
GPER deficiency in male mice results in insulin resistance, dyslipidemia, and a proinflammatory state. Endocrinology (2013) 1.03
Adipose tissue inflammation and reduced insulin sensitivity in ovariectomized mice occurs in the absence of increased adiposity. Endocrinology (2012) 1.03
Estradiol improves right ventricular function in rats with severe angioproliferative pulmonary hypertension: effects of endogenous and exogenous sex hormones. Am J Physiol Lung Cell Mol Physiol (2015) 1.02
Anti-Obesity and Anti-Diabetic Effects of Acacia Polyphenol in Obese Diabetic KKAy Mice Fed High-Fat Diet. Evid Based Complement Alternat Med (2011) 0.99
Female rats selectively bred for high intrinsic aerobic fitness are protected from ovariectomy-associated metabolic dysfunction. Am J Physiol Regul Integr Comp Physiol (2015) 0.99
Estradiol's beneficial effect on murine muscle function is independent of muscle activity. J Appl Physiol (1985) (2010) 0.98
Steroid receptor coactivator-1 mediates estrogenic actions to prevent body weight gain in female mice. Endocrinology (2012) 0.98
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A comparison of inflammatory and oxidative stress markers in adipose tissue from weight-matched obese male and female mice. Exp Diabetes Res (2012) 0.96
The Interactions of Obesity, Inflammation and Insulin Resistance in Breast Cancer. Cancers (Basel) (2015) 0.93
Bilateral oophorectomy, body mass index, and mortality in U.S. women aged 40 years and older. Cancer Prev Res (Phila) (2012) 0.91
Shp2 controls female body weight and energy balance by integrating leptin and estrogen signals. Mol Cell Biol (2012) 0.90
Olive oil effectively mitigates ovariectomy-induced osteoporosis in rats. BMC Complement Altern Med (2011) 0.89
Protective effects of white button mushroom (Agaricus bisporus) against hepatic steatosis in ovariectomized mice as a model of postmenopausal women. PLoS One (2011) 0.89
Cross-Talk between Metabolism and Reproduction: The Role of POMC and SF1 Neurons. Front Endocrinol (Lausanne) (2012) 0.88
Conjugated linoleic acid reduces body weight gain in ovariectomized female C57BL/6J mice. Nutr Res (2010) 0.87
Effects of treadmill exercise training on liver fat accumulation and estrogen receptor alpha expression in intact and ovariectomized rats with or without estrogen replacement treatment. Eur J Appl Physiol (2010) 0.87
Paracrine Interactions between Adipocytes and Tumor Cells Recruit and Modify Macrophages to the Mammary Tumor Microenvironment: The Role of Obesity and Inflammation in Breast Adipose Tissue. Cancers (Basel) (2015) 0.87
Effects of estradiol on cerebrospinal fluid levels of agouti-related protein in ovariectomized rhesus monkeys. Endocrinology (2010) 0.86
Effect of the estrous cycle and surgical ovariectomy on energy balance, fuel utilization, and physical activity in lean and obese female rats. Am J Physiol Regul Integr Comp Physiol (2010) 0.85
Estrogens prevent metabolic dysfunctions induced by circadian disruptions in female mice. Endocrinology (2015) 0.84
Ectopic lipid deposition and the metabolic profile of skeletal muscle in ovariectomized mice. Am J Physiol Regul Integr Comp Physiol (2012) 0.84
Prunus mume and Lithospermum erythrorhizon Extracts Synergistically Prevent Visceral Adiposity by Improving Energy Metabolism through Potentiating Hypothalamic Leptin and Insulin Signalling in Ovariectomized Rats. Evid Based Complement Alternat Med (2013) 0.84
Estrogen response element-independent signaling partially restores post-ovariectomy body weight gain but is not sufficient for 17β-estradiol's control of energy homeostasis. Steroids (2013) 0.83
Androgen (dihydrotestosterone)-mediated regulation of food intake and obesity in female mice. J Steroid Biochem Mol Biol (2013) 0.83
Ovariectomy and overeating palatable, energy-dense food increase subcutaneous adipose tissue more than intra-abdominal adipose tissue in rats. Biol Sex Differ (2011) 0.83
PPARG regulates gonadotropin-releasing hormone signaling in LbetaT2 cells in vitro and pituitary gonadotroph function in vivo in mice. Biol Reprod (2010) 0.83
GATA4 is a critical regulator of gonadectomy-induced adrenocortical tumorigenesis in mice. Endocrinology (2012) 0.83
Modulation of the activities of catalase, cu-zn, mn superoxide dismutase, and glutathione peroxidase in adipocyte from ovariectomised female rats with metabolic syndrome. Int J Endocrinol (2014) 0.82
AroER tri-screen is a biologically relevant assay for endocrine disrupting chemicals modulating the activity of aromatase and/or the estrogen receptor. Toxicol Sci (2014) 0.82
ERα upregulates Phd3 to ameliorate HIF-1 induced fibrosis and inflammation in adipose tissue. Mol Metab (2014) 0.81
Endogenous androgen deficiency enhances diet-induced hypercholesterolemia and atherosclerosis in low-density lipoprotein receptor-deficient mice. Gend Med (2012) 0.81
GC-TOF/MS-based metabolomic profiling of estrogen deficiency-induced obesity in ovariectomized rats. Acta Pharmacol Sin (2011) 0.81
Exercise training and calorie restriction influence the metabolic parameters in ovariectomized female rats. Oxid Med Cell Longev (2015) 0.81
Monocyte chemoattractant protein-1 deficiency attenuates oxidative stress and protects against ovariectomy-induced chronic inflammation in mice. PLoS One (2013) 0.81
Activation of Estrogen Response Element-independent ERα signaling protects female mice from diet-induced obesity. Endocrinology (2016) 0.81
Contrasting effects of increased and decreased dopamine transmission on latent inhibition in ovariectomized rats and their modulation by 17beta-estradiol: an animal model of menopausal psychosis? Neuropsychopharmacology (2010) 0.80
Progress in the molecular understanding of central regulation of body weight by estrogens. Obesity (Silver Spring) (2015) 0.80
Ovariectomy results in differential shifts in gut microbiota in low versus high aerobic capacity rats. Physiol Rep (2015) 0.80
Long-term Treatment with Oriental Medicinal Herb Artemisia princeps Alters Neuroplasticity in a Rat Model of Ovarian Hormone Deficiency. Exp Neurobiol (2015) 0.80
Lipolytic signaling in response to acute exercise is altered in female mice following ovariectomy. J Cell Biochem (2011) 0.80
Effects of ovariectomy and intrinsic aerobic capacity on tissue-specific insulin sensitivity. Am J Physiol Endocrinol Metab (2015) 0.80
Effects of Gengnianchun on learning and memory ability, neurotransmitter, cytokines, and leptin in ovariectomized rats. Int J Clin Exp Med (2015) 0.80
Testing the Critical Window Hypothesis of Timing and Duration of Estradiol Treatment on Hypothalamic Gene Networks in Reproductively Mature and Aging Female Rats. Endocrinology (2015) 0.79
Estrogen or raloxifene during postmenopausal weight loss: adiposity and cardiometabolic outcomes. Obesity (Silver Spring) (2013) 0.79
Loss of ovarian function in mice results in abrogated skeletal muscle PPARdelta and FoxO1-mediated gene expression. Biochem Biophys Res Commun (2009) 0.79
Association of bilateral oophorectomy and body fatness in a representative sample of US women. Gynecol Oncol (2013) 0.79
Ovarian status influenced the rate of body-weight change but not the total amount of body-weight gained or lost in female CBA/J mice. Exp Gerontol (2010) 0.79
The flavonoid, naringenin, decreases adipose tissue mass and attenuates ovariectomy-associated metabolic disturbances in mice. Nutr Metab (Lond) (2015) 0.79
Estrogen Protects against Obesity-Induced Mammary Gland Inflammation in Mice. Cancer Prev Res (Phila) (2015) 0.79
Blueberries improve glucose tolerance without altering body composition in obese postmenopausal mice. Obesity (Silver Spring) (2015) 0.79
Regulation of physiological and metabolic function of muscle by female sex steroids. Med Sci Sports Exerc (2012) 0.79
Strontium fructose 1,6-diphosphate prevents bone loss in a rat model of postmenopausal osteoporosis via the OPG/RANKL/RANK pathway. Acta Pharmacol Sin (2012) 0.79
Caloric restriction increases ratio of estrogen to androgen receptors expression in murine ovaries--potential therapeutic implications. J Ovarian Res (2015) 0.78
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Increased body fat mass and tissue lipotoxicity associated with ovariectomy or high-fat diet differentially affects bone and skeletal muscle metabolism in rats. Eur J Nutr (2014) 0.78
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An eGFP-expressing subpopulation of growth hormone secretagogue receptor cells are distinct from kisspeptin, tyrosine hydroxylase, and RFamide-related peptide neurons in mice. Peptides (2013) 0.77
Effects of diabetes mellitus on the rat liver during the postmenopausal period. J Mol Histol (2011) 0.77
Time-restricted feeding improves insulin resistance and hepatic steatosis in a mouse model of postmenopausal obesity. Metabolism (2016) 0.77
Regulation of energy expenditure by estradiol in premenopausal women. J Appl Physiol (1985) (2015) 0.77
Diminished satellite cells and elevated adipogenic gene expression in muscle as caused by ovariectomy are averted by low-magnitude mechanical signals. J Appl Physiol (1985) (2015) 0.76
Differential Effects of Dietary Fat Content and Protein Source on Bone Phenotype and Fatty Acid Oxidation in Female C57Bl/6 Mice. PLoS One (2016) 0.76
Estrogen suppresses adipogenesis by inhibiting S100A16 expression. J Mol Endocrinol (2014) 0.76
Using a novel coculture model to dissect the role of intramuscular lipid load on skeletal muscle insulin responsiveness under reduced estrogen conditions. Am J Physiol Endocrinol Metab (2013) 0.76
Ovariectomy is associated with metabolic impairments and enhanced mammary tumor growth in MKR mice. J Endocrinol (2015) 0.76
Cilostazol attenuates ovariectomy-induced bone loss by inhibiting osteoclastogenesis. PLoS One (2015) 0.76
Moderate intensity exercise inhibits macrophage infiltration and attenuates adipocyte inflammation in ovariectomized rats. J Exerc Nutrition Biochem (2014) 0.76
Gender Differences in Response to Prolonged Every-Other-Day Feeding on the Proliferation and Apoptosis of Hepatocytes in Mice. Nutrients (2016) 0.75
Estrogen deficiency in ovariectomized rats: can resistance training re-establish angiogenesis in visceral adipose tissue? Clinics (Sao Paulo) (2016) 0.75
Thyroid hormone and estrogen regulate exercise-induced growth hormone release. PLoS One (2015) 0.75
Core body temperature is lower in postmenopausal women than premenopausal women: potential implications for energy metabolism and midlife weight gain. Cardiovasc Endocrinol (2016) 0.75
Sequential Exposure to Obesogenic Factors in Females Rats: From Physiological Changes to Lipid Metabolism in Liver and Mesenteric Adipose Tissue. Sci Rep (2017) 0.75
Effect of Cross-Sex Hormonal Replacement on Antioxidant Enzymes in Rat Retroperitoneal Fat Adipocytes. Oxid Med Cell Longev (2016) 0.75
Hypoactivity following perturbed estrogen signaling in the medial amygdala. J Clin Invest (2015) 0.75
Voluntary Running Attenuates Metabolic Dysfunction in Ovariectomized Low-Fit Rats. Med Sci Sports Exerc (2016) 0.75
The Coexistence of Hypertension and Ovariectomy Additively Increases Cardiac Apoptosis. Int J Mol Sci (2016) 0.75
Physical training improves visceral adipose tissue health by remodelling extracellular matrix in rats with estrogen absence: a gene expression analysis. Int J Exp Pathol (2017) 0.75
Adipocytes and Macrophages Interplay in the Orchestration of Tumor Microenvironment: New Implications in Cancer Progression. Front Immunol (2017) 0.75
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Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J Clin Invest (2007) 20.19
TLR4 links innate immunity and fatty acid-induced insulin resistance. J Clin Invest (2006) 17.49
IKK-beta links inflammation to obesity-induced insulin resistance. Nat Med (2005) 12.07
Fat accumulation in the liver is associated with defects in insulin suppression of glucose production and serum free fatty acids independent of obesity in normal men. J Clin Endocrinol Metab (2002) 6.79
A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNK-dependent pathways. J Biol Chem (2007) 6.58
Adipocyte death, adipose tissue remodeling, and obesity complications. Diabetes (2007) 6.11
Ablation of CD11c-positive cells normalizes insulin sensitivity in obese insulin resistant animals. Cell Metab (2008) 5.10
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Intra-abdominal fat is a major determinant of the National Cholesterol Education Program Adult Treatment Panel III criteria for the metabolic syndrome. Diabetes (2004) 4.04
Liver peroxisome proliferator-activated receptor gamma contributes to hepatic steatosis, triglyceride clearance, and regulation of body fat mass. J Biol Chem (2003) 3.90
Interferon-gamma, a Th1 cytokine, regulates fat inflammation: a role for adaptive immunity in obesity. Circ Res (2008) 3.47
Adipocyte-specific gene expression and adipogenic steatosis in the mouse liver due to peroxisome proliferator-activated receptor gamma1 (PPARgamma1) overexpression. J Biol Chem (2002) 3.24
Increased visceral fat and decreased energy expenditure during the menopausal transition. Int J Obes (Lond) (2008) 3.18
Targeted disruption of inducible nitric oxide synthase protects against obesity-linked insulin resistance in muscle. Nat Med (2001) 3.14
Dead adipocytes, detected as crown-like structures, are prevalent in visceral fat depots of genetically obese mice. J Lipid Res (2008) 3.03
Osteopontin mediates obesity-induced adipose tissue macrophage infiltration and insulin resistance in mice. J Clin Invest (2007) 2.73
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Adipose tissue inflammation and increased ceramide content characterize subjects with high liver fat content independent of obesity. Diabetes (2007) 2.08
Upregulation of osteopontin expression is involved in the development of nonalcoholic steatohepatitis in a dietary murine model. Am J Physiol Gastrointest Liver Physiol (2004) 1.86
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Diabetic KKAy mice exhibit increased hepatic PPARgamma1 gene expression and develop hepatic steatosis upon chronic treatment with antidiabetic thiazolidinediones. J Hepatol (2001) 1.44
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