Published in Nat Struct Mol Biol on August 22, 2010
Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications. Genes Dev (2011) 5.60
DNA interstrand crosslink repair and cancer. Nat Rev Cancer (2011) 4.29
BRCA1 and BRCA2: different roles in a common pathway of genome protection. Nat Rev Cancer (2011) 3.85
Homologous recombination and its regulation. Nucleic Acids Res (2012) 2.44
RNF4, a SUMO-targeted ubiquitin E3 ligase, promotes DNA double-strand break repair. Genes Dev (2012) 2.16
Homologous recombination and human health: the roles of BRCA1, BRCA2, and associated proteins. Cold Spring Harb Perspect Biol (2015) 1.73
Unraveling the mechanism of BRCA2 in homologous recombination. Nat Struct Mol Biol (2011) 1.59
Replication stress and cancer. Nat Rev Cancer (2015) 1.43
Plk1 and CK2 act in concert to regulate Rad51 during DNA double strand break repair. Mol Cell (2012) 1.37
The epistatic relationship between BRCA2 and the other RAD51 mediators in homologous recombination. PLoS Genet (2011) 1.21
Coordination of DNA replication and recombination activities in the maintenance of genome stability. J Cell Biochem (2011) 1.15
Human nuclease/helicase DNA2 alleviates replication stress by promoting DNA end resection. Cancer Res (2012) 1.10
Using a fragment-based approach to target protein-protein interactions. Chembiochem (2013) 1.09
A cancer-associated BRCA2 mutation reveals masked nuclear export signals controlling localization. Nat Struct Mol Biol (2013) 1.04
Structure and mechanism of action of the BRCA2 breast cancer tumor suppressor. Nat Struct Mol Biol (2014) 1.03
DNA-pairing and annealing processes in homologous recombination and homology-directed repair. Cold Spring Harb Perspect Biol (2015) 1.03
RAD51C: a novel cancer susceptibility gene is linked to Fanconi anemia and breast cancer. Carcinogenesis (2010) 1.02
Plasticity of BRCA2 function in homologous recombination: genetic interactions of the PALB2 and DNA binding domains. PLoS Genet (2011) 1.02
Interactions between BRCA2 and RAD51 for promoting homologous recombination in Leishmania infantum. Nucleic Acids Res (2012) 1.02
A variant of the breast cancer type 2 susceptibility protein (BRC) repeat is essential for the RECQL5 helicase to interact with RAD51 recombinase for genome stabilization. J Biol Chem (2012) 1.01
HOP2-MND1 modulates RAD51 binding to nucleotides and DNA. Nat Commun (2014) 0.95
Promotion of BRCA2-Dependent Homologous Recombination by DSS1 via RPA Targeting and DNA Mimicry. Mol Cell (2015) 0.94
Tyrosine phosphorylation enhances RAD52-mediated annealing by modulating its DNA binding. EMBO J (2011) 0.94
Hereditary breast and ovarian cancer: new genes in confined pathways. Nat Rev Cancer (2016) 0.94
Phosphorylated RPA recruits PALB2 to stalled DNA replication forks to facilitate fork recovery. J Cell Biol (2014) 0.94
Inhibiting the DNA damage response as a therapeutic manoeuvre in cancer. Br J Pharmacol (2013) 0.93
Presynaptic filament dynamics in homologous recombination and DNA repair. Crit Rev Biochem Mol Biol (2011) 0.93
Functional assays for analysis of variants of uncertain significance in BRCA2. Hum Mutat (2013) 0.92
BRCA2 coordinates the activities of cell-cycle kinases to promote genome stability. Cell Rep (2014) 0.92
Rad51 Paralogs Remodel Pre-synaptic Rad51 Filaments to Stimulate Homologous Recombination. Cell (2015) 0.92
PALB2 self-interaction controls homologous recombination. Nucleic Acids Res (2012) 0.90
Male fertility defect associated with disrupted BRCA1-PALB2 interaction in mice. J Biol Chem (2014) 0.89
Interrogation of the protein-protein interactions between human BRCA2 BRC repeats and RAD51 reveals atomistic determinants of affinity. PLoS Comput Biol (2011) 0.88
Breast cancer proteins PALB2 and BRCA2 stimulate polymerase η in recombination-associated DNA synthesis at blocked replication forks. Cell Rep (2014) 0.87
Human RECQ5 helicase promotes repair of DNA double-strand breaks by synthesis-dependent strand annealing. Nucleic Acids Res (2013) 0.87
Homologs of breast cancer genes in plants. Front Plant Sci (2011) 0.86
BRCA2 diffuses as oligomeric clusters with RAD51 and changes mobility after DNA damage in live cells. J Cell Biol (2014) 0.85
Attenuating homologous recombination stimulates an AID-induced antileukemic effect. J Exp Med (2013) 0.85
Visualization and quantification of nascent RAD51 filament formation at single-monomer resolution. Proc Natl Acad Sci U S A (2014) 0.84
ATP-dependent nucleosome unwrapping catalyzed by human RAD51. Nucleic Acids Res (2013) 0.83
Mediators of homologous DNA pairing. Cold Spring Harb Perspect Biol (2014) 0.83
BLM SUMOylation regulates ssDNA accumulation at stalled replication forks. Front Genet (2013) 0.83
Novel insights into RAD51 activity and regulation during homologous recombination and DNA replication. Biochem Cell Biol (2016) 0.82
Poly(ADP-Ribose) Mediates the BRCA2-Dependent Early DNA Damage Response. Cell Rep (2015) 0.81
Coupling of Homologous Recombination and the Checkpoint by ATR. Mol Cell (2016) 0.81
Functions of Ubiquitin and SUMO in DNA Replication and Replication Stress. Front Genet (2016) 0.80
Contributions of the RAD51 N-terminal domain to BRCA2-RAD51 interaction. Nucleic Acids Res (2013) 0.80
BRUCE regulates DNA double-strand break response by promoting USP8 deubiquitination of BRIT1. Proc Natl Acad Sci U S A (2015) 0.80
Effect of the BRCA2 CTRD domain on RAD51 filaments analyzed by an ensemble of single molecule techniques. Nucleic Acids Res (2011) 0.80
BRCA2: one small step for DNA repair, one giant protein purified. Yale J Biol Med (2013) 0.79
ATM/ATR-mediated phosphorylation of PALB2 promotes RAD51 function. EMBO Rep (2016) 0.79
GST-His purification: a two-step affinity purification protocol yielding full-length purified proteins. J Vis Exp (2013) 0.79
Small-molecule inhibitors identify the RAD52-ssDNA interaction as critical for recovery from replication stress and for survival of BRCA2 deficient cells. Elife (2016) 0.79
Tyrosine phosphorylation stimulates activity of human RAD51 recombinase through altered nucleoprotein filament dynamics. Proc Natl Acad Sci U S A (2016) 0.79
DNA repair mechanisms in cancer development and therapy. Front Genet (2015) 0.78
A protective role for BRCA2 at stalled replication forks. Breast Cancer Res (2011) 0.78
Many ways to loop DNA. J Biol Chem (2013) 0.78
Nascent DNA synthesis during homologous recombination is synergistically promoted by the rad51 recombinase and DNA homology. Genetics (2014) 0.78
Distinct binding of BRCA2 BRC repeats to RAD51 generates differential DNA damage sensitivity. Nucleic Acids Res (2016) 0.77
Engineering Archeal Surrogate Systems for the Development of Protein-Protein Interaction Inhibitors against Human RAD51. J Mol Biol (2016) 0.76
Characterization of Brca2-deficient plants excludes the role of NHEJ and SSA in the meiotic chromosomal defect phenotype. PLoS One (2011) 0.76
High-resolution structure of the presynaptic RAD51 filament on single-stranded DNA by electron cryo-microscopy. Nucleic Acids Res (2016) 0.76
Cell biology of mitotic recombination. Cold Spring Harb Perspect Biol (2015) 0.76
Molding BRCA2 function through its interacting partners. Cell Cycle (2015) 0.76
Overexpression of BRCA1 attenuates the sensitivity of PC9 cells to gefitinib. Int J Clin Exp Pathol (2015) 0.76
MRG15-mediated tethering of PALB2 to unperturbed chromatin protects active genes from genotoxic stress. Proc Natl Acad Sci U S A (2017) 0.76
DNA repair: A protein giant in its entirety. Nature (2010) 0.75
Architectural plasticity of human BRCA2-RAD51 complexes in DNA break repair. Nucleic Acids Res (2017) 0.75
Unloading of homologous recombination factors is required for restoring double-stranded DNA at damage repair loci. EMBO J (2016) 0.75
The β-isoform of BCCIP promotes ADP release from the RAD51 presynaptic filament and enhances homologous DNA pairing. Nucleic Acids Res (2016) 0.75
The UBC Domain Is Required for BRUCE to Promote BRIT1/MCPH1 Function in DSB Signaling and Repair Post Formation of BRUCE-USP8-BRIT1 Complex. PLoS One (2015) 0.75
Role of the RAD51-SWI5-SFR1 Ensemble in homologous recombination. Nucleic Acids Res (2016) 0.75
The MMS22L-TONSL heterodimer directly promotes RAD51-dependent recombination upon replication stress. EMBO J (2016) 0.75
Dynamic unwrapping of nucleosomes by HsRAD51 that includes sliding and rotational motion of histone octamers. Nucleic Acids Res (2016) 0.75
A second DNA binding site in human BRCA2 promotes homologous recombination. Nat Commun (2016) 0.75
SMYD3 Promotes Homologous Recombination via Regulation of H3K4-mediated Gene Expression. Sci Rep (2017) 0.75
Non-catalytic Roles for XPG with BRCA1 and BRCA2 in Homologous Recombination and Genome Stability. Mol Cell (2016) 0.75
A Polar and Nucleotide-Dependent Mechanism of Action for RAD51 Paralogs in RAD51 Filament Remodeling. Mol Cell (2016) 0.75
Homologous Recombination in Protozoan Parasites and Recombinase Inhibitors. Front Microbiol (2017) 0.75
BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure. Science (2002) 6.32
Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis. Nat Rev Mol Cell Biol (2010) 5.35
Purification and characterization of the human Rad51 protein, an analogue of E. coli RecA. EMBO J (1994) 4.55
The BRCA2 homologue Brh2 nucleates RAD51 filament formation at a dsDNA-ssDNA junction. Nature (2005) 4.08
CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair. Nature (2005) 3.90
PALB2 is an integral component of the BRCA complex required for homologous recombination repair. Proc Natl Acad Sci U S A (2009) 2.98
Full-length archaeal Rad51 structure and mutants: mechanisms for RAD51 assembly and control by BRCA2. EMBO J (2003) 2.95
Targeted inactivation of mouse RAD52 reduces homologous recombination but not resistance to ionizing radiation. Mol Cell Biol (1998) 2.93
The BRC repeats of BRCA2 modulate the DNA-binding selectivity of RAD51. Cell (2009) 2.49
Rad52 protein associates with replication protein A (RPA)-single-stranded DNA to accelerate Rad51-mediated displacement of RPA and presynaptic complex formation. J Biol Chem (2002) 2.35
Assembly of RecA-like recombinases: distinct roles for mediator proteins in mitosis and meiosis. Proc Natl Acad Sci U S A (2001) 1.97
Functional interactions among yeast Rad51 recombinase, Rad52 mediator, and replication protein A in DNA strand exchange. J Biol Chem (2000) 1.91
Internal repeats in the BRCA2 protein sequence. Nat Genet (1996) 1.72
A region of human BRCA2 containing multiple BRC repeats promotes RAD51-mediated strand exchange. Nucleic Acids Res (2006) 1.68
The carboxyl terminus of Brca2 links the disassembly of Rad51 complexes to mitotic entry. Curr Biol (2009) 1.51
CeBRC-2 stimulates D-loop formation by RAD-51 and promotes DNA single-strand annealing. J Mol Biol (2006) 1.42
Interactions between human BRCA2 protein and the meiosis-specific recombinase DMC1. EMBO J (2007) 1.33
The BRC repeats of human BRCA2 differentially regulate RAD51 binding on single- versus double-stranded DNA to stimulate strand exchange. Proc Natl Acad Sci U S A (2009) 1.30
Dss1 interaction with Brh2 as a regulatory mechanism for recombinational repair. Mol Cell Biol (2007) 1.11
Evidence that the tumor-suppressor protein BRCA2 does not regulate cytokinesis in human cells. J Cell Sci (2010) 0.99
Cancer-associated mutations in BRC domains of BRCA2 affect homologous recombination induced by Rad51. J Mol Biol (2009) 0.88
Inactivation of RAD52 aggravates RAD54 defects in mice but not in Schizosaccharomyces pombe. DNA Repair (Amst) (2005) 0.85
The small-molecule inhibitor BI 2536 reveals novel insights into mitotic roles of polo-like kinase 1. Curr Biol (2007) 6.17
Concerted loading of Mcm2-7 double hexamers around DNA during DNA replication origin licensing. Cell (2009) 5.56
BI 2536, a potent and selective inhibitor of polo-like kinase 1, inhibits tumor growth in vivo. Curr Biol (2007) 5.17
Mechanism of replication-coupled DNA interstrand crosslink repair. Cell (2008) 4.53
DNA interstrand crosslink repair and cancer. Nat Rev Cancer (2011) 4.29
Identification of FAAP24, a Fanconi anemia core complex protein that interacts with FANCM. Mol Cell (2007) 4.28
CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair. Nature (2005) 3.90
RTEL1 maintains genomic stability by suppressing homologous recombination. Cell (2008) 3.84
Protein phosphatase 2A protects centromeric sister chromatid cohesion during meiosis I. Nature (2006) 3.81
Poly(ADP-ribose)-dependent regulation of DNA repair by the chromatin remodeling enzyme ALC1. Science (2009) 3.68
Poly(ADP-ribose)-binding zinc finger motifs in DNA repair/checkpoint proteins. Nature (2008) 3.67
Stabilization of RAD51 nucleoprotein filaments by the C-terminal region of BRCA2. Nat Struct Mol Biol (2007) 3.45
Identification of KIAA1018/FAN1, a DNA repair nuclease recruited to DNA damage by monoubiquitinated FANCD2. Cell (2010) 3.43
Identification of Holliday junction resolvases from humans and yeast. Nature (2008) 3.33
Structural and functional relationships of the XPF/MUS81 family of proteins. Annu Rev Biochem (2008) 3.32
Human DNA polymerase eta promotes DNA synthesis from strand invasion intermediates of homologous recombination. Mol Cell (2005) 3.16
RAD51C is required for Holliday junction processing in mammalian cells. Science (2004) 3.05
Arp2/3 is critical for lamellipodia and response to extracellular matrix cues but is dispensable for chemotaxis. Cell (2012) 2.98
Muscleblind-like 1 interacts with RNA hairpins in splicing target and pathogenic RNAs. Nucleic Acids Res (2007) 2.95
The neurodegenerative disease protein aprataxin resolves abortive DNA ligation intermediates. Nature (2006) 2.86
Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp loader hRad17-replication factor C complex in vitro. Proc Natl Acad Sci U S A (2003) 2.80
Synapsis of DNA ends by DNA-dependent protein kinase. EMBO J (2002) 2.62
Defective DNA repair and neurodegenerative disease. Cell (2007) 2.57
Identification and characterization of the human mus81-eme1 endonuclease. J Biol Chem (2003) 2.43
Sequential roles of Cdc42, Par-6, aPKC, and Lgl in the establishment of epithelial polarity during Drosophila embryogenesis. Dev Cell (2004) 2.39
Human RECQ5beta, a protein with DNA helicase and strand-annealing activities in a single polypeptide. EMBO J (2004) 2.33
FANCM connects the genome instability disorders Bloom's Syndrome and Fanconi Anemia. Mol Cell (2009) 2.29
Structure of the single-strand annealing domain of human RAD52 protein. Proc Natl Acad Sci U S A (2002) 2.24
Telomeric DNA in ALT cells is characterized by free telomeric circles and heterogeneous t-loops. Mol Cell Biol (2004) 2.23
Kinetochore recruitment of two nucleolar proteins is required for homolog segregation in meiosis I. Dev Cell (2003) 2.17
FANCM and FAAP24 function in ATR-mediated checkpoint signaling independently of the Fanconi anemia core complex. Mol Cell (2008) 2.14
Single-stranded DNA-binding protein hSSB1 is critical for genomic stability. Nature (2008) 2.12
Interplay between human DNA repair proteins at a unique double-strand break in vivo. EMBO J (2006) 2.09
Holliday junction resolution in human cells: two junction endonucleases with distinct substrate specificities. EMBO J (2002) 2.09
Regulatory control of the resolution of DNA recombination intermediates during meiosis and mitosis. Cell (2011) 2.08
BRCA2-dependent and independent formation of RAD51 nuclear foci. Oncogene (2003) 2.03
Polo-like kinase 1 directs assembly of the HsCyk-4 RhoGAP/Ect2 RhoGEF complex to initiate cleavage furrow formation. PLoS Biol (2009) 2.02
Termination factor-mediated DNA loop between termination and initiation sites drives mitochondrial rRNA synthesis. Cell (2005) 2.01
Aberrant chromosome morphology in human cells defective for Holliday junction resolution. Nature (2011) 1.97
XRCC3 and Rad51 modulate replication fork progression on damaged vertebrate chromosomes. Mol Cell (2003) 1.94
Involvement of human polynucleotide kinase in double-strand break repair by non-homologous end joining. EMBO J (2002) 1.93
Telomere maintenance requires the RAD51D recombination/repair protein. Cell (2004) 1.89
Preferential binding of ATR protein to UV-damaged DNA. Proc Natl Acad Sci U S A (2002) 1.87
RIDDLE immunodeficiency syndrome is linked to defects in 53BP1-mediated DNA damage signaling. Proc Natl Acad Sci U S A (2007) 1.79
Polo-like kinase 1 reaches beyond mitosis--cytokinesis, DNA damage response, and development. Curr Opin Cell Biol (2008) 1.76
RAD-51-dependent and -independent roles of a Caenorhabditis elegans BRCA2-related protein during DNA double-strand break repair. Mol Cell Biol (2005) 1.74
Direct interaction of FANCD2 with BRCA2 in DNA damage response pathways. Hum Mol Genet (2004) 1.73
Relocation of the chromosomal passenger complex prevents mitotic checkpoint engagement at anaphase. Curr Biol (2010) 1.72
RTEL-1 enforces meiotic crossover interference and homeostasis. Science (2010) 1.70
BRCA2 BRC motifs bind RAD51-DNA filaments. Proc Natl Acad Sci U S A (2005) 1.68
Eme1 is involved in DNA damage processing and maintenance of genomic stability in mammalian cells. EMBO J (2003) 1.68
Coordinated actions of SLX1-SLX4 and MUS81-EME1 for Holliday junction resolution in human cells. Mol Cell (2013) 1.67
C. elegans telomeres contain G-strand and C-strand overhangs that are bound by distinct proteins. Cell (2008) 1.65
RAD51C deficiency in mice results in early prophase I arrest in males and sister chromatid separation at metaphase II in females. J Cell Biol (2007) 1.62
Role of RAD51C and XRCC3 in genetic recombination and DNA repair. J Biol Chem (2006) 1.56
Mechanism of Holliday junction resolution by the human GEN1 protein. Genes Dev (2010) 1.54
Unpacking a gel-forming mucin: a view of MUC5B organization after granular release. Am J Physiol Lung Cell Mol Physiol (2009) 1.52
Mammalian mitochondrial DNA replication intermediates are essentially duplex but contain extensive tracts of RNA/DNA hybrid. J Mol Biol (2010) 1.50
Centralspindlin links the mitotic spindle to the plasma membrane during cytokinesis. Nature (2012) 1.48
Division of the nucleolus and its release of CDC14 during anaphase of meiosis I depends on separase, SPO12, and SLK19. Dev Cell (2003) 1.48
Functional overlap between the structure-specific nucleases Yen1 and Mus81-Mms4 for DNA-damage repair in S. cerevisiae. DNA Repair (Amst) (2010) 1.48
InTERTpreting telomerase structure and function. Nucleic Acids Res (2010) 1.47
Happy Hollidays: 40th anniversary of the Holliday junction. Nat Rev Mol Cell Biol (2004) 1.47
The basic domain of TRF2 directs binding to DNA junctions irrespective of the presence of TTAGGG repeats. J Biol Chem (2006) 1.45
Architecture of the bacteriophage T4 replication complex revealed with nanoscale biopointers. J Biol Chem (2006) 1.43
TRF2 promotes, remodels and protects telomeric Holliday junctions. EMBO J (2009) 1.42
DNA repair synthesis facilitates RAD52-mediated second-end capture during DSB repair. Mol Cell (2008) 1.41
Role of mammalian RAD51L2 (RAD51C) in recombination and genetic stability. J Biol Chem (2002) 1.41
Targeting of the RhoGEF Ect2 to the equatorial membrane controls cleavage furrow formation during cytokinesis. Dev Cell (2011) 1.40
Catalysis of strand exchange by the HSV-1 UL12 and ICP8 proteins: potent ICP8 recombinase activity is revealed upon resection of dsDNA substrate by nuclease. J Mol Biol (2004) 1.35
Replication fork regression in repetitive DNAs. Nucleic Acids Res (2006) 1.35
Interactions between human BRCA2 protein and the meiosis-specific recombinase DMC1. EMBO J (2007) 1.33
Telomere looping in P. sativum (common garden pea). Plant J (2003) 1.32
5-Azacytidine induced methyltransferase-DNA adducts block DNA replication in vivo. Cancer Res (2007) 1.31
RAD51 localization and activation following DNA damage. Philos Trans R Soc Lond B Biol Sci (2004) 1.29
Senataxin, defective in the neurodegenerative disorder ataxia with oculomotor apraxia 2, lies at the interface of transcription and the DNA damage response. Mol Cell Biol (2012) 1.27
Xrcc3 and Nbs1 are required for the production of extrachromosomal telomeric circles in human alternative lengthening of telomere cells. Cancer Res (2007) 1.27
Conformational changes modulate the activity of human RAD51 protein. J Mol Biol (2004) 1.26
Actions of aprataxin in multiple DNA repair pathways. J Biol Chem (2007) 1.24
Lagging strand synthesis in coordinated DNA synthesis by bacteriophage t7 replication proteins. J Mol Biol (2002) 1.24
The processing of Holliday junctions by BLM and WRN helicases is regulated by p53. J Biol Chem (2002) 1.22
Risk factors for persistent problems following acute whiplash injury: update of a systematic review and meta-analysis. J Orthop Sports Phys Ther (2013) 1.22
Regulation of the interaction of inosine monophosphate dehydrogenase with mycophenolic Acid by GTP. J Biol Chem (2005) 1.21
The carboxyl-terminal domain of bacteriophage T7 single-stranded DNA-binding protein modulates DNA binding and interaction with T7 DNA polymerase. J Biol Chem (2003) 1.21
Telomere loops and homologous recombination-dependent telomeric circles in a Kluyveromyces lactis telomere mutant strain. Mol Cell Biol (2007) 1.20
Specific interaction of IP6 with human Ku70/80, the DNA-binding subunit of DNA-PK. EMBO J (2002) 1.19
Solution structures of the two PBZ domains from human APLF and their interaction with poly(ADP-ribose). Nat Struct Mol Biol (2010) 1.19
The Werner syndrome protein binds replication fork and holliday junction DNAs as an oligomer. J Biol Chem (2008) 1.18
More complexity to the Bloom's syndrome complex. Genes Dev (2008) 1.16
Tandem affinity purification of functional TAP-tagged proteins from human cells. Nat Protoc (2007) 1.15