Published in Science on February 20, 2009
SIRT1 contributes to telomere maintenance and augments global homologous recombination. J Cell Biol (2010) 1.48
Acetylation of MnSOD directs enzymatic activity responding to cellular nutrient status or oxidative stress. Aging (Albany NY) (2011) 1.40
Gadd45 proteins: relevance to aging, longevity and age-related pathologies. Ageing Res Rev (2011) 1.19
Regulation of MnSOD enzymatic activity by Sirt3 connects the mitochondrial acetylome signaling networks to aging and carcinogenesis. Antioxid Redox Signal (2013) 1.09
Polyphenols and aging. Curr Aging Sci (2010) 1.06
Targeting autophagy for the treatment of liver diseases. Pharmacol Res (2012) 1.01
SIRT3 and SIRT4 are mitochondrial tumor suppressor proteins that connect mitochondrial metabolism and carcinogenesis. Cancer Metab (2014) 1.00
17β-Estradiol, aging, inflammation, and the stress response in the female heart. Endocrinology (2011) 0.99
Xenohormesis: health benefits from an eon of plant stress response evolution. Cell Stress Chaperones (2010) 0.96
Exploring the electrostatic repulsion model in the role of Sirt3 in directing MnSOD acetylation status and enzymatic activity. Free Radic Biol Med (2012) 0.90
Developing criteria for evaluation of geroprotectors as a key stage toward translation to the clinic. Aging Cell (2016) 0.90
Muscle heat shock protein 70 predicts insulin resistance with aging. J Gerontol A Biol Sci Med Sci (2014) 0.86
Hypoxia initiates sirtuin1-mediated vascular endothelial growth factor activation in choroidal endothelial cells through hypoxia inducible factor-2α. Mol Vis (2012) 0.85
SIRT3 overexpression antagonizes high glucose accelerated cellular senescence in human diploid fibroblasts via the SIRT3-FOXO1 signaling pathway. Age (Dordr) (2013) 0.83
Aging does not reduce heat shock protein 70 in the absence of chronic insulin resistance. J Gerontol A Biol Sci Med Sci (2012) 0.83
ROS production, intracellular HSP70 levels and their relationship in human neutrophils: effects of age. Oncotarget (2014) 0.82
Manganese Superoxide Dismutase Acetylation and Dysregulation, Due to Loss of SIRT3 Activity, Promote a Luminal B-Like Breast Carcinogenic-Permissive Phenotype. Antioxid Redox Signal (2016) 0.82
Transformation of eEF1Bδ into heat-shock response transcription factor by alternative splicing. EMBO Rep (2011) 0.81
Adaptive homeostasis. Mol Aspects Med (2016) 0.77
Stress-inducible regulation of heat shock factor 1 by the deacetylase SIRT1. Science (2009) 4.80
The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase. Mol Cell (2003) 8.34
Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. Mol Cell Biol (2007) 7.97
SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation. Nature (2010) 6.48
HIV reproducibly establishes a latent infection after acute infection of T cells in vitro. EMBO J (2003) 6.11
Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2. Proc Natl Acad Sci U S A (2006) 5.96
Towards an HIV cure: a global scientific strategy. Nat Rev Immunol (2012) 5.52
The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase. J Cell Biol (2002) 5.37
Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR. Mol Cell (2002) 5.19
Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation. Cell Metab (2010) 4.97
NF-kappaB p50 promotes HIV latency through HDAC recruitment and repression of transcriptional initiation. EMBO J (2005) 4.35
Conserved metabolic regulatory functions of sirtuins. Cell Metab (2008) 3.86
Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylase inhibitor. Science (2012) 3.52
SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome. Mol Cell (2011) 3.33
HIV persistence and the prospect of long-term drug-free remissions for HIV-infected individuals. Science (2010) 3.29
Sirtuins: Sir2-related NAD-dependent protein deacetylases. Genome Biol (2004) 3.00
Conserved P-TEFb-interacting domain of BRD4 inhibits HIV transcription. Proc Natl Acad Sci U S A (2007) 2.97
The first identification of lysine malonylation substrates and its regulatory enzyme. Mol Cell Proteomics (2011) 2.83
SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production. Cell Metab (2010) 2.77
Platform-independent and label-free quantitation of proteomic data using MS1 extracted ion chromatograms in skyline: application to protein acetylation and phosphorylation. Mol Cell Proteomics (2012) 2.66
CpG methylation controls reactivation of HIV from latency. PLoS Pathog (2009) 2.51
Epigenetic regulation of HIV-1 latency by cytosine methylation. PLoS Pathog (2009) 2.50
Repressive LTR nucleosome positioning by the BAF complex is required for HIV latency. PLoS Biol (2011) 2.49
Prostratin antagonizes HIV latency by activating NF-kappaB. J Biol Chem (2004) 2.47
Regulation of insulin secretion by SIRT4, a mitochondrial ADP-ribosyltransferase. J Biol Chem (2007) 2.37
SIRT1 regulates HIV transcription via Tat deacetylation. PLoS Biol (2005) 2.24
Structural basis of lysine-acetylated HIV-1 Tat recognition by PCAF bromodomain. Mol Cell (2002) 2.20
HDAC7, a thymus-specific class II histone deacetylase, regulates Nur77 transcription and TCR-mediated apoptosis. Immunity (2003) 2.10
Control of cytomegalovirus lytic gene expression by histone acetylation. EMBO J (2002) 2.06
Histone deacetylases inhibitors as anti-angiogenic agents altering vascular endothelial growth factor signaling. Oncogene (2002) 2.02
Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways. Proc Natl Acad Sci U S A (2013) 2.01
BET bromodomain-targeting compounds reactivate HIV from latency via a Tat-independent mechanism. Cell Cycle (2012) 1.88
The nexus of chromatin regulation and intermediary metabolism. Nature (2013) 1.87
Control of endothelial cell proliferation and migration by VEGF signaling to histone deacetylase 7. Proc Natl Acad Sci U S A (2008) 1.80
Protein kinase D1 phosphorylates HDAC7 and induces its nuclear export after T-cell receptor activation. J Biol Chem (2004) 1.79
The SWI/SNF chromatin-remodeling complex is a cofactor for Tat transactivation of the HIV promoter. J Biol Chem (2006) 1.77
The Cellular lysine methyltransferase Set7/9-KMT7 binds HIV-1 TAR RNA, monomethylates the viral transactivator Tat, and enhances HIV transcription. Cell Host Microbe (2010) 1.76
miRNAs regulate SIRT1 expression during mouse embryonic stem cell differentiation and in adult mouse tissues. Aging (Albany NY) (2010) 1.76
SIRT5 regulates the mitochondrial lysine succinylome and metabolic networks. Cell Metab (2013) 1.70
Histone deacetylase HDAC8 associates with smooth muscle alpha-actin and is essential for smooth muscle cell contractility. FASEB J (2005) 1.70
The serum response factor and a putative novel transcription factor regulate expression of the immediate-early gene Arc/Arg3.1 in neurons. J Neurosci (2009) 1.69
Mitochondrial sirtuins. Biochim Biophys Acta (2010) 1.67
Conserved enzymatic production and biological effect of O-acetyl-ADP-ribose by silent information regulator 2-like NAD+-dependent deacetylases. J Biol Chem (2002) 1.62
Mitochondrial protein acylation and intermediary metabolism: regulation by sirtuins and implications for metabolic disease. J Biol Chem (2012) 1.58
Mitotic regulation of SIRT2 by cyclin-dependent kinase 1-dependent phosphorylation. J Biol Chem (2007) 1.55
Mitochondrial sirtuins: regulators of protein acylation and metabolism. Trends Endocrinol Metab (2012) 1.52
Immunosenescence and HIV. Curr Opin Immunol (2012) 1.51
Interphase nucleo-cytoplasmic shuttling and localization of SIRT2 during mitosis. PLoS One (2007) 1.50
Transcriptional synergy between Tat and PCAF is dependent on the binding of acetylated Tat to the PCAF bromodomain. EMBO J (2002) 1.49
MicroRNAs of the miR-17∼92 family are critical regulators of T(FH) differentiation. Nat Immunol (2013) 1.48
Two-pronged binding with bromodomain-containing protein 4 liberates positive transcription elongation factor b from inactive ribonucleoprotein complexes. J Biol Chem (2011) 1.43
Acetylation of Tat defines a cyclinT1-independent step in HIV transactivation. Mol Cell (2003) 1.42
Mitochondrial acetylome analysis in a mouse model of alcohol-induced liver injury utilizing SIRT3 knockout mice. J Proteome Res (2012) 1.41
Whole-organism screening for gluconeogenesis identifies activators of fasting metabolism. Nat Chem Biol (2012) 1.39
Reactivation of latent HIV by histone deacetylase inhibitors. Trends Microbiol (2013) 1.35
Design and evaluation of 'Linkerless' hydroxamic acids as selective HDAC8 inhibitors. Bioorg Med Chem Lett (2007) 1.34
Regulatory signal transduction pathways for class IIa histone deacetylases. Curr Opin Pharmacol (2010) 1.34
Sirtuin-3 (SIRT3), a novel potential therapeutic target for oral cancer. Cancer (2010) 1.32
Structure-activity studies on splitomicin derivatives as sirtuin inhibitors and computational prediction of binding mode. J Med Chem (2008) 1.31
Breast cancer associated transcriptional repressor PLU-1/JARID1B interacts directly with histone deacetylases. Int J Cancer (2007) 1.30
Myosin phosphatase dephosphorylates HDAC7, controls its nucleocytoplasmic shuttling, and inhibits apoptosis in thymocytes. Genes Dev (2007) 1.29
SIRT3 and cancer: tumor promoter or suppressor? Biochim Biophys Acta (2011) 1.28
Subtype selective substrates for histone deacetylases. J Med Chem (2004) 1.25
Acetylation of mitochondrial proteins. Methods Enzymol (2009) 1.24
Expression of histone deacetylase 8, a class I histone deacetylase, is restricted to cells showing smooth muscle differentiation in normal human tissues. Am J Pathol (2004) 1.22
A new splice variant of the mouse SIRT3 gene encodes the mitochondrial precursor protein. PLoS One (2009) 1.21
Preparation of enzymatically active recombinant class III protein deacetylases. Methods (2005) 1.21
HIV latency: experimental systems and molecular models. FEMS Microbiol Rev (2012) 1.19
Three novel acetylation sites in the Foxp3 transcription factor regulate the suppressive activity of regulatory T cells. J Immunol (2012) 1.18
Dietary restriction: standing up for sirtuins. Science (2010) 1.17
Molecular mechanisms of HIV-1 proviral latency. Expert Rev Anti Infect Ther (2005) 1.16
Histone deacetylase 7 and FoxA1 in estrogen-mediated repression of RPRM. Mol Cell Biol (2009) 1.15
Transcriptional suppression of in vitro-integrated human immunodeficiency virus type 1 does not correlate with proviral DNA methylation. J Virol (2003) 1.15
The flavoring agent dihydrocoumarin reverses epigenetic silencing and inhibits sirtuin deacetylases. PLoS Genet (2005) 1.12
Partial chromosome sequence of Spiroplasma citri reveals extensive viral invasion and important gene decay. Appl Environ Microbiol (2010) 1.12
Destabilization of ERBB2 transcripts by targeting 3' untranslated region messenger RNA associated HuR and histone deacetylase-6. Mol Cancer Res (2008) 1.11
Epigenetic regulation of HIV latency. Curr Opin HIV AIDS (2011) 1.10
The sirtuins, oxidative stress and aging: an emerging link. Aging (Albany NY) (2013) 1.08
Sirtuin 3 (SIRT3) protein regulates long-chain acyl-CoA dehydrogenase by deacetylating conserved lysines near the active site. J Biol Chem (2013) 1.07
Understanding HIV latency: the road to an HIV cure. Annu Rev Med (2015) 1.07
Reactivation of latent HIV-1 in central memory CD4⁺ T cells through TLR-1/2 stimulation. Retrovirology (2013) 1.06
Adenosine mimetics as inhibitors of NAD+-dependent histone deacetylases, from kinase to sirtuin inhibition. J Med Chem (2006) 1.06
A novel corepressor, BCoR-L1, represses transcription through an interaction with CtBP. J Biol Chem (2007) 1.05
Histone deacetylase 7 functions as a key regulator of genes involved in both positive and negative selection of thymocytes. Mol Cell Biol (2007) 1.05
Dietary restriction attenuates age-associated muscle atrophy by lowering oxidative stress in mice even in complete absence of CuZnSOD. Aging Cell (2012) 1.03
Histone deacetylase 7 regulates cell survival and TCR signaling in CD4/CD8 double-positive thymocytes. J Immunol (2011) 1.03
Acetate metabolism and aging: An emerging connection. Mech Ageing Dev (2010) 1.03
In vivo, in vitro, and in silico analysis of methylation of the HIV-1 provirus. Methods (2010) 1.02
Tat acetylation: a regulatory switch between early and late phases in HIV transcription elongation. Novartis Found Symp (2004) 1.01
SIRT1 and SIRT3 deacetylate homologous substrates: AceCS1,2 and HMGCS1,2. Aging (Albany NY) (2011) 1.01
Tissue-resident macrophages are productively infected ex vivo by primary X4 isolates of human immunodeficiency virus type 1. J Virol (2005) 0.99
Thiobarbiturates as sirtuin inhibitors: virtual screening, free-energy calculations, and biological testing. ChemMedChem (2008) 0.99
Combination of biological screening in a cellular model of viral latency and virtual screening identifies novel compounds that reactivate HIV-1. J Virol (2012) 0.95
Phenylalanine-containing hydroxamic acids as selective inhibitors of class IIb histone deacetylases (HDACs). Bioorg Med Chem (2007) 0.95
SIRT4 regulates ATP homeostasis and mediates a retrograde signaling via AMPK. Aging (Albany NY) (2013) 0.94
Dual-color HIV reporters trace a population of latently infected cells and enable their purification. Virology (2013) 0.92
Pyridylalanine-containing hydroxamic acids as selective HDAC6 inhibitors. ChemMedChem (2009) 0.90
Nonisotopic substrate for assaying both human zinc and NAD+-dependent histone deacetylases. Anal Biochem (2003) 0.89
Impact papers on aging in 2009. Aging (Albany NY) (2010) 0.89
Sirtuin-3 (SIRT3) and the Hallmarks of Cancer. Genes Cancer (2013) 0.88
Metabolic regulation, mitochondria and the life-prolonging effect of rapamycin: a mini-review. Gerontology (2012) 0.87