Published in J Immunol on March 01, 2009
Exosomes released by islet-derived mesenchymal stem cells trigger autoimmune responses in NOD mice. Diabetes (2013) 1.62
Enterovirus infection, CXC chemokine ligand 10 (CXCL10), and CXCR3 circuit: a mechanism of accelerated beta-cell failure in fulminant type 1 diabetes. Diabetes (2009) 1.50
Defining the transcriptional and cellular landscape of type 1 diabetes in the NOD mouse. PLoS One (2013) 1.21
Molecular control of steady-state dendritic cell maturation and immune homeostasis. Annu Rev Immunol (2013) 1.13
Targeted regulation of self-peptide presentation prevents type I diabetes in mice without disrupting general immunocompetence. J Clin Invest (2010) 1.13
Loss of intra-islet CD20 expression may complicate efficacy of B-cell-directed type 1 diabetes therapies. Diabetes (2011) 1.12
A minor subset of Batf3-dependent antigen-presenting cells in islets of Langerhans is essential for the development of autoimmune diabetes. Immunity (2014) 1.11
Prevention of diabetes by FTY720-mediated stabilization of peri-islet tertiary lymphoid organs. Diabetes (2010) 1.10
Antigen presentation events in autoimmune diabetes. Curr Opin Immunol (2011) 1.08
The pancreas anatomy conditions the origin and properties of resident macrophages. J Exp Med (2015) 1.04
The dendritic cell response to classic, emerging, and homeostatic danger signals. Implications for autoimmunity. Front Immunol (2013) 0.94
Functional specialization of islet dendritic cell subsets. J Immunol (2012) 0.92
The central role of antigen presentation in islets of Langerhans in autoimmune diabetes. Curr Opin Immunol (2013) 0.90
Dendritic cell subsets in type 1 diabetes: friend or foe? Front Immunol (2013) 0.88
Antigen recognition in the islets changes with progression of autoimmune islet infiltration. J Immunol (2014) 0.87
An evolving autoimmune microenvironment regulates the quality of effector T cell restimulation and function. Proc Natl Acad Sci U S A (2014) 0.87
Beta cells transfer vesicles containing insulin to phagocytes for presentation to T cells. Proc Natl Acad Sci U S A (2015) 0.86
NK cells are not required for spontaneous autoimmune diabetes in NOD mice. PLoS One (2012) 0.83
Therapeutic regulatory T cells subvert effector T cell function in inflamed islets to halt autoimmune diabetes. J Immunol (2015) 0.82
The gene expression profile of CD11c+ CD8α- dendritic cells in the pre-diabetic pancreas of the NOD mouse. PLoS One (2014) 0.79
Evolving immune circuits are generated by flexible, motile, and sequential immunological synapses. Immunol Rev (2013) 0.79
The role of islet antigen presenting cells and the presentation of insulin in the initiation of autoimmune diabetes in the NOD mouse. Immunol Rev (2016) 0.75
Cognate antigen engagement on parenchymal cells stimulates CD8(+) T cell proliferation in situ. Nat Commun (2017) 0.75
Exposure to sequestered self-antigens in vivo is not sufficient for the induction of autoimmune diabetes. PLoS One (2017) 0.75
Antigen presentation events during the initiation of autoimmune diabetes in the NOD mouse. J Autoimmun (2016) 0.75
Cutting Edge: Origins, Recruitment, and Regulation of CD11c(+) Cells in Inflamed Islets of Autoimmune Diabetes Mice. J Immunol (2017) 0.75
The islet-resident macrophage is in an inflammatory state and senses microbial products in blood. J Exp Med (2017) 0.75
Crystal structure of the Aequorea victoria green fluorescent protein. Science (1996) 16.81
B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes. Immunity (2000) 15.44
Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo. J Exp Med (2001) 9.70
The molecular structure of green fluorescent protein. Nat Biotechnol (1996) 9.63
In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes. J Exp Med (2004) 8.00
Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice. Nat Immunol (2005) 7.44
Visualizing dendritic cell networks in vivo. Nat Immunol (2004) 7.13
The NOD mouse: a model of immune dysregulation. Annu Rev Immunol (2005) 6.71
Avoiding horror autotoxicus: the importance of dendritic cells in peripheral T cell tolerance. Proc Natl Acad Sci U S A (2002) 6.19
Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction. Immunity (2008) 6.08
Constitutive class I-restricted exogenous presentation of self antigens in vivo. J Exp Med (1996) 5.21
Demonstration and characterization of Ia-positive dendritic cells in the interstitial connective tissues of rat heart and other tissues, but not brain. J Exp Med (1981) 5.00
Immature, semi-mature and fully mature dendritic cells: which signals induce tolerance or immunity? Trends Immunol (2002) 4.64
Transgenic mice with green fluorescent protein-labeled pancreatic beta -cells. Am J Physiol Endocrinol Metab (2002) 4.45
Inflammatory mediators are insufficient for full dendritic cell activation and promote expansion of CD4+ T cell populations lacking helper function. Nat Immunol (2005) 4.22
Maturation stages of mouse dendritic cells in growth factor-dependent long-term cultures. J Exp Med (1997) 4.04
T helper cell subsets in insulin-dependent diabetes. Science (1995) 3.92
Disruption of E-cadherin-mediated adhesion induces a functionally distinct pathway of dendritic cell maturation. Immunity (2007) 3.58
Interleukin-12 is produced by dendritic cells and mediates T helper 1 development as well as interferon-gamma production by T helper 1 cells. Eur J Immunol (1996) 3.24
Physiological beta cell death triggers priming of self-reactive T cells by dendritic cells in a type-1 diabetes model. J Exp Med (2003) 2.94
Constitutive presentation of a natural tissue autoantigen exclusively by dendritic cells in the draining lymph node. J Exp Med (2002) 2.78
Insulin-induced remission in new-onset NOD mice is maintained by the PD-1-PD-L1 pathway. J Exp Med (2006) 2.68
Transport of peptide-MHC class II complexes in developing dendritic cells. Science (2000) 2.62
CD4+ T cell help impairs CD8+ T cell deletion induced by cross-presentation of self-antigens and favors autoimmunity. J Exp Med (1997) 2.49
Dynamics of pathogenic and suppressor T cells in autoimmune diabetes development. J Immunol (2003) 2.32
Immunohistochemical characterization of monocytes-macrophages and dendritic cells involved in the initiation of the insulitis and beta-cell destruction in NOD mice. Diabetes (1994) 2.17
Autoimmune diabetes onset results from qualitative rather than quantitative age-dependent changes in pathogenic T-cells. Diabetes (2005) 2.10
Why green fluorescent fusion proteins have not been observed in the vacuoles of higher plants. Plant J (2003) 1.99
The countervailing actions of myeloid and plasmacytoid dendritic cells control autoimmune diabetes in the nonobese diabetic mouse. J Immunol (2007) 1.89
Visualization of IL-12/23p40 in vivo reveals immunostimulatory dendritic cell migrants that promote Th1 differentiation. J Immunol (2006) 1.86
Studies in B7-deficient mice reveal a critical role for B7 costimulation in both induction and effector phases of experimental autoimmune encephalomyelitis. J Exp Med (1999) 1.69
Life cycle, migration and antigen presenting functions of spleen and lymph node dendritic cells: limitations of the Langerhans cells paradigm. Semin Immunol (2005) 1.65
Antigen presentation by dendritic cells in renal lymph nodes is linked to systemic and local injury to the kidney. Kidney Int (2005) 1.52
Dendritic cells in islets of Langerhans constitutively present beta cell-derived peptides bound to their class II MHC molecules. Proc Natl Acad Sci U S A (2008) 1.50
Macrophages and dendritic cells infiltrating islets with or without beta cells produce tumour necrosis factor-alpha in patients with recent-onset type 1 diabetes. Diabetologia (2007) 1.30
Effect of pH on thermal- and chemical-induced denaturation of GFP. Appl Biochem Biotechnol (2005) 1.26
Temporal changes in pancreatic islet composition in C57BL/6J-db/db (diabetes) mice. Diabetologia (1983) 1.17
Dendritic cells, DRiPs, and DALIS in the control of antigen processing. Immunol Rev (2005) 1.15
Dendritic cells and macrophages are essential for the retention of lymphocytes in (peri)-insulitis of the nonobese diabetic mouse: a phagocyte depletion study. Lab Invest (2005) 1.15
In situ analysis of pancreatic islets in rats developing diabetes. Appearance of nonendocrine cells with surface MHC class II antigens and cytoplasmic insulin immunoreactivity. J Clin Invest (1988) 0.95
Unexpected functional consequences of xenogeneic transgene expression in beta-cells of NOD mice. Diabetes Obes Metab (2007) 0.91
In situ characterization of dendritic cells occurring in the islets of nonobese diabetic mice during the development of insulitis. Pancreas (2000) 0.83
Differential coupling of second signals for cytotoxicity and proliferation in CD8+ T cell effectors: amplification of the lytic potential by B7. J Immunol (1999) 0.81
A noninvasive cell-based assay for monitoring proteolytic activity within a specific subcellular compartment. Anal Biochem (2002) 0.78
Tolerance induction to cultured islet allografts. I. Characterization of the tolerant state. Transplantation (1994) 0.77
CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells. J Exp Med (2006) 14.33
Innate immunity and intestinal microbiota in the development of Type 1 diabetes. Nature (2008) 12.45
In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes. J Exp Med (2004) 8.00
Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice. Nat Immunol (2005) 7.44
Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR-induced stop signal. Nat Immunol (2009) 5.20
Loss of integrin alpha(v)beta8 on dendritic cells causes autoimmunity and colitis in mice. Nature (2007) 4.94
Deletional tolerance mediated by extrathymic Aire-expressing cells. Science (2008) 4.10
Antigen-engaged B cells undergo chemotaxis toward the T zone and form motile conjugates with helper T cells. PLoS Biol (2005) 4.01
Type 2 innate lymphoid cells control eosinophil homeostasis. Nature (2013) 3.20
IRE1α induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress. Cell Metab (2012) 2.80
Insulin-induced remission in new-onset NOD mice is maintained by the PD-1-PD-L1 pathway. J Exp Med (2006) 2.68
Stabilized imaging of immune surveillance in the mouse lung. Nat Methods (2010) 2.66
Expansion of human regulatory T-cells from patients with type 1 diabetes. Diabetes (2008) 2.52
Visualizing stromal cell dynamics in different tumor microenvironments by spinning disk confocal microscopy. Dis Model Mech (2008) 2.34
Exendin-4 improves reversal of diabetes in NOD mice treated with anti-CD3 monoclonal antibody by enhancing recovery of beta-cells. Endocrinology (2007) 2.33
IL-2 reverses established type 1 diabetes in NOD mice by a local effect on pancreatic regulatory T cells. J Exp Med (2010) 2.21
A single class II myosin modulates T cell motility and stopping, but not synapse formation. Nat Immunol (2004) 2.20
How do CD4+CD25+ regulatory T cells control autoimmunity? Curr Opin Immunol (2005) 2.12
Tyrosine kinase inhibitors reverse type 1 diabetes in nonobese diabetic mice. Proc Natl Acad Sci U S A (2008) 2.06
Spatiotemporally separated antigen uptake by alveolar dendritic cells and airway presentation to T cells in the lung. J Exp Med (2012) 2.03
Marginating dendritic cells of the tumor microenvironment cross-present tumor antigens and stably engage tumor-specific T cells. Cancer Cell (2012) 1.95
Amoeboid T lymphocytes require the septin cytoskeleton for cortical integrity and persistent motility. Nat Cell Biol (2008) 1.88
Confinement-optimized three-dimensional T cell amoeboid motility is modulated via myosin IIA-regulated adhesions. Nat Immunol (2010) 1.82
Dynamics of p56lck translocation to the T cell immunological synapse following agonist and antagonist stimulation. Immunity (2002) 1.77
Suppression of disease in New Zealand Black/New Zealand White lupus-prone mice by adoptive transfer of ex vivo expanded regulatory T cells. J Immunol (2006) 1.75
Costimulation controls diabetes by altering the balance of pathogenic and regulatory T cells. J Clin Invest (2004) 1.74
Expansion of functional endogenous antigen-specific CD4+CD25+ regulatory T cells from nonobese diabetic mice. J Immunol (2005) 1.73
Ten-year outcome after rapid discontinuation of prednisone in adult primary kidney transplantation. Clin J Am Soc Nephrol (2012) 1.69
Therapeutic vaccination using CD4+CD25+ antigen-specific regulatory T cells. Proc Natl Acad Sci U S A (2004) 1.69
Myosin-IIA and ICAM-1 regulate the interchange between two distinct modes of T cell migration. J Immunol (2009) 1.63
Perivascular mast cells dynamically probe cutaneous blood vessels to capture immunoglobulin E. Immunity (2013) 1.62
Notch 1 signaling regulates peripheral T cell activation. Immunity (2004) 1.61
Antigen-specific regulatory T cells--ex vivo expansion and therapeutic potential. Semin Immunol (2006) 1.55
Surface-bound chemokines capture and prime T cells for synapse formation. Nat Immunol (2006) 1.53
A synaptic basis for paracrine interleukin-2 signaling during homotypic T cell interaction. Immunity (2008) 1.52
T regulatory cells in autoimmune diabetes: past challenges, future prospects. J Clin Immunol (2008) 1.52
Imaging synapse formation during thymocyte selection: inability of CD3zeta to form a stable central accumulation during negative selection. Immunity (2002) 1.51
Real-time analysis of T cell receptors in naive cells in vitro and in vivo reveals flexibility in synapse and signaling dynamics. J Exp Med (2010) 1.38
When ligand becomes receptor--tolerance via B7 signaling on DCs. Nat Immunol (2002) 1.25
Maternal T cells limit engraftment after in utero hematopoietic cell transplantation in mice. J Clin Invest (2011) 1.25
Anti-CD3 therapy promotes tolerance by selectively depleting pathogenic cells while preserving regulatory T cells. J Immunol (2011) 1.25
Control of cortical rigidity by the cytoskeleton: emerging roles for septins. Cytoskeleton (Hoboken) (2010) 1.24
Integration of the movement of signaling microclusters with cellular motility in immunological synapses. Nat Immunol (2012) 1.23
Islet transplantation in type 1 diabetic patients using calcineurin inhibitor-free immunosuppressive protocols based on T-cell adhesion or costimulation blockade. Transplantation (2010) 1.23
Host DNA released in response to aluminum adjuvant enhances MHC class II-mediated antigen presentation and prolongs CD4 T-cell interactions with dendritic cells. Proc Natl Acad Sci U S A (2013) 1.23
Two-photon imaging of the immune system: a custom technology platform for high-speed, multicolor tissue imaging of immune responses. Curr Top Microbiol Immunol (2009) 1.19
Expansion and conversion of human pancreatic ductal cells into insulin-secreting endocrine cells. Elife (2013) 1.19
IL-6 protects pancreatic islet beta cells from pro-inflammatory cytokines-induced cell death and functional impairment in vitro and in vivo. Transpl Immunol (2004) 1.16
Inability to induce tolerance through direct antigen presentation. Am J Transplant (2002) 1.16
Regulation of T cell priming by lymphoid stroma. PLoS One (2011) 1.14
Secondary T cell-T cell synaptic interactions drive the differentiation of protective CD8+ T cells. Nat Immunol (2013) 1.14
Spontaneous development of a pancreatic exocrine disease in CD28-deficient NOD mice. J Immunol (2008) 1.14
Quantifying signaling-induced reorientation of T cell receptors during immunological synapse formation. Proc Natl Acad Sci U S A (2002) 1.13
Mechanisms of PDL1-mediated regulation of autoimmune diabetes. Clin Immunol (2007) 1.11
The septin cytoskeleton facilitates membrane retraction during motility and blebbing. J Cell Biol (2012) 1.11
Prevention of diabetes by FTY720-mediated stabilization of peri-islet tertiary lymphoid organs. Diabetes (2010) 1.10
"I'm a keep rising. I'm a keep going forward, regardless": exploring Black men's resilience amid sociostructural challenges and stressors. Qual Health Res (2011) 1.10
Ex vivo-expanded CD4+CD25+ immunoregulatory T cells prevent graft-versus-host-disease by inhibiting activation/differentiation of pathogenic T cells. J Immunol (2006) 1.10
Autotaxin through lysophosphatidic acid stimulates polarization, motility, and transendothelial migration of naive T cells. J Immunol (2012) 1.10
New views of the immunological synapse: variations in assembly and function. Curr Opin Immunol (2004) 1.08
CTLA-4 regulates the requirement for cytokine-induced signals in T(H)2 lineage commitment. Nat Immunol (2003) 1.06
CD28 signals in the immature immunological synapse. J Immunol (2004) 1.06
Duration of antigen receptor signaling determines T-cell tolerance or activation. Proc Natl Acad Sci U S A (2010) 1.05
Imaging the function of regulatory T cells in vivo. Curr Opin Immunol (2006) 1.04
B cell-derived IL-10 suppresses inflammatory disease in Lyn-deficient mice. Proc Natl Acad Sci U S A (2011) 1.01
Mediation of T-cell activation by actin meshworks. Cold Spring Harb Perspect Biol (2010) 1.00
The role of CD28 and CTLA4 in the function and homeostasis of CD4+CD25+ regulatory T cells. Novartis Found Symp (2003) 1.00
Immunological synapse formation licenses CD40-CD40L accumulations at T-APC contact sites. J Immunol (2004) 0.99
Mechanisms of T cell motility and arrest: deciphering the relationship between intra- and extracellular determinants. Semin Immunol (2005) 0.96
Normal development and activation but altered cytokine production of Fyn-deficient CD4+ T cells. J Immunol (2008) 0.91
Plasmacytoid DCs and T(reg) cells: casual acquaintance or monogamous relationship? Nat Immunol (2006) 0.91
Requirements for prolongation of allograft survival with regulatory T cell infusion in lymphosufficient hosts. J Surg Res (2011) 0.91
Fetal intervention increases maternal T cell awareness of the foreign conceptus and can lead to immune-mediated fetal demise. J Immunol (2014) 0.90
Live imaging of the lung. Curr Protoc Cytom (2012) 0.89
Tumor immune profiling predicts response to anti-PD-1 therapy in human melanoma. J Clin Invest (2016) 0.89
Immunological synapses within context: patterns of cell-cell communication and their application in T-T interactions. Curr Top Microbiol Immunol (2010) 0.88
Triggering of T cell activation via CD4 dimers. J Immunol (2006) 0.88
Evidence that Cd101 is an autoimmune diabetes gene in nonobese diabetic mice. J Immunol (2011) 0.88
Cell-laden microwells for the study of multicellularity in lymphocyte fate decisions. Biomaterials (2010) 0.87
Activated T cell trans-endothelial migration relies on myosin-IIA contractility for squeezing the cell nucleus through endothelial cell barriers. PLoS One (2013) 0.86
T cell synapse assembly: proteins, motors and the underlying cell biology. Semin Immunol (2005) 0.86
Direct and indirect antigen presentation lead to deletion of donor-specific T cells after in utero hematopoietic cell transplantation in mice. Blood (2013) 0.86
Inhibition of VEGFR-2 reverses type 1 diabetes in NOD mice by abrogating insulitis and restoring islet function. Diabetes (2013) 0.85
Regulation of T-cell receptor signaling by the actin cytoskeleton and poroelastic cytoplasm. Immunol Rev (2013) 0.82
Outcomes of pancreas retransplantation. Transplantation (2015) 0.82
Peripheral tolerance and autoimmunity: lessons from in vivo imaging. Immunol Res (2013) 0.81
Donor-Reactive Regulatory T Cell Frequency Increases During Acute Cellular Rejection of Lung Allografts. Transplantation (2016) 0.80
Evolving immune circuits are generated by flexible, motile, and sequential immunological synapses. Immunol Rev (2013) 0.79
The potent role of graft-derived NKR-P1+TCRalphabeta+ T (NKT) cells in the spontaneous acceptance of rat liver allografts. Transplantation (2005) 0.79
Targeting and blocking B7 costimulatory molecules on antigen-presenting cells using CTLA4Ig-conjugated liposomes: in vitro characterization and in vivo factors affecting biodistribution. Pharm Res (2003) 0.79
Immunological characteristics of pancreas transplantation: review and our experimental experience. Pancreas (2003) 0.78
Identification of naturally processed CD4 T cell epitopes from the prostate-specific antigen kallikrein 4 using peptide-based in vitro stimulation. J Immunol (2002) 0.78
Clinical islet transplantation at the University of California, San Francisco. Clin Transpl (2010) 0.78