PubRank

David Schlessinger

Author PubWeight™ 441.98‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Biological, clinical and population relevance of 95 loci for blood lipids. Nature 2010 28.21
2 Newly identified loci that influence lipid concentrations and risk of coronary artery disease. Nat Genet 2008 25.83
3 Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet 2010 23.08
4 Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet 2008 22.35
5 Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet 2008 20.66
6 Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature 2010 20.01
7 New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet 2010 17.89
8 Identification of ten loci associated with height highlights new biological pathways in human growth. Nat Genet 2008 16.25
9 Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet 2008 15.94
10 Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. PLoS Genet 2007 14.99
11 Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet 2009 12.44
12 Variants in MTNR1B influence fasting glucose levels. Nat Genet 2008 10.85
13 Meta-analysis and imputation refines the association of 15q25 with smoking quantity. Nat Genet 2010 8.55
14 Heritability of cardiovascular and personality traits in 6,148 Sardinians. PLoS Genet 2006 8.19
15 Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet 2010 7.94
16 Common variants in the GDF5-UQCC region are associated with variation in human height. Nat Genet 2008 7.31
17 The DNA sequence of the human X chromosome. Nature 2005 6.97
18 Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution. PLoS Genet 2009 5.81
19 Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia. Proc Natl Acad Sci U S A 2008 5.27
20 Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations. PLoS Genet 2009 4.97
21 GWAS of 126,559 individuals identifies genetic variants associated with educational attainment. Science 2013 4.71
22 Variants within the immunoregulatory CBLB gene are associated with multiple sclerosis. Nat Genet 2010 4.69
23 DNA polymorphisms at the BCL11A, HBS1L-MYB, and beta-globin loci associate with fetal hemoglobin levels and pain crises in sickle cell disease. Proc Natl Acad Sci U S A 2008 4.46
24 Common variants at ten loci modulate the QT interval duration in the QTSCD Study. Nat Genet 2009 4.10
25 Genetic variants influencing circulating lipid levels and risk of coronary artery disease. Arterioscler Thromb Vasc Biol 2010 4.08
26 Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways. Diabetes 2010 4.07
27 Genetic loci influencing kidney function and chronic kidney disease. Nat Genet 2010 3.75
28 Genome-wide association study of PR interval. Nat Genet 2010 3.73
29 Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels. Circulation 2011 3.68
30 Fine mapping of five loci associated with low-density lipoprotein cholesterol detects variants that double the explained heritability. PLoS Genet 2011 3.56
31 Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels. J Clin Invest 2008 3.51
32 Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. Nat Genet 2010 3.37
33 Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nat Genet 2013 3.25
34 AGEMAP: a gene expression database for aging in mice. PLoS Genet 2007 3.22
35 Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet 2012 3.21
36 The GLUT9 gene is associated with serum uric acid levels in Sardinia and Chianti cohorts. PLoS Genet 2007 3.21
37 Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. Nat Genet 2011 3.18
38 New gene functions in megakaryopoiesis and platelet formation. Nature 2011 3.14
39 Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits. PLoS Genet 2013 2.83
40 FTO genotype is associated with phenotypic variability of body mass index. Nature 2012 2.77
41 Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors. Cell Stem Cell 2009 2.32
42 Foxl2 disruption causes mouse ovarian failure by pervasive blockage of follicle development. Hum Mol Genet 2004 2.15
43 Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways. Nat Genet 2012 2.12
44 Genome-wide association study of vitamin B6, vitamin B12, folate, and homocysteine blood concentrations. Am J Hum Genet 2009 1.87
45 Common variants in the SLCO1B3 locus are associated with bilirubin levels and unconjugated hyperbilirubinemia. Hum Mol Genet 2009 1.87
46 Genetic variants regulating immune cell levels in health and disease. Cell 2013 1.86
47 Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease. Circulation 2013 1.77
48 Phosphodiesterase 8B gene variants are associated with serum TSH levels and thyroid function. Am J Hum Genet 2008 1.77
49 IRAK-M is involved in the pathogenesis of early-onset persistent asthma. Am J Hum Genet 2007 1.77
50 Transcriptome analysis of mouse stem cells and early embryos. PLoS Biol 2003 1.75
51 A genome-wide association search for type 2 diabetes genes in African Americans. PLoS One 2012 1.72
52 Low-pass DNA sequencing of 1200 Sardinians reconstructs European Y-chromosome phylogeny. Science 2013 1.70
53 Genome-wide association scan of trait depression. Biol Psychiatry 2010 1.65
54 Independent and additive effects of cytokine patterns and the metabolic syndrome on arterial aging in the SardiNIA Study. Atherosclerosis 2010 1.65
55 Loss of Wnt4 and Foxl2 leads to female-to-male sex reversal extending to germ cells. Hum Mol Genet 2007 1.59
56 Facets of personality linked to underweight and overweight. Psychosom Med 2009 1.58
57 Analysis of the temporal requirement for eda in hair and sweat gland development. J Invest Dermatol 2008 1.55
58 EDA signaling and skin appendage development. Cell Cycle 2006 1.39
59 Foxl2 is required for commitment to ovary differentiation. Hum Mol Genet 2005 1.38
60 Cholesterol, triglycerides, and the Five-Factor Model of personality. Biol Psychol 2010 1.24
61 Overgrowth of a mouse model of the Simpson-Golabi-Behmel syndrome is independent of IGF signaling. Dev Biol 2002 1.24
62 Genome-wide analysis of BMI in adolescents and young adults reveals additional insight into the effects of genetic loci over the life course. Hum Mol Genet 2013 1.23
63 Foxl2 functions in sex determination and histogenesis throughout mouse ovary development. BMC Dev Biol 2009 1.23
64 A genome-wide association scan on the levels of markers of inflammation in Sardinians reveals associations that underpin its complex regulation. PLoS Genet 2012 1.23
65 Inducible mEDA-A1 transgene mediates sebaceous gland hyperplasia and differential formation of two types of mouse hair follicles. Hum Mol Genet 2003 1.20
66 Sex-specific correlates of walking speed in a wide age-ranged population. J Gerontol B Psychol Sci Soc Sci 2010 1.19
67 COL4A1 is associated with arterial stiffness by genome-wide association scan. Circ Cardiovasc Genet 2009 1.16
68 Personality and metabolic syndrome. Age (Dordr) 2010 1.15
69 An interstitial deletion-insertion involving chromosomes 2p25.3 and Xq27.1, near SOX3, causes X-linked recessive hypoparathyroidism. J Clin Invest 2005 1.14
70 Forkhead transcription factor FoxA1 regulates sweat secretion through Bestrophin 2 anion channel and Na-K-Cl cotransporter 1. Proc Natl Acad Sci U S A 2012 1.13
71 A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function. PLoS Genet 2013 1.12
72 Generation of mouse ES cell lines engineered for the forced induction of transcription factors. Sci Rep 2011 1.11
73 BDNF Val66Met is associated with introversion and interacts with 5-HTTLPR to influence neuroticism. Neuropsychopharmacology 2009 1.11
74 Plac8 and Plac9, novel placental-enriched genes identified through microarray analysis. Gene 2003 1.11
75 The central arterial burden of the metabolic syndrome is similar in men and women: the SardiNIA Study. Eur Heart J 2009 1.10
76 Systematic repression of transcription factors reveals limited patterns of gene expression changes in ES cells. Sci Rep 2013 1.08
77 Increased genetic vulnerability to smoking at CHRNA5 in early-onset smokers. Arch Gen Psychiatry 2012 1.08
78 Associations of large artery structure and function with adiposity: effects of age, gender, and hypertension. The SardiNIA Study. Atherosclerosis 2011 1.06
79 Mouse ovary developmental RNA and protein markers from gene expression profiling. Dev Biol 2005 1.05
80 Ectodysplasin regulates the lymphotoxin-beta pathway for hair differentiation. Proc Natl Acad Sci U S A 2006 1.04
81 Identification of a common variant in the TFR2 gene implicated in the physiological regulation of serum iron levels. Hum Mol Genet 2010 1.03
82 Requirement for Shh and Fox family genes at different stages in sweat gland development. Hum Mol Genet 2009 1.03
83 Personality traits in Sardinia: testing founder population effects on trait means and variances. Behav Genet 2006 1.02
84 Evolutionary diversification of SPANX-N sperm protein gene structure and expression. PLoS One 2007 1.02
85 PLAC1, a trophoblast-specific gene, is expressed throughout pregnancy in the human placenta and modulated by keratinocyte growth factor. Mol Reprod Dev 2002 1.02
86 Variants of the serotonin transporter gene and NEO-PI-R Neuroticism: No association in the BLSA and SardiNIA samples. Am J Med Genet B Neuropsychiatr Genet 2009 1.01
87 The EDA gene is a target of, but does not regulate Wnt signaling. Gene 2002 1.01
88 Dkk4 and Eda regulate distinctive developmental mechanisms for subtypes of mouse hair. PLoS One 2010 1.01
89 Effects of aging and calorie restriction on the global gene expression profiles of mouse testis and ovary. BMC Biol 2008 1.00
90 FOXL2 inactivation by a translocation 171 kb away: analysis of 500 kb of chromosome 3 for candidate long-range regulatory sequences. Genomics 2004 1.00
91 X-linked anhidrotic ectodermal dysplasia disruption yields a mouse model for ocular surface disease and resultant blindness. Am J Pathol 2005 0.99
92 The molecular genetic architecture of self-employment. PLoS One 2013 0.96
93 Neuroticism, depressive symptoms, and serum BDNF. Psychosom Med 2011 0.96
94 Determination and stability of sex. Bioessays 2007 0.95
95 FOXL2 and BMP2 act cooperatively to regulate follistatin gene expression during ovarian development. Endocrinology 2010 0.95
96 PLAC1 (Placenta-specific 1): a novel, X-linked gene with roles in reproductive and cancer biology. Prenat Diagn 2010 0.95
97 EDA targets revealed by skin gene expression profiles of wild-type, Tabby and Tabby EDA-A1 transgenic mice. Hum Mol Genet 2002 0.94
98 Cartilage hair hypoplasia mutations that lead to RMRP promoter inefficiency or RNA transcript instability. Am J Med Genet A 2007 0.94
99 Frizzled6 deficiency disrupts the differentiation process of nail development. J Invest Dermatol 2013 0.93
100 Impulsivity-related traits are associated with higher white blood cell counts. J Behav Med 2011 0.91
101 Aging of oocyte, ovary, and human reproduction. Ann N Y Acad Sci 2004 0.90
102 Trait antagonism and the progression of arterial thickening: women with antagonistic traits have similar carotid arterial thickness as men. Hypertension 2010 0.90
103 Antagonistic regulation of Cyp26b1 by transcription factors SOX9/SF1 and FOXL2 during gonadal development in mice. FASEB J 2011 0.89
104 Troy binding to lymphotoxin-alpha activates NF kappa B mediated transcription. Cell Cycle 2007 0.89
105 Personality traits prospectively predict verbal fluency in a lifespan sample. Psychol Aging 2011 0.89
106 Impaired FSHbeta expression in the pituitaries of Foxl2 mutant animals. Mol Endocrinol 2011 0.88
107 Mapping the road to resilience: novel math for the study of frailty. Mech Ageing Dev 2008 0.87
108 Notch gain of function in mouse periocular mesenchyme downregulates FoxL2 and impairs eyelid levator muscle formation, leading to congenital blepharophimosis. J Cell Sci 2011 0.87
109 Constitutively active Foxo3 in oocytes preserves ovarian reserve in mice. Nat Commun 2013 0.87
110 X-linked hypoparathyroidism region on Xq27 is evolutionarily conserved with regions on 3q26 and 13q34 and contains a novel P-type ATPase. Genomics 2004 0.84
111 Repertoire of mouse ectodysplasin-A (EDA-A) isoforms. Gene 2006 0.84
112 Bex3 associates with replicating mitochondria and is involved in possible growth control of F9 teratocarcinoma cells. Gene 2004 0.83
113 Impulsivity is associated with uric acid: evidence from humans and mice. Biol Psychiatry 2013 0.83
114 Genetics of serum BDNF: meta-analysis of the Val66Met and genome-wide association study. World J Biol Psychiatry 2011 0.83
115 The forkhead transcription factor Foxl2 is sumoylated in both human and mouse: sumoylation affects its stability, localization, and activity. PLoS One 2010 0.82
116 Personality traits and leptin. Psychosom Med 2013 0.82
117 FOXL2 transcriptionally represses Sf1 expression by antagonizing WT1 during ovarian development in mice. FASEB J 2014 0.82
118 Are personality traits associated with white-coat and masked hypertension? J Hypertens 2014 0.81
119 Lymphotoxin-beta regulates periderm differentiation during embryonic skin development. Hum Mol Genet 2007 0.81
120 Corrigendum: Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses. Nat Genet 2016 0.81
121 Chromatin properties of regulatory DNA probed by manipulation of transcription factors. J Comput Biol 2014 0.80
122 Shh is required for Tabby hair follicle development. Cell Cycle 2011 0.80
123 Transcriptional control of ovarian development in somatic cells. Semin Reprod Med 2007 0.79
124 Correction: Assessing Mitochondrial DNA Variation and Copy Number in Lymphocytes of ~2,000 Sardinians Using Tailored Sequencing Analysis Tools. PLoS Genet 2015 0.79
125 Personality traits and circadian blood pressure patterns: a 7-year prospective study. Psychosom Med 2014 0.79
126 Candidate EDA targets revealed by expression profiling of primary keratinocytes from Tabby mutant mice. Gene 2008 0.79
127 Longevity candidate genes and their association with personality traits in the elderly. Am J Med Genet B Neuropsychiatr Genet 2011 0.78
128 Germ cell formation from embryonic stem cells and the use of somatic cell nuclei in oocytes. Ann N Y Acad Sci 2011 0.78
129 Erratum: Whole-genome sequence-based analysis of thyroid function. Nat Commun 2015 0.77
130 SHAVE: shrinkage estimator measured for multiple visits increases power in GWAS of quantitative traits. Eur J Hum Genet 2012 0.76
131 Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study. PLoS Genet 2016 0.75
132 How to build a kangaroo the way a kangaroo builds itself. FASEB J 2009 0.75
133 Corrigendum: Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses. Nat Genet 2016 0.75
134 Corrigendum: Rare coding variants and X-linked loci associated with age at menarche. Nat Commun 2015 0.75