Published in Gene on September 24, 2008
Maternal cigarette smoking during pregnancy is associated with downregulation of miR-16, miR-21, and miR-146a in the placenta. Epigenetics (2010) 1.17
Salivary gland branching morphogenesis: a quantitative systems analysis of the Eda/Edar/NFkappaB paradigm. BMC Dev Biol (2009) 0.99
A novel role for the T-box transcription factor Tbx1 as a negative regulator of tumor cell growth in mice. Mol Carcinog (2011) 0.79
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods (2001) 414.27
WNT signals are required for the initiation of hair follicle development. Dev Cell (2002) 6.63
Molecular dissection of mesenchymal-epithelial interactions in the hair follicle. PLoS Biol (2005) 4.27
X-linked anhidrotic (hypohidrotic) ectodermal dysplasia is caused by mutation in a novel transmembrane protein. Nat Genet (1996) 3.90
X-linked anhidrotic ectodermal dysplasia with immunodeficiency is caused by impaired NF-kappaB signaling. Nat Genet (2001) 3.86
Involvement of a novel Tnf receptor homologue in hair follicle induction. Nat Genet (1999) 2.54
In vitro and in situ expression of IL-23 by keratinocytes in healthy skin and psoriasis lesions: enhanced expression in psoriatic skin. J Immunol (2006) 2.44
Jagged 1 is a beta-catenin target gene required for ectopic hair follicle formation in adult epidermis. Development (2006) 2.06
Gene defect in ectodermal dysplasia implicates a death domain adapter in development. Nature (2002) 1.95
A hypermorphic IkappaBalpha mutation is associated with autosomal dominant anhidrotic ectodermal dysplasia and T cell immunodeficiency. J Clin Invest (2003) 1.92
Generation of the primary hair follicle pattern. Proc Natl Acad Sci U S A (2006) 1.72
Requirement of NF-kappaB/Rel for the development of hair follicles and other epidermal appendices. Development (2001) 1.69
NF-kappaB transmits Eda A1/EdaR signalling to activate Shh and cyclin D1 expression, and controls post-initiation hair placode down growth. Development (2006) 1.66
In situ-synthesized novel microarray optimized for mouse stem cell and early developmental expression profiling. Genome Res (2003) 1.58
Ectodermal dysplasias. Am J Med Genet C Semin Med Genet (2004) 1.53
EDA signaling and skin appendage development. Cell Cycle (2006) 1.39
Sustained epithelial beta-catenin activity induces precocious hair development but disrupts hair follicle down-growth and hair shaft formation. Development (2008) 1.27
TRAF6-deficient mice display hypohidrotic ectodermal dysplasia. Proc Natl Acad Sci U S A (2002) 1.25
Inducible mEDA-A1 transgene mediates sebaceous gland hyperplasia and differential formation of two types of mouse hair follicles. Hum Mol Genet (2003) 1.20
Control of pelage hair follicle development and cycling by complex interactions between follistatin and activin. FASEB J (2003) 1.17
Ectodysplasin regulates the lymphotoxin-beta pathway for hair differentiation. Proc Natl Acad Sci U S A (2006) 1.04
Ectodermal dysplasias: not only 'skin' deep. Clin Genet (2000) 1.04
Involvement of the Edar signaling in the control of hair follicle involution (catagen). Am J Pathol (2006) 1.01
X-linked anhidrotic ectodermal dysplasia disruption yields a mouse model for ocular surface disease and resultant blindness. Am J Pathol (2005) 0.99
EDA targets revealed by skin gene expression profiles of wild-type, Tabby and Tabby EDA-A1 transgenic mice. Hum Mol Genet (2002) 0.94
Tbx1 is expressed at multiple sites of epithelial-mesenchymal interaction during early development of the facial complex. Int J Dev Biol (2006) 0.93
Wounds increase activin in skin and a vasoactive neuropeptide in sensory ganglia. Dev Biol (2004) 0.89
Desmoyokin/AHNAK protein localizes to the non-desmosomal keratinocyte cell surface of human epidermis. J Invest Dermatol (1995) 0.88
The role of heparin-binding EGF-like growth factor and amphiregulin in the epidermal proliferation of psoriasis in cooperation with TNFalpha. Arch Dermatol Res (2007) 0.87
Bmp7 mediates early signaling events during induction of chick epidermal organs. Dev Dyn (2004) 0.86
WNTs: multiple genes, multiple functions. J Invest Dermatol (2003) 0.85
Selective expression of calcium-binding proteins S100a8 and S100a9 at distinct sites of hair follicles. J Invest Dermatol (2001) 0.84
The association between endothelin-1 gene polymorphisms and susceptibility to vitiligo in a Korean population. Exp Dermatol (2007) 0.82
CD44 expression marks the onset of keratinocyte stratification and mesenchymal maturation into fibrous dermis in fetal human skin. J Histochem Cytochem (1999) 0.82
Lymphotoxin-beta regulates periderm differentiation during embryonic skin development. Hum Mol Genet (2007) 0.81
Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21
Newly identified loci that influence lipid concentrations and risk of coronary artery disease. Nat Genet (2008) 25.83
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet (2008) 22.35
Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet (2008) 20.66
Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89
Identification of ten loci associated with height highlights new biological pathways in human growth. Nat Genet (2008) 16.25
Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet (2008) 15.94
Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. PLoS Genet (2007) 14.99
Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet (2009) 12.44
Variants in MTNR1B influence fasting glucose levels. Nat Genet (2008) 10.85
Meta-analysis and imputation refines the association of 15q25 with smoking quantity. Nat Genet (2010) 8.55
Heritability of cardiovascular and personality traits in 6,148 Sardinians. PLoS Genet (2006) 8.19
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet (2010) 7.94
Common variants in the GDF5-UQCC region are associated with variation in human height. Nat Genet (2008) 7.31
The DNA sequence of the human X chromosome. Nature (2005) 6.97
Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution. PLoS Genet (2009) 5.81
Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia. Proc Natl Acad Sci U S A (2008) 5.27
Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations. PLoS Genet (2009) 4.97
GWAS of 126,559 individuals identifies genetic variants associated with educational attainment. Science (2013) 4.71
Variants within the immunoregulatory CBLB gene are associated with multiple sclerosis. Nat Genet (2010) 4.69
DNA polymorphisms at the BCL11A, HBS1L-MYB, and beta-globin loci associate with fetal hemoglobin levels and pain crises in sickle cell disease. Proc Natl Acad Sci U S A (2008) 4.46
Common variants at ten loci modulate the QT interval duration in the QTSCD Study. Nat Genet (2009) 4.10
Genetic variants influencing circulating lipid levels and risk of coronary artery disease. Arterioscler Thromb Vasc Biol (2010) 4.08
Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways. Diabetes (2010) 4.07
Genetic loci influencing kidney function and chronic kidney disease. Nat Genet (2010) 3.75
Genome-wide association study of PR interval. Nat Genet (2010) 3.73
Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels. Circulation (2011) 3.68
Fine mapping of five loci associated with low-density lipoprotein cholesterol detects variants that double the explained heritability. PLoS Genet (2011) 3.56
Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels. J Clin Invest (2008) 3.51
Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. Nat Genet (2010) 3.37
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nat Genet (2013) 3.25
AGEMAP: a gene expression database for aging in mice. PLoS Genet (2007) 3.22
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet (2012) 3.21
The GLUT9 gene is associated with serum uric acid levels in Sardinia and Chianti cohorts. PLoS Genet (2007) 3.21
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. Nat Genet (2011) 3.18
New gene functions in megakaryopoiesis and platelet formation. Nature (2011) 3.14
Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits. PLoS Genet (2013) 2.83
FTO genotype is associated with phenotypic variability of body mass index. Nature (2012) 2.77
Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors. Cell Stem Cell (2009) 2.32
Foxl2 disruption causes mouse ovarian failure by pervasive blockage of follicle development. Hum Mol Genet (2004) 2.15
Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways. Nat Genet (2012) 2.12
Genome-wide association study of vitamin B6, vitamin B12, folate, and homocysteine blood concentrations. Am J Hum Genet (2009) 1.87
Common variants in the SLCO1B3 locus are associated with bilirubin levels and unconjugated hyperbilirubinemia. Hum Mol Genet (2009) 1.87
Genetic variants regulating immune cell levels in health and disease. Cell (2013) 1.86
Phosphodiesterase 8B gene variants are associated with serum TSH levels and thyroid function. Am J Hum Genet (2008) 1.77
IRAK-M is involved in the pathogenesis of early-onset persistent asthma. Am J Hum Genet (2007) 1.77
Transcriptome analysis of mouse stem cells and early embryos. PLoS Biol (2003) 1.75
A genome-wide association search for type 2 diabetes genes in African Americans. PLoS One (2012) 1.72
Low-pass DNA sequencing of 1200 Sardinians reconstructs European Y-chromosome phylogeny. Science (2013) 1.70
Genome-wide association scan of trait depression. Biol Psychiatry (2010) 1.65
Independent and additive effects of cytokine patterns and the metabolic syndrome on arterial aging in the SardiNIA Study. Atherosclerosis (2010) 1.65
Loss of Wnt4 and Foxl2 leads to female-to-male sex reversal extending to germ cells. Hum Mol Genet (2007) 1.59
Facets of personality linked to underweight and overweight. Psychosom Med (2009) 1.58
Analysis of the temporal requirement for eda in hair and sweat gland development. J Invest Dermatol (2008) 1.55
EDA signaling and skin appendage development. Cell Cycle (2006) 1.39
Foxl2 is required for commitment to ovary differentiation. Hum Mol Genet (2005) 1.38
Cholesterol, triglycerides, and the Five-Factor Model of personality. Biol Psychol (2010) 1.24
Overgrowth of a mouse model of the Simpson-Golabi-Behmel syndrome is independent of IGF signaling. Dev Biol (2002) 1.24
Genome-wide analysis of BMI in adolescents and young adults reveals additional insight into the effects of genetic loci over the life course. Hum Mol Genet (2013) 1.23
Foxl2 functions in sex determination and histogenesis throughout mouse ovary development. BMC Dev Biol (2009) 1.23
A genome-wide association scan on the levels of markers of inflammation in Sardinians reveals associations that underpin its complex regulation. PLoS Genet (2012) 1.23
Inducible mEDA-A1 transgene mediates sebaceous gland hyperplasia and differential formation of two types of mouse hair follicles. Hum Mol Genet (2003) 1.20
Sex-specific correlates of walking speed in a wide age-ranged population. J Gerontol B Psychol Sci Soc Sci (2010) 1.19
COL4A1 is associated with arterial stiffness by genome-wide association scan. Circ Cardiovasc Genet (2009) 1.16
Personality and metabolic syndrome. Age (Dordr) (2010) 1.15
An interstitial deletion-insertion involving chromosomes 2p25.3 and Xq27.1, near SOX3, causes X-linked recessive hypoparathyroidism. J Clin Invest (2005) 1.14
Forkhead transcription factor FoxA1 regulates sweat secretion through Bestrophin 2 anion channel and Na-K-Cl cotransporter 1. Proc Natl Acad Sci U S A (2012) 1.13
A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function. PLoS Genet (2013) 1.12
Generation of mouse ES cell lines engineered for the forced induction of transcription factors. Sci Rep (2011) 1.11
BDNF Val66Met is associated with introversion and interacts with 5-HTTLPR to influence neuroticism. Neuropsychopharmacology (2009) 1.11
Plac8 and Plac9, novel placental-enriched genes identified through microarray analysis. Gene (2003) 1.11
The central arterial burden of the metabolic syndrome is similar in men and women: the SardiNIA Study. Eur Heart J (2009) 1.10
Cellular source and molecular form of TNF specify its distinct functions in organization of secondary lymphoid organs. Blood (2010) 1.10
Systematic repression of transcription factors reveals limited patterns of gene expression changes in ES cells. Sci Rep (2013) 1.08
Increased genetic vulnerability to smoking at CHRNA5 in early-onset smokers. Arch Gen Psychiatry (2012) 1.08
Associations of large artery structure and function with adiposity: effects of age, gender, and hypertension. The SardiNIA Study. Atherosclerosis (2011) 1.06
Mouse ovary developmental RNA and protein markers from gene expression profiling. Dev Biol (2005) 1.05
Ectodysplasin regulates the lymphotoxin-beta pathway for hair differentiation. Proc Natl Acad Sci U S A (2006) 1.04
Identification of a common variant in the TFR2 gene implicated in the physiological regulation of serum iron levels. Hum Mol Genet (2010) 1.03
Requirement for Shh and Fox family genes at different stages in sweat gland development. Hum Mol Genet (2009) 1.03
PLAC1, a trophoblast-specific gene, is expressed throughout pregnancy in the human placenta and modulated by keratinocyte growth factor. Mol Reprod Dev (2002) 1.02
Personality traits in Sardinia: testing founder population effects on trait means and variances. Behav Genet (2006) 1.02
Evolutionary diversification of SPANX-N sperm protein gene structure and expression. PLoS One (2007) 1.02
The EDA gene is a target of, but does not regulate Wnt signaling. Gene (2002) 1.01
Variants of the serotonin transporter gene and NEO-PI-R Neuroticism: No association in the BLSA and SardiNIA samples. Am J Med Genet B Neuropsychiatr Genet (2009) 1.01
Dkk4 and Eda regulate distinctive developmental mechanisms for subtypes of mouse hair. PLoS One (2010) 1.01
FOXL2 inactivation by a translocation 171 kb away: analysis of 500 kb of chromosome 3 for candidate long-range regulatory sequences. Genomics (2004) 1.00
Effects of aging and calorie restriction on the global gene expression profiles of mouse testis and ovary. BMC Biol (2008) 1.00
X-linked anhidrotic ectodermal dysplasia disruption yields a mouse model for ocular surface disease and resultant blindness. Am J Pathol (2005) 0.99
The molecular genetic architecture of self-employment. PLoS One (2013) 0.96
Neuroticism, depressive symptoms, and serum BDNF. Psychosom Med (2011) 0.96
FOXL2 and BMP2 act cooperatively to regulate follistatin gene expression during ovarian development. Endocrinology (2010) 0.95
Determination and stability of sex. Bioessays (2007) 0.95
PLAC1 (Placenta-specific 1): a novel, X-linked gene with roles in reproductive and cancer biology. Prenat Diagn (2010) 0.95
EDA targets revealed by skin gene expression profiles of wild-type, Tabby and Tabby EDA-A1 transgenic mice. Hum Mol Genet (2002) 0.94
Cartilage hair hypoplasia mutations that lead to RMRP promoter inefficiency or RNA transcript instability. Am J Med Genet A (2007) 0.94