Non-obese diabetic mice select a low-diversity repertoire of natural regulatory T cells.

Determinants of public T cell responses. Cell Res (2012) 1.09

Thymic negative selection is functional in NOD mice. J Exp Med (2012) 1.00

The T-cell receptor is not hardwired to engage MHC ligands. Proc Natl Acad Sci U S A (2012) 0.95

Model for comparative analysis of antigen receptor repertoires. J Theor Biol (2010) 0.95

CTLA-4 controls the thymic development of both conventional and regulatory T cells through modulation of the TCR repertoire. Proc Natl Acad Sci U S A (2012) 0.95

Estimating T-cell repertoire diversity: limitations of classical estimators and a new approach. Philos Trans R Soc Lond B Biol Sci (2015) 0.91

Single-cell mass cytometry of TCR signaling: amplification of small initial differences results in low ERK activation in NOD mice. Proc Natl Acad Sci U S A (2014) 0.90

H2 control of natural T regulatory cell frequency in the lymph node correlates with susceptibility to day 3 thymectomy-induced autoimmune disease. J Immunol (2010) 0.86

T cell populations in the pancreatic lymph node naturally and consistently expand and contract in NOD mice as disease progresses. Mol Immunol (2012) 0.80

A Bayesian Semi-parametric Approach for the Differential Analysis of Sequence Counts Data. J R Stat Soc Ser C Appl Stat (2014) 0.78

Reversible lacrimal gland-protective regulatory T-cell dysfunction underlies male-specific autoimmune dacryoadenitis in the non-obese diabetic mouse model of Sjögren syndrome. Immunology (2015) 0.78

Next-Generation Sequencing Reveals Restriction and Clonotypic Expansion of Treg Cells in Juvenile Idiopathic Arthritis. Arthritis Rheumatol (2016) 0.77

Modeling the T cell immune response: a fascinating challenge. J Pharmacokinet Pharmacodyn (2014) 0.77

Reduction of T cell receptor diversity in NOD mice prevents development of type 1 diabetes but not Sjögren's syndrome. PLoS One (2014) 0.75

Recognition of the peripheral self by naturally arising CD25+ CD4+ T cell receptors. Immunity (2004) 6.89

An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires. Nat Immunol (2006) 6.16

Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity. Nat Genet (2007) 5.68

Nonself-antigens are the cognate specificities of Foxp3+ regulatory T cells. Immunity (2007) 3.98

The repertoire of T cells shaped by a single MHC/peptide ligand. Cell (1996) 3.04

Tumor necrosis factor-alpha regulation of CD4+CD25+ T cell levels in NOD mice. Proc Natl Acad Sci U S A (2002) 2.45

Dynamics of pathogenic and suppressor T cells in autoimmune diabetes development. J Immunol (2003) 2.32

TCR-based lineage tracing: no evidence for conversion of conventional into regulatory T cells in response to a natural self-antigen in pancreatic islets. J Exp Med (2007) 2.15

Single cell analysis shows decreasing FoxP3 and TGFbeta1 coexpressing CD4+CD25+ regulatory T cells during autoimmune diabetes. J Exp Med (2005) 2.05

Neonatal beta-cell apoptosis: a trigger for autoimmune diabetes? Diabetes (2000) 1.92

The defect in T-cell regulation in NOD mice is an effect on the T-cell effectors. Proc Natl Acad Sci U S A (2008) 1.85

Quantitative and qualitative changes in V-J alpha rearrangements during mouse thymocytes differentiation: implication for a limited T cell receptor alpha chain repertoire. J Exp Med (2002) 1.62

A Shannon entropy analysis of immunoglobulin and T cell receptor. Mol Immunol (1997) 1.58

Generalized resistance to thymic deletion in the NOD mouse; a polygenic trait characterized by defective induction of Bim. Immunity (2004) 1.57

Assessment of hepatitis C virus sequence complexity by electrophoretic mobilities of both single-and double-stranded DNAs. J Clin Microbiol (1998) 1.53

Enhanced thymic selection of FoxP3+ regulatory T cells in the NOD mouse model of autoimmune diabetes. Proc Natl Acad Sci U S A (2007) 1.51

A sudden decline in active membrane-bound TGF-beta impairs both T regulatory cell function and protection against autoimmune diabetes. J Immunol (2004) 1.48

Autoreactivity of T cells from nonobese diabetic mice: an I-Ag7-dependent reaction. Proc Natl Acad Sci U S A (1998) 1.34

T-cell compartments of prediabetic NOD mice. Diabetes (2003) 1.27

Ex vivo analysis of thymic CD4 T cells in nonobese diabetic mice with tetramers generated from I-A(g7)/class II-associated invariant chain peptide precursors. J Immunol (2003) 1.22

Slamf1, the NKT cell control gene Nkt1. J Immunol (2007) 1.20

An Abd transgene prevents diabetes in nonobese diabetic mice by inducing regulatory T cells. Proc Natl Acad Sci U S A (1993) 1.14

Detection and characterization of T cells specific for BDC2.5 T cell-stimulating peptides. J Immunol (2003) 1.11

A molecular marker for thymocyte-positive selection: selection of CD4 single-positive thymocytes with shorter TCRB CDR3 during T cell development. J Immunol (2002) 0.99

Deranged early T cell development in immunodeficient strains of nonobese diabetic mice. J Immunol (2004) 0.98

Public T cell receptor beta-chains are not advantaged during positive selection. J Immunol (2008) 0.96

Development of autoreactive diabetogenic T cells in the thymus of NOD mice. J Autoimmun (2004) 0.83

Self-recognition and the biased mature repertoire in TCR beta transgenic mice: the exception that supports the rule. Trends Immunol (2002) 0.80

TCR-alpha CDR3 loop audition regulates positive selection. J Immunol (2006) 0.79

Innate immunity and intestinal microbiota in the development of Type 1 diabetes. Nature (2008) 12.45

Bone marrow mesenchymal stem cells inhibit the response of naive and memory antigen-specific T cells to their cognate peptide. Blood (2002) 5.14

Treatment with CD20-specific antibody prevents and reverses autoimmune diabetes in mice. J Clin Invest (2007) 2.81

Cutting edge: the Foxp3 target miR-155 contributes to the development of regulatory T cells. J Immunol (2009) 2.51

Non-redundant role for the transcription factor Gli1 at multiple stages of thymocyte development. Cell Cycle (2010) 2.32

Cutting edge: the phosphoinositide 3-kinase p110 delta is critical for the function of CD4+CD25+Foxp3+ regulatory T cells. J Immunol (2006) 2.29

Fc-dependent depletion of activated T cells occurs through CD40L-specific antibody rather than costimulation blockade. Nat Med (2003) 1.92

Regulatory T cells, derived from naïve CD4+CD25- T cells by in vitro Foxp3 gene transfer, can induce transplantation tolerance. Transplantation (2005) 1.86

Autoreactive CD8 T cells in organ-specific autoimmunity: emerging targets for therapeutic intervention. Immunity (2002) 1.74

Therapeutic targeting of Syk in autoimmune diabetes. J Immunol (2010) 1.69

Degenerate self-reactive human T-cell receptor causes spontaneous autoimmune disease in mice. Nat Med (2004) 1.52

Presentation of antigen by endothelial cells and chemoattraction are required for homing of insulin-specific CD8+ T cells. J Exp Med (2003) 1.52

The complementary roles of deletion and regulation in transplantation tolerance. Nat Rev Immunol (2003) 1.50

Spin waves and revised crystal structure of honeycomb iridate Na2IrO3. Phys Rev Lett (2012) 1.49

Early secreted antigen ESAT-6 of Mycobacterium tuberculosis promotes protective T helper 17 cell responses in a toll-like receptor-2-dependent manner. PLoS Pathog (2011) 1.46

Induction and acceleration of insulitis/diabetes in mice with a viral mimic (polyinosinic-polycytidylic acid) and an insulin self-peptide. Proc Natl Acad Sci U S A (2002) 1.40

Novel immunotherapies for immune-mediated haemolytic anaemia in dogs and people. Vet J (2016) 1.40

The role of direct presentation by donor dendritic cells in rejection of minor histocompatibility antigen-mismatched skin and hematopoietic cell grafts. Transplantation (2011) 1.40

Analysis of the T-cell receptor repertoires of tumor-infiltrating conventional and regulatory T cells reveals no evidence for conversion in carcinogen-induced tumors. Cancer Res (2010) 1.21

Mesenchymal stromal cells and regulatory T cells: the Yin and Yang of peripheral tolerance? Immunol Cell Biol (2012) 1.21

Expression of transgene encoded TGF-beta in islets prevents autoimmune diabetes in NOD mice by a local mechanism. J Autoimmun (2002) 1.20

Physiologic and aberrant regulation of memory T-cell trafficking by the costimulatory molecule CD28. Blood (2007) 1.20

Depletion of regulatory T cells by anti-GITR mAb as a novel mechanism for cancer immunotherapy. Cancer Immunol Immunother (2010) 1.16

The effect of innate immunity on autoimmune diabetes and the expression of Toll-like receptors on pancreatic islets. J Immunol (2004) 1.15

Cognate recognition of the endothelium induces HY-specific CD8+ T-lymphocyte transendothelial migration (diapedesis) in vivo. Blood (2003) 1.12

B-cells promote intra-islet CD8+ cytotoxic T-cell survival to enhance type 1 diabetes. Diabetes (2008) 1.12

Ig gene-like molecule CD31 plays a nonredundant role in the regulation of T-cell immunity and tolerance. Proc Natl Acad Sci U S A (2010) 1.11

TGF-beta signaling is required for the function of insulin-reactive T regulatory cells. J Clin Invest (2006) 1.09

Activation of the Hedgehog signaling pathway in T-lineage cells inhibits TCR repertoire selection in the thymus and peripheral T-cell activation. Blood (2007) 1.09

C1q enhances IFN-gamma production by antigen-specific T cells via the CD40 costimulatory pathway on dendritic cells. Blood (2009) 1.09

In vitro expansion improves in vivo regulation by CD4+CD25+ regulatory T cells. J Immunol (2008) 1.09

Repression of hedgehog signal transduction in T-lineage cells increases TCR-induced activation and proliferation. Cell Cycle (2008) 1.07

Role of immunoproteasomes in cross-presentation. J Immunol (2006) 1.05

The Gli3 transcription factor expressed in the thymus stroma controls thymocyte negative selection via Hedgehog-dependent and -independent mechanisms. J Immunol (2009) 1.01

Cellular and humoral immune responses in the early stages of diabetic nephropathy in NOD mice. J Autoimmun (2009) 1.00

Mice lacking C1q or C3 show accelerated rejection of minor H disparate skin grafts and resistance to induction of tolerance. Eur J Immunol (2010) 0.99

Inhibition of AMP-activated protein kinase protects pancreatic beta-cells from cytokine-mediated apoptosis and CD8+ T-cell-induced cytotoxicity. Diabetes (2007) 0.99

Disordered IL-33/ST2 activation in decidualizing stromal cells prolongs uterine receptivity in women with recurrent pregnancy loss. PLoS One (2012) 0.98

T cells from Programmed Death-1 deficient mice respond poorly to Mycobacterium tuberculosis infection. PLoS One (2011) 0.97

Pten loss in CD4 T cells enhances their helper function but does not lead to autoimmunity or lymphoma. J Immunol (2012) 0.97

Public T cell receptor beta-chains are not advantaged during positive selection. J Immunol (2008) 0.96

Globosides but not isoglobosides can impact the development of invariant NKT cells and their interaction with dendritic cells. J Immunol (2012) 0.96

The T-cell receptor is not hardwired to engage MHC ligands. Proc Natl Acad Sci U S A (2012) 0.95

CTLA-4 controls the thymic development of both conventional and regulatory T cells through modulation of the TCR repertoire. Proc Natl Acad Sci U S A (2012) 0.95

Identification of the immunodominant HY H2-D(k) epitope and evaluation of the role of direct and indirect antigen presentation in HY responses. J Immunol (2005) 0.94

Sonic hedgehog negatively regulates pre-TCR-induced differentiation by a Gli2-dependent mechanism. Blood (2009) 0.93

Expansion of CD8+ cytotoxic T cells in vitro and in vivo using MHC class I tetramers. Tumour Biol (2007) 0.93

TLR4 regulates cardiac lipid accumulation and diabetic heart disease in the nonobese diabetic mouse model of type 1 diabetes. Am J Physiol Heart Circ Physiol (2012) 0.92

CD4+CD25+ T cells as immunoregulatory T cells in vitro. Eur J Immunol (2002) 0.92

Characterizing the glycome of the mammalian immune system. Immunol Cell Biol (2008) 0.92

Identification and characterization of a lupus suppressor 129 locus on chromosome 3. J Immunol (2010) 0.91

Does the PI3K pathway promote or antagonize regulatory T cell development and function? Front Immunol (2012) 0.91

IL-10-conditioned dendritic cells prevent autoimmune diabetes in NOD and humanized HLA-DQ8/RIP-B7.1 mice. Clin Immunol (2011) 0.90

The dual effects of B cell depletion on antigen-specific T cells in BDC2.5NOD mice. J Immunol (2012) 0.89

Regulation of murine normal and stress-induced erythropoiesis by Desert Hedgehog. Blood (2012) 0.89

Paraneoplastic hypercalcemia in a dog with benign renal angiomyxoma. J Vet Diagn Invest (2010) 0.89

Protection of islet grafts through transforming growth factor-β-induced tolerogenic dendritic cells. Diabetes (2013) 0.89

Altered B:9-23 insulin, when administered intranasally with cholera toxin adjuvant, suppresses the expression of insulin autoantibodies and prevents diabetes. J Immunol (2007) 0.88

Functional plasticity of antigen-specific regulatory T cells in context of tumor. J Immunol (2011) 0.88

Breed-specific hematological phenotypes in the dog: a natural resource for the genetic dissection of hematological parameters in a mammalian species. PLoS One (2013) 0.88

TLR9 deficiency promotes CD73 expression in T cells and diabetes protection in nonobese diabetic mice. J Immunol (2013) 0.87

Natural regulation of immunity to minor histocompatibility antigens. J Immunol (2007) 0.87

Human CD8 responses to a complete epitope set from preproinsulin: implications for approaches to epitope discovery. J Clin Immunol (2008) 0.87

Role of endogenous annexin-A1 in the regulation of thymocyte positive and negative selection. Cell Cycle (2010) 0.87

Combination treatment with anti-CD20 and oral anti-CD3 prevents and reverses autoimmune diabetes. Diabetes (2013) 0.86

T cell receptor CDR3 loops influence alphabeta pairing. Mol Immunol (2010) 0.86

Converting antigen-specific diabetogenic CD4 and CD8 T cells to TGF-beta producing non-pathogenic regulatory cells following FoxP3 transduction. J Autoimmun (2007) 0.86

The role of gut microbiota in the development of type 1, type 2 diabetes mellitus and obesity. Rev Endocr Metab Disord (2015) 0.86

Inhibition of membrane type-1 matrix metalloproteinase by cancer drugs interferes with the homing of diabetogenic T cells into the pancreas. J Biol Chem (2005) 0.86

Phenotypic and functional characterization of a CD4(+) CD25(high) FOXP3(high) regulatory T-cell population in the dog. Immunology (2010) 0.86

Human DQ8 can substitute for murine I-Ag7 in the selection of diabetogenic T cells restricted to I-Ag7. J Immunol (2002) 0.85

Gene expression of selected signature cytokines of T cell subsets in duodenal tissues of dogs with and without inflammatory bowel disease. Vet Immunol Immunopathol (2012) 0.85

The cellular prion protein is preferentially expressed by CD4+ CD25+ Foxp3+ regulatory T cells. Immunology (2008) 0.85

Inflammatory regulation by TLR3 in acute hepatitis. J Immunol (2009) 0.84

Selective immunotargeting of diabetogenic CD4 T cells by genetically redirected T cells. Immunology (2014) 0.84

Anergic T cells exert antigen-independent inhibition of cell-cell interactions via chemokine metabolism. Blood (2003) 0.83

Role of L-selectin in the development of autoimmune diabetes in non-obese diabetic mice. Int Immunol (2004) 0.82

An islet-specific pulse of TGF-β abrogates CTL function and promotes β cell survival independent of Foxp3+ T cells. J Immunol (2011) 0.82

Immunotargeting of insulin reactive CD8 T cells to prevent diabetes. J Autoimmun (2010) 0.82

Reduced regulatory T cell diversity in NOD mice is linked to early events in the thymus. J Immunol (2014) 0.82

Na2IrO3 as a novel relativistic Mott insulator with a 340-meV gap. Phys Rev Lett (2012) 0.82

CD86 has sustained costimulatory effects on CD8 T cells. J Immunol (2007) 0.82

A novel role for Hedgehog in T-cell receptor signaling: implications for development and immunity. Cell Cycle (2007) 0.82

An important role of prostanoid receptor EP2 in host resistance to Mycobacterium tuberculosis infection in mice. J Infect Dis (2012) 0.82

The role of Gr1+ cells after anti-CD20 treatment in type 1 diabetes in nonobese diabetic mice. J Immunol (2011) 0.81

CD4+ T cell-derived novel peptide Thp5 induces interleukin-4 production in CD4+ T cells to direct T helper 2 cell differentiation. J Biol Chem (2011) 0.81

Use of a non-depleting anti-CD4 antibody to modulate the immune response to coagulation factors VIII and IX. Br J Haematol (2002) 0.81

Restricted TCR-alpha CDR3 diversity disadvantages natural regulatory T cell development in the B6.2.16 beta-chain transgenic mouse. J Immunol (2010) 0.81

Peptide-specific, TCR-alpha-driven, coreceptor-independent negative selection in TCR alpha-chain transgenic mice. J Immunol (2009) 0.80

Sialoadhesin ligand expression identifies a subset of CD4+Foxp3- T cells with a distinct activation and glycosylation profile. J Immunol (2013) 0.80

Low-intensity transplant regimens facilitate recruitment of donor-specific regulatory T cells that promote hematopoietic engraftment. Proc Natl Acad Sci U S A (2007) 0.80

Anti-CD20 treatment prolongs syngeneic islet graft survival and delays the onset of recurrent autoimmune diabetes. Ann N Y Acad Sci (2008) 0.80

A crucial role of CD4 T cells as a functional source of CD154 in the initiation of insulin-dependent diabetes mellitus in the non-obese diabetic mouse. Int Immunol (2003) 0.80

Hepatitis mouse models: from acute-to-chronic autoimmune hepatitis. Int J Exp Pathol (2014) 0.79