Published in Nature on March 17, 2002
Highly integrated single-base resolution maps of the epigenome in Arabidopsis. Cell (2008) 32.65
Establishing, maintaining and modifying DNA methylation patterns in plants and animals. Nat Rev Genet (2010) 15.70
Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing. Genes Dev (2005) 12.15
Linking DNA methylation and histone modification: patterns and paradigms. Nat Rev Genet (2009) 12.08
DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA. Nature (2007) 11.14
Distinct epigenomic landscapes of pluripotent and lineage-committed human cells. Cell Stem Cell (2010) 8.74
Locus-specific control of asymmetric and CpNpG methylation by the DRM and CMT3 methyltransferase genes. Proc Natl Acad Sci U S A (2002) 5.49
The lysine demethylase LSD1 (KDM1) is required for maintenance of global DNA methylation. Nat Genet (2008) 4.40
The DNA methyltransferases associate with HP1 and the SUV39H1 histone methyltransferase. Nucleic Acids Res (2003) 4.36
Finding the fifth base: genome-wide sequencing of cytosine methylation. Genome Res (2009) 4.16
Identification of genetic elements that autonomously determine DNA methylation states. Nat Genet (2011) 4.04
The SET-domain protein superfamily: protein lysine methyltransferases. Genome Biol (2005) 3.93
Arabidopsis MET1 cytosine methyltransferase mutants. Genetics (2003) 3.90
Distinct mechanisms determine transposon inheritance and methylation via small interfering RNA and histone modification. PLoS Biol (2003) 3.71
The SRA methyl-cytosine-binding domain links DNA and histone methylation. Curr Biol (2007) 3.70
Lessons from the genome sequence of Neurospora crassa: tracing the path from genomic blueprint to multicellular organism. Microbiol Mol Biol Rev (2004) 3.67
Dual histone H3 methylation marks at lysines 9 and 27 required for interaction with CHROMOMETHYLASE3. EMBO J (2004) 3.51
DNA methylation controls histone H3 lysine 9 methylation and heterochromatin assembly in Arabidopsis. EMBO J (2002) 3.50
Functional cooperation between HP1 and DNMT1 mediates gene silencing. Genes Dev (2007) 3.43
RNAi, DRD1, and histone methylation actively target developmentally important non-CG DNA methylation in arabidopsis. PLoS Genet (2006) 3.41
De novo DNA methylation promoted by G9a prevents reprogramming of embryonically silenced genes. Nat Struct Mol Biol (2008) 3.33
PolIVb influences RNA-directed DNA methylation independently of its role in siRNA biogenesis. Proc Natl Acad Sci U S A (2008) 3.33
OsSPL14 promotes panicle branching and higher grain productivity in rice. Nat Genet (2010) 3.23
Arabidopsis TFL2/LHP1 specifically associates with genes marked by trimethylation of histone H3 lysine 27. PLoS Genet (2007) 3.11
Two-step recruitment of RNA-directed DNA methylation to tandem repeats. PLoS Biol (2006) 3.09
G9a/GLP complexes independently mediate H3K9 and DNA methylation to silence transcription. EMBO J (2008) 3.08
Comprehensive analysis of silencing mutants reveals complex regulation of the Arabidopsis methylome. Cell (2013) 3.02
H3K9 methyltransferase G9a and the related molecule GLP. Genes Dev (2011) 3.01
Dimethylation of histone H3 lysine 9 is a critical mark for DNA methylation and gene silencing in Arabidopsis thaliana. Chromosoma (2004) 3.00
KDM1B is a histone H3K4 demethylase required to establish maternal genomic imprints. Nature (2009) 2.98
Structure of the Neurospora SET domain protein DIM-5, a histone H3 lysine methyltransferase. Cell (2002) 2.94
Myc represses transcription through recruitment of DNA methyltransferase corepressor. EMBO J (2004) 2.94
An Arabidopsis SET domain protein required for maintenance but not establishment of DNA methylation. EMBO J (2002) 2.92
Histone H3-K9 methyltransferase ESET is essential for early development. Mol Cell Biol (2004) 2.92
Genome-wide analysis of mono-, di- and trimethylation of histone H3 lysine 4 in Arabidopsis thaliana. Genome Biol (2009) 2.86
In vitro and in vivo analyses of a Phe/Tyr switch controlling product specificity of histone lysine methyltransferases. J Biol Chem (2004) 2.86
DNA methylation in ES cells requires the lysine methyltransferase G9a but not its catalytic activity. EMBO J (2008) 2.81
Erasure of CpG methylation in Arabidopsis alters patterns of histone H3 methylation in heterochromatin. Proc Natl Acad Sci U S A (2003) 2.70
Genome-wide association of histone H3 lysine nine methylation with CHG DNA methylation in Arabidopsis thaliana. PLoS One (2008) 2.69
Interphase chromosomes in Arabidopsis are organized as well defined chromocenters from which euchromatin loops emanate. Proc Natl Acad Sci U S A (2002) 2.60
Discovery of induced point mutations in maize genes by TILLING. BMC Plant Biol (2004) 2.57
Maintenance of DNA methylation during the Arabidopsis life cycle is essential for parental imprinting. Plant Cell (2006) 2.53
Structural basis for recognition of H3K4 methylation status by the DNA methyltransferase 3A ATRX-DNMT3-DNMT3L domain. EMBO Rep (2009) 2.50
Locus-specific control of DNA methylation by the Arabidopsis SUVH5 histone methyltransferase. Plant Cell (2006) 2.46
RNA-directed DNA methylation in Arabidopsis. Proc Natl Acad Sci U S A (2002) 2.46
Silencing of transgene transcription precedes methylation of promoter DNA and histone H3 lysine 9. EMBO J (2003) 2.43
The genome sequence of the model ascomycete fungus Podospora anserina. Genome Biol (2008) 2.43
Regulation and function of DNA methylation in plants and animals. Cell Res (2011) 2.41
Selective epigenetic control of retrotransposition in Arabidopsis. Nature (2009) 2.41
Chromatin methylation activity of Dnmt3a and Dnmt3a/3L is guided by interaction of the ADD domain with the histone H3 tail. Nucleic Acids Res (2010) 2.39
Genome-wide and organ-specific landscapes of epigenetic modifications and their relationships to mRNA and small RNA transcriptomes in maize. Plant Cell (2009) 2.39
Cancer DNA methylation: molecular mechanisms and clinical implications. Clin Cancer Res (2009) 2.31
Mass spectrometry analysis of Arabidopsis histone H3 reveals distinct combinations of post-translational modifications. Nucleic Acids Res (2004) 2.28
Histone modification and the control of heterochromatic gene silencing in Drosophila. Chromosome Res (2006) 2.28
RNA interference: biology, mechanism, and applications. Microbiol Mol Biol Rev (2003) 2.19
Dual binding of chromomethylase domains to H3K9me2-containing nucleosomes directs DNA methylation in plants. Cell (2012) 2.19
Tandem repeats upstream of the Arabidopsis endogene SDC recruit non-CG DNA methylation and initiate siRNA spreading. Genes Dev (2008) 2.16
Non-CG methylation patterns shape the epigenetic landscape in Arabidopsis. Nat Struct Mol Biol (2013) 2.14
G9a interacts with Snail and is critical for Snail-mediated E-cadherin repression in human breast cancer. J Clin Invest (2012) 2.12
Antagonism between DNA and H3K27 methylation at the imprinted Rasgrf1 locus. PLoS Genet (2008) 2.08
LHP1, the Arabidopsis homologue of HETEROCHROMATIN PROTEIN1, is required for epigenetic silencing of FLC. Proc Natl Acad Sci U S A (2006) 2.08
The Heterochromatin Protein 1 family. Genome Biol (2006) 2.05
Pivotal role of AtSUVH2 in heterochromatic histone methylation and gene silencing in Arabidopsis. EMBO J (2005) 2.04
An Arabidopsis jmjC domain protein protects transcribed genes from DNA methylation at CHG sites. EMBO J (2009) 2.00
MORC family ATPases required for heterochromatin condensation and gene silencing. Science (2012) 1.97
Imprinting and seed development. Plant Cell (2004) 1.91
The barrier function of an insulator couples high histone acetylation levels with specific protection of promoter DNA from methylation. Genes Dev (2002) 1.89
High-resolution mapping of epigenetic modifications of the rice genome uncovers interplay between DNA methylation, histone methylation, and gene expression. Plant Cell (2008) 1.85
ATXR5 and ATXR6 are H3K27 monomethyltransferases required for chromatin structure and gene silencing. Nat Struct Mol Biol (2009) 1.85
Differential regulation of strand-specific transcripts from Arabidopsis centromeric satellite repeats. PLoS Genet (2005) 1.83
Association of UHRF1 with methylated H3K9 directs the maintenance of DNA methylation. Nat Struct Mol Biol (2012) 1.77
Coordinated chromatin control: structural and functional linkage of DNA and histone methylation. Biochemistry (2010) 1.74
Connections between epigenetic gene silencing and human disease. Mutat Res (2007) 1.72
Zebra fish Dnmt1 and Suv39h1 regulate organ-specific terminal differentiation during development. Mol Cell Biol (2006) 1.71
Histone code modifications on pluripotential nuclei of reprogrammed somatic cells. Mol Cell Biol (2004) 1.67
Genes and transposons are differentially methylated in plants, but not in mammals. Genome Res (2003) 1.66
The effect of stress on genome regulation and structure. Ann Bot (2004) 1.66
Regulation of heterochromatic DNA replication by histone H3 lysine 27 methyltransferases. Nature (2010) 1.63
BRU1, a novel link between responses to DNA damage and epigenetic gene silencing in Arabidopsis. Genes Dev (2004) 1.62
Epigenetic regulation of killer immunoglobulin-like receptor expression in T cells. Blood (2009) 1.62
Relics of repeat-induced point mutation direct heterochromatin formation in Neurospora crassa. Genome Res (2008) 1.61
Direct interaction between DNA methyltransferase DIM-2 and HP1 is required for DNA methylation in Neurospora crassa. Mol Cell Biol (2008) 1.58
Roles of dynamic and reversible histone acetylation in plant development and polyploidy. Biochim Biophys Acta (2007) 1.58
Transgenerational epigenetic inheritance in plants. Biochim Biophys Acta (2011) 1.58
Viral genome methylation as an epigenetic defense against geminiviruses. J Virol (2008) 1.58
SRA-domain proteins required for DRM2-mediated de novo DNA methylation. PLoS Genet (2008) 1.57
Effects of length and location on the cellular response to double-stranded RNA. Microbiol Mol Biol Rev (2004) 1.57
H3 lysine 9 methylation is maintained on a transcribed inverted repeat by combined action of SUVH6 and SUVH4 methyltransferases. Mol Cell Biol (2005) 1.56
Chromatin and siRNA pathways cooperate to maintain DNA methylation of small transposable elements in Arabidopsis. Genome Biol (2005) 1.55
Chimeric DNA methyltransferases target DNA methylation to specific DNA sequences and repress expression of target genes. Nucleic Acids Res (2006) 1.52
Stress-induced activation of heterochromatic transcription. PLoS Genet (2010) 1.51
Histone deacetylase inhibitor depsipeptide activates silenced genes through decreasing both CpG and H3K9 methylation on the promoter. Mol Cell Biol (2008) 1.48
Comparative analysis of SET domain proteins in maize and Arabidopsis reveals multiple duplications preceding the divergence of monocots and dicots. Plant Physiol (2003) 1.47
A SNF2-like protein facilitates dynamic control of DNA methylation. EMBO Rep (2005) 1.46
Distinctive core histone post-translational modification patterns in Arabidopsis thaliana. PLoS One (2007) 1.46
Histone modifications: combinatorial complexity or cumulative simplicity? Proc Natl Acad Sci U S A (2005) 1.45
Chromatin inactivation precedes de novo DNA methylation during the progressive epigenetic silencing of the RASSF1A promoter. Mol Cell Biol (2005) 1.45
Small RNA-directed epigenetic natural variation in Arabidopsis thaliana. PLoS Genet (2008) 1.43
Molecular coupling of DNA methylation and histone methylation. Epigenomics (2010) 1.43
Adenosine kinase is inactivated by geminivirus AL2 and L2 proteins. Plant Cell (2003) 1.43
Shotgun bisulphite sequencing of the Arabidopsis genome reveals DNA methylation patterning. Nature (2008) 26.78
Establishing, maintaining and modifying DNA methylation patterns in plants and animals. Nat Rev Genet (2010) 15.70
Genetic and functional diversification of small RNA pathways in plants. PLoS Biol (2004) 12.21
ARGONAUTE4 control of locus-specific siRNA accumulation and DNA and histone methylation. Science (2003) 9.54
Genome-wide erasure of DNA methylation in mouse primordial germ cells is affected by AID deficiency. Nature (2010) 8.84
UHRF1 plays a role in maintaining DNA methylation in mammalian cells. Science (2007) 7.90
Criteria for annotation of plant MicroRNAs. Plant Cell (2008) 7.49
Epigenetic inheritance in plants. Nature (2007) 7.40
Conservation and divergence of methylation patterning in plants and animals. Proc Natl Acad Sci U S A (2010) 7.30
Small interfering RNA-induced transcriptional gene silencing in human cells. Science (2004) 7.29
Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma. Cancer Cell (2012) 6.71
Gardening the genome: DNA methylation in Arabidopsis thaliana. Nat Rev Genet (2005) 6.39
Dissecting Arabidopsis thaliana DICER function in small RNA processing, gene silencing and DNA methylation patterning. Nat Genet (2006) 5.81
Locus-specific control of asymmetric and CpNpG methylation by the DRM and CMT3 methyltransferase genes. Proc Natl Acad Sci U S A (2002) 5.49
Role of the arabidopsis DRM methyltransferases in de novo DNA methylation and gene silencing. Curr Biol (2002) 5.47
Relationship between nucleosome positioning and DNA methylation. Nature (2010) 5.27
An ARGONAUTE4-containing nuclear processing center colocalized with Cajal bodies in Arabidopsis thaliana. Cell (2006) 5.22
Epigenetic reprogramming in plant and animal development. Science (2010) 5.18
RNA silencing genes control de novo DNA methylation. Science (2004) 5.11
One-way control of FWA imprinting in Arabidopsis endosperm by DNA methylation. Science (2003) 5.00
Interplay between two epigenetic marks. DNA methylation and histone H3 lysine 9 methylation. Curr Biol (2002) 4.98
The Arabidopsis chromatin-modifying nuclear siRNA pathway involves a nucleolar RNA processing center. Cell (2006) 4.82
DICER-LIKE1: blind men and elephants in Arabidopsis development. Trends Plant Sci (2002) 4.72
DEMETER, a DNA glycosylase domain protein, is required for endosperm gene imprinting and seed viability in arabidopsis. Cell (2002) 4.31
Whole-genome analysis of histone H3 lysine 27 trimethylation in Arabidopsis. PLoS Biol (2007) 4.30
Role of the DRM and CMT3 methyltransferases in RNA-directed DNA methylation. Curr Biol (2003) 4.27
MicroRNAs and other small RNAs enriched in the Arabidopsis RNA-dependent RNA polymerase-2 mutant. Genome Res (2006) 4.08
Applications of DNA tiling arrays for whole-genome analysis. Genomics (2005) 3.94
Methylation of tRNAAsp by the DNA methyltransferase homolog Dnmt2. Science (2006) 3.87
Reiterated WG/GW motifs form functionally and evolutionarily conserved ARGONAUTE-binding platforms in RNAi-related components. Genes Dev (2007) 3.75
The SRA methyl-cytosine-binding domain links DNA and histone methylation. Curr Biol (2007) 3.70
DNA methylation profiling identifies CG methylation clusters in Arabidopsis genes. Curr Biol (2005) 3.54
Role of Arabidopsis ARGONAUTE4 in RNA-directed DNA methylation triggered by inverted repeats. Curr Biol (2004) 3.54
Dual histone H3 methylation marks at lysines 9 and 27 required for interaction with CHROMOMETHYLASE3. EMBO J (2004) 3.51
DNA methylation controls histone H3 lysine 9 methylation and heterochromatin assembly in Arabidopsis. EMBO J (2002) 3.50
5-Hydroxymethylcytosine is associated with enhancers and gene bodies in human embryonic stem cells. Genome Biol (2011) 3.48
RNAi, DRD1, and histone methylation actively target developmentally important non-CG DNA methylation in arabidopsis. PLoS Genet (2006) 3.41
The SRA domain of UHRF1 flips 5-methylcytosine out of the DNA helix. Nature (2008) 3.28
Role of CG and non-CG methylation in immobilization of transposons in Arabidopsis. Curr Biol (2003) 3.11
Two-step recruitment of RNA-directed DNA methylation to tandem repeats. PLoS Biol (2006) 3.09
Role of RNA polymerase IV in plant small RNA metabolism. Proc Natl Acad Sci U S A (2007) 3.05
Comprehensive analysis of silencing mutants reveals complex regulation of the Arabidopsis methylome. Cell (2013) 3.02
Dimethylation of histone H3 lysine 9 is a critical mark for DNA methylation and gene silencing in Arabidopsis thaliana. Chromosoma (2004) 3.00
Genome-wide analysis for discovery of rice microRNAs reveals natural antisense microRNAs (nat-miRNAs). Proc Natl Acad Sci U S A (2008) 2.92
Genome-wide analysis of mono-, di- and trimethylation of histone H3 lysine 4 in Arabidopsis thaliana. Genome Biol (2009) 2.86
Genome-wide association of histone H3 lysine nine methylation with CHG DNA methylation in Arabidopsis thaliana. PLoS One (2008) 2.69
Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomas. Cancer Cell (2013) 2.50
MicroRNAs inhibit the translation of target mRNAs on the endoplasmic reticulum in Arabidopsis. Cell (2013) 2.28
Mass spectrometry analysis of Arabidopsis histone H3 reveals distinct combinations of post-translational modifications. Nucleic Acids Res (2004) 2.28
Dual binding of chromomethylase domains to H3K9me2-containing nucleosomes directs DNA methylation in plants. Cell (2012) 2.19
Regulation of DNMT1 stability through SET7-mediated lysine methylation in mammalian cells. Proc Natl Acad Sci U S A (2009) 2.18
Tandem repeats upstream of the Arabidopsis endogene SDC recruit non-CG DNA methylation and initiate siRNA spreading. Genes Dev (2008) 2.16
Histone methylation in higher plants. Annu Rev Plant Biol (2010) 2.13
Substrate specificity and kinetic mechanism of mammalian G9a histone H3 methyltransferase. J Biol Chem (2004) 2.09
LHP1, the Arabidopsis homologue of HETEROCHROMATIN PROTEIN1, is required for epigenetic silencing of FLC. Proc Natl Acad Sci U S A (2006) 2.08
DDR complex facilitates global association of RNA polymerase V to promoters and evolutionarily young transposons. Nat Struct Mol Biol (2012) 2.07
A protein complex required for polymerase V transcripts and RNA- directed DNA methylation in Arabidopsis. Curr Biol (2010) 1.99
MORC family ATPases required for heterochromatin condensation and gene silencing. Science (2012) 1.97
The Arabidopsis LHP1 protein colocalizes with histone H3 Lys27 trimethylation. Nat Struct Mol Biol (2007) 1.93
ATXR5 and ATXR6 are H3K27 monomethyltransferases required for chromatin structure and gene silencing. Nat Struct Mol Biol (2009) 1.85
A unified phylogeny-based nomenclature for histone variants. Epigenetics Chromatin (2012) 1.82
Polymerase IV occupancy at RNA-directed DNA methylation sites requires SHH1. Nature (2013) 1.82
The Putative RNA-dependent RNA polymerase RDR6 acts synergistically with ASYMMETRIC LEAVES1 and 2 to repress BREVIPEDICELLUS and MicroRNA165/166 in Arabidopsis leaf development. Plant Cell (2005) 1.80
UHRF1 binds G9a and participates in p21 transcriptional regulation in mammalian cells. Nucleic Acids Res (2008) 1.80
Tissue-specific distribution and dynamic changes of 5-hydroxymethylcytosine in mammalian genomes. J Biol Chem (2011) 1.80
Loss of function of OsDCL1 affects microRNA accumulation and causes developmental defects in rice. Plant Physiol (2005) 1.77
Arabidopsis REF6 is a histone H3 lysine 27 demethylase. Nat Genet (2011) 1.74
DNA methylation dynamics, metabolic fluxes, gene splicing, and alternative phenotypes in honey bees. Proc Natl Acad Sci U S A (2012) 1.65
Regulation of heterochromatic DNA replication by histone H3 lysine 27 methyltransferases. Nature (2010) 1.63
SHH1, a homeodomain protein required for DNA methylation, as well as RDR2, RDM4, and chromatin remodeling factors, associate with RNA polymerase IV. PLoS Genet (2011) 1.61
ZBED6, a novel transcription factor derived from a domesticated DNA transposon regulates IGF2 expression and muscle growth. PLoS Biol (2009) 1.61
IDN1 and IDN2 are required for de novo DNA methylation in Arabidopsis thaliana. Nat Struct Mol Biol (2009) 1.59
SRA-domain proteins required for DRM2-mediated de novo DNA methylation. PLoS Genet (2008) 1.57
Chromatin and siRNA pathways cooperate to maintain DNA methylation of small transposable elements in Arabidopsis. Genome Biol (2005) 1.55
Mutations in regulators of the epigenome and their connections to global chromatin patterns in cancer. Nat Rev Genet (2013) 1.53
Distinct roles of the methylcytosine oxidases Tet1 and Tet2 in mouse embryonic stem cells. Proc Natl Acad Sci U S A (2014) 1.50
RNA interference knockdown of DNA methyl-transferase 3 affects gene alternative splicing in the honey bee. Proc Natl Acad Sci U S A (2013) 1.49
Loss of the DNA methyltransferase MET1 Induces H3K9 hypermethylation at PcG target genes and redistribution of H3K27 trimethylation to transposons in Arabidopsis thaliana. PLoS Genet (2012) 1.48
Plants regenerated from tissue culture contain stable epigenome changes in rice. Elife (2013) 1.48
Epigenetic modifications in plants: an evolutionary perspective. Curr Opin Plant Biol (2011) 1.45
Small RNA-directed epigenetic natural variation in Arabidopsis thaliana. PLoS Genet (2008) 1.43
A dual flip-out mechanism for 5mC recognition by the Arabidopsis SUVH5 SRA domain and its impact on DNA methylation and H3K9 dimethylation in vivo. Genes Dev (2011) 1.43
Roles of DCL4 and DCL3b in rice phased small RNA biogenesis. Plant J (2011) 1.42
Stage-specific roles for tet1 and tet2 in DNA demethylation in primordial germ cells. Cell Stem Cell (2013) 1.40
Single-base resolution maps of cultivated and wild rice methylomes and regulatory roles of DNA methylation in plant gene expression. BMC Genomics (2012) 1.40
ARGONAUTE10 and ARGONAUTE1 regulate the termination of floral stem cells through two microRNAs in Arabidopsis. PLoS Genet (2011) 1.40
SDG714, a histone H3K9 methyltransferase, is involved in Tos17 DNA methylation and transposition in rice. Plant Cell (2007) 1.39
Transcriptome and methylome interactions in rice hybrids. Proc Natl Acad Sci U S A (2012) 1.39
Arginine methylation mediated by the Arabidopsis homolog of PRMT5 is essential for proper pre-mRNA splicing. Proc Natl Acad Sci U S A (2010) 1.36
Comparative analysis of JmjC domain-containing proteins reveals the potential histone demethylases in Arabidopsis and rice. J Integr Plant Biol (2008) 1.35
Catalytic properties and kinetic mechanism of human recombinant Lys-9 histone H3 methyltransferase SUV39H1: participation of the chromodomain in enzymatic catalysis. Biochemistry (2006) 1.34
Oryza sativa dicer-like4 reveals a key role for small interfering RNA silencing in plant development. Plant Cell (2007) 1.30
Dynamic regulation of ARGONAUTE4 within multiple nuclear bodies in Arabidopsis thaliana. PLoS Genet (2008) 1.30
Identification and expression analysis of miRNAs from nitrogen-fixing soybean nodules. Biochem Biophys Res Commun (2008) 1.30
The impact of Arabidopsis on human health: diversifying our portfolio. Cell (2008) 1.27