Published in Nat Prod Rep on November 22, 2006
The Bet v 1 fold: an ancient, versatile scaffold for binding of large, hydrophobic ligands. BMC Evol Biol (2008) 2.15
Biosynthesis of the salinosporamide A polyketide synthase substrate chloroethylmalonyl-coenzyme A from S-adenosyl-L-methionine. Proc Natl Acad Sci U S A (2009) 1.91
Evolution of polyketide synthases in bacteria. Proc Natl Acad Sci U S A (2008) 1.78
Biosynthesis of polyketide synthase extender units. Nat Prod Rep (2009) 1.66
New insights into the formation of fungal aromatic polyketides. Nat Rev Microbiol (2010) 1.59
Biosynthesis of the allylmalonyl-CoA extender unit for the FK506 polyketide synthase proceeds through a dedicated polyketide synthase and facilitates the mutasynthesis of analogues. J Am Chem Soc (2010) 1.49
Biosynthesis of aromatic polyketides in bacteria. Acc Chem Res (2009) 1.34
Total synthesis of (+)-roxaticin via C-C bond forming transfer hydrogenation: a departure from stoichiometric chiral reagents, auxiliaries, and premetalated nucleophiles in polyketide construction. J Am Chem Soc (2010) 1.34
Redirecting the cyclization steps of fungal polyketide synthase. J Am Chem Soc (2007) 1.32
Flavoenzymes: versatile catalysts in biosynthetic pathways. Nat Prod Rep (2013) 1.23
Comparative characterization of fungal anthracenone and naphthacenedione biosynthetic pathways reveals an α-hydroxylation-dependent Claisen-like cyclization catalyzed by a dimanganese thioesterase. J Am Chem Soc (2011) 1.22
A sea of biosynthesis: marine natural products meet the molecular age. Nat Prod Rep (2010) 1.19
Genomes to natural products PRediction Informatics for Secondary Metabolomes (PRISM). Nucleic Acids Res (2015) 1.17
Moenomycin family antibiotics: chemical synthesis, biosynthesis, and biological activity. Nat Prod Rep (2010) 1.15
Functional analysis of environmental DNA-derived type II polyketide synthases reveals structurally diverse secondary metabolites. Proc Natl Acad Sci U S A (2011) 1.14
Engineering microbial factories for synthesis of value-added products. J Ind Microbiol Biotechnol (2011) 1.13
Engineered biosynthesis of bacterial aromatic polyketides in Escherichia coli. Proc Natl Acad Sci U S A (2008) 1.12
In vivo and in vitro analysis of the hedamycin polyketide synthase. Chem Biol (2009) 1.08
An environmental DNA-derived type II polyketide biosynthetic pathway encodes the biosynthesis of the pentacyclic polyketide erdacin. Angew Chem Int Ed Engl (2009) 1.05
Cyclization of aromatic polyketides from bacteria and fungi. Nat Prod Rep (2010) 1.05
A biosynthetic pathway for BE-7585A, a 2-thiosugar-containing angucycline-type natural product. J Am Chem Soc (2010) 1.04
Biocatalysts and small molecule products from metagenomic studies. Curr Opin Chem Biol (2012) 1.04
Cloning and characterization of the ravidomycin and chrysomycin biosynthetic gene clusters. Chembiochem (2010) 1.03
Flavin-mediated dual oxidation controls an enzymatic Favorskii-type rearrangement. Nature (2013) 1.02
Binding and "pKa" modulation of a polycyclic substrate analogue in a type II polyketide acyl carrier protein. ACS Chem Biol (2011) 1.00
Biochemical analysis of the biosynthetic pathway of an anticancer tetracycline SF2575. J Am Chem Soc (2009) 0.98
A PKS/NRPS/FAS hybrid gene cluster from Serratia plymuthica RVH1 encoding the biosynthesis of three broad spectrum, zeamine-related antibiotics. PLoS One (2013) 0.98
Arimetamycin A: improving clinically relevant families of natural products through sequence-guided screening of soil metagenomes. Angew Chem Int Ed Engl (2013) 0.94
Probing the compatibility of type II ketosynthase-carrier protein partners. Chembiochem (2008) 0.94
Cloning, sequencing, heterologous expression, and mechanistic analysis of A-74528 biosynthesis. J Am Chem Soc (2010) 0.93
Antimicrobial activities of jadomycin B and structurally related analogues. Antimicrob Agents Chemother (2008) 0.93
Engineering polyketide synthases and nonribosomal peptide synthetases. Curr Opin Struct Biol (2013) 0.92
Biochemical and structural characterization of germicidin synthase: analysis of a type III polyketide synthase that employs acyl-ACP as a starter unit donor. J Am Chem Soc (2012) 0.92
PKMiner: a database for exploring type II polyketide synthases. BMC Microbiol (2012) 0.90
The structure of SpnF, a standalone enzyme that catalyzes [4 + 2] cycloaddition. Nat Chem Biol (2015) 0.90
Engineered polyketide biosynthesis and biocatalysis in Escherichia coli. Appl Microbiol Biotechnol (2010) 0.88
Biosynthesis of the mycotoxin tenuazonic acid by a fungal NRPS-PKS hybrid enzyme. Nat Commun (2015) 0.87
Novel intermolecular iterative mechanism for biosynthesis of mycoketide catalyzed by a bimodular polyketide synthase. PLoS Biol (2008) 0.87
Decoding and engineering tetracycline biosynthesis. Metab Eng (2008) 0.87
Expanded natural product diversity revealed by analysis of lanthipeptide-like gene clusters in actinobacteria. Appl Environ Microbiol (2015) 0.86
Mechanism and engineering of polyketide chain initiation in fredericamycin biosynthesis. J Am Chem Soc (2010) 0.86
Oxytetracycline biosynthesis. J Biol Chem (2010) 0.86
Starter unit flexibility for engineered product synthesis by the nonreducing polyketide synthase PksA. ACS Chem Biol (2015) 0.86
Actinomycetes from the South China Sea sponges: isolation, diversity, and potential for aromatic polyketides discovery. Front Microbiol (2015) 0.85
Structural and biochemical characterization of ZhuI aromatase/cyclase from the R1128 polyketide pathway. Biochemistry (2011) 0.85
High metabolomic microdiversity within co-occurring isolates of the extremely halophilic bacterium Salinibacter ruber. PLoS One (2013) 0.84
Evolution of chemical diversity by coordinated gene swaps in type II polyketide gene clusters. Proc Natl Acad Sci U S A (2015) 0.84
Protein engineering towards natural product synthesis and diversification. J Ind Microbiol Biotechnol (2011) 0.83
Lomaiviticin biosynthesis employs a new strategy for starter unit generation. Org Lett (2014) 0.83
Functional gene-guided discovery of type II polyketides from culturable actinomycetes associated with soft coral Scleronephthya sp. PLoS One (2012) 0.82
A ketosynthase homolog uses malonyl units to form esters in cervimycin biosynthesis. Nat Chem Biol (2011) 0.82
Natural Products and the Gene Cluster Revolution. Trends Microbiol (2016) 0.81
Mining soil metagenomes to better understand the evolution of natural product structural diversity: pentangular polyphenols as a case study. J Am Chem Soc (2014) 0.81
Total (bio)synthesis: strategies of nature and of chemists. Top Curr Chem (2010) 0.81
Analysis of the ketosynthase-chain length factor heterodimer from the fredericamycin polyketide synthase. Chem Biol (2011) 0.81
Oxidative Cyclization in Natural Product Biosynthesis. Chem Rev (2016) 0.81
Recent advances in the biosynthesis of unusual polyketide synthase substrates. Nat Prod Rep (2016) 0.79
Harnessing natural product assembly lines: structure, promiscuity, and engineering. J Ind Microbiol Biotechnol (2015) 0.78
Divergent evolution of an atypical S-adenosyl-l-methionine-dependent monooxygenase involved in anthracycline biosynthesis. Proc Natl Acad Sci U S A (2015) 0.78
Expression, purification and crystallization of the cofactor-independent monooxygenase SnoaB from the nogalamycin biosynthetic pathway. Acta Crystallogr Sect F Struct Biol Cryst Commun (2009) 0.78
Identification and biotechnological application of novel regulatory genes involved in Streptomyces polyketide overproduction through reverse engineering strategy. Biomed Res Int (2013) 0.77
Characterization of the two-component monooxygenase system AlnT/AlnH reveals early timing of quinone formation in alnumycin biosynthesis. J Bacteriol (2012) 0.77
Effective Antibiofilm Polyketides against Staphylococcus aureus from the Pyranonaphthoquinone Biosynthetic Pathways of Streptomyces Species. Antimicrob Agents Chemother (2015) 0.77
Ectopic expression and functional characterization of type III polyketide synthase mutants from Emblica officinalis Gaertn. Plant Cell Rep (2016) 0.76
Policing starter unit selection of the enterocin type II polyketide synthase by the type II thioesterase EncL. Bioorg Med Chem (2011) 0.76
Synthetic biology of antimicrobial discovery. ACS Synth Biol (2012) 0.76
Structural and functional analysis of two di-domain aromatase/cyclases from type II polyketide synthases. Proc Natl Acad Sci U S A (2015) 0.76
Properties of lanK-based regulatory circuit involved in landomycin biosynthesis in Streptomyces cyanogenus S136. Genetika (2010) 0.76
Insights into Complex Oxidation during BE-7585A Biosynthesis: Structural Determination and Analysis of the Polyketide Monooxygenase BexE. ACS Chem Biol (2016) 0.76
Hydroxyl regioisomerization of anthracycline catalyzed by a four-enzyme cascade. Proc Natl Acad Sci U S A (2017) 0.75
Griseorhodins D-F, neuroactive intermediates and end products of post-PKS tailoring modification in Griseorhodin biosynthesis. J Nat Prod (2014) 0.75
Comparative Genomics of Pathogens Causing Brown Spot Disease of Tobacco: Alternaria longipes and Alternaria alternata. PLoS One (2016) 0.75
Biosynthesis of Oxytetracycline by Streptomyces rimosus: Past, Present and Future Directions in the Development of Tetracycline Antibiotics. Food Technol Biotechnol (2017) 0.75
Formation of an Angular Aromatic Polyketide from a Linear Anthrene Precursor via Oxidative Rearrangement. Cell Chem Biol (2017) 0.75
Phylogeny-guided (meta)genome mining approach for the targeted discovery of new microbial natural products. J Ind Microbiol Biotechnol (2016) 0.75
A cryptic polyene biosynthetic gene cluster in Streptomyces calvus is expressed upon complementation with a functional bldA gene. Chem Biol (2013) 1.59
Structure and action of the C-C bond-forming glycosyltransferase UrdGT2 involved in the biosynthesis of the antibiotic urdamycin. J Mol Biol (2007) 1.28
Genes and enzymes involved in caffeic acid biosynthesis in the actinomycete Saccharothrix espanaensis. J Bacteriol (2006) 1.19
Generation of new landomycins by combinatorial biosynthetic manipulation of the LndGT4 gene of the landomycin E cluster in S. globisporus. Chem Biol (2004) 1.17
A genomic screening approach to the structure-guided identification of drug candidates from natural sources. Chembiochem (2007) 1.13
The glycosyltransferase UrdGT2 catalyzes both C- and O-glycosidic sugar transfers. Angew Chem Int Ed Engl (2004) 1.13
Structure and function of the antibiotic resistance-mediating methyltransferase AviRb from Streptomyces viridochromogenes. J Mol Biol (2005) 1.10
Biosynthesis of the terpene phenalinolactone in Streptomyces sp. Tü6071: analysis of the gene cluster and generation of derivatives. Chem Biol (2006) 1.06
Engineered urdamycin glycosyltransferases are broadened and altered in substrate specificity. Chem Biol (2002) 1.05
Coordination of export and glycosylation of landomycins in Streptomyces cyanogenus S136. FEMS Microbiol Lett (2008) 1.05
Organisation of the biosynthetic gene cluster and tailoring enzymes in the biosynthesis of the tetracyclic quinone glycoside antibiotic polyketomycin. Chembiochem (2009) 1.04
Beta-glucuronidase as a sensitive and versatile reporter in actinomycetes. Appl Environ Microbiol (2011) 1.03
Glycosyltransferases involved in the biosynthesis of biologically active natural products that contain oligosaccharides. Mol Biosyst (2005) 1.01
Iteratively acting glycosyltransferases involved in the hexasaccharide biosynthesis of landomycin A. Chem Biol (2005) 1.01
Glycosyltransferases, important tools for drug design. Curr Top Med Chem (2008) 0.99
Generation of novel landomycins M and O through targeted gene disruption. Chembiochem (2005) 0.99
The avilamycin resistance determinants AviRa and AviRb methylate 23S rRNA at the guanosine 2535 base and the uridine 2479 ribose. Mol Microbiol (2003) 0.98
Urdamycin L: a novel metabolic shunt product that provides evidence for the role of the urdM gene in the urdamycin A biosynthetic pathway of Streptomyces fradiae TU 2717. Chembiochem (2003) 0.96
Genes and enzymes involved in bacterial isoprenoid biosynthesis. Curr Opin Chem Biol (2009) 0.96
Rationally designed glycosylated premithramycins: hybrid aromatic polyketides using genes from three different biosynthetic pathways. J Am Chem Soc (2002) 0.96
Deoxysugars in bioactive natural products: development of novel derivatives by altering the sugar pattern. Curr Top Med Chem (2008) 0.96
Actinomycetes biosynthetic potential: how to bridge in silico and in vivo? J Ind Microbiol Biotechnol (2013) 0.95
Heterologous expression and genetic engineering of the phenalinolactone biosynthetic gene cluster by using red/ET recombineering. Chembiochem (2008) 0.94
Design, construction and characterisation of a synthetic promoter library for fine-tuned gene expression in actinomycetes. Metab Eng (2013) 0.93
Functional expression of the Cre recombinase in actinomycetes. Appl Microbiol Biotechnol (2008) 0.93
A bacterial glycosyltransferase gene toolbox: generation and applications. Phytochemistry (2009) 0.92
Generation of new landomycins with altered saccharide patterns through over-expression of the glycosyltransferase gene lanGT3 in the biosynthetic gene cluster of landomycin A in Streptomyces cyanogenus S-136. Chembiochem (2007) 0.92
Site-specific recombination strategies for engineering actinomycete genomes. Appl Environ Microbiol (2012) 0.92
Marker removal from actinomycetes genome using Flp recombinase. Gene (2008) 0.91
Function of lanGT3, a glycosyltransferase gene involved in landomycin A biosynthesis. Chembiochem (2004) 0.90
Features and applications of bacterial glycosyltransferases: current state and prospects. Appl Microbiol Biotechnol (2008) 0.90
Cloning and heterologous expression of the aranciamycin biosynthetic gene cluster revealed a new flexible glycosyltransferase. Chembiochem (2007) 0.89
On the acceptor substrate of C-glycosyltransferase UrdGT2: three prejadomycin C-Glycosides from an engineered mutant of Streptomyces globisporus 1912 DeltalndE(urdGT2). Angew Chem Int Ed Engl (2006) 0.89
LanV, a bifunctional enzyme: aromatase and ketoreductase during landomycin A biosynthesis. Chembiochem (2005) 0.89
LanGT2 Catalyzes the First Glycosylation Step during landomycin A biosynthesis. Chembiochem (2005) 0.88
The future of natural products as a source of new antibiotics. Curr Opin Investig Drugs (2007) 0.87
Pleiotropic regulatory genes bldA, adpA and absB are implicated in production of phosphoglycolipid antibiotic moenomycin. Open Biol (2013) 0.87
Complete genome sequence of producer of the glycopeptide antibiotic Aculeximycin Kutzneria albida DSM 43870T, a representative of minor genus of Pseudonocardiaceae. BMC Genomics (2014) 0.86
Rational design of an aryl-C-glycoside catalyst from a natural product O-glycosyltransferase. Chem Biol (2011) 0.86
The C-Glycosyltransferase UrdGT2 is unselective toward d- and l-configured nucleotide-bound rhodinoses. J Am Chem Soc (2003) 0.86
Chapter 12. The power of glycosyltransferases to generate bioactive natural compounds. Methods Enzymol (2009) 0.86
Function of lanI in regulation of landomycin A biosynthesis in Streptomyces cyanogenus S136 and cross-complementation studies with Streptomyces antibiotic regulatory proteins encoding genes. Arch Microbiol (2007) 0.85
I-SceI endonuclease: a new tool for DNA repair studies and genetic manipulations in streptomyces. Appl Microbiol Biotechnol (2010) 0.85
Differences in the substrate specificity of glycosyltransferases involved in landomycins A and E biosynthesis. Appl Microbiol Biotechnol (2009) 0.85
Regio- and stereoselective intermolecular oxidative phenol coupling in Streptomyces. J Am Chem Soc (2014) 0.84
Actinomycetes genome engineering approaches. Antonie Van Leeuwenhoek (2012) 0.84
Expression of the landomycin biosynthetic gene cluster in a PKS mutant of Streptomyces fradiae is dependent on the coexpression of a putative transcriptional activator gene. FEMS Microbiol Lett (2004) 0.84
Cloning and sequencing of the biosynthetic gene cluster for saquayamycin Z and galtamycin B and the elucidation of the assembly of their saccharide chains. Chembiochem (2009) 0.84
Insights into the pamamycin biosynthesis. Angew Chem Int Ed Engl (2014) 0.83
Engineering a function into a glycosyltransferase. Chem Biol (2009) 0.83
The pathway-specific regulatory genes, tei15* and tei16*, are the master switches of teicoplanin production in Actinoplanes teichomyceticus. Appl Microbiol Biotechnol (2014) 0.82
Crystal structure of the avilamycin resistance-conferring methyltransferase AviRa from Streptomyces viridochromogenes. J Mol Biol (2003) 0.82
Genes involved in formation and attachment of a two-carbon chain as a component of eurekanate, a branched-chain sugar moiety of avilamycin A. Appl Environ Microbiol (2005) 0.82
It works: combinatorial biosynthesis for generating novel glycosylated compounds. Mol Microbiol (2005) 0.82
In vivo Tn5-based transposon mutagenesis of Streptomycetes. Appl Microbiol Biotechnol (2009) 0.82
Novel avilamycin derivatives with improved polarity generated by targeted gene disruption. Chem Biol (2004) 0.81
A strategy for cloning glycosyltransferase genes involved in natural product biosynthesis. Appl Microbiol Biotechnol (2007) 0.81
Development of intergeneric conjugal gene transfer system in Streptomyces diastatochromogenes 1628 and its application for improvement of toyocamycin production. Curr Microbiol (2013) 0.81
Genes encoding enzymes responsible for biosynthesis of L-lyxose and attachment of eurekanate during avilamycin biosynthesis. Chem Biol (2005) 0.81
Generation of Streptomyces globisporus SMY622 strain with increased landomycin E production and it's initial characterization. J Antibiot (Tokyo) (2004) 0.81
A transposon-based strategy to identify the regulatory gene network responsible for landomycin E biosynthesis. FEMS Microbiol Lett (2013) 0.80
Complete genome sequence of Saccharothrix espanaensis DSM 44229(T) and comparison to the other completely sequenced Pseudonocardiaceae. BMC Genomics (2012) 0.80
Rational saccharide extension by using the natural product glycosyltransferase LanGT4. Chembiochem (2004) 0.80
Cloning, purification and characterization of a functional anthracycline glycosyltransferase. J Biotechnol (2006) 0.80
Lorneic acids C and D, new trialkyl-substituted aromatic acids isolated from a terrestrial Streptomyces sp. J Antibiot (Tokyo) (2013) 0.80
SimReg1 is a master switch for biosynthesis and export of simocyclinone D8 and its precursors. AMB Express (2012) 0.79
In vivo random mutagenesis of streptomycetes using mariner-based transposon Himar1. Appl Microbiol Biotechnol (2012) 0.79
Overexpression of ribosome recycling factor is responsible for improvement of nucleotide antibiotic-toyocamycin in Streptomyces diastatochromogenes 1628. Appl Microbiol Biotechnol (2014) 0.79
Unusual site-specific DNA integration into the highly active pseudo-attB of the Streptomyces albus J1074 genome. Appl Microbiol Biotechnol (2014) 0.78
Novel natural compounds obtained by genome-based screening and genetic engineering. Curr Opin Drug Discov Devel (2005) 0.78
Genome sequence of Streptomyces sp. strain Tü6071. J Bacteriol (2011) 0.78
The active conformation of avilamycin A is conferred by AviX12, a radical AdoMet enzyme. J Biol Chem (2006) 0.78
Characterization and analysis of the regulatory network involved in control of lipomycin biosynthesis in Streptomyces aureofaciens Tü117. Appl Microbiol Biotechnol (2009) 0.78
Chemoenzymatic and bioenzymatic synthesis of carbohydrate containing natural products. Top Curr Chem (2010) 0.78
SorF: a glycosyltransferase with promiscuous donor substrate specificity in vitro. Chembiochem (2007) 0.78
Genome engineering in actinomycetes using site-specific recombinases. Appl Microbiol Biotechnol (2013) 0.78
A putative proteinase gene is involved in regulation of landomycin E biosynthesis in Streptomyces globisporus 1912. FEMS Microbiol Lett (2006) 0.77
Novel and tightly regulated resorcinol and cumate-inducible expression systems for Streptomyces and other actinobacteria. Appl Microbiol Biotechnol (2014) 0.77