Implementation of clinical practice guidelines for ventilator-associated pneumonia: a multicenter prospective study.

Introducing the Comprehensive Unit-based Safety Program for mechanically ventilated patients in Saudi Arabian Intensive Care Units. Ann Thorac Med (2017) 1.39

Infection prevention in the emergency department. Ann Emerg Med (2014) 0.89

Thromboprophylaxis patterns and determinants in critically ill patients: a multicenter audit. Crit Care (2014) 0.83

Year in review 2013: Critical Care--respiratory infections. Crit Care (2014) 0.83

A systematic approach for developing a ventilator-associated pneumonia prevention bundle. Am J Infect Control (2016) 0.80

The impact of antimicrobial resistance and aging in VAP outcomes: experience from a large tertiary care center. PLoS One (2014) 0.80

Management of infections in critically ill patients. Surg Infect (Larchmt) (2014) 0.78

The conundrum of clinical practice guidelines. Can J Hosp Pharm (2013) 0.78

Systematic implementation of evidence-based guidelines in intensive care medicine: resistance to change is human nature. Crit Care Med (2013) 0.77

Probiotics: Prevention of Severe Pneumonia and Endotracheal Colonization Trial-PROSPECT: a pilot trial. Trials (2016) 0.75

Prevention of nosocomial infections in critically ill patients with lactoferrin (PREVAIL study): study protocol for a randomized controlled trial. Trials (2016) 0.75

Prompting physicians to address a daily checklist for antibiotics: do we need a co-pilot in the ICU? Curr Opin Crit Care (2013) 0.75

Intensive versus conventional glucose control in critically ill patients. N Engl J Med (2009) 26.30

Critically ill patients with 2009 influenza A(H1N1) infection in Canada. JAMA (2009) 13.00

One-year outcomes in survivors of the acute respiratory distress syndrome. N Engl J Med (2003) 11.77

Vasopressin versus norepinephrine infusion in patients with septic shock. N Engl J Med (2008) 11.00

Functional disability 5 years after acute respiratory distress syndrome. N Engl J Med (2011) 9.96

A randomized trial of glutamine and antioxidants in critically ill patients. N Engl J Med (2013) 8.94

Randomized trials stopped early for benefit: a systematic review. JAMA (2005) 8.43

Transfusion strategies for patients in pediatric intensive care units. N Engl J Med (2007) 7.21

A guide for the design and conduct of self-administered surveys of clinicians. CMAJ (2008) 6.72

Daily sedation interruption in mechanically ventilated critically ill patients cared for with a sedation protocol: a randomized controlled trial. JAMA (2012) 6.69

High-frequency oscillation in early acute respiratory distress syndrome. N Engl J Med (2013) 6.56

Ventilation strategy using low tidal volumes, recruitment maneuvers, and high positive end-expiratory pressure for acute lung injury and acute respiratory distress syndrome: a randomized controlled trial. JAMA (2008) 6.39

Intensive insulin therapy and mortality among critically ill patients: a meta-analysis including NICE-SUGAR study data. CMAJ (2009) 6.27

Hypoglycemia and risk of death in critically ill patients. N Engl J Med (2012) 6.17

Stopping randomized trials early for benefit and estimation of treatment effects: systematic review and meta-regression analysis. JAMA (2010) 5.90

A randomized trial of diagnostic techniques for ventilator-associated pneumonia. N Engl J Med (2006) 5.74

Comparison of mortality between private for-profit and private not-for-profit hemodialysis centers: a systematic review and meta-analysis. JAMA (2002) 5.57

An official ATS statement: grading the quality of evidence and strength of recommendations in ATS guidelines and recommendations. Am J Respir Crit Care Med (2006) 5.29

Prevention of VTE in nonsurgical patients: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest (2012) 5.02

A systematic review and meta-analysis of studies comparing mortality rates of private for-profit and private not-for-profit hospitals. CMAJ (2002) 4.84

Initiation of inappropriate antimicrobial therapy results in a fivefold reduction of survival in human septic shock. Chest (2009) 4.51

Early combination antibiotic therapy yields improved survival compared with monotherapy in septic shock: a propensity-matched analysis. Crit Care Med (2010) 4.39

Need for expertise based randomised controlled trials. BMJ (2005) 4.34

Toothbrushing for critically ill mechanically ventilated patients: a systematic review and meta-analysis of randomized trials evaluating ventilator-associated pneumonia. Crit Care Med (2013) 4.29

An observational study of orthopaedic abstracts and subsequent full-text publications. J Bone Joint Surg Am (2002) 4.25

Fluid resuscitation in sepsis: a systematic review and network meta-analysis. Ann Intern Med (2014) 3.96

Clinical consequences of red cell storage in the critically ill. Transfusion (2006) 3.57

The effect of selenium therapy on mortality in patients with sepsis syndrome: a systematic review and meta-analysis of randomized controlled trials. Crit Care Med (2013) 3.43

Family satisfaction with care in the intensive care unit: results of a multiple center study. Crit Care Med (2002) 3.36

Barriers to full-text publication following presentation of abstracts at annual orthopaedic meetings. J Bone Joint Surg Am (2003) 3.36

Quality of care in for-profit and not-for-profit nursing homes: systematic review and meta-analysis. BMJ (2009) 3.22

Intensive care unit quality improvement: a "how-to" guide for the interdisciplinary team. Crit Care Med (2006) 3.15

Methodology for the development of antithrombotic therapy and prevention of thrombosis guidelines: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest (2012) 3.14

Subglottic secretion drainage for the prevention of ventilator-associated pneumonia: a systematic review and meta-analysis. Crit Care Med (2011) 3.14

The relationship between nutritional intake and clinical outcomes in critically ill patients: results of an international multicenter observational study. Intensive Care Med (2009) 3.11

Patient and healthcare professional factors influencing end-of-life decision-making during critical illness: a systematic review. Crit Care Med (2011) 3.07

Canadian survey of the use of sedatives, analgesics, and neuromuscular blocking agents in critically ill patients. Crit Care Med (2006) 3.06

Methodologic issues in systematic reviews and meta-analyses. Clin Orthop Relat Res (2003) 2.90

Rationing critical care beds: a systematic review. Crit Care Med (2004) 2.86

The efficacy and safety of heparin in patients with sepsis: a systematic review and metaanalysis. Crit Care Med (2015) 2.85

Fluids after cardiac surgery: a pilot study of the use of colloids versus crystalloids. Crit Care Med (2010) 2.82

The Very Elderly Admitted to ICU: A Quality Finish? Crit Care Med (2015) 2.77

Interaction of vasopressin infusion, corticosteroid treatment, and mortality of septic shock. Crit Care Med (2009) 2.77

Payments for care at private for-profit and private not-for-profit hospitals: a systematic review and meta-analysis. CMAJ (2004) 2.76

Safety of cell therapy with mesenchymal stromal cells (SafeCell): a systematic review and meta-analysis of clinical trials. PLoS One (2012) 2.75

One-Year Outcomes in Caregivers of Critically Ill Patients. N Engl J Med (2016) 2.73

Acute rehabilitation practices in critically ill children: a multicenter study. Pediatr Crit Care Med (2014) 2.71

Candida in the respiratory tract secretions of critically ill patients and the impact of antifungal treatment: a randomized placebo controlled pilot trial (CANTREAT study). Intensive Care Med (2014) 2.70

Clinical practice guidelines for the use of noninvasive positive-pressure ventilation and noninvasive continuous positive airway pressure in the acute care setting. CMAJ (2011) 2.67

Longitudinal changes in procalcitonin in a heterogeneous group of critically ill patients. Crit Care Med (2012) 2.65

Clinician predictions of intensive care unit mortality. Crit Care Med (2004) 2.65

End-of-life care for the critically ill: A national intensive care unit survey. Crit Care Med (2006) 2.61

Angiopoietin-1 and angiopoietin-2 as clinically informative prognostic biomarkers of morbidity and mortality in severe sepsis. Crit Care Med (2011) 2.59

Nutritional practices and their relationship to clinical outcomes in critically ill children--an international multicenter cohort study*. Crit Care Med (2012) 2.53

Age of transfused blood in critically ill adults. N Engl J Med (2015) 2.52

Multicentre, cluster-randomized clinical trial of algorithms for critical-care enteral and parenteral therapy (ACCEPT). CMAJ (2004) 2.45

Oral decontamination for prevention of pneumonia in mechanically ventilated adults: systematic review and meta-analysis. BMJ (2007) 2.44

Use of non-invasive ventilation to wean critically ill adults off invasive ventilation: meta-analysis and systematic review. BMJ (2009) 2.44

Impact of enteral feeding protocols on enteral nutrition delivery: results of a multicenter observational study. JPEN J Parenter Enteral Nutr (2010) 2.39

The design and interpretation of pilot trials in clinical research in critical care. Crit Care Med (2009) 2.38

Nonleg venous thrombosis in critically ill adults: a nested prospective cohort study. JAMA Intern Med (2014) 2.36

Probiotics in the critically ill: a systematic review of the randomized trial evidence. Crit Care Med (2012) 2.35

Red blood cell transfusion thresholds in pediatric patients with sepsis. Pediatr Crit Care Med (2011) 2.35

Refinement, scoring, and validation of the Family Satisfaction in the Intensive Care Unit (FS-ICU) survey. Crit Care Med (2007) 2.34

Gastrointestinal promotility drugs in the critical care setting: a systematic review of the evidence. Crit Care Med (2002) 2.34

Effect of nitric oxide on oxygenation and mortality in acute lung injury: systematic review and meta-analysis. BMJ (2007) 2.33

Mortality predictions in the intensive care unit: comparing physicians with scoring systems. Crit Care Med (2006) 2.29

A phase II randomized placebo-controlled trial of omega-3 fatty acids for the treatment of acute lung injury. Crit Care Med (2011) 2.27

Written informed consent and selection bias in observational studies using medical records: systematic review. BMJ (2009) 2.27

Perioperative cardiac events in patients undergoing noncardiac surgery: a review of the magnitude of the problem, the pathophysiology of the events and methods to estimate and communicate risk. CMAJ (2005) 2.27

A systematic review of studies comparing health outcomes in Canada and the United States. Open Med (2007) 2.26

Dying in the ICU: perspectives of family members. Chest (2003) 2.25

Glutamine supplementation in serious illness: a systematic review of the evidence. Crit Care Med (2002) 2.24

Thrombocytopenia in critically ill patients receiving thromboprophylaxis: frequency, risk factors, and outcomes. Chest (2013) 2.24

Systematic reviewers neglect bias that results from trials stopped early for benefit. J Clin Epidemiol (2007) 2.20

Diagnostic and prognostic implications of endotoxemia in critical illness: results of the MEDIC study. J Infect Dis (2004) 2.17

A prospective, observational registry of patients with severe sepsis: the Canadian Sepsis Treatment and Response Registry. Crit Care Med (2009) 2.17

Management of the critically ill patient with severe acute pancreatitis. Crit Care Med (2004) 2.16

Failure of anticoagulant thromboprophylaxis: risk factors in medical-surgical critically ill patients*. Crit Care Med (2015) 2.16