Published in Genes Dev on January 01, 1991
Compilation of vertebrate-encoded transcription factors. Nucleic Acids Res (1992) 5.35
Hedgehog signaling in the neural crest cells regulates the patterning and growth of facial primordia. Genes Dev (2004) 3.83
Sox9 is required for determination of the chondrogenic cell lineage in the cranial neural crest. Proc Natl Acad Sci U S A (2003) 2.64
The AP-2 family of transcription factors. Genome Biol (2005) 2.46
Cre-mediated gene inactivation demonstrates that FGF8 is required for cell survival and patterning of the first branchial arch. Genes Dev (1999) 2.42
An Fgf8 mouse mutant phenocopies human 22q11 deletion syndrome. Development (2002) 2.31
The transcription factor MTF-1 is essential for basal and heavy metal-induced metallothionein gene expression. EMBO J (1994) 2.19
Ablation of specific expression domains reveals discrete functions of ectoderm- and endoderm-derived FGF8 during cardiovascular and pharyngeal development. Development (2003) 2.09
BMP receptor IA is required in mammalian neural crest cells for development of the cardiac outflow tract and ventricular myocardium. Development (2004) 1.93
Generation of neural crest-derived peripheral neurons and floor plate cells from mouse and primate embryonic stem cells. Proc Natl Acad Sci U S A (2003) 1.93
Identification of binding sites for transcription factors NF-kappa B and AP-2 in the promoter region of the human heme oxygenase 1 gene. Proc Natl Acad Sci U S A (1994) 1.85
Transcriptional activation by Myc is under negative control by the transcription factor AP-2. EMBO J (1995) 1.82
The developmentally regulated transcription factor AP-2 is involved in c-erbB-2 overexpression in human mammary carcinoma. Proc Natl Acad Sci U S A (1995) 1.76
Enhanced apoptotic cell death of renal epithelial cells in mice lacking transcription factor AP-2beta. Genes Dev (1997) 1.76
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Transcription factor AP2 and its role in epidermal-specific gene expression. Proc Natl Acad Sci U S A (1991) 1.70
A ubiquitous factor (HF-1a) and a distinct muscle factor (HF-1b/MEF-2) form an E-box-independent pathway for cardiac muscle gene expression. Mol Cell Biol (1992) 1.61
Probing keratinocyte and differentiation specificity of the human K5 promoter in vitro and in transgenic mice. Mol Cell Biol (1993) 1.59
An alternatively spliced mRNA from the AP-2 gene encodes a negative regulator of transcriptional activation by AP-2. Mol Cell Biol (1993) 1.58
Loss of AP-2 results in downregulation of c-KIT and enhancement of melanoma tumorigenicity and metastasis. EMBO J (1998) 1.56
Promoter mutations that increase amyloid precursor-protein expression are associated with Alzheimer disease. Am J Hum Genet (2006) 1.55
Identification of the neurofibromatosis type 1 gene product. Proc Natl Acad Sci U S A (1991) 1.55
AP-2-null cells disrupt morphogenesis of the eye, face, and limbs in chimeric mice. Proc Natl Acad Sci U S A (1998) 1.51
Induction of neural crest in Xenopus by transcription factor AP2alpha. Proc Natl Acad Sci U S A (2003) 1.43
Transcriptional regulation of the human manganese superoxide dismutase gene: the role of specificity protein 1 (Sp1) and activating protein-2 (AP-2). Biochem J (2002) 1.42
A molecular wound response program associated with regeneration initiation in planarians. Genes Dev (2012) 1.41
RB and c-Myc activate expression of the E-cadherin gene in epithelial cells through interaction with transcription factor AP-2. Mol Cell Biol (1998) 1.39
Multiple regulatory elements contribute differentially to muscle creatine kinase enhancer activity in skeletal and cardiac muscle. Mol Cell Biol (1993) 1.34
Redundant activities of Tfap2a and Tfap2c are required for neural crest induction and development of other non-neural ectoderm derivatives in zebrafish embryos. Dev Biol (2006) 1.33
Genomic organization of the melanoma-associated glycoprotein MUC18: implications for the evolution of the immunoglobulin domains. Proc Natl Acad Sci U S A (1993) 1.31
Transcriptional activation by AP-2alpha is modulated by the oncogene DEK. Nucleic Acids Res (2003) 1.31
Decreased embryonic retinoic acid synthesis results in a DiGeorge syndrome phenotype in newborn mice. Proc Natl Acad Sci U S A (2003) 1.30
Current perspectives of the signaling pathways directing neural crest induction. Cell Mol Life Sci (2012) 1.30
Transcription Factors Pax6 and AP-2alpha Interact To Coordinate Corneal Epithelial Repair by Controlling Expression of Matrix Metalloproteinase Gelatinase B. Mol Cell Biol (2004) 1.29
Gpr177/mouse Wntless is essential for Wnt-mediated craniofacial and brain development. Dev Dyn (2011) 1.24
Defining the regulatory factors required for epidermal gene expression. Mol Cell Biol (2000) 1.22
Transcriptional regulation of the AP-2alpha promoter by BTEB-1 and AP-2rep, a novel wt-1/egr-related zinc finger repressor. Mol Cell Biol (1999) 1.21
Novel TFAP2B mutations that cause Char syndrome provide a genotype-phenotype correlation. Am J Hum Genet (2001) 1.20
Activation of transcription factor AP-2 mediates UVA radiation- and singlet oxygen-induced expression of the human intercellular adhesion molecule 1 gene. Proc Natl Acad Sci U S A (1996) 1.19
Analysis of early human neural crest development. Dev Biol (2010) 1.17
Relationship between neural crest cells and cranial mesoderm during head muscle development. PLoS One (2009) 1.17
An autoregulatory loop directs the tissue-specific expression of p63 through a long-range evolutionarily conserved enhancer. Mol Cell Biol (2006) 1.13
A polymorphism in the EAAT2 promoter is associated with higher glutamate concentrations and higher frequency of progressing stroke. J Exp Med (2006) 1.12
Coactivator PC4 mediates AP-2 transcriptional activity and suppresses ras-induced transformation dependent on AP-2 transcriptional interference. Mol Cell Biol (1999) 1.10
Expression of transcription factor AP-2alpha predicts survival in epithelial ovarian cancer. Br J Cancer (2000) 1.09
Tbx1 controls cardiac neural crest cell migration during arch artery development by regulating Gbx2 expression in the pharyngeal ectoderm. Development (2009) 1.09
The Hectd1 ubiquitin ligase is required for development of the head mesenchyme and neural tube closure. Dev Biol (2007) 1.06
Transcription factor AP-2 regulates human immunodeficiency virus type 1 gene expression. J Virol (1994) 1.05
Functional interaction between a RARE and an AP-2 binding site in the regulation of the human HOX A4 gene promoter. Nucleic Acids Res (1996) 1.05
Conditional deletion of activating protein 2alpha (AP-2alpha) in the developing retina demonstrates non-cell-autonomous roles for AP-2alpha in optic cup development. Mol Cell Biol (2007) 1.04
The genomic structure of the human AP-2 transcription factor. Nucleic Acids Res (1994) 1.04
SOX10 directly modulates ERBB3 transcription via an intronic neural crest enhancer. BMC Dev Biol (2011) 1.03
A mutation in the promoter of the lipoprotein lipase (LPL) gene in a patient with familial combined hyperlipidemia and low LPL activity. Proc Natl Acad Sci U S A (1995) 1.01
Nuclear translocation of a maternal CCAAT factor at the start of gastrulation activates Xenopus GATA-2 transcription. EMBO J (1995) 1.01
Temporally regulated neural crest transcription factors distinguish neuroectodermal tumors of varying malignancy and differentiation. Neoplasia (2005) 1.01
Developmental regulation of transcription factor AP-2 during Xenopus laevis embryogenesis. Nucleic Acids Res (1991) 1.00
AP-2alpha knockout mice exhibit optic cup patterning defects and failure of optic stalk morphogenesis. Hum Mol Genet (2010) 1.00
Disrupting hedgehog and WNT signaling interactions promotes cleft lip pathogenesis. J Clin Invest (2014) 0.99
Phenotypic and molecular assessment of seven patients with 6p25 deletion syndrome: relevance to ocular dysgenesis and hearing impairment. BMC Med Genet (2004) 0.97
The presence of both negative and positive elements in the 5'-flanking sequence of the rat Na,K-ATPase alpha 3 subunit gene are required for brain expression in transgenic mice. Nucleic Acids Res (1994) 0.97
GAS41 interacts with transcription factor AP-2beta and stimulates AP-2beta-mediated transactivation. Nucleic Acids Res (2006) 0.95
Cloning, characterization, and mapping of a murine promiscuous chemokine receptor gene: homolog of the human Duffy gene. Genome Res (1997) 0.94
Beta-catenin deficiency causes DiGeorge syndrome-like phenotypes through regulation of Tbx1. Development (2010) 0.94
Reduced TFAP2A function causes variable optic fissure closure and retinal defects and sensitizes eye development to mutations in other morphogenetic regulators. Hum Genet (2009) 0.94
The promoters of the survival motor neuron gene (SMN) and its copy (SMNc) share common regulatory elements. Am J Hum Genet (1999) 0.94
Hoxa1 lineage tracing indicates a direct role for Hoxa1 in the development of the inner ear, the heart, and the third rhombomere. Dev Biol (2010) 0.93
Transcription factor AP-2 and monoaminergic functions in the central nervous system. J Neural Transm (Vienna) (2005) 0.92
Identification and analysis of a conserved Tcfap2a intronic enhancer element required for expression in facial and limb bud mesenchyme. Mol Cell Biol (2007) 0.92
An ENU-induced mutation in AP-2alpha leads to middle ear and ocular defects in Doarad mice. Mamm Genome (2004) 0.92
Gene expression profiling at early organogenesis reveals both common and diverse mechanisms in foregut patterning. Dev Biol (2011) 0.91
A proline-rich transcriptional activation domain in murine HOXD-4 (HOX-4.2). Nucleic Acids Res (1994) 0.90
AP-2 family members regulate basal and cAMP-induced expression of human chorionic gonadotropin. Nucleic Acids Res (2000) 0.89
Bone morphogenic protein signalling suppresses differentiation of pluripotent cells by maintaining expression of E-Cadherin. Elife (2013) 0.89
Localization of cis-acting sequences in the latency-related promoter of bovine herpesvirus 1 which are regulated by neuronal cell type factors and immediate-early genes. J Virol (1992) 0.89
Cell type-specific gene expression in the neuroendocrine system. A neuroendocrine-specific regulatory element in the promoter of chromogranin A, a ubiquitous secretory granule core protein. J Clin Invest (1994) 0.88
PKC-dependent stimulation of the human MCT1 promoter involves transcription factor AP2. Am J Physiol Gastrointest Liver Physiol (2008) 0.88
Tissue restricted expression and chromosomal localization of the YB-1 gene encoding a 42 kD nuclear CCAAT binding protein. Nucleic Acids Res (1992) 0.88
Failure in post-transcriptional processing is a possible inactivation mechanism of AP-2alpha in cutaneous melanoma. Br J Cancer (2000) 0.87
Cell delamination in the mesencephalic neural fold and its implication for the origin of ectomesenchyme. Development (2013) 0.86
Regulation of the noradrenaline neurotransmitter phenotype by the transcription factor AP-2beta. J Biol Chem (2008) 0.85
Sp1 and AP2 regulate but do not constitute TATA-less human TAF(II)55 core promoter activity. Nucleic Acids Res (2002) 0.84
Evidence for association of two variants of the nociceptin/orphanin FQ receptor gene OPRL1 with vulnerability to develop opiate addiction in Caucasians. Psychiatr Genet (2010) 0.84
Comparative and functional analysis of the AP2 promoter indicates that conserved octamer and initiator elements are critical for activity. Nucleic Acids Res (1996) 0.84
Reversal of epigenetic silencing of AP-2alpha results in increased zinc uptake in DU-145 and LNCaP prostate cancer cells. Carcinogenesis (2011) 0.84
Transcription of the histone H5 gene is regulated by three differentiation-specific enhancers. Mol Cell Biol (1993) 0.84
cis-acting elements involved in transcriptional regulation of the herpes simplex virus type 1 latency-associated promoter 1 (LAP1) in vitro and in vivo. J Virol (1996) 0.83
Dbx1-expressing cells are necessary for the survival of the mammalian anterior neural and craniofacial structures. PLoS One (2011) 0.83
Genetic and functional analysis of the von Hippel-Lindau (VHL) tumour suppressor gene promoter. J Med Genet (2002) 0.82
Extensive molecular differences between anterior- and posterior-half-sclerotomes underlie somite polarity and spinal nerve segmentation. BMC Dev Biol (2009) 0.82
Notochordal and foregut abnormalities correlate with elevated neural crest apoptosis in Patch embryos. Birth Defects Res A Clin Mol Teratol (2011) 0.82
Glial cells: old cells with new twists. Acta Histochem (2007) 0.81
Identification of a novel intronic enhancer responsible for the transcriptional regulation of musashi1 in neural stem/progenitor cells. Mol Brain (2011) 0.81
The complete murine cDNA sequence of the transcription factor AP-2. Nucleic Acids Res (1993) 0.81
Bone morphogenetic protein signaling is required in the dorsal neural folds before neurulation for the induction of spinal neural crest cells and dorsal neurons. Dev Dyn (2011) 0.81
Involvement of AP-2 binding sites in regulation of human beta-glucuronidase. Naunyn Schmiedebergs Arch Pharmacol (2004) 0.81
In vivo expression of ephrinA5-Fc in mice results in cephalic neural crest agenesis and craniofacial abnormalities. Mol Cells (2014) 0.81
Cloning and partial characterization of the mouse glutamine:fructose-6-phosphate amidotransferase (GFAT) gene promoter. Nucleic Acids Res (1997) 0.81
Cleft palate defect of Dlx1/2-/- mutant mice is caused by lack of vertical outgrowth in the posterior palate. Dev Dyn (2012) 0.80
Frontal nasal prominence expression driven by Tcfap2a relies on a conserved binding site for STAT proteins. Dev Dyn (2006) 0.80
A retinoic acid responsive Hoxa3 transgene expressed in embryonic pharyngeal endoderm, cardiac neural crest and a subdomain of the second heart field. PLoS One (2011) 0.79
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The promoter-specific transcription factor Sp1 binds to upstream sequences in the SV40 early promoter. Cell (1983) 15.09
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Purified transcription factor AP-1 interacts with TPA-inducible enhancer elements. Cell (1987) 14.62
Control of eukaryotic messenger RNA synthesis by sequence-specific DNA-binding proteins. Nature (1985) 14.41
Analysis of Sp1 in vivo reveals multiple transcriptional domains, including a novel glutamine-rich activation motif. Cell (1988) 12.68
Purification and biochemical characterization of the promoter-specific transcription factor, Sp1. Science (1986) 12.58
Isolation of cDNA encoding transcription factor Sp1 and functional analysis of the DNA binding domain. Cell (1987) 12.30
Two distinct transcription factors bind to the HSV thymidine kinase promoter in vitro. Cell (1985) 11.03
The binding site on SV40 DNA for a T antigen-related protein. Cell (1978) 10.58
Human proto-oncogene c-jun encodes a DNA binding protein with structural and functional properties of transcription factor AP-1. Science (1987) 10.25
A cellular DNA-binding protein that activates eukaryotic transcription and DNA replication. Cell (1987) 10.22
Regulation of simian virus 40 early transcription in vitro by a purified tumor antigen. Proc Natl Acad Sci U S A (1980) 10.22
Isolation of transcription factors that discriminate between different promoters recognized by RNA polymerase II. Cell (1983) 8.85
The proline-rich transcriptional activator of CTF/NF-I is distinct from the replication and DNA binding domain. Cell (1989) 8.60
Mechanism of transcriptional activation by Sp1: evidence for coactivators. Cell (1990) 8.18
Activation of the AIDS retrovirus promoter by the cellular transcription factor, Sp1. Science (1986) 8.01
Structure and function of a human TAFII250 double bromodomain module. Science (2000) 8.00
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Positive and negative regulation of transcription in vitro: enhancer-binding protein AP-2 is inhibited by SV40 T antigen. Cell (1987) 7.51
Construction and analysis of simian virus 40 origins defective in tumor antigen binding and DNA replication. Proc Natl Acad Sci U S A (1980) 7.04
Multiple specific contacts between a mammalian transcription factor and its cognate promoters. Nature (1985) 6.77
Activation of transcription by two factors that bind promoter and enhancer sequences of the human metallothionein gene and SV40. Nature (1987) 6.76
A family of human CCAAT-box-binding proteins active in transcription and DNA replication: cloning and expression of multiple cDNAs. Nature (1988) 6.54
Leucine repeats and an adjacent DNA binding domain mediate the formation of functional cFos-cJun heterodimers. Science (1989) 6.51
Fos-associated protein p39 is the product of the jun proto-oncogene. Science (1988) 6.34
Isolation of coactivators associated with the TATA-binding protein that mediate transcriptional activation. Cell (1991) 6.04
Molecular cloning and functional analysis of Drosophila TAF110 reveal properties expected of coactivators. Cell (1993) 5.91
Negative regulation of viral enhancers in undifferentiated embryonic stem cells. Cell (1985) 5.88
Orchestrated response: a symphony of transcription factors for gene control. Genes Dev (2000) 5.86
O-glycosylation of eukaryotic transcription factors: implications for mechanisms of transcriptional regulation. Cell (1988) 5.82
McrA and McrB restriction phenotypes of some E. coli strains and implications for gene cloning. Nucleic Acids Res (1988) 5.76
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Bidirectional SV40 transcription mediated by tandem Sp1 binding interactions. Science (1985) 5.00
Transcription factors that activate the Ultrabithorax promoter in developmentally staged extracts. Cell (1988) 4.87
A POU-domain transcription factor in early stem cells and germ cells of the mammalian embryo. Nature (1990) 4.69
Functional domains and upstream activation properties of cloned human TATA binding protein. Science (1990) 4.67
SV40 gene expression is modulated by the cooperative binding of T antigen to DNA. Cell (1981) 4.64
Drosophila TAFII40 interacts with both a VP16 activation domain and the basal transcription factor TFIIB. Cell (1993) 4.57
Know your neighbors: three phenotypes in null mutants of the myogenic bHLH gene MRF4. Cell (1996) 4.55
Different activation domains of Sp1 govern formation of multimers and mediate transcriptional synergism. Genes Dev (1991) 4.54
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Cloning and expression of human TAFII250: a TBP-associated factor implicated in cell-cycle regulation. Nature (1993) 4.38
The activities of two Ets-related transcription factors required for Drosophila eye development are modulated by the Ras/MAPK pathway. Cell (1994) 4.30
A glutamine-rich hydrophobic patch in transcription factor Sp1 contacts the dTAFII110 component of the Drosophila TFIID complex and mediates transcriptional activation. Proc Natl Acad Sci U S A (1994) 4.27
Phosphorylation of the transcription factor PHO4 by a cyclin-CDK complex, PHO80-PHO85. Science (1994) 4.24
Transcription from a TATA-less promoter requires a multisubunit TFIID complex. Genes Dev (1991) 4.23
Functional cooperativity between transcription factors UBF1 and SL1 mediates human ribosomal RNA synthesis. Science (1988) 4.17
The TATA-binding protein and associated factors are integral components of the RNA polymerase I transcription factor, SL1. Cell (1992) 4.11
Assembly of recombinant TFIID reveals differential coactivator requirements for distinct transcriptional activators. Cell (1994) 4.06
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Direct interaction between Sp1 and the BPV enhancer E2 protein mediates synergistic activation of transcription. Cell (1991) 3.46
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The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1. Nature (1999) 2.61
Requirement of tissue-selective TBP-associated factor TAFII105 in ovarian development. Science (2001) 2.59
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