Published in Nature on October 22, 1985
Three trans-acting regulatory proteins of herpes simplex virus modulate immediate-early gene expression in a pathway involving positive and negative feedback regulation. J Virol (1985) 5.63
Different activation domains stimulate transcription from remote ('enhancer') and proximal ('promoter') positions. EMBO J (1992) 4.05
The interleukin 12 p40 gene promoter is primed by interferon gamma in monocytic cells. J Exp Med (1996) 3.82
Fine mapping of the latency-related gene of herpes simplex virus type 1: alternative splicing produces distinct latency-related RNAs containing open reading frames. J Virol (1988) 3.51
Developmental regulation of Dictyostelium discoideum actin gene fusions carried on low-copy and high-copy transformation vectors. Mol Cell Biol (1986) 3.20
Organization of the murine Mx gene and characterization of its interferon- and virus-inducible promoter. Mol Cell Biol (1988) 3.19
Physical and functional domains of the herpes simplex virus transcriptional regulatory protein ICP4. J Virol (1988) 3.14
Binding of the herpes simplex virus immediate-early gene product ICP4 to its own transcription start site. J Virol (1987) 3.09
Differential interactions of promoter elements in stress responses of the Arabidopsis Adh gene. Plant Physiol (1994) 2.92
Host cell proteins bind to the cis-acting site required for virion-mediated induction of herpes simplex virus 1 alpha genes. Proc Natl Acad Sci U S A (1987) 2.90
DNA-binding site of major regulatory protein alpha 4 specifically associated with promoter-regulatory domains of alpha genes of herpes simplex virus type 1. Proc Natl Acad Sci U S A (1986) 2.85
Multiple transcription start sites, DNase I-hypersensitive sites, and an opposite-strand exon in the 5' region of the CHO dhfr gene. Mol Cell Biol (1986) 2.82
Developmental expression of Sp1 in the mouse. Mol Cell Biol (1991) 2.73
Activation of human immunodeficiency virus by herpesvirus infection: identification of a region within the long terminal repeat that responds to a trans-acting factor encoded by herpes simplex virus 1. Proc Natl Acad Sci U S A (1987) 2.66
Comparative anatomy of the human APRT gene and enzyme: nucleotide sequence divergence and conservation of a nonrandom CpG dinucleotide arrangement. Proc Natl Acad Sci U S A (1987) 2.49
Chromatin structure is required to block transcription of the methylated herpes simplex virus thymidine kinase gene. Proc Natl Acad Sci U S A (1987) 2.35
Contactpoint analysis of the HeLa nuclear factor I recognition site reveals symmetrical binding at one side of the DNA helix. EMBO J (1987) 2.30
Comparison of upstream sequence requirements for positive and negative regulation of a herpes simplex virus immediate-early gene by three virus-encoded trans-acting factors. J Virol (1987) 2.27
Delineation of the cis-acting element mediating EBNA-2 transactivation of latent infection membrane protein expression. J Virol (1991) 2.16
Isolation and characterization of the human catalase gene. Nucleic Acids Res (1986) 2.12
A zinc-responsive factor interacts with a metal-regulated enhancer element (MRE) of the mouse metallothionein-I gene. EMBO J (1988) 2.10
Analysis of DNA sequences which regulate the transcription of herpes simplex virus immediate early gene 3: DNA sequences required for enhancer-like activity and response to trans-activation by a virion polypeptide. Nucleic Acids Res (1986) 2.08
Herpes simplex virus immediate early infected-cell polypeptide 4 binds to DNA and promotes transcription. Proc Natl Acad Sci U S A (1986) 2.07
The genomic structure of the murine ICSBP gene reveals the presence of the gamma interferon-responsive element, to which an ISGF3 alpha subunit (or similar) molecule binds. Mol Cell Biol (1993) 2.06
Herpes simplex virus immediate-early promoters are responsive to virus and cell trans-acting factors. J Virol (1987) 1.96
Identification of two factors required for transcription of the ovalbumin gene. Mol Cell Biol (1986) 1.96
Sequences of the 5' portion of the human c-sis gene: characterization of the transcriptional promoter and regulation of expression of the protein product by 5' untranslated mRNA sequences. Nucleic Acids Res (1987) 1.91
VP16-dependent association of chromatin-modifying coactivators and underrepresentation of histones at immediate-early gene promoters during herpes simplex virus infection. J Virol (2004) 1.89
During lytic infection herpes simplex virus type 1 is associated with histones bearing modifications that correlate with active transcription. J Virol (2004) 1.84
Induction of the transcription factor Sp1 during human cytomegalovirus infection mediates upregulation of the p65 and p105/p50 NF-kappaB promoters. J Virol (1997) 1.78
Identification of a promoter mapping within the reiterated sequences that flank the herpes simplex virus type 1 UL region. J Virol (1993) 1.77
A retinoic acid response element is present in the mouse cellular retinol binding protein I (mCRBPI) promoter. EMBO J (1991) 1.74
Structure of the human oestrogen-responsive gene pS2. Nucleic Acids Res (1987) 1.70
Interaction of distinct nuclear proteins with sequences controlling the expression of polyomavirus early genes. Mol Cell Biol (1986) 1.69
Differentiation and DNA contact points of host proteins binding at the cis site for virion-mediated induction of alpha genes of herpes simplex virus 1. J Virol (1988) 1.68
Association of herpes simplex virus regulatory protein ICP4 with sequences spanning the ICP4 gene transcription initiation site. Nucleic Acids Res (1988) 1.60
Herpes simplex virus alpha protein ICP27 possesses separable positive and negative regulatory activities. J Virol (1989) 1.59
The control of herpes simplex virus type-1 late gene transcription: a 'TATA-box'/cap site region is sufficient for fully efficient regulated activity. Nucleic Acids Res (1986) 1.58
Control of alpha-herpesvirus IE gene expression by HCF-1 coupled chromatin modification activities. Biochim Biophys Acta (2009) 1.56
The novel coactivator C1 (HCF) coordinates multiprotein enhancer formation and mediates transcription activation by GABP. EMBO J (2000) 1.55
Activation of the human immunodeficiency virus by herpes simplex virus type 1. J Virol (1987) 1.55
Dissection of immediate-early gene promoters from herpes simplex virus: sequences that respond to the virus transcriptional activators. J Virol (1987) 1.53
Mithramycin blocks protein binding and function of the SV40 early promoter. J Clin Invest (1989) 1.53
Characterization of the DNA-binding properties of herpes simplex virus regulatory protein ICP4. J Virol (1989) 1.51
A single DNA-binding transcription factor is sufficient for activation from a distant enhancer and/or from a promoter position. EMBO J (1990) 1.48
Analysis of the transcript of the herpes simplex virus DNA polymerase gene provides evidence that polymerase expression is inefficient at the level of translation. J Virol (1988) 1.43
ICP4-binding sites in the promoter and coding regions of the herpes simplex virus gD gene contribute to activation of in vitro transcription by ICP4. J Virol (1989) 1.40
Heavy metal ions in transcription factors from HeLa cells: Sp1, but not octamer transcription factor requires zinc for DNA binding and for activator function. Nucleic Acids Res (1988) 1.39
Conservation of glutamine-rich transactivation function between yeast and humans. Mol Cell Biol (2000) 1.32
Binding of cellular proteins to the regulatory region of BK virus DNA. J Virol (1988) 1.31
Purification and characterization of chicken ovalbumin gene upstream promoter transcription factor from homologous oviduct cells. Mol Cell Biol (1987) 1.28
DNA binding and gene regulation by the herpes simplex virus type 1 protein ICP4 and involvement of the TATA element. J Virol (1989) 1.27
Identification of promoter elements required for in vitro transcription of hamster 3-hydroxy-3-methylglutaryl coenzyme A reductase gene. Proc Natl Acad Sci U S A (1987) 1.24
Induction of cellular transcription factors in trigeminal ganglia of mice by corneal scarification, herpes simplex virus type 1 infection, and explantation of trigeminal ganglia. J Virol (1991) 1.24
Transcriptional activities of mammalian genomes at sites of recombination with foreign DNA. J Virol (1987) 1.23
DNA binding by the herpes simplex virus type 1 ICP4 protein is necessary for efficient down regulation of the ICP0 promoter. J Virol (1989) 1.21
Herpes simplex virus type 1 ICP0 protein does not accumulate in the nucleus of primary neurons in culture. J Virol (2000) 1.20
A single regulatory region modulates both cis activation and trans activation of the herpes simplex virus VP5 promoter in transient-expression assays in vivo. J Virol (1986) 1.18
Role for DNA-protein interaction in activation of the herpes simplex virus glycoprotein D gene. J Virol (1988) 1.18
An octamer motif contributes to the expression of the retinoic acid-regulated zinc finger gene Rex-1 (Zfp-42) in F9 teratocarcinoma cells. Mol Cell Biol (1993) 1.17
IFI16 restricts HSV-1 replication by accumulating on the hsv-1 genome, repressing HSV-1 gene expression, and directly or indirectly modulating histone modifications. PLoS Pathog (2014) 1.15
The anaerobic responsive element contains two GC-rich sequences essential for binding a nuclear protein and hypoxic activation of the maize Adh1 promoter. Nucleic Acids Res (1991) 1.15
Multiple transcription factors interact with the adenovirus-2 EII-late promoter: evidence for a novel CCAAT recognition factor. Nucleic Acids Res (1987) 1.15
Analysis of herpes simplex virus ICP0 promoter function in sensory neurons during acute infection, establishment of latency, and reactivation in vivo. J Virol (2003) 1.15
Utp14b: a unique retrogene within a gene that has acquired multiple promoters and a specific function in spermatogenesis. Dev Biol (2007) 1.14
Varicella-zoster virus DNA polymerase and major DNA-binding protein genes have overlapping divergent promoters. J Virol (1993) 1.13
Relationship between TATA-binding protein and herpes simplex virus type 1 ICP4 DNA-binding sites in complex formation and repression of transcription. J Virol (1995) 1.11
Molecular structure of the gene and the 5'-flanking region of the human lymphocyte immunoglobulin E receptor. Nucleic Acids Res (1987) 1.09
Cell-specific expression of the human gastrin gene: evidence for a control element located downstream of the TATA box. Mol Cell Biol (1987) 1.08
Regulation of transcription in vitro from herpes simplex virus genes. J Virol (1986) 1.06
Sequences involved in accurate and efficient transcription of human c-myc genes microinjected into frog oocytes. Mol Cell Biol (1986) 1.06
Selective cloning and sequence analysis of the human L1 (LINE-1) sequences which transposed in the relatively recent past. Nucleic Acids Res (1990) 1.03
Enhancer activation by a single type of transcription factor shows cell type dependence. EMBO J (1991) 1.02
A directly repeated sequence in the beta-globin promoter regulates transcription in murine erythroleukemia cells. Mol Cell Biol (1990) 1.01
Autocatalytic proteolysis of the transcription factor-coactivator C1 (HCF): a potential role for proteolytic regulation of coactivator function. Proc Natl Acad Sci U S A (2000) 1.01
Recruitment of the transcriptional coactivator HCF-1 to viral immediate-early promoters during initiation of reactivation from latency of herpes simplex virus type 1. J Virol (2009) 0.98
Factor interactions at simian virus 40 GC-box promoter elements in intact nuclei. Mol Cell Biol (1987) 0.98
Neurons differentially activate the herpes simplex virus type 1 immediate-early gene ICP0 and ICP27 promoters in transgenic mice. J Virol (2002) 0.97
Glucocorticoid activation of chromogranin A gene expression. Identification and characterization of a novel glucocorticoid response element. J Clin Invest (1994) 0.97
A GC-box motif upstream of the B19 parvovirus unique promoter is important for in vitro transcription. J Virol (1989) 0.97
Cellular transcription factors enhance herpes simplex virus type 1 oriS-dependent DNA replication. J Virol (1998) 0.96
The dynamics of HCF-1 modulation of herpes simplex virus chromatin during initiation of infection. Viruses (2013) 0.94
Transcriptional control of microRNA expression in C. elegans: promoting better understanding. RNA Biol (2009) 0.94
Identification of DNA sequences required for mouse APRT gene expression. Nucleic Acids Res (1988) 0.93
The transgenic ICP4 promoter is activated in Schwann cells in trigeminal ganglia of mice latently infected with herpes simplex virus type 1. J Virol (2001) 0.92
A single cell cycle genes homology region (CHR) controls cell cycle-dependent transcription of the cdc25C phosphatase gene and is able to cooperate with E2F or Sp1/3 sites. Nucleic Acids Res (2002) 0.91
Linker scan analysis of the early regulatory region of human papovavirus BK. J Virol (1988) 0.90
Herpes simplex virus type 1 entry is inhibited by the cobalt chelate complex CTC-96. J Virol (2001) 0.89
Alternative inducers of the rat metallothionein I gene cause distinct changes in chromatin structure in the 5' region of the gene. Mol Cell Biol (1986) 0.89
The herpes simplex virus type 1 major capsid protein (VP5-UL19) promoter contains two cis-acting elements influencing late expression. J Virol (1994) 0.88
Transcription initiation sites and structural organization of the extreme 5' region of the rat neural cell adhesion molecule gene. Mol Cell Biol (1990) 0.88
Mutually exclusive binding of two cellular factors within a critical promoter region of the gene for the IE110k protein of herpes simplex virus. J Virol (1993) 0.87
An upstream control region required for inducible transcription of the mouse H1(zero) histone gene during terminal differentiation. Mol Cell Biol (1995) 0.85
Highly recurring sequence elements identified in eukaryotic DNAs by computer analysis are often homologous to regulatory sequences or protein binding sites. Nucleic Acids Res (1987) 0.81
HSV-1-based vectors for gene therapy of neurological diseases and brain tumors: part I. HSV-1 structure, replication and pathogenesis. Neoplasia (1999) 0.81
Interactions of the zinc-regulated factor (ZiRF1) with the mouse metallothionein Ia promoter. Biochem J (1997) 0.80
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The promoter-specific transcription factor Sp1 binds to upstream sequences in the SV40 early promoter. Cell (1983) 15.09
Affinity purification of sequence-specific DNA binding proteins. Proc Natl Acad Sci U S A (1986) 14.92
Purified transcription factor AP-1 interacts with TPA-inducible enhancer elements. Cell (1987) 14.62
Control of eukaryotic messenger RNA synthesis by sequence-specific DNA-binding proteins. Nature (1985) 14.41
Analysis of Sp1 in vivo reveals multiple transcriptional domains, including a novel glutamine-rich activation motif. Cell (1988) 12.68
Purification and biochemical characterization of the promoter-specific transcription factor, Sp1. Science (1986) 12.58
Isolation of cDNA encoding transcription factor Sp1 and functional analysis of the DNA binding domain. Cell (1987) 12.30
Two distinct transcription factors bind to the HSV thymidine kinase promoter in vitro. Cell (1985) 11.03
The binding site on SV40 DNA for a T antigen-related protein. Cell (1978) 10.58
Human proto-oncogene c-jun encodes a DNA binding protein with structural and functional properties of transcription factor AP-1. Science (1987) 10.25
A cellular DNA-binding protein that activates eukaryotic transcription and DNA replication. Cell (1987) 10.22
Regulation of simian virus 40 early transcription in vitro by a purified tumor antigen. Proc Natl Acad Sci U S A (1980) 10.22
A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA. Cell (1998) 10.14
Isolation of transcription factors that discriminate between different promoters recognized by RNA polymerase II. Cell (1983) 8.85
The proline-rich transcriptional activator of CTF/NF-I is distinct from the replication and DNA binding domain. Cell (1989) 8.60
Mechanism of transcriptional activation by Sp1: evidence for coactivators. Cell (1990) 8.18
Activation of the AIDS retrovirus promoter by the cellular transcription factor, Sp1. Science (1986) 8.01
Structure and function of a human TAFII250 double bromodomain module. Science (2000) 8.00
Transcriptional selectivity of viral genes in mammalian cells. Cell (1986) 7.95
Nucleolar transcription factor hUBF contains a DNA-binding motif with homology to HMG proteins. Nature (1990) 7.91
Positive and negative regulation of transcription in vitro: enhancer-binding protein AP-2 is inhibited by SV40 T antigen. Cell (1987) 7.51
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Multiple specific contacts between a mammalian transcription factor and its cognate promoters. Nature (1985) 6.77
Activation of transcription by two factors that bind promoter and enhancer sequences of the human metallothionein gene and SV40. Nature (1987) 6.76
A family of human CCAAT-box-binding proteins active in transcription and DNA replication: cloning and expression of multiple cDNAs. Nature (1988) 6.54
Leucine repeats and an adjacent DNA binding domain mediate the formation of functional cFos-cJun heterodimers. Science (1989) 6.51
Fos-associated protein p39 is the product of the jun proto-oncogene. Science (1988) 6.34
Isolation of coactivators associated with the TATA-binding protein that mediate transcriptional activation. Cell (1991) 6.04
Molecular cloning and functional analysis of Drosophila TAF110 reveal properties expected of coactivators. Cell (1993) 5.91
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Bidirectional SV40 transcription mediated by tandem Sp1 binding interactions. Science (1985) 5.00
Transcription factors that activate the Ultrabithorax promoter in developmentally staged extracts. Cell (1988) 4.87
Functional domains and upstream activation properties of cloned human TATA binding protein. Science (1990) 4.67
SV40 gene expression is modulated by the cooperative binding of T antigen to DNA. Cell (1981) 4.64
Drosophila TAFII40 interacts with both a VP16 activation domain and the basal transcription factor TFIIB. Cell (1993) 4.57
Different activation domains of Sp1 govern formation of multimers and mediate transcriptional synergism. Genes Dev (1991) 4.54
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Synergistic activation by the glutamine-rich domains of human transcription factor Sp1. Cell (1989) 4.49
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Cloning and expression of human TAFII250: a TBP-associated factor implicated in cell-cycle regulation. Nature (1993) 4.38
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A glutamine-rich hydrophobic patch in transcription factor Sp1 contacts the dTAFII110 component of the Drosophila TFIID complex and mediates transcriptional activation. Proc Natl Acad Sci U S A (1994) 4.27
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Phosphorylation of the transcription factor PHO4 by a cyclin-CDK complex, PHO80-PHO85. Science (1994) 4.24
Transcription from a TATA-less promoter requires a multisubunit TFIID complex. Genes Dev (1991) 4.23
Functional cooperativity between transcription factors UBF1 and SL1 mediates human ribosomal RNA synthesis. Science (1988) 4.17
The TATA-binding protein and associated factors are integral components of the RNA polymerase I transcription factor, SL1. Cell (1992) 4.11
Assembly of recombinant TFIID reveals differential coactivator requirements for distinct transcriptional activators. Cell (1994) 4.06
GC box binding induces phosphorylation of Sp1 by a DNA-dependent protein kinase. Cell (1990) 4.04
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p53 transcriptional activation mediated by coactivators TAFII40 and TAFII60. Science (1995) 3.74
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Direct interaction between Sp1 and the BPV enhancer E2 protein mediates synergistic activation of transcription. Cell (1991) 3.46
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Antibody directed against Bacillus subtilis rho factor purified by sodium dodecyl sulfate slab gel electrophoresis. Effect on transcription by RNA polymerase in crude extracts of vegetative and sporulating cells. J Biol Chem (1975) 2.73
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Two distinct nuclear transcription factors recognize loop and bulge residues of the HIV-1 TAR RNA hairpin. Genes Dev (1991) 2.49
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SV40 T antigen binding site mutations that affect autoregulation. Cell (1983) 2.43
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