Published in Proc Natl Acad Sci U S A on December 07, 2009
Maintaining genome stability at the replication fork. Nat Rev Mol Cell Biol (2010) 5.88
The Smc complexes in DNA damage response. Cell Biosci (2012) 1.31
The Smc5/6 complex and Esc2 influence multiple replication-associated recombination processes in Saccharomyces cerevisiae. Mol Biol Cell (2010) 1.22
Homologous recombination-dependent rescue of deficiency in the structural maintenance of chromosomes (Smc) 5/6 complex. J Biol Chem (2010) 1.05
Restriction of replication fork regression activities by a conserved SMC complex. Mol Cell (2014) 1.04
Processing of DNA structures via DNA unwinding and branch migration by the S. cerevisiae Mph1 protein. DNA Repair (Amst) (2011) 1.01
NSMCE2 suppresses cancer and aging in mice independently of its SUMO ligase activity. EMBO J (2015) 1.00
Smc5/6 coordinates formation and resolution of joint molecules with chromosome morphology to ensure meiotic divisions. PLoS Genet (2013) 0.99
DNA repair and global sumoylation are regulated by distinct Ubc9 noncovalent complexes. Mol Cell Biol (2011) 0.98
During replication stress, non-SMC element 5 (NSE5) is required for Smc5/6 protein complex functionality at stalled forks. J Biol Chem (2012) 0.96
Rad5-dependent DNA repair functions of the Saccharomyces cerevisiae FANCM protein homolog Mph1. J Biol Chem (2012) 0.95
Genetic and physical interactions between the yeast ELG1 gene and orthologs of the Fanconi anemia pathway. Cell Cycle (2013) 0.91
Meiotic DNA joint molecule resolution depends on Nse5-Nse6 of the Smc5-Smc6 holocomplex. Nucleic Acids Res (2012) 0.91
The Smc5-Smc6 complex regulates recombination at centromeric regions and affects kinetochore protein sumoylation during normal growth. PLoS One (2012) 0.90
Smc5/6-Mms21 prevents and eliminates inappropriate recombination intermediates in meiosis. PLoS Genet (2013) 0.89
Inhibition of the Smc5/6 complex during meiosis perturbs joint molecule formation and resolution without significantly changing crossover or non-crossover levels. PLoS Genet (2013) 0.87
ATPase-dependent control of the Mms21 SUMO ligase during DNA repair. PLoS Biol (2015) 0.86
Regulation of DNA pairing in homologous recombination. Cold Spring Harb Perspect Biol (2014) 0.86
DNA damage checkpoint and recombinational repair differentially affect the replication stress tolerance of Smc6 mutants. Mol Biol Cell (2013) 0.85
DNA break-induced sumoylation is enabled by collaboration between a SUMO ligase and the ssDNA-binding complex RPA. Genes Dev (2015) 0.85
Rtt107 Is a Multi-functional Scaffold Supporting Replication Progression with Partner SUMO and Ubiquitin Ligases. Mol Cell (2015) 0.85
Biochemical studies of the Saccharomyces cerevisiae Mph1 helicase on junction-containing DNA structures. Nucleic Acids Res (2011) 0.82
Functions and regulation of the multitasking FANCM family of DNA motor proteins. Genes Dev (2015) 0.82
Fanconi-like crosslink repair in yeast. Genome Integr (2012) 0.81
Concerted and differential actions of two enzymatic domains underlie Rad5 contributions to DNA damage tolerance. Nucleic Acids Res (2015) 0.81
Nse1-dependent recruitment of Smc5/6 to lesion-containing loci contributes to the repair defects of mutant complexes. Mol Biol Cell (2011) 0.81
Loss of Caenorhabditis elegans BRCA1 promotes genome stability during replication in smc-5 mutants. Genetics (2014) 0.81
Functions of Ubiquitin and SUMO in DNA Replication and Replication Stress. Front Genet (2016) 0.80
Selective modulation of the functions of a conserved DNA motor by a histone fold complex. Genes Dev (2015) 0.79
Roles of DNA helicases in the mediation and regulation of homologous recombination. Adv Exp Med Biol (2013) 0.79
Sgs1 and Mph1 Helicases Enforce the Recombination Execution Checkpoint During DNA Double-Strand Break Repair in Saccharomyces cerevisiae. Genetics (2016) 0.79
Resolution by unassisted Top3 points to template switch recombination intermediates during DNA replication. J Biol Chem (2013) 0.78
Mte1 interacts with Mph1 and promotes crossover recombination and telomere maintenance. Genes Dev (2016) 0.78
MTE1 Functions with MPH1 in Double-Strand Break Repair. Genetics (2016) 0.78
Differential regulation of the anti-crossover and replication fork regression activities of Mph1 by Mte1. Genes Dev (2016) 0.77
A genetic screen for high copy number suppressors of the synthetic lethality between elg1Δ and srs2Δ in yeast. G3 (Bethesda) (2013) 0.77
Smc5/6 Mediated Sumoylation of the Sgs1-Top3-Rmi1 Complex Promotes Removal of Recombination Intermediates. Cell Rep (2016) 0.77
Binding of the Fkh1 Forkhead Associated Domain to a Phosphopeptide within the Mph1 DNA Helicase Regulates Mating-Type Switching in Budding Yeast. PLoS Genet (2016) 0.76
Incision of damaged DNA in the presence of an impaired Smc5/6 complex imperils genome stability. Nucleic Acids Res (2016) 0.75
Replication-Associated Recombinational Repair: Lessons from Budding Yeast. Genes (Basel) (2016) 0.75
Mms21 SUMO Ligase Activity Promotes Nucleolar Function in Saccharomyces cerevisiae. Genetics (2016) 0.75
The Rtt107 BRCT scaffold and its partner modification enzymes collaborate to promote replication. Nucleus (2016) 0.75
Histone H2B mono-ubiquitylation maintains genomic integrity at stalled replication forks. Nucleic Acids Res (2016) 0.75
Choreography of the DNA damage response: spatiotemporal relationships among checkpoint and repair proteins. Cell (2004) 9.74
GFP tagging of budding yeast chromosomes reveals that protein-protein interactions can mediate sister chromatid cohesion. Curr Biol (1996) 6.49
Srs2 and Sgs1-Top3 suppress crossovers during double-strand break repair in yeast. Cell (2003) 5.45
Systematic pathway analysis using high-resolution fitness profiling of combinatorial gene deletions. Nat Genet (2007) 4.59
A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M. Nat Genet (2005) 4.57
A SUMO ligase is part of a nuclear multiprotein complex that affects DNA repair and chromosomal organization. Proc Natl Acad Sci U S A (2005) 3.62
Ubc9- and mms21-mediated sumoylation counteracts recombinogenic events at damaged replication forks. Cell (2006) 3.60
Live-cell imaging reveals replication of individual replicons in eukaryotic replication factories. Cell (2006) 3.56
Rad51-dependent DNA structures accumulate at damaged replication forks in sgs1 mutants defective in the yeast ortholog of BLM RecQ helicase. Genes Dev (2005) 2.91
The Fanconi anemia protein FANCM can promote branch migration of Holliday junctions and replication forks. Mol Cell (2008) 2.68
The vertebrate Hef ortholog is a component of the Fanconi anemia tumor-suppressor pathway. Nat Struct Mol Biol (2005) 2.55
Yeast Mph1 helicase dissociates Rad51-made D-loops: implications for crossover control in mitotic recombination. Genes Dev (2009) 2.43
Human MMS21/NSE2 is a SUMO ligase required for DNA repair. Mol Cell Biol (2005) 2.31
The FANCM ortholog Fml1 promotes recombination at stalled replication forks and limits crossing over during DNA double-strand break repair. Mol Cell (2008) 2.19
Nse2, a component of the Smc5-6 complex, is a SUMO ligase required for the response to DNA damage. Mol Cell Biol (2005) 2.16
Chromosomal association of the Smc5/6 complex reveals that it functions in differently regulated pathways. Mol Cell (2006) 2.13
The RecQ helicase-topoisomerase III-Rmi1 complex: a DNA structure-specific 'dissolvasome'? Trends Biochem Sci (2007) 1.97
Yeast MPH1 gene functions in an error-free DNA damage bypass pathway that requires genes from Homologous recombination, but not from postreplicative repair. Genetics (2004) 1.76
Saccharomyces cerevisiae MPH1 gene, required for homologous recombination-mediated mutation avoidance, encodes a 3' to 5' DNA helicase. J Biol Chem (2005) 1.69
The Nse5-Nse6 dimer mediates DNA repair roles of the Smc5-Smc6 complex. Mol Cell Biol (2006) 1.65
Mrc1 and Srs2 are major actors in the regulation of spontaneous crossover. EMBO J (2006) 1.65
Crystal structure and functional implications of Pyrococcus furiosus hef helicase domain involved in branched DNA processing. Structure (2005) 1.59
Smc5/6: a link between DNA repair and unidirectional replication? Nat Rev Mol Cell Biol (2008) 1.52
Composition and architecture of the Schizosaccharomyces pombe Rad18 (Smc5-6) complex. Mol Cell Biol (2005) 1.50
Cooperation of the N-terminal Helicase and C-terminal endonuclease activities of Archaeal Hef protein in processing stalled replication forks. J Biol Chem (2004) 1.49
Sgs1 regulates gene conversion tract lengths and crossovers independently of its helicase activity. Mol Cell Biol (2006) 1.45
The Saccharomyces cerevisiae Esc2 and Smc5-6 proteins promote sister chromatid junction-mediated intra-S repair. Mol Biol Cell (2009) 1.44
The unnamed complex: what do we know about Smc5-Smc6? Chromosome Res (2009) 1.39
Mph1p promotes gross chromosomal rearrangement through partial inhibition of homologous recombination. J Cell Biol (2008) 1.28
SMC6 is required for MMS-induced interchromosomal and sister chromatid recombinations in Saccharomyces cerevisiae. DNA Repair (Amst) (2004) 1.26
Architecture of the Smc5/6 Complex of Saccharomyces cerevisiae Reveals a Unique Interaction between the Nse5-6 Subcomplex and the Hinge Regions of Smc5 and Smc6. J Biol Chem (2009) 1.23
Esc2 and Sgs1 act in functionally distinct branches of the homologous recombination repair pathway in Saccharomyces cerevisiae. Mol Biol Cell (2009) 1.22
Identification of the proteins, including MAGEG1, that make up the human SMC5-6 protein complex. Mol Cell Biol (2007) 1.21
The Smc5-Smc6 DNA repair complex. bridging of the Smc5-Smc6 heads by the KLEISIN, Nse4, and non-Kleisin subunits. J Biol Chem (2006) 1.20
The MPH1 gene of Saccharomyces cerevisiae functions in Okazaki fragment processing. J Biol Chem (2009) 0.97
Allelism of Saccharomyces cerevisiae gene PSO10, involved in error-prone repair of psoralen-induced DNA damage, with SUMO ligase-encoding MMS21. Curr Genet (2008) 0.78
A draft sequence for the genome of the domesticated silkworm (Bombyx mori). Science (2004) 6.62
Selective small-molecule inhibitor reveals critical mitotic functions of human CDK1. Proc Natl Acad Sci U S A (2006) 5.16
Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy. Proc Natl Acad Sci U S A (2006) 4.68
Survival of DNA damage in yeast directly depends on increased dNTP levels allowed by relaxed feedback inhibition of ribonucleotide reductase. Cell (2003) 3.91
Ubc9- and mms21-mediated sumoylation counteracts recombinogenic events at damaged replication forks. Cell (2006) 3.60
Outcomes after stereotactic lung radiotherapy or wedge resection for stage I non-small-cell lung cancer. J Clin Oncol (2010) 3.59
All TRAFs are not created equal: common and distinct molecular mechanisms of TRAF-mediated signal transduction. J Cell Sci (2002) 3.31
IL-17 produced by neutrophils regulates IFN-gamma-mediated neutrophil migration in mouse kidney ischemia-reperfusion injury. J Clin Invest (2009) 3.30
Homologous recombination and its regulation. Nucleic Acids Res (2012) 2.44
Selective sphingosine 1-phosphate 1 receptor activation reduces ischemia-reperfusion injury in mouse kidney. Am J Physiol Renal Physiol (2006) 2.39
Renal ischemia-reperfusion injury and adenosine 2A receptor-mediated tissue protection: role of macrophages. Am J Physiol Renal Physiol (2004) 2.27
Renal ischemia-reperfusion injury and adenosine 2A receptor-mediated tissue protection: the role of CD4+ T cells and IFN-gamma. J Immunol (2006) 2.22
Renal protection from ischemia mediated by A2A adenosine receptors on bone marrow-derived cells. J Clin Invest (2003) 2.22
Regulatory T cells suppress innate immunity in kidney ischemia-reperfusion injury. J Am Soc Nephrol (2009) 2.18
Dendritic cells tolerized with adenosine A₂AR agonist attenuate acute kidney injury. J Clin Invest (2012) 2.00
The Slx5-Slx8 complex affects sumoylation of DNA repair proteins and negatively regulates recombination. Mol Cell Biol (2007) 1.77
Ultrasound prevents renal ischemia-reperfusion injury by stimulating the splenic cholinergic anti-inflammatory pathway. J Am Soc Nephrol (2013) 1.76
Smc5-Smc6 mediate DNA double-strand-break repair by promoting sister-chromatid recombination. Nat Cell Biol (2006) 1.71
Extensive DNA damage-induced sumoylation contributes to replication and repair and acts in addition to the mec1 checkpoint. Mol Cell (2012) 1.70
Vagus nerve stimulation mediates protection from kidney ischemia-reperfusion injury through α7nAChR+ splenocytes. J Clin Invest (2016) 1.56
Subclinical hypertensive heart disease in black patients with elevated blood pressure in an inner-city emergency department. Ann Emerg Med (2012) 1.54
Domain 2 of nonstructural protein 5A (NS5A) of hepatitis C virus is natively unfolded. Biochemistry (2007) 1.53
Adenosine A2A receptor activation attenuates inflammation and injury in diabetic nephropathy. Am J Physiol Renal Physiol (2005) 1.52
Predicting comatose patients with acute stroke outcome using middle-latency somatosensory evoked potentials. Clin Neurophysiol (2011) 1.49
Premature Cdk1/Cdc5/Mus81 pathway activation induces aberrant replication and deleterious crossover. EMBO J (2013) 1.45
The Saccharomyces cerevisiae Esc2 and Smc5-6 proteins promote sister chromatid junction-mediated intra-S repair. Mol Biol Cell (2009) 1.44
Aquaporin 4 molecular mimicry and implications for neuromyelitis optica. J Neuroimmunol (2013) 1.42
Analysis of second malignancies after modern radiotherapy versus prostatectomy for localized prostate cancer. Radiother Oncol (2010) 1.41
Nucleoporins prevent DNA damage accumulation by modulating Ulp1-dependent sumoylation processes. Mol Biol Cell (2007) 1.39
Comparison of acute and late toxicities for three modern high-dose radiation treatment techniques for localized prostate cancer. Int J Radiat Oncol Biol Phys (2010) 1.35
Activation of sphingosine-1-phosphate 1 receptor in the proximal tubule protects against ischemia-reperfusion injury. J Am Soc Nephrol (2010) 1.31
Sgs1 function in the repair of DNA replication intermediates is separable from its role in homologous recombinational repair. EMBO J (2009) 1.29
Dose escalation improves cancer-related events at 10 years for intermediate- and high-risk prostate cancer patients treated with hypofractionated high-dose-rate boost and external beam radiotherapy. Int J Radiat Oncol Biol Phys (2011) 1.27
Noncanonical role of the 9-1-1 clamp in the error-free DNA damage tolerance pathway. Mol Cell (2012) 1.27
Architecture of the Smc5/6 Complex of Saccharomyces cerevisiae Reveals a Unique Interaction between the Nse5-6 Subcomplex and the Hinge Regions of Smc5 and Smc6. J Biol Chem (2009) 1.23
The Smc5/6 complex and Esc2 influence multiple replication-associated recombination processes in Saccharomyces cerevisiae. Mol Biol Cell (2010) 1.22
Copper cofactor delivery in plant cells. Curr Opin Plant Biol (2006) 1.22
Replication and recombination factors contributing to recombination-dependent bypass of DNA lesions by template switch. PLoS Genet (2010) 1.19
SUMOylation regulates telomere length homeostasis by targeting Cdc13. Nat Struct Mol Biol (2011) 1.17
Cooperation of sumoylated chromosomal proteins in rDNA maintenance. PLoS Genet (2008) 1.16
Rad52 SUMOylation affects the efficiency of the DNA repair. Nucleic Acids Res (2010) 1.14
Sonic Hedgehog signaling impairs ionizing radiation-induced checkpoint activation and induces genomic instability. J Cell Biol (2008) 1.14
Transcriptome analysis of Cymbidium sinense and its application to the identification of genes associated with floral development. BMC Genomics (2013) 1.10
Autocrine adenosine signaling promotes regulatory T cell-mediated renal protection. J Am Soc Nephrol (2012) 1.07
Divergent roles of sphingosine kinases in kidney ischemia-reperfusion injury. Kidney Int (2008) 1.07
Gli1 induces G2/M arrest and apoptosis in hippocampal but not tumor-derived neural stem cells. Stem Cells (2008) 1.06
Impaired adult neurogenesis in mice lacking the transcription factor E2F1. Mol Cell Neurosci (2002) 1.04
Percentage of positive biopsy cores: a better risk stratification model for prostate cancer? Int J Radiat Oncol Biol Phys (2011) 1.03
Iron-sulfur cluster biogenesis in chloroplasts. Involvement of the scaffold protein CpIscA. Plant Physiol (2005) 1.03
Synthesis of macrocycles via cobalt-mediated [2 + 2 + 2] cycloadditions. J Am Chem Soc (2005) 1.02
Structural and functional insights into the roles of the Mms21 subunit of the Smc5/6 complex. Mol Cell (2009) 1.01
Characterization of Arabidopsis thaliana SufE2 and SufE3: functions in chloroplast iron-sulfur cluster assembly and Nad synthesis. J Biol Chem (2007) 1.00
DNA bending facilitates the error-free DNA damage tolerance pathway and upholds genome integrity. EMBO J (2014) 1.00
High-dose-rate brachytherapy as monotherapy delivered in two fractions within one day for favorable/intermediate-risk prostate cancer: preliminary toxicity data. Int J Radiat Oncol Biol Phys (2011) 1.00
Sulfamoylbenzamide derivatives inhibit the assembly of hepatitis B virus nucleocapsids. J Virol (2013) 0.99
Dual roles of the SUMO-interacting motif in the regulation of Srs2 sumoylation. Nucleic Acids Res (2012) 0.98
Ubc9 is required for damage-tolerance and damage-induced interchromosomal homologous recombination in S. cerevisiae. DNA Repair (Amst) (2004) 0.98
Differential gene induction by genetic and ligand-mediated activation of the Sonic hedgehog pathway in neural stem cells. Dev Biol (2007) 0.97
Preclinical characterization of GS-9669, a thumb site II inhibitor of the hepatitis C virus NS5B polymerase. Antimicrob Agents Chemother (2012) 0.97
Limitations of the American Society of Therapeutic Radiology and Oncology Consensus Panel guidelines on the use of accelerated partial breast irradiation. Int J Radiat Oncol Biol Phys (2010) 0.97
Dose-volume analysis of predictors for gastrointestinal toxicity after concurrent full-dose gemcitabine and radiotherapy for locally advanced pancreatic adenocarcinoma. Int J Radiat Oncol Biol Phys (2011) 0.97
Continuous venovenous hemofiltration versus extended daily hemofiltration in patients with septic acute kidney injury: a retrospective cohort study. Crit Care (2014) 0.96
During replication stress, non-SMC element 5 (NSE5) is required for Smc5/6 protein complex functionality at stalled forks. J Biol Chem (2012) 0.96
The N-terminal domain of tumor suppressor p53 is involved in the molecular interaction with the anti-apoptotic protein Bcl-Xl. Biochem Biophys Res Commun (2006) 0.95
Rad52 sumoylation and its involvement in the efficient induction of homologous recombination. DNA Repair (Amst) (2008) 0.95
Rad5-dependent DNA repair functions of the Saccharomyces cerevisiae FANCM protein homolog Mph1. J Biol Chem (2012) 0.95
Cumulated Ca2⁺ spike duration underlies Ca2⁺ oscillation frequency-regulated NFκB transcriptional activity. J Cell Sci (2011) 0.94
Intrafraction variation of mean tumor position during image-guided hypofractionated stereotactic body radiotherapy for lung cancer. Int J Radiat Oncol Biol Phys (2011) 0.93
Discovery of the first C-nucleoside HCV polymerase inhibitor (GS-6620) with demonstrated antiviral response in HCV infected patients. J Med Chem (2013) 0.93
Regulation of inflammatory cytokine expression in pulmonary epithelial cells by pre-B-cell colony-enhancing factor via a nonenzymatic and AP-1-dependent mechanism. J Biol Chem (2009) 0.92
Sequential activation of Snail1 and N-Myc modulates sonic hedgehog-induced transformation of neural cells. Cancer Res (2011) 0.92
Biogenesis of iron-sulfur cluster proteins in plastids. Genet Eng (N Y) (2006) 0.92
Selective blockade of lysophosphatidic acid LPA3 receptors reduces murine renal ischemia-reperfusion injury. Am J Physiol Renal Physiol (2003) 0.92
Tumor volume as a predictor of survival and local control in patients with brain metastases treated with Gamma Knife surgery. J Neurosurg (2013) 0.91
Natural IgM anti-leukocyte autoantibodies attenuate excess inflammation mediated by innate and adaptive immune mechanisms involving Th-17. J Immunol (2012) 0.91
Dendritic cell sphingosine 1-phosphate receptor-3 regulates Th1-Th2 polarity in kidney ischemia-reperfusion injury. J Immunol (2012) 0.91
Optimization of fabrication parameters to produce chitosan-tripolyphosphate nanoparticles for delivery of tea catechins. J Agric Food Chem (2008) 0.91
Small molecule inhibitors of ER α-glucosidases are active against multiple hemorrhagic fever viruses. Antiviral Res (2013) 0.91
Six-year experience routinely using moderate deep inspiration breath-hold for the reduction of cardiac dose in left-sided breast irradiation for patients with early-stage or locally advanced breast cancer. Am J Clin Oncol (2013) 0.91
The Smc5-Smc6 complex regulates recombination at centromeric regions and affects kinetochore protein sumoylation during normal growth. PLoS One (2012) 0.90
The MDM2-binding region in the transactivation domain of p53 also acts as a Bcl-X(L)-binding motif. Biochemistry (2009) 0.89
Novel bis(indolyl)maleimide pyridinophanes that are potent, selective inhibitors of glycogen synthase kinase-3. Bioorg Med Chem Lett (2007) 0.89
Therapeutic doses of cranial irradiation induce hippocampus-dependent cognitive deficits in young mice. J Neurooncol (2011) 0.89
Brachytherapy provides comparable outcomes and improved cost-effectiveness in the treatment of low/intermediate prostate cancer. Brachytherapy (2012) 0.89
Crystal structure of the FK506 binding domain of Plasmodium falciparum FKBP35 in complex with FK506. Biochemistry (2008) 0.88
Twenty-year outcomes after breast-conserving surgery and definitive radiotherapy for mammographically detected ductal carcinoma in situ. Ann Surg Oncol (2012) 0.88
A self-learning fuzzy discrete event system for HIV/AIDS treatment regimen selection. IEEE Trans Syst Man Cybern B Cybern (2007) 0.87
Targeting the SUMO E2 conjugating enzyme Ubc9 interaction for anti-cancer drug design. Anticancer Agents Med Chem (2009) 0.87
Prognostic significance of neuroendocrine differentiation in patients with Gleason score 8-10 prostate cancer treated with primary radiotherapy. Int J Radiat Oncol Biol Phys (2011) 0.86
DNA damage checkpoint and recombinational repair differentially affect the replication stress tolerance of Smc6 mutants. Mol Biol Cell (2013) 0.85