Gli2 trafficking links Hedgehog-dependent activation of Smoothened in the primary cilium to transcriptional activation in the nucleus.

PubWeight™: 2.43‹?› | Rank: Top 2%

🔗 View Article (PMID 19996169)

Published in Proc Natl Acad Sci U S A on December 08, 2009

Authors

Jynho Kim1, Masaki Kato, Philip A Beachy

Author Affiliations

1: Department of Developmental Biology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.

Articles citing this

(truncated to the top 100)

The primary cilium: a signalling centre during vertebrate development. Nat Rev Genet (2010) 8.81

The mechanisms of Hedgehog signalling and its roles in development and disease. Nat Rev Mol Cell Biol (2013) 3.84

Trafficking to the ciliary membrane: how to get across the periciliary diffusion barrier? Annu Rev Cell Dev Biol (2010) 3.38

Primary cilia are specialized calcium signalling organelles. Nature (2013) 2.63

Itraconazole and arsenic trioxide inhibit Hedgehog pathway activation and tumor growth associated with acquired resistance to smoothened antagonists. Cancer Cell (2013) 2.62

The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins. Genes Dev (2010) 2.60

Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth. Cancer Cell (2010) 2.54

Targeting Hedgehog--a cancer stem cell pathway. Clin Cancer Res (2010) 2.50

A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu-Gli protein complexes. J Cell Biol (2010) 2.47

Small-molecule inhibitors of the AAA+ ATPase motor cytoplasmic dynein. Nature (2012) 2.16

Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector. Proc Natl Acad Sci U S A (2010) 2.00

Human hepatic stem cell and maturational liver lineage biology. Hepatology (2011) 1.99

A crucial requirement for Hedgehog signaling in small cell lung cancer. Nat Med (2011) 1.97

A Smoothened-Evc2 complex transduces the Hedgehog signal at primary cilia. Dev Cell (2012) 1.92

The Hedgehog signal transduction network. Sci Signal (2012) 1.80

Proteomics of Primary Cilia by Proximity Labeling. Dev Cell (2015) 1.74

Complex interactions between genes controlling trafficking in primary cilia. Nat Genet (2011) 1.65

Cilia in the CNS: the quiet organelle claims center stage. Neuron (2011) 1.59

Intraflagellar transport protein 122 antagonizes Sonic Hedgehog signaling and controls ciliary localization of pathway components. Proc Natl Acad Sci U S A (2011) 1.58

Apical abscission alters cell polarity and dismantles the primary cilium during neurogenesis. Science (2014) 1.57

Scoring a backstage pass: mechanisms of ciliogenesis and ciliary access. J Cell Biol (2012) 1.55

A novel protein LZTFL1 regulates ciliary trafficking of the BBSome and Smoothened. PLoS Genet (2011) 1.49

Genome-wide RNAi screen reveals disease-associated genes that are common to Hedgehog and Wnt signaling. Sci Signal (2011) 1.45

Heterotrimeric Gi proteins link Hedgehog signaling to activation of Rho small GTPases to promote fibroblast migration. J Biol Chem (2011) 1.41

IFT25 links the signal-dependent movement of Hedgehog components to intraflagellar transport. Dev Cell (2012) 1.40

Hedgehog pathway as a drug target: Smoothened inhibitors in development. Onco Targets Ther (2012) 1.27

Broad-minded links cell cycle-related kinase to cilia assembly and hedgehog signal transduction. Dev Cell (2010) 1.25

Cilia functions in development. Curr Opin Cell Biol (2012) 1.24

Hedgehog secretion and signal transduction in vertebrates. J Biol Chem (2012) 1.24

Short-rib polydactyly and Jeune syndromes are caused by mutations in WDR60. Am J Hum Genet (2013) 1.20

Gli protein activity is controlled by multisite phosphorylation in vertebrate Hedgehog signaling. Cell Rep (2013) 1.18

Hedgehog signaling from the primary cilium to the nucleus: an emerging picture of ciliary localization, trafficking and transduction. Curr Opin Genet Dev (2013) 1.18

The relationship between sonic Hedgehog signaling, cilia, and neural tube defects. Birth Defects Res A Clin Mol Teratol (2010) 1.16

Cycling of the signaling protein phospholipase D through cilia requires the BBSome only for the export phase. J Cell Biol (2013) 1.16

Hedgehog pathway modulation by multiple lipid binding sites on the smoothened effector of signal response. Dev Cell (2013) 1.15

A novel murine allele of Intraflagellar Transport Protein 172 causes a syndrome including VACTERL-like features with hydrocephalus. Hum Mol Genet (2011) 1.13

Hedgehog signaling in cholangiocytes. Curr Opin Gastroenterol (2011) 1.11

SPOP promotes tumorigenesis by acting as a key regulatory hub in kidney cancer. Cancer Cell (2014) 1.11

Hedgehog signalling in gut development, physiology and cancer. J Physiol (2011) 1.09

Hedgehog signalling regulates liver sinusoidal endothelial cell capillarisation. Gut (2012) 1.08

Neuropilins are positive regulators of Hedgehog signal transduction. Genes Dev (2011) 1.07

Gli-similar (Glis) Krüppel-like zinc finger proteins: insights into their physiological functions and critical roles in neonatal diabetes and cystic renal disease. Histol Histopathol (2010) 1.04

Sonic hedgehog signaling in the lung. From development to disease. Am J Respir Cell Mol Biol (2015) 1.02

Mutations in mouse Ift144 model the craniofacial, limb and rib defects in skeletal ciliopathies. Hum Mol Genet (2012) 1.00

Coordinated translocation of mammalian Gli proteins and suppressor of fused to the primary cilium. PLoS One (2010) 1.00

Elevated Hedgehog/Gli signaling causes beta-cell dedifferentiation in mice. Proc Natl Acad Sci U S A (2011) 0.99

The primary cilium as a cellular receiver: organizing ciliary GPCR signaling. Curr Opin Cell Biol (2016) 0.99

Glucocorticoid compounds modify smoothened localization and hedgehog pathway activity. Chem Biol (2012) 0.98

Meckel-Gruber syndrome and the role of primary cilia in kidney, skeleton, and central nervous system development. Organogenesis (2013) 0.98

G-protein-coupled receptors, Hedgehog signaling and primary cilia. Semin Cell Dev Biol (2014) 0.96

Regulated membrane protein entry into flagella is facilitated by cytoplasmic microtubules and does not require IFT. Curr Biol (2013) 0.95

Insect stage-specific receptor adenylate cyclases are localized to distinct subdomains of the Trypanosoma brucei Flagellar membrane. Eukaryot Cell (2014) 0.93

Intestinal cell kinase, a protein associated with endocrine-cerebro-osteodysplasia syndrome, is a key regulator of cilia length and Hedgehog signaling. Proc Natl Acad Sci U S A (2014) 0.92

Uni-directional ciliary membrane protein trafficking by a cytoplasmic retrograde IFT motor and ciliary ectosome shedding. Elife (2015) 0.92

Targeting the Sonic Hedgehog Signaling Pathway: Review of Smoothened and GLI Inhibitors. Cancers (Basel) (2016) 0.91

Regulation of Sufu activity by p66β and Mycbp provides new insight into vertebrate Hedgehog signaling. Genes Dev (2014) 0.91

Interaction of PACAP with Sonic hedgehog reveals complex regulation of the hedgehog pathway by PKA. Cell Signal (2013) 0.91

Centrosomal protein DZIP1 regulates Hedgehog signaling by promoting cytoplasmic retention of transcription factor GLI3 and affecting ciliogenesis. J Biol Chem (2013) 0.90

The transcriptional activator Gli2 modulates T-cell receptor signalling through attenuation of AP-1 and NFκB activity. J Cell Sci (2015) 0.90

Integration of Hedgehog and mutant FLT3 signaling in myeloid leukemia. Sci Transl Med (2015) 0.89

ICK is essential for cell type-specific ciliogenesis and the regulation of ciliary transport. EMBO J (2014) 0.89

Sonic hedgehog regulates presynaptic terminal size, ultrastructure and function in hippocampal neurons. J Cell Sci (2012) 0.89

Canonical and non-canonical Hedgehog signalling and the control of metabolism. Semin Cell Dev Biol (2014) 0.89

Subcellular localization of Patched and Smoothened, the receptors for Sonic hedgehog signaling, in the hippocampal neuron. J Comp Neurol (2011) 0.88

The role of ciliary trafficking in Hedgehog receptor signaling. Sci Signal (2015) 0.87

A central region of Gli2 regulates its localization to the primary cilium and transcriptional activity. J Cell Sci (2014) 0.87

Recruitment of β-Arrestin into Neuronal Cilia Modulates Somatostatin Receptor Subtype 3 Ciliary Localization. Mol Cell Biol (2015) 0.86

Transcriptional regulation of graded Hedgehog signaling. Semin Cell Dev Biol (2014) 0.86

Hedgehog Signaling in the Maintenance of Cancer Stem Cells. Cancers (Basel) (2015) 0.85

Kif3a deficiency reverses the skeletal abnormalities in Pkd1 deficient mice by restoring the balance between osteogenesis and adipogenesis. PLoS One (2010) 0.84

Smoothened determines β-arrestin-mediated removal of the G protein-coupled receptor Gpr161 from the primary cilium. J Cell Biol (2016) 0.83

Arhgap36-dependent activation of Gli transcription factors. Proc Natl Acad Sci U S A (2014) 0.82

Simultaneous measurement of smoothened entry into and exit from the primary cilium. PLoS One (2014) 0.82

The heterotrimeric kinesin-2 complex interacts with and regulates GLI protein function. J Cell Sci (2015) 0.82

IFT80 is essential for chondrocyte differentiation by regulating Hedgehog and Wnt signaling pathways. Exp Cell Res (2013) 0.81

Bifurcating action of Smoothened in Hedgehog signaling is mediated by Dlg5. Genes Dev (2015) 0.81

A mutation in the mouse ttc26 gene leads to impaired hedgehog signaling. PLoS Genet (2014) 0.80

Suppressor of fused impedes Ci/Gli nuclear import by opposing Trn/Kapβ2 in Hedgehog signaling. J Cell Sci (2014) 0.79

The Rilp-like proteins Rilpl1 and Rilpl2 regulate ciliary membrane content. Mol Biol Cell (2012) 0.79

Intraflagellar transport 27 is essential for hedgehog signaling but dispensable for ciliogenesis during hair follicle morphogenesis. Development (2015) 0.78

Developmental signaling: does it bridge the gap between cilia dysfunction and renal cystogenesis? Birth Defects Res C Embryo Today (2014) 0.78

NL-103, a novel dual-targeted inhibitor of histone deacetylases and hedgehog pathway, effectively overcomes vismodegib resistance conferred by Smo mutations. Pharmacol Res Perspect (2014) 0.78

Inversion of Sonic hedgehog action on its canonical pathway by electrical activity. Proc Natl Acad Sci U S A (2015) 0.78

Regulation of Hedgehog signaling by ubiquitination. Front Biol (Beijing) (2015) 0.78

The Hedgehog signalling pathway in bone formation. Int J Oral Sci (2015) 0.78

A Comparison of Ci/Gli Activity as Regulated by Sufu in Drosophila and Mammalian Hedgehog Response. PLoS One (2015) 0.78

Ciliary Entry of the Hedgehog Transcriptional Activator Gli2 Is Mediated by the Nuclear Import Machinery but Differs from Nuclear Transport in Being Imp-α/β1-Independent. PLoS One (2016) 0.77

Regulation of hedgehog signaling by Myc-interacting zinc finger protein 1, Miz1. PLoS One (2013) 0.77

Arsenic inhibits hedgehog signaling during P19 cell differentiation. Toxicol Appl Pharmacol (2014) 0.77

Computational prediction and experimental validation of novel Hedgehog-responsive enhancers linked to genes of the Hedgehog pathway. BMC Dev Biol (2016) 0.77

Pitchfork and Gprasp2 Target Smoothened to the Primary Cilium for Hedgehog Pathway Activation. PLoS One (2016) 0.76

Primary cilia in pancreatic development and disease. Birth Defects Res C Embryo Today (2014) 0.76

Hedgehog-induced phosphorylation by CK1 sustains the activity of Ci/Gli activator. Proc Natl Acad Sci U S A (2014) 0.76

INPP5E regulates phosphoinositide-dependent cilia transition zone function. J Cell Biol (2016) 0.76

Regulation of Hedgehog Signalling Inside and Outside the Cell. J Dev Biol (2016) 0.76

Association of SMO polymorphisms and neural tube defects in the Chinese population from Shanxi Province. Int J Clin Exp Med (2013) 0.75

Protein transport in growing and steady-state cilia. Traffic (2017) 0.75

Hedgehog Signaling Non-Canonical Activated by Pro-Inflammatory Cytokines in Pancreatic Ductal Adenocarcinoma. J Cancer (2016) 0.75

Hedgehog signaling in the stomach. Curr Opin Pharmacol (2016) 0.75

A Presenilin-2-ARF4 trafficking axis modulates Notch signaling during epidermal differentiation. J Cell Biol (2016) 0.75

Articles cited by this

Mutations affecting segment number and polarity in Drosophila. Nature (1980) 18.72

Hedgehog signaling in animal development: paradigms and principles. Genes Dev (2001) 14.75

Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function. Nature (1996) 11.46

Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine. Nature (2000) 10.04

Neuronal specification in the spinal cord: inductive signals and transcriptional codes. Nat Rev Genet (2000) 9.54

Vertebrate Smoothened functions at the primary cilium. Nature (2005) 9.24

Patched1 regulates hedgehog signaling at the primary cilium. Science (2007) 9.21

Hedgehog signalling in the mouse requires intraflagellar transport proteins. Nature (2003) 8.38

Hedgehog signaling in development and cancer. Dev Cell (2008) 6.60

Small molecule modulation of Smoothened activity. Proc Natl Acad Sci U S A (2002) 6.55

HEF1-dependent Aurora A activation induces disassembly of the primary cilium. Cell (2007) 6.50

Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function. PLoS Genet (2005) 6.15

Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb. Cell (2000) 6.08

Cilia and Hedgehog responsiveness in the mouse. Proc Natl Acad Sci U S A (2005) 5.87

Hedgehog: functions and mechanisms. Genes Dev (2008) 5.69

Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia. Nature (2009) 4.99

Cilia and developmental signaling. Annu Rev Cell Dev Biol (2007) 4.88

Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway. Development (2002) 4.80

Kidney-specific inactivation of the KIF3A subunit of kinesin-II inhibits renal ciliogenesis and produces polycystic kidney disease. Proc Natl Acad Sci U S A (2003) 4.47

Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors. Development (2005) 4.32

Disruption of the basal body compromises proteasomal function and perturbs intracellular Wnt response. Nat Genet (2007) 4.24

Gamma-tubulin is a highly conserved component of the centrosome. Cell (1991) 4.15

Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation. Development (2000) 3.91

Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists. J Biol (2002) 3.85

Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli. Dev Biol (2005) 3.63

Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation. Mol Cell Biol (2006) 3.29

The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development. Curr Biol (2009) 2.63

Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved. Genes Dev (2009) 2.59

Hedgehog signal transduction by Smoothened: pharmacologic evidence for a 2-step activation process. Proc Natl Acad Sci U S A (2009) 2.47

Nuclear trafficking of Cubitus interruptus in the transcriptional regulation of Hedgehog target gene expression. Cell (1999) 2.34

Intraflagellar transport, cilia, and mammalian Hedgehog signaling: analysis in mouse embryonic fibroblasts. Dev Dyn (2008) 2.30

Divergence of hedgehog signal transduction mechanism between Drosophila and mammals. Dev Cell (2006) 2.12

Dorsal-ventral patterning of the spinal cord requires Gli3 transcriptional repressor activity. Genes Dev (2002) 2.10

Selective translocation of intracellular Smoothened to the primary cilium in response to Hedgehog pathway modulation. Proc Natl Acad Sci U S A (2009) 2.04

Evidence for the direct involvement of {beta}TrCP in Gli3 protein processing. Proc Natl Acad Sci U S A (2005) 2.02

Mouse Kif7/Costal2 is a cilia-associated protein that regulates Sonic hedgehog signaling. Proc Natl Acad Sci U S A (2009) 1.95

Genetics of ventral forebrain development and holoprosencephaly. Curr Opin Genet Dev (2000) 1.90

Kinesin-2 is a motor for late endosomes and lysosomes. Traffic (2005) 1.85

Multisite protein kinase A and glycogen synthase kinase 3beta phosphorylation leads to Gli3 ubiquitination by SCFbetaTrCP. Mol Cell Biol (2006) 1.82

The primary cilium at the crossroads of mammalian hedgehog signaling. Curr Top Dev Biol (2008) 1.75

Smoothened adopts multiple active and inactive conformations capable of trafficking to the primary cilium. PLoS One (2009) 1.42

Hedgehog signaling to distinct cell types differentially regulates coronary artery and vein development. Development (2008) 1.40

Inhibition of microtubule assembly in osteoblasts stimulates bone morphogenetic protein 2 expression and bone formation through transcription factor Gli2. Mol Cell Biol (2008) 1.10

Articles by these authors

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened. Genes Dev (2002) 8.56

Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours. Nature (2003) 8.14

Hedgehog signalling in prostate regeneration, neoplasia and metastasis. Nature (2004) 6.82

Small molecule modulation of Smoothened activity. Proc Natl Acad Sci U S A (2002) 6.55

Medulloblastoma growth inhibition by hedgehog pathway blockade. Science (2002) 6.53

Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer. Nature (2003) 6.07

Minimizing the risk of reporting false positives in large-scale RNAi screens. Nat Methods (2006) 5.96

The Hedgehog response network: sensors, switches, and routers. Science (2004) 5.20

Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia. Nature (2009) 4.99

Disruption of the basal body compromises proteasomal function and perturbs intracellular Wnt response. Nat Genet (2007) 4.24

Identification of Hedgehog pathway components by RNAi in Drosophila cultured cells. Science (2003) 3.63

Prevalence of off-target effects in Drosophila RNA interference screens. Nature (2006) 3.38

Hedgehog signaling maintains a tumor stem cell compartment in multiple myeloma. Proc Natl Acad Sci U S A (2007) 3.23

Hedgehog/Wnt feedback supports regenerative proliferation of epithelial stem cells in bladder. Nature (2011) 3.15

Itraconazole and arsenic trioxide inhibit Hedgehog pathway activation and tumor growth associated with acquired resistance to smoothened antagonists. Cancer Cell (2013) 2.62

Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth. Cancer Cell (2010) 2.54

Influence of hepatitis B virus genotypes on the progression of chronic type B liver disease. Hepatology (2003) 2.38

Novel lipid modifications of secreted protein signals. Annu Rev Biochem (2004) 2.37

A defective response to Hedgehog signaling in disorders of cholesterol biosynthesis. Nat Genet (2003) 2.29

Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2. Science (2004) 2.19

A genomewide screen for components of the RNAi pathway in Drosophila cultured cells. Proc Natl Acad Sci U S A (2006) 2.04

Hedgehog signal transduction via Smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2. Mol Cell (2003) 2.02

Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector. Proc Natl Acad Sci U S A (2010) 2.00

Re-evaluation of fatty acid metabolism-related gene expression in nonalcoholic fatty liver disease. Int J Mol Med (2007) 1.89

ProMode: a database of normal mode analyses on protein molecules with a full-atom model. Bioinformatics (2004) 1.89

Open-label, exploratory phase II trial of oral itraconazole for the treatment of basal cell carcinoma. J Clin Oncol (2014) 1.86

Hedgehog-responsive candidate cell of origin for diffuse intrinsic pontine glioma. Proc Natl Acad Sci U S A (2011) 1.86

Scube/You activity mediates release of dually lipid-modified Hedgehog signal in soluble form. Genes Dev (2012) 1.84

Oxysterols are novel activators of the hedgehog signaling pathway in pluripotent mesenchymal cells. J Biol Chem (2007) 1.83

Extensive phosphorylation of Smoothened in Hedgehog pathway activation. Proc Natl Acad Sci U S A (2004) 1.81

Hedgehog-mediated patterning of the mammalian embryo requires transporter-like function of dispatched. Cell (2002) 1.77

FK506 activates BMPR2, rescues endothelial dysfunction, and reverses pulmonary hypertension. J Clin Invest (2013) 1.65

STAM proteins bind ubiquitinated proteins on the early endosome via the VHS domain and ubiquitin-interacting motif. Mol Biol Cell (2003) 1.63

SREBP-1c, regulated by the insulin and AMPK signaling pathways, plays a role in nonalcoholic fatty liver disease. Int J Mol Med (2008) 1.60

Patterning axon targeting of olfactory receptor neurons by coupled hedgehog signaling at two distinct steps. Cell (2010) 1.57

Roles for Hedgehog signaling in androgen production and prostate ductal morphogenesis. Dev Biol (2004) 1.50

Genetic and biochemical definition of the Hedgehog receptor. Genes Dev (2010) 1.47

Defective cerebellar response to mitogenic Hedgehog signaling in Down [corrected] syndrome mice. Proc Natl Acad Sci U S A (2006) 1.47

Structure of a heparin-dependent complex of Hedgehog and Ihog. Proc Natl Acad Sci U S A (2006) 1.47

The mode of Hedgehog binding to Ihog homologues is not conserved across different phyla. Nature (2008) 1.47

Song memory in female birds: neuronal activation suggests phonological coding. Neuroreport (2010) 1.43

Gene expression of periostin in the early stage of fracture healing detected by cDNA microarray analysis. J Orthop Res (2004) 1.43

HTR1A Gene Polymorphisms and 5-HT1A Receptor Partial Agonist Antipsychotics Efficacy in Schizophrenia. J Clin Psychopharmacol (2015) 1.42

Molecular mechanisms of Sonic hedgehog mutant effects in holoprosencephaly. Proc Natl Acad Sci U S A (2005) 1.40

The minimum information required for a glycomics experiment (MIRAGE) project: improving the standards for reporting mass-spectrometry-based glycoanalytic data. Mol Cell Proteomics (2013) 1.34

Identification of a cKit(+) colonic crypt base secretory cell that supports Lgr5(+) stem cells in mice. Gastroenterology (2012) 1.32

Liver X receptor in cooperation with SREBP-1c is a major lipid synthesis regulator in nonalcoholic fatty liver disease. Hepatol Res (2008) 1.31

Dally-like core protein and its mammalian homologues mediate stimulatory and inhibitory effects on Hedgehog signal response. Proc Natl Acad Sci U S A (2010) 1.21

Hedgehog pathway modulation by multiple lipid binding sites on the smoothened effector of signal response. Dev Cell (2013) 1.15

Identification of genes up-regulated by histone deacetylase inhibition with cDNA microarray and exploration of epigenetic alterations on hepatoma cells. J Hepatol (2004) 1.13

Impact of cholesterol metabolism and the LXRalpha-SREBP-1c pathway on nonalcoholic fatty liver disease. Int J Mol Med (2009) 1.08

Sequence divergence and loss-of-function phenotypes of S locus F-box brothers genes are consistent with non-self recognition by multiple pollen determinants in self-incompatibility of Japanese pear (Pyrus pyrifolia). Plant J (2011) 1.08

WURCS: the Web3 unique representation of carbohydrate structures. J Chem Inf Model (2014) 1.07

A role for Hrs in endosomal sorting of ligand-stimulated and unstimulated epidermal growth factor receptor. Exp Cell Res (2004) 1.07

Sorting of GPI-anchored proteins into ER exit sites by p24 proteins is dependent on remodeled GPI. J Cell Biol (2011) 1.06

Targeted inhibition of hedgehog signaling by cyclopamine prodrugs for advanced prostate cancer. Bioorg Med Chem (2008) 1.06

Misexpression of Sox9 in mouse limb bud mesenchyme induces polydactyly and rescues hypodactyly mice. Matrix Biol (2006) 1.06

Gene expression profiling reveals the mechanism and pathophysiology of mouse liver regeneration. J Biol Chem (2003) 1.05

Expression profile of lipid metabolism-associated genes in hepatitis C virus-infected human liver. Hepatol Res (2010) 1.01

Truncating loss-of-function mutations of DISP1 contribute to holoprosencephaly-like microform features in humans. Hum Genet (2009) 1.01

Structure of the protein core of the glypican Dally-like and localization of a region important for hedgehog signaling. Proc Natl Acad Sci U S A (2011) 1.00

Increased hepatic expression of dipeptidyl peptidase-4 in non-alcoholic fatty liver disease and its association with insulin resistance and glucose metabolism. Mol Med Rep (2011) 1.00

Brain endothelial cells produce amyloid {beta} from amyloid precursor protein 770 and preferentially secrete the O-glycosylated form. J Biol Chem (2010) 0.99

Effects of insulin resistance and hepatic lipid accumulation on hepatic mRNA expression levels of apoB, MTP and L-FABP in non-alcoholic fatty liver disease. Exp Ther Med (2011) 0.94

Differential requirements for shh in mammary tissue and hair follicle morphogenesis. Dev Biol (2002) 0.94

Black-tea polyphenols decrease micellar solubility of cholesterol in vitro and intestinal absorption of cholesterol in rats. J Agric Food Chem (2010) 0.93

Bisphenol a diglycidyl ether (BADGE) suppresses tumor necrosis factor-alpha production as a PPARgamma agonist in the murine macrophage-like cell line, RAW 264.7. Cell Biol Int (2002) 0.92

S100A11 gene identified by in-house cDNA microarray as an accurate predictor of lymph node metastases of gastric cancer. Oncol Rep (2004) 0.91

[A case of hepatocellular carcinoma with respiratory failure caused by widespread tumor microemboli]. Fukuoka Igaku Zasshi (2011) 0.89

Identification of the p33(ING1)-regulated genes that include cyclin B1 and proto-oncogene DEK by using cDNA microarray in a mouse mammary epithelial cell line NMuMG. Cancer Res (2002) 0.88

Simplified procedure for the estimation of glomerular filtration rate following intravenous administration of iodixanol in cats. Am J Vet Res (2012) 0.88

Changes in the expression of cholesterol metabolism-associated genes in HCV-infected liver: a novel target for therapy? Int J Mol Med (2009) 0.88

Reduced hepatic expression of adipose tissue triglyceride lipase and CGI-58 may contribute to the development of non-alcoholic fatty liver disease in patients with insulin resistance. Scand J Gastroenterol (2008) 0.88

A new parameter using serum lactate dehydrogenase and alanine aminotransferase level is useful for predicting the prognosis of patients at an early stage of acute liver injury: a retrospective study. Comp Hepatol (2008) 0.87

Low-frequency of bacteremia after endoscopic submucosal dissection of the stomach. Dig Endosc (2011) 0.86

Therapeutic effect of ARBs on insulin resistance and liver injury in patients with NAFLD and chronic hepatitis C: a pilot study. Int J Mol Med (2008) 0.86

Characterization of dRFX2, a novel RFX family protein in Drosophila. Nucleic Acids Res (2004) 0.86

Add-on therapy of pitavastatin and eicosapentaenoic acid improves outcome of peginterferon plus ribavirin treatment for chronic hepatitis C. J Med Virol (2012) 0.86

Potential role of branched-chain amino acids in glucose metabolism through the accelerated induction of the glucose-sensing apparatus in the liver. J Cell Biochem (2011) 0.86

NPC1L1 inhibitor ezetimibe is a reliable therapeutic agent for non-obese patients with nonalcoholic fatty liver disease. Lipids Health Dis (2010) 0.86

The state of cholesterol metabolism in the liver of patients with primary biliary cirrhosis: the role of MDR3 expression. Hepatol Int (2009) 0.86

Second-generation antipsychotics in the treatment of major depressive disorder: current evidence. Expert Rev Neurother (2013) 0.85

Acute liver failure caused by drug-induced hypersensitivity syndrome associated with hyperferritinemia. World J Gastroenterol (2011) 0.85

The significance of differences in fatty acid metabolism between obese and non-obese patients with non-alcoholic fatty liver disease. Int J Mol Med (2008) 0.85

The current strategy for managing pancreatic neuroendocrine tumors in multiple endocrine neoplasia type 1. Gut Liver (2012) 0.84

A 12-week randomized, open-label study of perospirone versus aripiprazole in the treatment of Japanese schizophrenia patients. Prog Neuropsychopharmacol Biol Psychiatry (2012) 0.83

Black-tea polyphenols suppress postprandial hypertriacylglycerolemia by suppressing lymphatic transport of dietary fat in rats. J Agric Food Chem (2009) 0.83

Randomized clinical comparison of perospirone and risperidone in patients with schizophrenia: Kansai Psychiatric Multicenter Study. Psychiatry Clin Neurosci (2009) 0.83

Identification of candidate genes for Sjögren's syndrome using MRL/lpr mouse model of Sjögren's syndrome and cDNA microarray analysis. Immunol Lett (2002) 0.83

N-glycans of SREC-I (scavenger receptor expressed by endothelial cells): essential role for ligand binding, trafficking and stability. Glycobiology (2012) 0.83

The alpha 2A-adrenergic receptor gene polymorphism modifies antidepressant responses to milnacipran. J Clin Psychopharmacol (2008) 0.83

Partial splenic embolization facilitates completion of interferon therapy in patients with chronic HCV infection and hypersplenism. J Gastroenterol (2005) 0.83

Transcriptional activation by extradenticle in the Drosophila visceral mesoderm. Dev Biol (2006) 0.83

Lactate dehydrogenase production in hepatocytes is increased at an early stage of acute liver failure. Exp Ther Med (2011) 0.82

Association between lipid accumulation and the cannabinoid system in Huh7 cells expressing HCV genes. Int J Mol Med (2011) 0.82

Drosophila distal-less negatively regulates dDREF by inhibiting its DNA binding activity. Biochim Biophys Acta (2006) 0.82

Comparative analysis of gene expressions among avian brains: a molecular approach to the evolution of vocal learning. Brain Res Bull (2007) 0.82

Simple and sensitive method for measurement of metoclopramide in cattle plasma by LC-MS/MS using a multimode chromatography. J Vet Med Sci (2012) 0.82

The serotonin transporter gene and effectiveness of SSRIs. Expert Rev Neurother (2008) 0.82