PubRank

Michael W Parker

Author PubWeight™ 137.32‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Siah ubiquitin ligase is structurally related to TRAF and modulates TNF-alpha signaling. Nat Struct Biol 2002 2.32
2 Do current therapeutic anti-Aβ antibodies for Alzheimer's disease engage the target? Acta Neuropathol 2014 2.25
3 AMPK beta subunit targets metabolic stress sensing to glycogen. Curr Biol 2003 2.19
4 Human factor H-related protein 5 has cofactor activity, inhibits C3 convertase activity, binds heparin and C-reactive protein, and associates with lipoprotein. J Immunol 2005 1.92
5 Model for growth hormone receptor activation based on subunit rotation within a receptor dimer. Nat Struct Mol Biol 2005 1.83
6 The structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor activation. Cell 2008 1.83
7 Elucidation of the substrate binding site of Siah ubiquitin ligase. Structure 2006 1.79
8 Anxiety over GABA(A) receptor structure relieved by AChBP. Trends Biochem Sci 2002 1.74
9 Critical role for the second extracellular loop in the binding of both orthosteric and allosteric G protein-coupled receptor ligands. J Biol Chem 2007 1.70
10 The granulocyte-macrophage colony-stimulating factor receptor: linking its structure to cell signaling and its role in disease. Blood 2009 1.63
11 Molecular dissection of the interaction between amyloid precursor protein and its neuronal trafficking receptor SorLA/LR11. Biochemistry 2006 1.63
12 Insights into the action of the superfamily of cholesterol-dependent cytolysins from studies of intermedilysin. Proc Natl Acad Sci U S A 2005 1.63
13 Cytoplasmic ATP-sensing domains regulate gating of skeletal muscle ClC-1 chloride channels. J Biol Chem 2005 1.62
14 Structures of perfringolysin O suggest a pathway for activation of cholesterol-dependent cytolysins. J Mol Biol 2007 1.54
15 Structural basis for glycogen recognition by AMP-activated protein kinase. Structure 2005 1.50
16 An activation-specific platelet inhibitor that can be turned on/off by medically used hypothermia. Arterioscler Thromb Vasc Biol 2011 1.46
17 Rowe and Kahn's model of successful aging revisited: positive spirituality--the forgotten factor. Gerontologist 2002 1.44
18 Intrasteric control of AMPK via the gamma1 subunit AMP allosteric regulatory site. Protein Sci 2004 1.41
19 Oseltamivir resistance and the H274Y neuraminidase mutation in seasonal, pandemic and highly pathogenic influenza viruses. Drugs 2009 1.41
20 Structure and evolution of a novel dimeric enzyme from a clinically important bacterial pathogen. J Biol Chem 2008 1.38
21 Structure of the Alzheimer's disease amyloid precursor protein copper binding domain. A regulator of neuronal copper homeostasis. J Biol Chem 2003 1.38
22 Federated repositories of X-ray diffraction images. Acta Crystallogr D Biol Crystallogr 2008 1.33
23 Inhibition of skeletal muscle ClC-1 chloride channels by low intracellular pH and ATP. J Biol Chem 2007 1.32
24 A rivet model for channel formation by aerolysin-like pore-forming toxins. EMBO J 2006 1.28
25 Molecular determinants of ginkgolide binding in the glycine receptor pore. J Neurochem 2006 1.28
26 From glutathione transferase to pore in a CLIC. Eur Biophys J 2002 1.23
27 The identification and structure of the membrane-spanning domain of the Clostridium septicum alpha toxin. J Biol Chem 2004 1.22
28 The GM-CSF/IL-3/IL-5 cytokine receptor family: from ligand recognition to initiation of signaling. Immunol Rev 2012 1.20
29 Amyloid-beta-anti-amyloid-beta complex structure reveals an extended conformation in the immunodominant B-cell epitope. J Mol Biol 2008 1.17
30 Structural characterization of respiratory syncytial virus fusion inhibitor escape mutants: homology model of the F protein and a syncytium formation assay. Virology 2003 1.17
31 Altered kinetics and benzodiazepine sensitivity of a GABAA receptor subunit mutation [gamma 2(R43Q)] found in human epilepsy. Proc Natl Acad Sci U S A 2002 1.14
32 Molecular evolution of glutathione S-transferases in the genus Drosophila. Genetics 2007 1.14
33 Mapping the intermedilysin-human CD59 receptor interface reveals a deep correspondence with the binding site on CD59 for complement binding proteins C8alpha and C9. J Biol Chem 2011 1.12
34 Solution conformation and heparin-induced dimerization of the full-length extracellular domain of the human amyloid precursor protein. J Mol Biol 2006 1.07
35 Insights into the structural basis for zinc inhibition of the glycine receptor. J Biol Chem 2003 1.05
36 Conversion of a transmembrane to a water-soluble protein complex by a single point mutation. Nat Struct Biol 2002 1.04
37 A proposed structural basis for picrotoxinin and picrotin binding in the glycine receptor pore. J Neurochem 2007 1.04
38 Substrate-mediated stabilization of a tetrameric drug target reveals Achilles heel in anthrax. J Biol Chem 2009 1.03
39 Bapineuzumab captures the N-terminus of the Alzheimer's disease amyloid-beta peptide in a helical conformation. Sci Rep 2013 1.02
40 Molecular basis of cytokine receptor activation. IUBMB Life 2010 1.01
41 The purification, crystallization and preliminary X-ray diffraction analysis of dihydrodipicolinate synthase from Clostridium botulinum. Acta Crystallogr Sect F Struct Biol Cryst Commun 2008 1.01
42 Structure of the Janus protein human CLIC2. J Mol Biol 2007 1.01
43 Purification, crystallization and preliminary X-ray diffraction studies to near-atomic resolution of dihydrodipicolinate synthase from methicillin-resistant Staphylococcus aureus. Acta Crystallogr Sect F Struct Biol Cryst Commun 2008 0.99
44 Direct involvement of the TEN domain at the active site of human telomerase. Nucleic Acids Res 2010 0.98
45 Monomer-monomer interactions propagate structural transitions necessary for pore formation by the cholesterol-dependent cytolysins. J Biol Chem 2012 0.97
46 Hsp90 increases LIM kinase activity by promoting its homo-dimerization. FASEB J 2006 0.96
47 Nitrosylation of human glutathione transferase P1-1 with dinitrosyl diglutathionyl iron complex in vitro and in vivo. J Biol Chem 2005 0.96
48 TRIM16 acts as an E3 ubiquitin ligase and can heterodimerize with other TRIM family members. PLoS One 2012 0.95
49 GSTB1-1 from Proteus mirabilis: a snapshot of an enzyme in the evolutionary pathway from a redox enzyme to a conjugating enzyme. J Biol Chem 2002 0.95
50 Targeting acute myeloid leukemia by dual inhibition of PI3K signaling and Cdk9-mediated Mcl-1 transcription. Blood 2013 0.94
51 Contrasting, species-dependent modulation of copper-mediated neurotoxicity by the Alzheimer's disease amyloid precursor protein. J Neurosci 2002 0.94
52 Crystallization and preliminary X-ray analysis of dihydrodipicolinate synthase from Clostridium botulinum in the presence of its substrate pyruvate. Acta Crystallogr Sect F Struct Biol Cryst Commun 2009 0.94
53 Insights into interactions between the alpha-helical region of the salmon calcitonin antagonists and the human calcitonin receptor using photoaffinity labeling. J Biol Chem 2005 0.94
54 Structural studies of the Alzheimer's amyloid precursor protein copper-binding domain reveal how it binds copper ions. J Mol Biol 2006 0.93
55 The GM-CSF receptor family: mechanism of activation and implications for disease. Growth Factors 2012 0.93
56 Identification and characterization of a new cognitive enhancer based on inhibition of insulin-regulated aminopeptidase. FASEB J 2008 0.93
57 Molecular determinants of common gating of a ClC chloride channel. Nat Commun 2013 0.92
58 Expression, purification, crystallization and preliminary X-ray diffraction analysis of dihydrodipicolinate synthase from Bacillus anthracis in the presence of pyruvate. Acta Crystallogr Sect F Struct Biol Cryst Commun 2009 0.92
59 Crystal structure of a putative methyltransferase from Mycobacterium tuberculosis: misannotation of a genome clarified by protein structural analysis. J Bacteriol 2003 0.91
60 Structure of the lectin regulatory domain of the cholesterol-dependent cytolysin lectinolysin reveals the basis for its lewis antigen specificity. Structure 2012 0.91
61 Solid-phase synthesis of homodimeric peptides: preparation of covalently-linked dimers of amyloid beta peptide. Chem Commun (Camb) 2009 0.90
62 Purification, crystallization, small-angle X-ray scattering and preliminary X-ray diffraction analysis of the SH2 domain of the Csk-homologous kinase. Acta Crystallogr Sect F Struct Biol Cryst Commun 2011 0.90
63 Lymphotoxin α induces apoptosis, necroptosis and inflammatory signals with the same potency as tumour necrosis factor. FEBS J 2013 0.89
64 Clarification of the role of key active site residues of glutathione transferase zeta/maleylacetoacetate isomerase by a new spectrophotometric technique. Biochem J 2003 0.89
65 Parallel screening of low molecular weight fragment libraries: do differences in methodology affect hit identification? J Biomol Screen 2012 0.89
66 Crystallization and preliminary X-ray diffraction analysis of the Fab fragment of WO2, an antibody specific for the Abeta peptides associated with Alzheimer's disease. Acta Crystallogr Sect F Struct Biol Cryst Commun 2008 0.88
67 Signalling by the βc family of cytokines. Cytokine Growth Factor Rev 2013 0.88
68 Amiloride is a competitive inhibitor of coxsackievirus B3 RNA polymerase. J Virol 2011 0.88
69 Characterization of pathogenic human monoclonal autoantibodies against GM-CSF. Proc Natl Acad Sci U S A 2013 0.88
70 Identification of essential residues in the Erm(B) rRNA methyltransferase of Clostridium perfringens. Antimicrob Agents Chemother 2002 0.88
71 Copper binding to the Alzheimer's disease amyloid precursor protein. Eur Biophys J 2007 0.88
72 Development of cognitive enhancers based on inhibition of insulin-regulated aminopeptidase. BMC Neurosci 2008 0.87
73 Tropisetron modulation of the glycine receptor: femtomolar potentiation and a molecular determinant of inhibition. J Neurochem 2006 0.87
74 Rational design of an organometallic glutathione transferase inhibitor. Angew Chem Int Ed Engl 2009 0.86
75 Phosphorylation of syndapin I F-BAR domain at two helix-capping motifs regulates membrane tubulation. Proc Natl Acad Sci U S A 2012 0.86
76 Crystallization and preliminary X-ray analysis of the human-specific toxin intermedilysin. Acta Crystallogr D Biol Crystallogr 2004 0.86
77 Glutamic acid-65 is an essential residue for catalysis in Proteus mirabilis glutathione S-transferase B1-1. Biochem J 2002 0.86
78 Identification of modulating residues defining the catalytic cleft of insulin-regulated aminopeptidase. Biochem Cell Biol 2008 0.85
79 Recognition and detoxification of the insecticide DDT by Drosophila melanogaster glutathione S-transferase D1. J Mol Biol 2010 0.85
80 Regulation of insulin-regulated membrane aminopeptidase activity by its C-terminal domain. Biochemistry 2011 0.85
81 The extended catalysis of glutathione transferase. FEBS Lett 2010 0.84
82 Identification and development of specific inhibitors for insulin-regulated aminopeptidase as a new class of cognitive enhancers. Br J Pharmacol 2011 0.84
83 Crystal structure of the HIV-1 integrase core domain in complex with sucrose reveals details of an allosteric inhibitory binding site. FEBS Lett 2010 0.84
84 Intracellular β-nicotinamide adenine dinucleotide inhibits the skeletal muscle ClC-1 chloride channel. J Biol Chem 2012 0.84
85 Diuretic drug binding to human glutathione transferase P1-1: potential role of Cys-101 revealed in the double mutant C47S/Y108V. J Mol Recognit 2011 0.83
86 Calorimetric and structural studies of the nitric oxide carrier S-nitrosoglutathione bound to human glutathione transferase P1-1. Protein Sci 2006 0.83
87 Glutathione transferase P1-1: self-preservation of an anti-cancer enzyme. Biochem J 2003 0.83
88 Properties and utility of the peculiar mixed disulfide in the bacterial glutathione transferase B1-1. Biochemistry 2002 0.83
89 Preventing serpin aggregation: the molecular mechanism of citrate action upon antitrypsin unfolding. Protein Sci 2008 0.83
90 Religiousness and Longitudinal Trajectories in Elders' Functional Status. Res Aging 2008 0.83
91 Contribution of glycine 146 to a conserved folding module affecting stability and refolding of human glutathione transferase p1-1. J Biol Chem 2002 0.83
92 Abeta targets of the biosimilar antibodies of Bapineuzumab, Crenezumab, Solanezumab in comparison to an antibody against N‑truncated Abeta in sporadic Alzheimer disease cases and mouse models. Acta Neuropathol 2015 0.82
93 Cloning, expression and crystallization of dihydrodipicolinate reductase from methicillin-resistant Staphylococcus aureus. Acta Crystallogr Sect F Struct Biol Cryst Commun 2009 0.82
94 Phenylalanine-544 plays a key role in substrate and inhibitor binding by providing a hydrophobic packing point at the active site of insulin-regulated aminopeptidase. Mol Pharmacol 2010 0.82
95 The anti-cancer drug chlorambucil as a substrate for the human polymorphic enzyme glutathione transferase P1-1: kinetic properties and crystallographic characterisation of allelic variants. J Mol Biol 2008 0.82
96 Structure of Alzheimer's disease amyloid precursor protein copper-binding domain at atomic resolution. Acta Crystallogr Sect F Struct Biol Cryst Commun 2007 0.81
97 Structural basis for antibody discrimination between two hormones that recognize the parathyroid hormone receptor. J Biol Chem 2009 0.81
98 Studies of glutathione transferase P1-1 bound to a platinum(IV)-based anticancer compound reveal the molecular basis of its activation. Chemistry 2011 0.81
99 The impact of nitric oxide toxicity on the evolution of the glutathione transferase superfamily: a proposal for an evolutionary driving force. J Biol Chem 2013 0.81
100 Disarming bacterial virulence through chemical inhibition of the DNA binding domain of an AraC-like transcriptional activator protein. J Biol Chem 2013 0.81
101 Cytokine receptor activation at the cell surface. Curr Opin Struct Biol 2012 0.80
102 Dihydropyridine inhibition of the glycine receptor: subunit selectivity and a molecular determinant of inhibition. Neuropharmacology 2008 0.80
103 Cloning, expression, purification and crystallization of dihydrodipicolinate synthase from the psychrophile Shewanella benthica. Acta Crystallogr Sect F Struct Biol Cryst Commun 2010 0.80
104 Phosphorylation of serine 779 in fibroblast growth factor receptor 1 and 2 by protein kinase C(epsilon) regulates Ras/mitogen-activated protein kinase signaling and neuronal differentiation. J Biol Chem 2013 0.80
105 Naturally occurring Phe151Leu substitution near a conserved folding module lowers stability of glutathione transferase P1-1. Biochim Biophys Acta 2003 0.80
106 Crystallization of dihydrodipicolinate synthase from a clinical isolate of Streptococcus pneumoniae. Acta Crystallogr Sect F Struct Biol Cryst Commun 2009 0.80
107 Identification and characterization of GSTT3, a third murine Theta class glutathione transferase. Biochem J 2002 0.80
108 Crystal structure of human insulin-regulated aminopeptidase with specificity for cyclic peptides. Protein Sci 2014 0.79
109 Molecular and structural insight into lysine selection on substrate and ubiquitin lysine 48 by the ubiquitin-conjugating enzyme Cdc34. Cell Cycle 2013 0.79
110 Transportation Difficulty of Black and White Rural Older Adults. J Appl Gerontol 2010 0.79
111 Binding and kinetic mechanisms of the Zeta class glutathione transferase. J Biol Chem 2004 0.78
112 Crystallization of the glycogen-binding domain of the AMP-activated protein kinase beta subunit and preliminary X-ray analysis. Acta Crystallogr Sect F Struct Biol Cryst Commun 2004 0.78
113 Fragment-based design of ligands targeting a novel site on the integrase enzyme of human immunodeficiency virus 1. ChemMedChem 2010 0.78
114 Synthesis, structure-activity relationships and brain uptake of a novel series of benzopyran inhibitors of insulin-regulated aminopeptidase. J Med Chem 2014 0.78
115 Proteins: membrane binding and pore formation. Introduction. Adv Exp Med Biol 2010 0.78
116 Thiophene inhibitors of PDE4: crystal structures show a second binding mode at the catalytic domain of PDE4D2. Bioorg Med Chem Lett 2011 0.78
117 Crystallization and preliminary X-ray diffraction analysis of human endoplasmic reticulum aminopeptidase 2. Acta Crystallogr Sect F Struct Biol Cryst Commun 2012 0.78
118 Influence of the H-site residue 108 on human glutathione transferase P1-1 ligand binding: structure-thermodynamic relationships and thermal stability. Protein Sci 2009 0.78
119 Functional limitations and religious service attendance among African American and white older adults. Health Soc Work 2006 0.77
120 Expression, purification, crystallization and preliminary X-ray diffraction analysis of chloride intracellular channel 2 (CLIC2). Acta Crystallogr Sect F Struct Biol Cryst Commun 2007 0.77
121 Optimised expression and purification of recombinant human indoleamine 2,3-dioxygenase. Protein Expr Purif 2004 0.77
122 PEGylation of a proprotein convertase peptide inhibitor for vaginal route of drug delivery: in vitro bioactivity, stability and in vivo pharmacokinetics. Peptides 2012 0.77
123 Structural approaches to probing metal interaction with proteins. J Inorg Biochem 2012 0.77
124 Structure of the lysine specific protease Kgp from Porphyromonas gingivalis, a target for improved oral health. Protein Sci 2014 0.77
125 Anti-Aβ antibody target engagement: a response to Siemers et al. Acta Neuropathol 2014 0.77
126 Engineering a new C-terminal tail in the H-site of human glutathione transferase P1-1: structural and functional consequences. J Mol Biol 2003 0.77
127 Crystallization and preliminary X-ray analysis of glutathione transferases from cyanobacteria. Acta Crystallogr Sect F Struct Biol Cryst Commun 2009 0.77
128 Thermodynamic description of the effect of the mutation Y49F on human glutathione transferase P1-1 in binding with glutathione and the inhibitor S-hexylglutathione. J Biol Chem 2003 0.77
129 Crystallization and preliminary X-ray diffraction analysis of the ternary human GM-CSF receptor complex. Acta Crystallogr Sect F Struct Biol Cryst Commun 2008 0.76
130 Crystallization of the receptor-binding domain of parathyroid hormone-related protein in complex with a neutralizing monoclonal antibody Fab fragment. Acta Crystallogr Sect F Struct Biol Cryst Commun 2009 0.76
131 Crystallization and preliminary crystallographic studies of the copper-binding domain of the amyloid precursor protein of Alzheimer's disease. Acta Crystallogr Sect F Struct Biol Cryst Commun 2004 0.76
132 Manipulating the Lewis antigen specificity of the cholesterol-dependent cytolysin lectinolysin. Front Immunol 2012 0.76
133 Predicting the Trajectories of Perceived Pain Intensity in Southern Community-Dwelling Older Adults: The Role of Religiousness. Res Aging 2013 0.75
134 Preparation, crystallization and preliminary X-ray diffraction analysis of two intestinal fatty-acid binding proteins in the presence of 11-(dansylamino)undecanoic acid. Acta Crystallogr Sect F Struct Biol Cryst Commun 2011 0.75
135 Crystal structure of the Leishmania major MIX protein: a scaffold protein that mediates protein-protein interactions. Protein Sci 2011 0.75
136 Small molecule proprotein convertase inhibitors for inhibition of embryo implantation. PLoS One 2013 0.75
137 An Escherichia coli cell-free system for recombinant protein synthesis on a milligram scale. Methods Mol Biol 2011 0.75
138 Crystallization and preliminary X-ray diffraction analysis of the unliganded human growth hormone receptor. Acta Crystallogr D Biol Crystallogr 2004 0.75