Published in J Cell Biol on July 29, 2013
RPA-coated single-stranded DNA as a platform for post-translational modifications in the DNA damage response. Cell Res (2014) 1.10
Coupling of human DNA excision repair and the DNA damage checkpoint in a defined in vitro system. J Biol Chem (2014) 1.09
Distinct but Concerted Roles of ATR, DNA-PK, and Chk1 in Countering Replication Stress during S Phase. Mol Cell (2015) 1.08
Human single-stranded DNA binding protein 1 (hSSB1/NABP2) is required for the stability and repair of stalled replication forks. Nucleic Acids Res (2014) 0.94
The role of the dysfunctional akt-related pathway in cancer: establishment and maintenance of a malignant cell phenotype, resistance to therapy, and future strategies for drug development. Scientifica (Cairo) (2013) 0.89
DNA-PKcs is required to maintain stability of Chk1 and Claspin for optimal replication stress response. Nucleic Acids Res (2014) 0.86
Over-expression of DNA-PKcs in renal cell carcinoma regulates mTORC2 activation, HIF-2α expression and cell proliferation. Sci Rep (2016) 0.85
DNA mismatch repair and the DNA damage response. DNA Repair (Amst) (2015) 0.83
Coordinated nuclease activities counteract Ku at single-ended DNA double-strand breaks. Nat Commun (2016) 0.80
Distinct genetic control of homologous recombination repair of Cas9-induced double-strand breaks, nicks and paired nicks. Nucleic Acids Res (2016) 0.79
Replication of an Autonomous Human Parvovirus in Non-dividing Human Airway Epithelium Is Facilitated through the DNA Damage and Repair Pathways. PLoS Pathog (2016) 0.78
HARP preferentially co-purifies with RPA bound to DNA-PK and blocks RPA phosphorylation. Epigenetics (2014) 0.78
TLK1B mediated phosphorylation of Rad9 regulates its nuclear/cytoplasmic localization and cell cycle checkpoint. BMC Mol Biol (2016) 0.75
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science (2007) 20.11
DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature (2005) 18.30
Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. Science (2003) 18.29
The DNA-damage response in human biology and disease. Nature (2009) 17.86
Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions. Nature (2005) 14.65
Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes Dev (2001) 12.46
Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint. Genes Dev (2000) 11.49
The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen. Cell (1993) 7.17
TopBP1 activates the ATR-ATRIP complex. Cell (2006) 6.29
The DNA-dependent protein kinase. Genes Dev (1999) 5.80
Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint. Genes Dev (2005) 5.53
Multiple mechanisms control chromosome integrity after replication fork uncoupling and restart at irreparable UV lesions. Mol Cell (2006) 4.44
Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in Xenopus egg extracts. Genes Dev (2000) 3.96
Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts. Mol Cell (2000) 3.65
Ku autoantigen is the regulatory component of a template-associated protein kinase that phosphorylates RNA polymerase II. Proc Natl Acad Sci U S A (1992) 3.58
The structural determinants of checkpoint activation. Genes Dev (2007) 3.53
The structure-specific endonuclease Mus81 contributes to replication restart by generating double-strand DNA breaks. Nat Struct Mol Biol (2007) 3.38
Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA-PK complexes. EMBO J (1999) 3.13
Single-stranded DNA orchestrates an ATM-to-ATR switch at DNA breaks. Mol Cell (2009) 3.12
A cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutations. Nat Struct Mol Biol (2011) 3.10
ATRIP binding to replication protein A-single-stranded DNA promotes ATR-ATRIP localization but is dispensable for Chk1 phosphorylation. Mol Biol Cell (2005) 3.08
A DNA-activated protein kinase from HeLa cell nuclei. Mol Cell Biol (1990) 2.95
Analysis of the mechanism of interaction of simian Ku protein with DNA. Nucleic Acids Res (1991) 2.76
HeLa nuclear protein recognizing DNA termini and translocating on DNA forming a regular DNA-multimeric protein complex. J Mol Biol (1989) 2.73
Binding of Ku protein to DNA. Measurement of affinity for ends and demonstration of binding to nicks. J Biol Chem (1993) 2.66
The Bloom's syndrome helicase can promote the regression of a model replication fork. J Biol Chem (2006) 2.65
Topoisomerase I poisoning results in PARP-mediated replication fork reversal. Nat Struct Mol Biol (2012) 2.44
EBP-80, a transcription factor closely resembling the human autoantigen Ku, recognizes single- to double-strand transitions in DNA. J Biol Chem (1993) 2.34
Remodeling of DNA replication structures by the branch point translocase FANCM. Proc Natl Acad Sci U S A (2008) 2.20
The human RNA surveillance factor UPF1 is required for S phase progression and genome stability. Curr Biol (2006) 2.16
DNA-PK: the means to justify the ends? Adv Immunol (2008) 2.14
Sequential and synergistic modification of human RPA stimulates chromosomal DNA repair. J Biol Chem (2007) 1.94
RPA2 is a direct downstream target for ATR to regulate the S-phase checkpoint. J Biol Chem (2006) 1.79
ATR-dependent phosphorylation of DNA-dependent protein kinase catalytic subunit in response to UV-induced replication stress. Mol Cell Biol (2006) 1.73
Replication protein A interactions with DNA. 2. Characterization of double-stranded DNA-binding/helix-destabilization activities and the role of the zinc-finger domain in DNA interactions. Biochemistry (1999) 1.67
More forks on the road to replication stress recovery. J Mol Cell Biol (2011) 1.64
Ataxia-telangiectasia mutated (ATM)-dependent activation of ATR occurs through phosphorylation of TopBP1 by ATM. J Biol Chem (2007) 1.61
Phosphatidyl inositol 3-kinase-like serine/threonine protein kinases (PIKKs) are required for DNA damage-induced phosphorylation of the 32 kDa subunit of replication protein A at threonine 21. Nucleic Acids Res (2004) 1.56
Reconstitution of RPA-covered single-stranded DNA-activated ATR-Chk1 signaling. Proc Natl Acad Sci U S A (2010) 1.53
Distinct roles for DNA-PK, ATM and ATR in RPA phosphorylation and checkpoint activation in response to replication stress. Nucleic Acids Res (2012) 1.47
Premature Cdk1/Cdc5/Mus81 pathway activation induces aberrant replication and deleterious crossover. EMBO J (2013) 1.45
On the mechanisms of Ku protein binding to DNA. Biochem Biophys Res Commun (1992) 1.39
Oncogenes induce genotoxic stress by mitotic processing of unusual replication intermediates. J Cell Biol (2013) 1.37
The Mre11-Rad50-Nbs1 complex mediates activation of TopBP1 by ATM. Mol Biol Cell (2009) 1.33
Phosphorylation of Chk1 by ATM- and Rad3-related (ATR) in Xenopus egg extracts requires binding of ATRIP to ATR but not the stable DNA-binding or coiled-coil domains of ATRIP. J Biol Chem (2005) 1.30
Differential involvement of phosphatidylinositol 3-kinase-related protein kinases in hyperphosphorylation of replication protein A2 in response to replication-mediated DNA double-strand breaks. Genes Cells (2006) 1.28
Continued primer synthesis at stalled replication forks contributes to checkpoint activation. J Cell Biol (2010) 1.27
The role of RPA2 phosphorylation in homologous recombination in response to replication arrest. Carcinogenesis (2010) 1.14
DNA-PK-dependent RPA2 hyperphosphorylation facilitates DNA repair and suppresses sister chromatid exchange. PLoS One (2011) 1.00
The complementary strand of the human T-cell leukemia virus type 1 RNA genome encodes a bZIP transcription factor that down-regulates viral transcription. J Virol (2002) 3.01
The Fanconi anemia protein FANCM can promote branch migration of Holliday junctions and replication forks. Mol Cell (2008) 2.68
Identification and characterization of the human mus81-eme1 endonuclease. J Biol Chem (2003) 2.43
A histone-fold complex and FANCM form a conserved DNA-remodeling complex to maintain genome stability. Mol Cell (2010) 2.36
Remodeling of DNA replication structures by the branch point translocase FANCM. Proc Natl Acad Sci U S A (2008) 2.20
HBZ interacts with JunD and stimulates its transcriptional activity. FEBS Lett (2004) 1.63
Malt1-dependent RelB cleavage promotes canonical NF-kappaB activation in lymphocytes and lymphoma cell lines. Proc Natl Acad Sci U S A (2011) 1.48
FANCD2 binds MCM proteins and controls replisome function upon activation of s phase checkpoint signaling. Mol Cell (2013) 1.34
FANCM regulates DNA chain elongation and is stabilized by S-phase checkpoint signalling. EMBO J (2009) 1.31
Definition of a short region of XPG necessary for TFIIH interaction and stable recruitment to sites of UV damage. Mol Cell Biol (2004) 1.31
Nuclear localization of HTLV-I bZIP factor (HBZ) is mediated by three distinct motifs. J Cell Sci (2005) 1.27
The HBZ-SP1 isoform of human T-cell leukemia virus type I represses JunB activity by sequestration into nuclear bodies. Retrovirology (2007) 1.18
MRE11-RAD50-NBS1 is a critical regulator of FANCD2 stability and function during DNA double-strand break repair. EMBO J (2009) 0.98
ASAP is a novel substrate of the oncogenic mitotic kinase Aurora-A: phosphorylation on Ser625 is essential to spindle formation and mitosis. Hum Mol Genet (2007) 0.95
The founding members of xeroderma pigmentosum group G produce XPG protein with severely impaired endonuclease activity. J Invest Dermatol (2002) 0.94
Human T-cell lymphotropic virus type 1-transformed cells induce angiogenesis and establish functional gap junctions with endothelial cells. Blood (2002) 0.92
DNA repair pathways in human multiple myeloma: role in oncogenesis and potential targets for treatment. Cell Cycle (2013) 0.86
The role of the Fanconi anemia network in the response to DNA replication stress. Crit Rev Biochem Mol Biol (2009) 0.83
A DNA repair pathway score predicts survival in human multiple myeloma: the potential for therapeutic strategy. Oncotarget (2014) 0.82
Fos family protein degradation by the proteasome. Biochem Soc Trans (2008) 0.80
DNA repair in diffuse large B-cell lymphoma: a molecular portrait. Br J Haematol (2014) 0.76