Published in Nucleic Acids Res on November 27, 2012
Common genetic variants influence human subcortical brain structures. Nature (2015) 2.40
The 2013 Nucleic Acids Research Database Issue and the online molecular biology database collection. Nucleic Acids Res (2012) 1.66
Characterization of constitutive CTCF/cohesin loci: a possible role in establishing topological domains in mammalian genomes. BMC Genomics (2013) 1.03
DNA methylation and differentiation: silencing, upregulation and modulation of gene expression. Epigenomics (2013) 0.97
CTCF and Rad21 act as host cell restriction factors for Kaposi's sarcoma-associated herpesvirus (KSHV) lytic replication by modulating viral gene transcription. PLoS Pathog (2014) 0.91
CTCF Recruits Centromeric Protein CENP-E to the Pericentromeric/Centromeric Regions of Chromosomes through Unusual CTCF-Binding Sites. Cell Rep (2015) 0.85
A dynamic CTCF chromatin binding landscape promotes DNA hydroxymethylation and transcriptional induction of adipocyte differentiation. Nucleic Acids Res (2014) 0.84
NuChart: an R package to study gene spatial neighbourhoods with multi-omics annotations. PLoS One (2013) 0.82
Spectral identification of topological domains. Bioinformatics (2016) 0.80
The dual specificity phosphatase 2 gene is hypermethylated in human cancer and regulated by epigenetic mechanisms. BMC Cancer (2016) 0.80
Cistrome Data Browser: a data portal for ChIP-Seq and chromatin accessibility data in human and mouse. Nucleic Acids Res (2016) 0.79
Genome-Wide Profiling of PARP1 Reveals an Interplay with Gene Regulatory Regions and DNA Methylation. PLoS One (2015) 0.77
Epigenetic regulation of differential HLA-A allelic expression levels. Hum Mol Genet (2015) 0.77
Epigenetics of the myotonic dystrophy-associated DMPK gene neighborhood. Epigenomics (2016) 0.77
Loss of cohesin complex components STAG2 or STAG3 confers resistance to BRAF inhibition in melanoma. Nat Med (2016) 0.76
The Human GATA1 Gene Retains a 5' Insulator That Maintains Chromosomal Architecture and GATA1 Expression Levels in Splenic Erythroblasts. Mol Cell Biol (2015) 0.76
Deconvolution of Ensemble Chromatin Interaction Data Reveals the Latent Mixing Structures in Cell Subpopulations. J Comput Biol (2016) 0.75
Links between DNA methylation and nucleosome occupancy in the human genome. Epigenetics Chromatin (2017) 0.75
An imprinted non-coding genomic cluster at 14q32 defines clinically relevant molecular subtypes in osteosarcoma across multiple independent datasets. J Hematol Oncol (2017) 0.75
Insecticide resistance mediated by an exon skipping event. Mol Ecol (2016) 0.75
A promising hypothesis of c-KIT methylation/ expression paradox in c-KIT (+) squamous cell carcinoma of uterine cervix ----- CTCF transcriptional repressor regulates c-KIT proto-oncogene expression. Diagn Pathol (2015) 0.75
Epigenetic silencing of the XAF1 gene is mediated by the loss of CTCF binding. Sci Rep (2015) 0.75
Epstein-Barr Virus Rta-Mediated Accumulation of DNA Methylation Interferes with CTCF Binding in both Host and Viral Genomes. J Virol (2017) 0.75
The human genome browser at UCSC. Genome Res (2002) 168.23
High-resolution profiling of histone methylations in the human genome. Cell (2007) 85.74
A gene atlas of the mouse and human protein-encoding transcriptomes. Proc Natl Acad Sci U S A (2004) 44.81
The ENCODE (ENCyclopedia Of DNA Elements) Project. Science (2004) 38.24
Comprehensive mapping of long-range interactions reveals folding principles of the human genome. Science (2009) 29.83
Integration of external signaling pathways with the core transcriptional network in embryonic stem cells. Cell (2008) 28.29
Topological domains in mammalian genomes identified by analysis of chromatin interactions. Nature (2012) 18.23
Analysis of the vertebrate insulator protein CTCF-binding sites in the human genome. Cell (2007) 16.66
A user's guide to the encyclopedia of DNA elements (ENCODE). PLoS Biol (2011) 16.53
CTCF: master weaver of the genome. Cell (2009) 15.09
Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 gene. Nature (2000) 14.91
Cohesin mediates transcriptional insulation by CCCTC-binding factor. Nature (2008) 12.01
Genome-wide identification of in vivo protein-DNA binding sites from ChIP-Seq data. Nucleic Acids Res (2008) 8.89
Global analysis of the insulator binding protein CTCF in chromatin barrier regions reveals demarcation of active and repressive domains. Genome Res (2008) 7.41
CTCF is a uniquely versatile transcription regulator linked to epigenetics and disease. Trends Genet (2001) 6.80
CTCF-mediated functional chromatin interactome in pluripotent cells. Nat Genet (2011) 6.55
Comprehensive genome-wide protein-DNA interactions detected at single-nucleotide resolution. Cell (2011) 6.29
An exceptionally conserved transcriptional repressor, CTCF, employs different combinations of zinc fingers to bind diverged promoter sequences of avian and mammalian c-myc oncogenes. Mol Cell Biol (1996) 5.74
CTCF-promoted RNA polymerase II pausing links DNA methylation to splicing. Nature (2011) 5.50
Transposable elements have rewired the core regulatory network of human embryonic stem cells. Nat Genet (2010) 5.26
Systematic discovery of regulatory motifs in conserved regions of the human genome, including thousands of CTCF insulator sites. Proc Natl Acad Sci U S A (2007) 4.91
CTCF physically links cohesin to chromatin. Proc Natl Acad Sci U S A (2008) 4.89
High-resolution genome-wide in vivo footprinting of diverse transcription factors in human cells. Genome Res (2010) 4.69
A novel sequence-specific DNA binding protein which interacts with three regularly spaced direct repeats of the CCCTC-motif in the 5'-flanking sequence of the chicken c-myc gene. Oncogene (1990) 3.96
Waves of retrotransposon expansion remodel genome organization and CTCF binding in multiple mammalian lineages. Cell (2012) 3.48
Cell type specificity of chromatin organization mediated by CTCF and cohesin. Proc Natl Acad Sci U S A (2010) 3.03
The binding sites for the chromatin insulator protein CTCF map to DNA methylation-free domains genome-wide. Genome Res (2004) 2.78
NestedMICA: sensitive inference of over-represented motifs in nucleic acid sequence. Nucleic Acids Res (2005) 2.58
Does CTCF mediate between nuclear organization and gene expression? Bioessays (2010) 2.02
CTCFBSDB: a CTCF-binding site database for characterization of vertebrate genomic insulators. Nucleic Acids Res (2007) 1.89
RNA-Seq Atlas--a reference database for gene expression profiling in normal tissue by next-generation sequencing. Bioinformatics (2012) 1.74
Widespread site-dependent buffering of human regulatory polymorphism. PLoS Genet (2012) 1.72
Intra- and inter-chromosomal interactions correlate with CTCF binding genome wide. Mol Syst Biol (2010) 1.59
CTCF binding site classes exhibit distinct evolutionary, genomic, epigenomic and transcriptomic features. Genome Biol (2009) 1.38
Genome-wide CTCF distribution in vertebrates defines equivalent sites that aid the identification of disease-associated genes. Nat Struct Mol Biol (2011) 1.31
Draft genome of the wheat A-genome progenitor Triticum urartu. Nature (2013) 2.86
HIV prevalence in China: integration of surveillance data and a systematic review. Lancet Infect Dis (2013) 2.82
Hepatitis C virus infection in former commercial plasma/blood donors in rural Shanxi Province, China: the China Integrated Programs for Research on AIDS. J Infect Dis (2005) 2.47
Marijuana use and the risk of lung and upper aerodigestive tract cancers: results of a population-based case-control study. Cancer Epidemiol Biomarkers Prev (2006) 2.32
HIV and syphilis prevalence among men who have sex with men: a cross-sectional survey of 61 cities in China. Clin Infect Dis (2013) 2.24
Prediction of the phenotypic effects of non-synonymous single nucleotide polymorphisms using structural and evolutionary information. Bioinformatics (2005) 2.21
Overexpression of NGF in mouse urothelium leads to neuronal hyperinnervation, pelvic sensitivity, and changes in urinary bladder function. Am J Physiol Regul Integr Comp Physiol (2009) 2.11
PolymiRTS Database: linking polymorphisms in microRNA target sites with complex traits. Nucleic Acids Res (2006) 1.96
CTCFBSDB: a CTCF-binding site database for characterization of vertebrate genomic insulators. Nucleic Acids Res (2007) 1.89
nsSNPAnalyzer: identifying disease-associated nonsynonymous single nucleotide polymorphisms. Nucleic Acids Res (2005) 1.87
Organization of the Caenorhabditis elegans small non-coding transcriptome: genomic features, biogenesis, and expression. Genome Res (2005) 1.77
PolymiRTS Database 3.0: linking polymorphisms in microRNAs and their target sites with human diseases and biological pathways. Nucleic Acids Res (2013) 1.67
Two-dimensional standing wave total internal reflection fluorescence microscopy: superresolution imaging of single molecular and biological specimens. Biophys J (2007) 1.53
Efficient RNA/Cas9-mediated genome editing in Xenopus tropicalis. Development (2014) 1.53
PolymiRTS Database 2.0: linking polymorphisms in microRNA target sites with human diseases and complex traits. Nucleic Acids Res (2011) 1.49
Inactivation of Wnt inhibitory factor-1 (WIF1) expression by epigenetic silencing is a common event in breast cancer. Carcinogenesis (2006) 1.47
Integrative genetic analysis of transcription modules: towards filling the gap between genetic loci and inherited traits. Hum Mol Genet (2005) 1.46
Inferring gene transcriptional modulatory relations: a genetical genomics approach. Hum Mol Genet (2005) 1.43
Epigenetic silencing of a Ca(2+)-regulated Ras GTPase-activating protein RASAL defines a new mechanism of Ras activation in human cancers. Proc Natl Acad Sci U S A (2007) 1.43
GeneInfoViz: constructing and visualizing gene relation networks. In Silico Biol (2004) 1.35
CMTM3, located at the critical tumor suppressor locus 16q22.1, is silenced by CpG methylation in carcinomas and inhibits tumor cell growth through inducing apoptosis. Cancer Res (2009) 1.27
Mouse gammadelta T cells are capable of expressing MHC class II molecules, and of functioning as antigen-presenting cells. J Neuroimmunol (2008) 1.25
Anti-inflammatory role of IL-17 in experimental autoimmune uveitis. J Immunol (2009) 1.23
Requirement and functional redundancy of Ib subgroup bHLH proteins for iron deficiency responses and uptake in Arabidopsis thaliana. Mol Plant (2012) 1.22
The tumor suppressor Wnt inhibitory factor 1 is frequently methylated in nasopharyngeal and esophageal carcinomas. Lab Invest (2007) 1.19
Lentivirus-mediated gene transfer and expression in established human tumor antigen-specific cytotoxic T cells and primary unstimulated T cells. Hum Gene Ther (2003) 1.09
Rates of HIV, syphilis, and HCV infections among different demographic groups of female sex workers in Guangxi China: evidence from 2010 national sentinel surveillance data. AIDS Care (2013) 1.09
Fungus-mediated green synthesis of silver nanoparticles using Aspergillus terreus. Int J Mol Sci (2011) 1.09
SomamiR: a database for somatic mutations impacting microRNA function in cancer. Nucleic Acids Res (2012) 1.08
Small molecule-capped gold nanoparticles as potent antibacterial agents that target Gram-negative bacteria. J Am Chem Soc (2010) 1.08
RO1138452 and RO3244794: characterization of structurally distinct, potent and selective IP (prostacyclin) receptor antagonists. Br J Pharmacol (2006) 1.08
Wash-out of DMSO does not improve the speed of engraftment of cord blood transplantation: follow-up of 46 adult patients with units shipped from a single cord blood bank. Transfusion (2003) 1.07
Role of inhibition in respiratory pattern generation. J Neurosci (2013) 1.04
Combining gene expression QTL mapping and phenotypic spectrum analysis to uncover gene regulatory relationships. Mamm Genome (2006) 1.04
Surface-enhanced Raman spectroscopy: substrate-related issues. Anal Bioanal Chem (2009) 1.03
Distinct inspiratory rhythm and pattern generating mechanisms in the preBötzinger complex. J Neurosci (2013) 1.03
An integrative genomics strategy for systematic characterization of genetic loci modulating phenotypes. Hum Mol Genet (2007) 1.03
Profiling Caenorhabditis elegans non-coding RNA expression with a combined microarray. Nucleic Acids Res (2006) 1.03
Reactive oxygen species-induced cytotoxic effects of zinc oxide nanoparticles in rat retinal ganglion cells. Toxicol In Vitro (2012) 1.02
Co-overexpression FIT with AtbHLH38 or AtbHLH39 in Arabidopsis-enhanced cadmium tolerance via increased cadmium sequestration in roots and improved iron homeostasis of shoots. Plant Physiol (2011) 1.02
Klotho is silenced through promoter hypermethylation in gastric cancer. Am J Cancer Res (2010) 1.01
Sphingosine 1-phosphate receptor agonist FTY720-phosphate causes marginal zone B cell displacement. J Leukoc Biol (2005) 0.99
[A randomized control trial of mycophenolate mofeil treatment in severe IgA nephropathy]. Zhonghua Yi Xue Za Zhi (2002) 0.99
Ketamine/xylazine attenuates LPS-induced iNOS expression in various rat tissues. J Surg Res (2003) 0.97
FL-CTL assay: fluorolysometric determination of cell-mediated cytotoxicity using green fluorescent protein and red fluorescent protein expressing target cells. J Immunol Methods (2005) 0.97
Lentiviral vectors with CMV or MHCII promoters administered in vivo: immune reactivity versus persistence of expression. Mol Ther (2007) 0.97
Immuno-stimulating properties of diosgenyl saponins isolated from Paris polyphylla. Bioorg Med Chem Lett (2007) 0.96
Resveratrol attenuates ischemia/reperfusion injury in neonatal cardiomyocytes and its underlying mechanism. PLoS One (2012) 0.95
Growth factor expression in a murine model of cryoglobulinemia. Kidney Int (2003) 0.95
The tumor suppressor gene DLEC1 is frequently silenced by DNA methylation in hepatocellular carcinoma and induces G1 arrest in cell cycle. J Hepatol (2007) 0.94
TP53 R249S mutations, exposure to aflatoxin, and occurrence of hepatocellular carcinoma in a cohort of chronic hepatitis B virus carriers from Qidong, China. Cancer Epidemiol Biomarkers Prev (2009) 0.92
CMTM5 exhibits tumor suppressor activities and is frequently silenced by methylation in carcinoma cell lines. Clin Cancer Res (2007) 0.92
MiR-335, an adipogenesis-related microRNA, is involved in adipose tissue inflammation. Cell Biochem Biophys (2014) 0.92
Polymorphisms of tumor-related genes IL-10, PSCA, MTRR and NOC3L are associated with the risk of gastric cancer in the Chinese Han population. Cancer Epidemiol (2012) 0.91
Crystal structures, thermal decompositions and sensitivity properties of [Cu(ethylenediamine)2(nitroformate)2] and [Cd(ethylenediamine)3](nitroformate)2. J Hazard Mater (2008) 0.91
Lung endothelial cell apoptosis during ischemic acute kidney injury. Shock (2012) 0.90
Trp53 negatively regulates autoimmunity via the STAT3-Th17 axis. FASEB J (2011) 0.90
BS69, a specific adaptor in the latent membrane protein 1-mediated c-Jun N-terminal kinase pathway. Mol Cell Biol (2006) 0.90
miRNA biogenesis enzyme Drosha is required for vascular smooth muscle cell survival. PLoS One (2013) 0.89
HIV-related behavioral risk factors among older female sex workers in Guangxi, China. AIDS Care (2014) 0.88
Tanshinone IIA-induced attenuation of lung injury in endotoxemic mice is associated with reduction of hypoxia-inducible factor 1α expression. Am J Respir Cell Mol Biol (2011) 0.88
Oral interferon-alpha treatment of mice with cryoglobulinemic glomerulonephritis. Am J Kidney Dis (2002) 0.88
Clean substrates prepared by chemical adsorption of iodide followed by electrochemical oxidation for surface-enhanced Raman spectroscopic study of cell membrane. Anal Chem (2008) 0.88
Hepatitis C virus infection in China: an emerging public health issue. J Viral Hepat (2014) 0.87
Dietary mineral and trace element intake and squamous cell carcinoma of the esophagus in a Chinese population. Nutr Cancer (2006) 0.86
Genetic ablation or pharmacological blockade of dipeptidyl peptidase IV does not impact T cell-dependent immune responses. BMC Immunol (2009) 0.85
Transcriptional adaptation to Clcn5 knockout in proximal tubules of mouse kidney. Physiol Genomics (2008) 0.85
[Epidemiological characteristics of hepatitis C in China, 1997-2011]. Zhonghua Liu Xing Bing Xue Za Zhi (2013) 0.85
Gastric nitric oxide synthase expression during endotoxemia: implications in mucosal defense in rats. Gastroenterology (2002) 0.85
Functional impacts of non-synonymous single nucleotide polymorphisms: selective constraint and structural environments. FEBS Lett (2006) 0.85
Effects of a rhizobacterium on the growth of and chromium remediation by Lemna minor. Environ Sci Pollut Res Int (2015) 0.84
Bayesian Network Webserver: a comprehensive tool for biological network modeling. Bioinformatics (2013) 0.84
Integrative analysis of somatic mutations altering microRNA targeting in cancer genomes. PLoS One (2012) 0.84
Host genetics and Chlamydia disease: prediction and validation of disease severity mechanisms. PLoS One (2012) 0.84
Systematic analysis of microRNA targeting impacted by small insertions and deletions in human genome. PLoS One (2012) 0.84
Cholecystokinin secretagogue-induced gastroprotection: role of nitric oxide and blood flow. Am J Physiol Gastrointest Liver Physiol (2002) 0.84
Tanshinone IIA reduces lethality and acute lung injury in LPS-treated mice by inhibition of PLA2 activity. Eur J Pharmacol (2009) 0.83
Induction of NF-kappaB, IkappaB-alpha, and iNOS in rat gastric mucosa during endotoxemia. J Surg Res (2002) 0.83
Early clinical evaluation of AcrySof ReSTOR multifocal intraocular lens for treatment of cataract. Ophthalmologica (2007) 0.83
SKB1/PRMT5-mediated histone H4R3 dimethylation of Ib subgroup bHLH genes negatively regulates iron homeostasis in Arabidopsis thaliana. Plant J (2013) 0.83
Retinoic acid derived from the fetal ovary initiates meiosis in mouse germ cells. J Cell Physiol (2013) 0.83
Selective inhibition of the cyanobacterium, Microcystis, by a Streptomyces sp. Biotechnol Lett (2009) 0.83
Long-term outcomes following en bloc resection for sacral tumor: a retrospective analysis of 93 cases. Orthopedics (2011) 0.83
Common single nucleotide polymorphisms and keratoconus in the Han Chinese population. Ophthalmic Genet (2013) 0.82
Stem cell tracking with optically active nanoparticles. Am J Nucl Med Mol Imaging (2013) 0.82
Zinc oxide nanoparticles induce rat retinal ganglion cell damage through bcl-2, caspase-9 and caspase-12 pathways. J Nanosci Nanotechnol (2013) 0.82
Treatment- and population-dependent activity patterns of behavioral and expression QTLs. PLoS One (2012) 0.82
Ulinastatin inhibits unilateral ureteral obstruction-induced renal interstitial fibrosis in rats via transforming growth factor β (TGF-β)/Smad signalling pathways. Int Immunopharmacol (2013) 0.82
Mussel-inspired anchoring for patterning cells using polydopamine. Langmuir (2011) 0.82
Regulation of Son of sevenless by the membrane-actin linker protein ezrin. Proc Natl Acad Sci U S A (2013) 0.82
Mediator subunit 16 functions in the regulation of iron uptake gene expression in Arabidopsis. New Phytol (2014) 0.81
Discrimination of raw and vinegar-processed Genkwa Flos using metabolomics coupled with multivariate data analysis: a discrimination study with metabolomics coupled with PCA. Fitoterapia (2012) 0.81
Combined use of hydroxypropyl-β-cyclodextrin and ionic liquids for the simultaneous enantioseparation of four azole antifungals by CE and a study of the synergistic effect. J Sep Sci (2013) 0.81
Selected polymorphisms of GSTP1 and TERT were associated with glioma risk in Han Chinese. Cancer Epidemiol (2012) 0.81
Heterozygous disruption of renal outer medullary potassium channel in rats is associated with reduced blood pressure. Hypertension (2013) 0.81