Published in Adv Exp Med Biol on January 01, 2013
Discovering new medicines targeting helicases: challenges and recent progress. J Biomol Screen (2013) 0.85
Two steps forward, one step back: determining XPD helicase mechanism by single-molecule fluorescence and high-resolution optical tweezers. DNA Repair (Amst) (2014) 0.83
Checkpoint-dependent and independent roles of the Werner syndrome protein in preserving genome integrity in response to mild replication stress. Nucleic Acids Res (2014) 0.81
Simultaneous binding to the tracking strand, displaced strand and the duplex of a DNA fork enhances unwinding by Dda helicase. Nucleic Acids Res (2014) 0.79
Inflammatory stress and sarcomagenesis: a vicious interplay. Cell Stress Chaperones (2013) 0.77
The Human RecQ4 Helicase Contains a Functional RecQ C-terminal Region (RQC) That Is Essential for Activity. J Biol Chem (2016) 0.77
Reversibly locked thionucleobase pairs in DNA to study base flipping enzymes. Beilstein J Org Chem (2014) 0.76
Application of the microfluidic-assisted replication track analysis to measure DNA repair in human and mouse cells. Methods (2016) 0.75
Positional cloning of the Werner's syndrome gene. Science (1996) 10.98
The Bloom's syndrome gene product is homologous to RecQ helicases. Cell (1995) 9.91
The Bloom's syndrome helicase suppresses crossing over during homologous recombination. Nature (2003) 8.68
Structure and mechanism of helicases and nucleic acid translocases. Annu Rev Biochem (2007) 7.83
The BRCT domain is a phospho-protein binding domain. Science (2003) 7.42
A manyfold increase in sister chromatid exchanges in Bloom's syndrome lymphocytes. Proc Natl Acad Sci U S A (1974) 6.51
Mechanisms of helicase-catalyzed DNA unwinding. Annu Rev Biochem (1996) 5.81
DNA helicases Sgs1 and BLM promote DNA double-strand break resection. Genes Dev (2008) 5.07
BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function. Cell (2001) 5.05
DNA interstrand crosslink repair and cancer. Nat Rev Cancer (2011) 4.29
Replication stress induces sister-chromatid bridging at fragile site loci in mitosis. Nat Cell Biol (2009) 4.15
The BRCA1-interacting helicase BRIP1 is deficient in Fanconi anemia. Nat Genet (2005) 4.13
Translocation and unwinding mechanisms of RNA and DNA helicases. Annu Rev Biophys (2008) 3.86
BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair. Genes Dev (2011) 3.47
BACH1 is critical for homologous recombination and appears to be the Fanconi anemia gene product FANCJ. Cancer Cell (2005) 3.44
XPD helicase structures and activities: insights into the cancer and aging phenotypes from XPD mutations. Cell (2008) 3.14
Non-hexameric DNA helicases and translocases: mechanisms and regulation. Nat Rev Mol Cell Biol (2008) 3.00
FANCJ helicase defective in Fanconia anemia and breast cancer unwinds G-quadruplex DNA to defend genomic stability. Mol Cell Biol (2008) 2.88
Human exonuclease 1 and BLM helicase interact to resect DNA and initiate DNA repair. Proc Natl Acad Sci U S A (2008) 2.70
The DNA repair helicases XPD and FancJ have essential iron-sulfur domains. Mol Cell (2006) 2.61
The Werner syndrome helicase and exonuclease cooperate to resolve telomeric D loops in a manner regulated by TRF1 and TRF2. Mol Cell (2004) 2.60
Rothmund-Thomson syndrome. Orphanet J Rare Dis (2010) 2.49
Shining a light on xeroderma pigmentosum. J Invest Dermatol (2012) 2.33
TWINKLE Has 5' -> 3' DNA helicase activity and is specifically stimulated by mitochondrial single-stranded DNA-binding protein. J Biol Chem (2003) 2.24
Structure of the DNA repair helicase XPD. Cell (2008) 2.16
Basal transcription defect discriminates between xeroderma pigmentosum and trichothiodystrophy in XPD patients. Mol Cell (2003) 2.12
Mechanisms of RecQ helicases in pathways of DNA metabolism and maintenance of genomic stability. Biochem J (2006) 1.99
Interaction between the helicases genetically linked to Fanconi anemia group J and Bloom's syndrome. EMBO J (2011) 1.95
FANCJ is a structure-specific DNA helicase associated with the maintenance of genomic G/C tracts. J Biol Chem (2008) 1.93
Mechanisms of helicases. J Biol Chem (2006) 1.90
DNA-damage repair; the good, the bad, and the ugly. EMBO J (2008) 1.89
Mutant mitochondrial helicase Twinkle causes multiple mtDNA deletions and a late-onset mitochondrial disease in mice. Proc Natl Acad Sci U S A (2005) 1.88
The FANCJ/MutLalpha interaction is required for correction of the cross-link response in FA-J cells. EMBO J (2007) 1.86
Defects in mitochondrial DNA replication and human disease. Crit Rev Biochem Mol Biol (2011) 1.86
A RECQ5-RNA polymerase II association identified by targeted proteomic analysis of human chromatin. Proc Natl Acad Sci U S A (2008) 1.86
Distinct roles for the XPB/p52 and XPD/p44 subcomplexes of TFIIH in damaged DNA opening during nucleotide excision repair. Mol Cell (2007) 1.85
The RecQ DNA helicases in DNA repair. Annu Rev Genet (2010) 1.85
Human premature aging, DNA repair and RecQ helicases. Nucleic Acids Res (2007) 1.84
Roles of Werner syndrome protein in protection of genome integrity. DNA Repair (Amst) (2010) 1.82
Crystal structure of the FeS cluster-containing nucleotide excision repair helicase XPD. PLoS Biol (2008) 1.81
Chl1p, a DNA helicase-like protein in budding yeast, functions in sister-chromatid cohesion. Genetics (2004) 1.76
The spectrum of WRN mutations in Werner syndrome patients. Hum Mutat (2006) 1.75
The DNA helicase activity of BLM is necessary for the correction of the genomic instability of bloom syndrome cells. Mol Biol Cell (1999) 1.73
DNA charge transport as a first step in coordinating the detection of lesions by repair proteins. Proc Natl Acad Sci U S A (2012) 1.71
Structure, function and evolution of the XPD family of iron-sulfur-containing 5'-->3' DNA helicases. Biochem Soc Trans (2009) 1.69
Expression of catalytic mutants of the mtDNA helicase Twinkle and polymerase POLG causes distinct replication stalling phenotypes. Nucleic Acids Res (2007) 1.69
The Fanconi anaemia pathway orchestrates incisions at sites of crosslinked DNA. J Pathol (2011) 1.68
The iron-containing domain is essential in Rad3 helicases for coupling of ATP hydrolysis to DNA translocation and for targeting the helicase to the single-stranded DNA-double-stranded DNA junction. J Biol Chem (2007) 1.66
Welcome the family of FANCJ-like helicases to the block of genome stability maintenance proteins. Cell Mol Life Sci (2009) 1.54
RECQL, a member of the RecQ family of DNA helicases, suppresses chromosomal instability. Mol Cell Biol (2006) 1.54
DNA damage response and transcription. DNA Repair (Amst) (2011) 1.54
A history of TFIIH: two decades of molecular biology on a pivotal transcription/repair factor. DNA Repair (Amst) (2011) 1.52
WRN mutations in Werner syndrome patients: genomic rearrangements, unusual intronic mutations and ethnic-specific alterations. Hum Genet (2010) 1.50
Human RECQ1 and RECQ4 helicases play distinct roles in DNA replication initiation. Mol Cell Biol (2010) 1.50
Revisiting the craniosynostosis-radial ray hypoplasia association: Baller-Gerold syndrome caused by mutations in the RECQL4 gene. J Med Genet (2005) 1.46
Iron-sulphur clusters in nucleic acid processing enzymes. Curr Opin Struct Biol (2011) 1.46
Inhibition of helicase activity by a small molecule impairs Werner syndrome helicase (WRN) function in the cellular response to DNA damage or replication stress. Proc Natl Acad Sci U S A (2011) 1.45
Human RECQ helicases: roles in DNA metabolism, mutagenesis and cancer biology. Semin Cancer Biol (2010) 1.44
Syndrome-causing mutations of the BLM gene in persons in the Bloom's Syndrome Registry. Hum Mutat (2007) 1.44
Warsaw breakage syndrome, a cohesinopathy associated with mutations in the XPD helicase family member DDX11/ChlR1. Am J Hum Genet (2010) 1.42
The DNA helicase ChlR1 is required for sister chromatid cohesion in mammalian cells. J Cell Sci (2006) 1.42
A mutation in the XPB/ERCC3 DNA repair transcription gene, associated with trichothiodystrophy. Am J Hum Genet (1997) 1.40
Characterization of the enzymatic activity of hChlR1, a novel human DNA helicase. Nucleic Acids Res (2000) 1.38
Human RECQ1 is a DNA damage responsive protein required for genotoxic stress resistance and suppression of sister chromatid exchanges. PLoS One (2007) 1.38
Biological contexts for DNA charge transport chemistry. Curr Opin Chem Biol (2008) 1.37
Functional interaction of p53 and BLM DNA helicase in apoptosis. J Biol Chem (2001) 1.37
Phenotypic heterogeneity in the XPB DNA helicase gene (ERCC3): xeroderma pigmentosum without and with Cockayne syndrome. Hum Mutat (2006) 1.31
Redox signaling between DNA repair proteins for efficient lesion detection. Proc Natl Acad Sci U S A (2009) 1.30
Functional and structural studies of the nucleotide excision repair helicase XPD suggest a polarity for DNA translocation. EMBO J (2011) 1.28
Loss of ChlR1 helicase in mouse causes lethality due to the accumulation of aneuploid cells generated by cohesion defects and placental malformation. Cell Cycle (2007) 1.25
Studies with the human cohesin establishment factor, ChlR1. Association of ChlR1 with Ctf18-RFC and Fen1. J Biol Chem (2008) 1.24
Twinkle mutations associated with autosomal dominant progressive external ophthalmoplegia lead to impaired helicase function and in vivo mtDNA replication stalling. Hum Mol Genet (2008) 1.23
WRN, the protein deficient in Werner syndrome, plays a critical structural role in optimizing DNA repair. Aging Cell (2003) 1.23
DNA helicase and helicase-nuclease enzymes with a conserved iron-sulfur cluster. Nucleic Acids Res (2012) 1.20
Cerebro-oculo-facio-skeletal syndrome with a nucleotide excision-repair defect and a mutated XPD gene, with prenatal diagnosis in a triplet pregnancy. Am J Hum Genet (2001) 1.20
Biochemical characterization of Warsaw breakage syndrome helicase. J Biol Chem (2011) 1.19
The involvement of human RECQL4 in DNA double-strand break repair. Aging Cell (2010) 1.15
RECQL4 is essential for the transport of p53 to mitochondria in normal human cells in the absence of exogenous stress. J Cell Sci (2012) 1.15
Hereditary breast cancer and the BRCA1-associated FANCJ/BACH1/BRIP1. Future Oncol (2011) 1.11
Targeting the FANCJ-BRCA1 interaction promotes a switch from recombination to poleta-dependent bypass. Oncogene (2010) 1.10
RECQ5 helicase associates with the C-terminal repeat domain of RNA polymerase II during productive elongation phase of transcription. Nucleic Acids Res (2010) 1.08
RecQ helicases in DNA double strand break repair and telomere maintenance. Mutat Res (2011) 1.08
Werner syndrome and mutations of the WRN and LMNA genes in France. Hum Mutat (2006) 1.07
The Werner syndrome protein has separable recombination and survival functions. DNA Repair (Amst) (2004) 1.05
RECQL4, the protein mutated in Rothmund-Thomson syndrome, functions in telomere maintenance. J Biol Chem (2011) 1.04
Diverged nuclear localization of Werner helicase in human and mouse cells. Oncogene (2001) 1.04
Regulation of translocation polarity by helicase domain 1 in SF2B helicases. EMBO J (2011) 1.04
Fanconi anemia group J mutation abolishes its DNA repair function by uncoupling DNA translocation from helicase activity or disruption of protein-DNA complexes. Blood (2010) 1.02
Rescue of replication failure by Fanconi anaemia proteins. Chromosoma (2011) 1.02
Structural and functional characterizations reveal the importance of a zinc binding domain in Bloom's syndrome helicase. Nucleic Acids Res (2005) 1.02
Superfamily I helicases as modular components of DNA-processing machines. Biochem Soc Trans (2011) 1.02
Structural and functional analyses of disease-causing missense mutations in Bloom syndrome protein. Nucleic Acids Res (2007) 1.01
BLM has early and late functions in homologous recombination repair in mouse embryonic stem cells. Oncogene (2010) 1.01
Disease variants of the human mitochondrial DNA helicase encoded by C10orf2 differentially alter protein stability, nucleotide hydrolysis, and helicase activity. J Biol Chem (2010) 1.00
Fanconi anemia and Bloom's syndrome crosstalk through FANCJ-BLM helicase interaction. Trends Genet (2011) 1.00
The long unwinding road: XPB and XPD helicases in damaged DNA opening. Cell Cycle (2010) 0.99
Point mutations causing Bloom's syndrome abolish ATPase and DNA helicase activities of the BLM protein. Oncogene (1998) 0.99
RECQL4 localizes to mitochondria and preserves mitochondrial DNA integrity. Aging Cell (2012) 0.99
Human mitochondrial DNA helicase TWINKLE is both an unwinding and annealing helicase. J Biol Chem (2012) 0.99
RECQL5 cooperates with Topoisomerase II alpha in DNA decatenation and cell cycle progression. Nucleic Acids Res (2011) 0.98
FANCJ helicase defective in Fanconia anemia and breast cancer unwinds G-quadruplex DNA to defend genomic stability. Mol Cell Biol (2008) 2.88
Biochemical analysis of the DNA unwinding and strand annealing activities catalyzed by human RECQ1. J Biol Chem (2005) 2.11
Mechanisms of RecQ helicases in pathways of DNA metabolism and maintenance of genomic stability. Biochem J (2006) 1.99
Interaction between the helicases genetically linked to Fanconi anemia group J and Bloom's syndrome. EMBO J (2011) 1.95
The FANCJ/MutLalpha interaction is required for correction of the cross-link response in FA-J cells. EMBO J (2007) 1.86
Analysis of the DNA substrate specificity of the human BACH1 helicase associated with breast cancer. J Biol Chem (2005) 1.67
WRN helicase and FEN-1 form a complex upon replication arrest and together process branchmigrating DNA structures associated with the replication fork. Mol Biol Cell (2003) 1.61
Analysis of the unwinding activity of the dimeric RECQ1 helicase in the presence of human replication protein A. Nucleic Acids Res (2004) 1.60
G-quadruplex nucleic acids and human disease. FEBS J (2010) 1.58
Werner protein is a target of DNA-dependent protein kinase in vivo and in vitro, and its catalytic activities are regulated by phosphorylation. J Biol Chem (2002) 1.56
RECQL, a member of the RecQ family of DNA helicases, suppresses chromosomal instability. Mol Cell Biol (2006) 1.54
Detection of G-quadruplex DNA in mammalian cells. Nucleic Acids Res (2013) 1.53
Physical and functional mapping of the replication protein a interaction domain of the werner and bloom syndrome helicases. J Biol Chem (2005) 1.52
Inhibition of helicase activity by a small molecule impairs Werner syndrome helicase (WRN) function in the cellular response to DNA damage or replication stress. Proc Natl Acad Sci U S A (2011) 1.45
FANCJ uses its motor ATPase to destabilize protein-DNA complexes, unwind triplexes, and inhibit RAD51 strand exchange. J Biol Chem (2009) 1.43
Colocalization, physical, and functional interaction between Werner and Bloom syndrome proteins. J Biol Chem (2002) 1.39
Stimulation of flap endonuclease-1 by the Bloom's syndrome protein. J Biol Chem (2003) 1.39
Human RECQ1 is a DNA damage responsive protein required for genotoxic stress resistance and suppression of sister chromatid exchanges. PLoS One (2007) 1.38
RECQ1 helicase interacts with human mismatch repair factors that regulate genetic recombination. J Biol Chem (2005) 1.36
The transcriptional response after oxidative stress is defective in Cockayne syndrome group B cells. Oncogene (2003) 1.30
The processing of Holliday junctions by BLM and WRN helicases is regulated by p53. J Biol Chem (2002) 1.22
In vivo function of the conserved non-catalytic domain of Werner syndrome helicase in DNA replication. Hum Mol Genet (2004) 1.21
DNA helicase and helicase-nuclease enzymes with a conserved iron-sulfur cluster. Nucleic Acids Res (2012) 1.20
RECQ1 possesses DNA branch migration activity. J Biol Chem (2008) 1.19
Biochemical characterization of Warsaw breakage syndrome helicase. J Biol Chem (2011) 1.19
Differential requirement for the ATPase domain of the Cockayne syndrome group B gene in the processing of UV-induced DNA damage and 8-oxoguanine lesions in human cells. Nucleic Acids Res (2002) 1.16
Inhibition of BACH1 (FANCJ) helicase by backbone discontinuity is overcome by increased motor ATPase or length of loading strand. Nucleic Acids Res (2006) 1.15
Biochemical and kinetic characterization of the DNA helicase and exonuclease activities of werner syndrome protein. J Biol Chem (2004) 1.14
The exonucleolytic and endonucleolytic cleavage activities of human exonuclease 1 are stimulated by an interaction with the carboxyl-terminal region of the Werner syndrome protein. J Biol Chem (2003) 1.09
Unique and important consequences of RECQ1 deficiency in mammalian cells. Cell Cycle (2008) 1.09
The interaction site of Flap Endonuclease-1 with WRN helicase suggests a coordination of WRN and PCNA. Nucleic Acids Res (2005) 1.08
Functional consequences of mutations in the conserved SF2 motifs and post-translational phosphorylation of the CSB protein. Nucleic Acids Res (2003) 1.07
p53 modulates RPA-dependent and RPA-independent WRN helicase activity. Cancer Res (2005) 1.06
Phenotypic consequences of mutations in the conserved motifs of the putative helicase domain of the human Cockayne syndrome group B gene. Gene (2002) 1.06
Modulation of Werner syndrome protein function by a single mutation in the conserved RecQ domain. J Biol Chem (2005) 1.05
Distinct roles of RECQ1 in the maintenance of genomic stability. DNA Repair (Amst) (2010) 1.05
FANCJ helicase uniquely senses oxidative base damage in either strand of duplex DNA and is stimulated by replication protein A to unwind the damaged DNA substrate in a strand-specific manner. J Biol Chem (2009) 1.04
Cockayne syndrome group B protein has novel strand annealing and exchange activities. Nucleic Acids Res (2006) 1.04
Fanconi anemia group J mutation abolishes its DNA repair function by uncoupling DNA translocation from helicase activity or disruption of protein-DNA complexes. Blood (2010) 1.02
FANCJ helicase operates in the Fanconi Anemia DNA repair pathway and the response to replicational stress. Curr Mol Med (2009) 1.00
Fanconi anemia and Bloom's syndrome crosstalk through FANCJ-BLM helicase interaction. Trends Genet (2011) 1.00
BRCA-FA pathway as a target for anti-tumor drugs. Anticancer Agents Med Chem (2008) 1.00
Global genome repair of 8-oxoG in hamster cells requires a functional CSB gene product. Oncogene (2002) 1.00
DNA helicases as targets for anti-cancer drugs. Curr Med Chem Anticancer Agents (2005) 1.00
Specialization among iron-sulfur cluster helicases to resolve G-quadruplex DNA structures that threaten genomic stability. J Biol Chem (2013) 0.99
Hitting the bull's eye: novel directed cancer therapy through helicase-targeted synthetic lethality. J Cell Biochem (2009) 0.97
Disease-causing missense mutations in human DNA helicase disorders. Mutat Res (2012) 0.95
Mechanism of DNA resection during intrachromosomal recombination and immunoglobulin class switching. J Exp Med (2012) 0.95
Molecular functions and cellular roles of the ChlR1 (DDX11) helicase defective in the rare cohesinopathy Warsaw breakage syndrome. Cell Mol Life Sci (2014) 0.95
Fanconi anemia group J helicase and MRE11 nuclease interact to facilitate the DNA damage response. Mol Cell Biol (2013) 0.93
WRN helicase defective in the premature aging disorder Werner syndrome genetically interacts with topoisomerase 3 and restores the top3 slow growth phenotype of sgs1 top3. Aging (Albany NY) (2009) 0.92
Human RECQ1 interacts with Ku70/80 and modulates DNA end-joining of double-strand breaks. PLoS One (2013) 0.92
RECQ1 is required for cellular resistance to replication stress and catalyzes strand exchange on stalled replication fork structures. Cell Cycle (2012) 0.91
Identification and biochemical characterization of a novel mutation in DDX11 causing Warsaw breakage syndrome. Hum Mutat (2012) 0.90
Human replication protein A melts a DNA triple helix structure in a potent and specific manner. Biochemistry (2008) 0.89
Impact papers on aging in 2009. Aging (Albany NY) (2010) 0.89
Helicases as prospective targets for anti-cancer therapy. Anticancer Agents Med Chem (2008) 0.88
Targeting an Achilles' heel of cancer with a WRN helicase inhibitor. Cell Cycle (2013) 0.87
DNA repair helicases as targets for anti-cancer therapy. Curr Med Chem (2007) 0.86
Helicase-inactivating mutations as a basis for dominant negative phenotypes. Cell Cycle (2010) 0.86
Mechanistic and biological aspects of helicase action on damaged DNA. Cell Cycle (2010) 0.86
Werner syndrome helicase has a critical role in DNA damage responses in the absence of a functional fanconi anemia pathway. Cancer Res (2013) 0.86
The Q motif of Fanconi anemia group J protein (FANCJ) DNA helicase regulates its dimerization, DNA binding, and DNA repair function. J Biol Chem (2012) 0.86
Inhibition of Werner syndrome helicase activity by benzo[a]pyrene diol epoxide adducts can be overcome by replication protein A. J Biol Chem (2005) 0.85
FANCJ/BACH1 acetylation at lysine 1249 regulates the DNA damage response. PLoS Genet (2012) 0.84
Tetraplex binding molecules as anti-cancer agents. Recent Pat Anticancer Drug Discov (2006) 0.82
Processing of DNA replication and repair intermediates by the concerted action of RecQ helicases and Rad2 structure-specific nucleases. Protein Pept Lett (2008) 0.82
Delineation of WRN helicase function with EXO1 in the replicational stress response. DNA Repair (Amst) (2010) 0.82
Pathways defective in the human premature aging disease Werner syndrome. Biogerontology (2002) 0.81
Put on your thinking cap: G-quadruplexes, helicases, and telomeres. Aging (Albany NY) (2011) 0.80
DNA repair and replication fork helicases are differentially affected by alkyl phosphotriester lesion. J Biol Chem (2012) 0.79
Inhibition of Werner syndrome helicase activity by benzo[c]phenanthrene diol epoxide dA adducts in DNA is both strand-and stereoisomer-dependent. J Biol Chem (2003) 0.79
What is wrong with Fanconi anemia cells? Cell Cycle (2014) 0.79
A new development in DNA repair modulation: discovery of a BLM helicase inhibitor. Cell Cycle (2013) 0.78
Molecular biology: The Bloom's complex mousetrap. Nature (2008) 0.78
DNA repair as a target for anti-cancer therapy. Anticancer Agents Med Chem (2008) 0.77
Molecular analyses of DNA helicases involved in the replicational stress response. Methods (2010) 0.77
Genetic mutants illuminate the roles of RecQ helicases in recombinational repair or response to replicational stress. Cell Cycle (2010) 0.76
Premature aging syndrome gene WRN genetically interacts with a topoisomerase. Cell Cycle (2009) 0.76
Functional analyses of human DNA repair proteins important for aging and genomic stability using yeast genetics. DNA Repair (Amst) (2012) 0.75
Setting the stage for cohesion establishment by the replication fork. Cell Cycle (2012) 0.75
Finding a needle in the haystack: recognition of DNA damage by collaboration between DNA repair proteins able to perform DNA charge transport. Cell Cycle (2012) 0.75
Genetic studies of human DNA repair proteins using yeast as a model system. J Vis Exp (2010) 0.75