Published in Stem Cells on April 01, 2010
Induced pluripotency: history, mechanisms, and applications. Genes Dev (2010) 4.89
Progress in understanding reprogramming to the induced pluripotent state. Nat Rev Genet (2011) 2.81
Applications of next-generation sequencing technologies to diagnostic virology. Int J Mol Sci (2011) 1.64
Lentivirus-mediated reprogramming of somatic cells in the absence of transgenic transcription factors. Mol Ther (2010) 1.13
Stem cell gene therapy: the risks of insertional mutagenesis and approaches to minimize genotoxicity. Front Med (2011) 1.05
High-efficiency transduction of rhesus hematopoietic repopulating cells by a modified HIV1-based lentiviral vector. Mol Ther (2012) 0.98
Mechanistic insights into reprogramming to induced pluripotency. J Cell Physiol (2011) 0.92
Assessing the risks of genotoxicity in the therapeutic development of induced pluripotent stem cells. Mol Ther (2012) 0.90
Modified lentiviral LTRs allow Flp recombinase-mediated cassette exchange and in vivo tracing of "factor-free" induced pluripotent stem cells. Mol Ther (2014) 0.89
Quantitative shearing linear amplification polymerase chain reaction: an improved method for quantifying lentiviral vector insertion sites in transplanted hematopoietic cell systems. Hum Gene Ther Methods (2015) 0.85
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Generation of integration-free induced hepatocyte-like cells from mouse fibroblasts. Sci Rep (2015) 0.78
Lack of genotoxicity due to foamy virus vector integration in human iPSCs. Gene Ther (2013) 0.78
Significant differences in genotoxicity induced by retrovirus integration in human T cells and induced pluripotent stem cells. Gene (2013) 0.77
Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell (2006) 120.51
Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell (2007) 101.42
Induced pluripotent stem cell lines derived from human somatic cells. Science (2007) 71.50
Reprogramming of human somatic cells to pluripotency with defined factors. Nature (2007) 30.84
LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1. Science (2003) 19.77
Human induced pluripotent stem cells free of vector and transgene sequences. Science (2009) 17.16
Disease-specific induced pluripotent stem cells. Cell (2008) 16.95
Generation of mouse induced pluripotent stem cells without viral vectors. Science (2008) 15.25
Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons. Science (2008) 14.26
Induced pluripotent stem cells generated without viral integration. Science (2008) 13.38
HIV-1 integration in the human genome favors active genes and local hotspots. Cell (2002) 12.60
Induced pluripotent stem cells from a spinal muscular atrophy patient. Nature (2008) 12.21
Generation of induced pluripotent stem cells using recombinant proteins. Cell Stem Cell (2009) 11.65
Generation of pluripotent stem cells from adult mouse liver and stomach cells. Science (2008) 10.55
Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1. Nat Med (2006) 9.68
Retroviral DNA integration: ASLV, HIV, and MLV show distinct target site preferences. PLoS Biol (2004) 8.27
Functional cardiomyocytes derived from human induced pluripotent stem cells. Circ Res (2009) 7.09
Pluripotent stem cells induced from adult neural stem cells by reprogramming with two factors. Nature (2008) 7.07
Hematopoietic stem cell gene transfer in a tumor-prone mouse model uncovers low genotoxicity of lentiviral vector integration. Nat Biotechnol (2006) 5.58
Epigenetic reprogramming and induced pluripotency. Development (2009) 4.90
Reprogramming of murine and human somatic cells using a single polycistronic vector. Proc Natl Acad Sci U S A (2008) 4.48
Human-induced pluripotent stem cells from blood cells of healthy donors and patients with acquired blood disorders. Blood (2009) 4.22
Genome-wide analysis of retroviral DNA integration. Nat Rev Microbiol (2005) 3.98
High-resolution insertion-site analysis by linear amplification-mediated PCR (LAM-PCR). Nat Methods (2007) 3.90
Murine leukemia induced by retroviral gene marking. Science (2002) 3.59
Clonal dominance of hematopoietic stem cells triggered by retroviral gene marking. Science (2005) 3.58
Distinct genomic integration of MLV and SIV vectors in primate hematopoietic stem and progenitor cells. PLoS Biol (2004) 3.48
The genotoxic potential of retroviral vectors is strongly modulated by vector design and integration site selection in a mouse model of HSC gene therapy. J Clin Invest (2009) 3.34
Generation of induced pluripotent stem cells from adult rhesus monkey fibroblasts. Cell Stem Cell (2008) 3.15
Stoichiometric and temporal requirements of Oct4, Sox2, Klf4, and c-Myc expression for efficient human iPSC induction and differentiation. Proc Natl Acad Sci U S A (2009) 2.86
Hot spots of retroviral integration in human CD34+ hematopoietic cells. Blood (2007) 2.79
Generation of induced pluripotent stem cells from human cord blood. Cell Stem Cell (2009) 2.78
DNA bar coding and pyrosequencing to analyze adverse events in therapeutic gene transfer. Nucleic Acids Res (2008) 2.64
High-level sustained transgene expression in human embryonic stem cells using lentiviral vectors. Stem Cells (2003) 2.42
Genotoxicity of retroviral integration in hematopoietic cells. Mol Ther (2006) 2.34
Recurrent retroviral vector integration at the Mds1/Evi1 locus in nonhuman primate hematopoietic cells. Blood (2005) 2.27
Comprehensive genomic access to vector integration in clinical gene therapy. Nat Med (2009) 2.19
Analysis of lentiviral vector integration in HIV+ study subjects receiving autologous infusions of gene modified CD4+ T cells. Mol Ther (2009) 1.97
Globin lentiviral vector insertions can perturb the expression of endogenous genes in beta-thalassemic hematopoietic cells. Mol Ther (2008) 1.78
Acute myeloid leukemia is associated with retroviral gene transfer to hematopoietic progenitor cells in a rhesus macaque. Blood (2006) 1.78
Retroviral vector silencing during iPS cell induction: an epigenetic beacon that signals distinct pluripotent states. J Cell Biochem (2008) 1.71
Retroviral DNA integration: HIV and the role of LEDGF/p75. Trends Genet (2006) 1.62
Does retroviral insertional mutagenesis play a role in the generation of induced pluripotent stem cells? Mol Ther (2008) 1.47
Fibroblast-derived induced pluripotent stem cells show no common retroviral vector insertions. Stem Cells (2009) 1.41
Murine leukemia virus vector integration favors promoter regions and regional hot spots in a human T-cell line. Biochem Biophys Res Commun (2006) 1.05
Induced pluripotent stem cell lines derived from human somatic cells. Science (2007) 71.50
Human DNA methylomes at base resolution show widespread epigenomic differences. Nature (2009) 34.27
Histone modifications at human enhancers reflect global cell-type-specific gene expression. Nature (2009) 24.41
Human induced pluripotent stem cells free of vector and transgene sequences. Science (2009) 17.16
The NIH Roadmap Epigenomics Mapping Consortium. Nat Biotechnol (2010) 13.99
Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells. Nature (2011) 13.94
ProbeMatch: rapid alignment of oligonucleotides to genome allowing both gaps and mismatches. Bioinformatics (2009) 13.34
Induced pluripotent stem cells from a spinal muscular atrophy patient. Nature (2008) 12.21
RNA-Seq gene expression estimation with read mapping uncertainty. Bioinformatics (2009) 10.74
Somatic coding mutations in human induced pluripotent stem cells. Nature (2011) 9.50
Recurrent gain of chromosomes 17q and 12 in cultured human embryonic stem cells. Nat Biotechnol (2003) 9.15
Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation. Nat Med (2003) 8.95
Distinct epigenomic landscapes of pluripotent and lineage-committed human cells. Cell Stem Cell (2010) 8.74
Whole-genome analysis of histone H3 lysine 4 and lysine 27 methylation in human embryonic stem cells. Cell Stem Cell (2007) 8.59
Derivation of human embryonic stem cells in defined conditions. Nat Biotechnol (2006) 8.28
MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells. Cell (2009) 8.14
A diversity profile of the human skin microbiota. Genome Res (2008) 7.65
Feeder-independent culture of human embryonic stem cells. Nat Methods (2006) 7.61
Neural differentiation of human induced pluripotent stem cells follows developmental principles but with variable potency. Proc Natl Acad Sci U S A (2010) 7.31
Functional cardiomyocytes derived from human induced pluripotent stem cells. Circ Res (2009) 7.09
Basic FGF and suppression of BMP signaling sustain undifferentiated proliferation of human ES cells. Nat Methods (2005) 6.37
DNase-chip: a high-resolution method to identify DNase I hypersensitive sites using tiled microarrays. Nat Methods (2006) 6.25
BMP4 initiates human embryonic stem cell differentiation to trophoblast. Nat Biotechnol (2002) 6.20
Chemically defined conditions for human iPSC derivation and culture. Nat Methods (2011) 5.84
Homologous recombination in human embryonic stem cells. Nat Biotechnol (2003) 5.77
Genome-wide mapping of DNase hypersensitive sites using massively parallel signature sequencing (MPSS). Genome Res (2005) 5.71
Human embryonic stem cells develop into multiple types of cardiac myocytes: action potential characterization. Circ Res (2003) 5.12
NANOG is a direct target of TGFbeta/activin-mediated SMAD signaling in human ESCs. Cell Stem Cell (2008) 4.88
Short interfering RNAs can induce unexpected and divergent changes in the levels of untargeted proteins in mammalian cells. Proc Natl Acad Sci U S A (2004) 4.85
EBSeq: an empirical Bayes hierarchical model for inference in RNA-seq experiments. Bioinformatics (2013) 4.79
Gene expression patterns in human embryonic stem cells and human pluripotent germ cell tumors. Proc Natl Acad Sci U S A (2003) 4.67
Human embryonic stem cell-derived CD34+ cells: efficient production in the coculture with OP9 stromal cells and analysis of lymphohematopoietic potential. Blood (2004) 4.32
The genome of the ctenophore Mnemiopsis leidyi and its implications for cell type evolution. Science (2013) 4.07
Eltrombopag and improved hematopoiesis in refractory aplastic anemia. N Engl J Med (2012) 3.93
Epigenomic analysis of multilineage differentiation of human embryonic stem cells. Cell (2013) 3.81
MRI detection of single particles for cellular imaging. Proc Natl Acad Sci U S A (2004) 3.67
Nanog and transcriptional networks in embryonic stem cell pluripotency. Cell Res (2007) 3.56
Efficient genome engineering in human pluripotent stem cells using Cas9 from Neisseria meningitidis. Proc Natl Acad Sci U S A (2013) 3.53
Distinct genomic integration of MLV and SIV vectors in primate hematopoietic stem and progenitor cells. PLoS Biol (2004) 3.48
Identifying gene regulatory elements by genome-wide recovery of DNase hypersensitive sites. Proc Natl Acad Sci U S A (2004) 3.41
Directed differentiation of dopaminergic neuronal subtypes from human embryonic stem cells. Stem Cells (2005) 3.38
Cell type-specific DNA methylation patterns in the human breast. Proc Natl Acad Sci U S A (2008) 2.99
Extracellular matrix promotes highly efficient cardiac differentiation of human pluripotent stem cells: the matrix sandwich method. Circ Res (2012) 2.91
Deoxymyoglobin is a nitrite reductase that generates nitric oxide and regulates mitochondrial respiration. Circ Res (2007) 2.91
Basic fibroblast growth factor support of human embryonic stem cell self-renewal. Stem Cells (2005) 2.78
Serial cardiac magnetic resonance imaging of injected mesenchymal stem cells. Circulation (2003) 2.75
Actin-myosin contractility is responsible for the reduced viability of dissociated human embryonic stem cells. Cell Stem Cell (2010) 2.69
Caspase activity mediates the differentiation of embryonic stem cells. Cell Stem Cell (2008) 2.68
Leukosialin (CD43) defines hematopoietic progenitors in human embryonic stem cell differentiation cultures. Blood (2006) 2.66
High purity human-induced pluripotent stem cell-derived cardiomyocytes: electrophysiological properties of action potentials and ionic currents. Am J Physiol Heart Circ Physiol (2011) 2.65
A mesoderm-derived precursor for mesenchymal stem and endothelial cells. Cell Stem Cell (2010) 2.58
Polyclonal long-term repopulating stem cell clones in a primate model. Blood (2002) 2.53
Surface antigens of human embryonic stem cells: changes upon differentiation in culture. J Anat (2002) 2.52
Highly efficient endosomal labeling of progenitor and stem cells with large magnetic particles allows magnetic resonance imaging of single cells. Blood (2003) 2.50
High-level sustained transgene expression in human embryonic stem cells using lentiviral vectors. Stem Cells (2003) 2.42
Genetic correction and analysis of induced pluripotent stem cells from a patient with gyrate atrophy. Proc Natl Acad Sci U S A (2011) 2.41
Proteomic and phosphoproteomic comparison of human ES and iPS cells. Nat Methods (2011) 2.39
Genotoxicity of retroviral integration in hematopoietic cells. Mol Ther (2006) 2.34
A multicenter study of glucocerebrosidase mutations in dementia with Lewy bodies. JAMA Neurol (2013) 2.32
Mass spectrometry identifies and quantifies 74 unique histone H4 isoforms in differentiating human embryonic stem cells. Proc Natl Acad Sci U S A (2008) 2.29
Recurrent retroviral vector integration at the Mds1/Evi1 locus in nonhuman primate hematopoietic cells. Blood (2005) 2.27
Optic vesicle-like structures derived from human pluripotent stem cells facilitate a customized approach to retinal disease treatment. Stem Cells (2011) 2.26
Pluripotent stem cell lines. Genes Dev (2008) 2.25
Ronin is essential for embryogenesis and the pluripotency of mouse embryonic stem cells. Cell (2008) 2.21
Trophoblast differentiation in embryoid bodies derived from human embryonic stem cells. Endocrinology (2003) 2.15
FGF2 sustains NANOG and switches the outcome of BMP4-induced human embryonic stem cell differentiation. Cell Stem Cell (2011) 2.11
A germ cell origin of embryonic stem cells? Development (2005) 2.09
Defined substrates for human embryonic stem cell growth identified from surface arrays. ACS Chem Biol (2007) 2.08
N-terminal pro-brain natriuretic peptide levels and risk of death in sickle cell disease. JAMA (2006) 2.04
Imatinib inhibits T-cell receptor-mediated T-cell proliferation and activation in a dose-dependent manner. Blood (2004) 2.01
Quantitative selection of DNA aptamers through microfluidic selection and high-throughput sequencing. Proc Natl Acad Sci U S A (2010) 2.01
Efficient gene transfer into rhesus repopulating hematopoietic stem cells using a simian immunodeficiency virus-based lentiviral vector system. Blood (2004) 1.99
Eltrombopag restores trilineage hematopoiesis in refractory severe aplastic anemia that can be sustained on discontinuation of drug. Blood (2013) 1.97
Human embryonic stem cell phosphoproteome revealed by electron transfer dissociation tandem mass spectrometry. Proc Natl Acad Sci U S A (2009) 1.95
Rabbit ATG but not horse ATG promotes expansion of functional CD4+CD25highFOXP3+ regulatory T cells in vitro. Blood (2008) 1.95
Efficient generation of transgene-free induced pluripotent stem cells from normal and neoplastic bone marrow and cord blood mononuclear cells. Blood (2011) 1.92
AMD3100 mobilizes hematopoietic stem cells with long-term repopulating capacity in nonhuman primates. Blood (2006) 1.79
Acute myeloid leukemia is associated with retroviral gene transfer to hematopoietic progenitor cells in a rhesus macaque. Blood (2006) 1.78
Passaging and colony expansion of human pluripotent stem cells by enzyme-free dissociation in chemically defined culture conditions. Nat Protoc (2012) 1.74
Dynamic chromatin states in human ES cells reveal potential regulatory sequences and genes involved in pluripotency. Cell Res (2011) 1.72
Intercellular transfer to signalling endosomes regulates an ex vivo bone marrow niche. Nat Cell Biol (2009) 1.61
Identification of neural crest and glial enhancers at the mouse Sox10 locus through transgenesis in zebrafish. PLoS Genet (2008) 1.60
Outcomes and risks of granulocyte colony-stimulating factor in patients with coronary artery disease. J Am Coll Cardiol (2005) 1.58
Crystallographic identification of a noncompetitive inhibitor binding site on the hepatitis C virus NS5B RNA polymerase enzyme. J Virol (2003) 1.57
Clinical genomic database. Proc Natl Acad Sci U S A (2013) 1.54
Conserved regulation of MAP kinase expression by PUF RNA-binding proteins. PLoS Genet (2007) 1.51
The NOD2-RICK complex signals from the plasma membrane. J Biol Chem (2007) 1.50
A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome Res (2013) 1.48
A study of the relationships between oligonucleotide properties and hybridization signal intensities from NimbleGen microarray datasets. Nucleic Acids Res (2008) 1.47
Identification of the hemogenic endothelial progenitor and its direct precursor in human pluripotent stem cell differentiation cultures. Cell Rep (2012) 1.46
The microwell control of embryoid body size in order to regulate cardiac differentiation of human embryonic stem cells. Biomaterials (2009) 1.46
Evaluation of de novo transcriptome assemblies from RNA-Seq data. Genome Biol (2014) 1.46
MicroRNA 92b controls the G1/S checkpoint gene p57 in human embryonic stem cells. Stem Cells (2009) 1.43
PGC-1alpha integrates insulin signaling, mitochondrial regulation, and bioenergetic function in skeletal muscle. J Biol Chem (2008) 1.43