Published in Nat Cell Biol on March 01, 2010
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Formin follows function: a muscle-specific isoform of FHOD3 is regulated by CK2 phosphorylation and promotes myofibril maintenance. J Cell Biol (2010) 1.24
Vps34 deficiency reveals the importance of endocytosis for podocyte homeostasis. J Am Soc Nephrol (2013) 1.09
MAPK15/ERK8 stimulates autophagy by interacting with LC3 and GABARAP proteins. Autophagy (2012) 1.05
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NRBF2 regulates autophagy and prevents liver injury by modulating Atg14L-linked phosphatidylinositol-3 kinase III activity. Nat Commun (2014) 0.94
KEAP1 is a redox sensitive target that arbitrates the opposing radiosensitive effects of parthenolide in normal and cancer cells. Cancer Res (2013) 0.90
Sulfasalazine impacts on ferroptotic cell death and alleviates the tumor microenvironment and glioma-induced brain edema. Oncotarget (2016) 0.88
Inflammatory cytokines protect retinal pigment epithelial cells from oxidative stress-induced death. PLoS One (2013) 0.86
Recombinant protein rVP1 upregulates BECN1-independent autophagy, MAPK1/3 phosphorylation and MMP9 activity via WIPI1/WIPI2 to promote macrophage migration. Autophagy (2012) 0.85
Impaired autophagic function in rat islets with aging. Age (Dordr) (2012) 0.82
The role of autophagy in Parkinson's disease: rotenone-based modeling. Behav Brain Funct (2013) 0.82
Autophagy in Diabetic Retinopathy. Curr Neuropharmacol (2016) 0.81
Autophagy defect is associated with low glucose-induced apoptosis in 661W photoreceptor cells. PLoS One (2013) 0.80
miR-Let7A Modulates Autophagy Induction in LPS-Activated Microglia. Exp Neurobiol (2015) 0.79
Hippocampal endosomal, lysosomal, and autophagic dysregulation in mild cognitive impairment: correlation with aβ and tau pathology. J Neuropathol Exp Neurol (2015) 0.78
A role for ABCG2 beyond drug transport: Regulation of autophagy. Autophagy (2016) 0.78
Phellinus linteus Mycelium Alleviates Myocardial Ischemia-Reperfusion Injury through Autophagic Regulation. Front Pharmacol (2017) 0.78
Tenovin-6 impairs autophagy by inhibiting autophagic flux. Cell Death Dis (2017) 0.76
The crucial role of vitamin C and its transporter (SVCT2) in bone marrow stromal cell autophagy and apoptosis. Stem Cell Res (2015) 0.76
Targeting autophagy sensitizes BRAF-mutant thyroid cancer to vemurafenib. J Clin Endocrinol Metab (2016) 0.75
Chlorine-induced cardiopulmonary injury. Ann N Y Acad Sci (2016) 0.75
Autophagy inhibition enhances photocytotoxicity of Photosan-II in human colorectal cancer cells. Oncotarget (2016) 0.75
IP3 accumulation and/or inositol depletion: two downstream lithium's effects that may mediate its behavioral and cellular changes. Transl Psychiatry (2016) 0.75
Activation of the Amino Acid Response Pathway Blunts the Effects of Cardiac Stress. J Am Heart Assoc (2017) 0.75
Prolonged exposure of mouse and human podocytes to insulin induces insulin resistance through lysosomal and proteasomal degradation of the insulin receptor. Diabetologia (2017) 0.75
The tumor suppressor LKB1 regulates starvation-induced autophagy under systemic metabolic stress. Sci Rep (2017) 0.75
BRAF V600E-dependent role of autophagy in uveal melanoma. J Cancer Res Clin Oncol (2016) 0.75
Loss of autophagy in the central nervous system causes neurodegeneration in mice. Nature (2006) 21.40
Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice. Cell (2007) 14.63
Autophagy suppresses tumorigenesis through elimination of p62. Cell (2009) 9.95
The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1. Nat Cell Biol (2010) 6.95
A role for NBR1 in autophagosomal degradation of ubiquitinated substrates. Mol Cell (2009) 6.88
Deletion of NEMO/IKKgamma in liver parenchymal cells causes steatohepatitis and hepatocellular carcinoma. Cancer Cell (2007) 5.91
The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover. Cell (2006) 5.18
Ref(2)P, the Drosophila melanogaster homologue of mammalian p62, is required for the formation of protein aggregates in adult brain. J Cell Biol (2008) 2.90
NBR1 and p62 as cargo receptors for selective autophagy of ubiquitinated targets. Cell Cycle (2009) 2.12
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy (2007) 20.92
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p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death. J Cell Biol (2005) 18.23
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins. Nature (2009) 6.99
The biogenesis of multivesicular endosomes. Nat Rev Mol Cell Biol (2004) 6.31
Hrs sorts ubiquitinated proteins into clathrin-coated microdomains of early endosomes. Nat Cell Biol (2002) 5.83
Programmed autophagy in the Drosophila fat body is induced by ecdysone through regulation of the PI3K pathway. Dev Cell (2004) 4.53
Functional multivesicular bodies are required for autophagic clearance of protein aggregates associated with neurodegenerative disease. J Cell Biol (2007) 4.30
Protein sorting into multivesicular endosomes. Curr Opin Cell Biol (2003) 4.04
Regulation of membrane traffic by phosphoinositide 3-kinases. J Cell Sci (2006) 3.72
Endocytic pathways regulate Toll-like receptor 4 signaling and link innate and adaptive immunity. EMBO J (2006) 3.07
Hrs regulates multivesicular body formation via ESCRT recruitment to endosomes. J Cell Biol (2003) 3.07
STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes. J Biol Chem (2003) 3.00
Regulation of ubiquitin-binding proteins by monoubiquitination. Nat Cell Biol (2006) 2.99
The E3 ubiquitin ligase AIP4 mediates ubiquitination and sorting of the G protein-coupled receptor CXCR4. Dev Cell (2003) 2.97
Ref(2)P, the Drosophila melanogaster homologue of mammalian p62, is required for the formation of protein aggregates in adult brain. J Cell Biol (2008) 2.90
Misfolding diverts CFTR from recycling to degradation: quality control at early endosomes. J Cell Biol (2004) 2.74
Modulation of receptor recycling and degradation by the endosomal kinesin KIF16B. Cell (2005) 2.67
Endosomal and non-endosomal functions of ESCRT proteins. Trends Cell Biol (2006) 2.61
Double-sided ubiquitin binding of Hrs-UIM in endosomal protein sorting. Nat Struct Mol Biol (2006) 2.47
ESCRTs and Fab1 regulate distinct steps of autophagy. Curr Biol (2007) 2.46
Ubiquitination of alpha 5 beta 1 integrin controls fibroblast migration through lysosomal degradation of fibronectin-integrin complexes. Dev Cell (2010) 2.37
Alfy, a novel FYVE-domain-containing protein associated with protein granules and autophagic membranes. J Cell Sci (2004) 2.35
PtdIns(3)P controls cytokinesis through KIF13A-mediated recruitment of FYVE-CENT to the midbody. Nat Cell Biol (2010) 2.33
The Rab11a GTPase controls Toll-like receptor 4-induced activation of interferon regulatory factor-3 on phagosomes. Immunity (2010) 2.29
SLC9A6 mutations cause X-linked mental retardation, microcephaly, epilepsy, and ataxia, a phenotype mimicking Angelman syndrome. Am J Hum Genet (2008) 2.16
The mammalian phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) regulates endosome-to-TGN retrograde transport. J Cell Sci (2006) 2.12
The selective macroautophagic degradation of aggregated proteins requires the PI3P-binding protein Alfy. Mol Cell (2010) 2.12
Defective downregulation of receptor tyrosine kinases in cancer. EMBO J (2004) 2.05
p62/SQSTM1 and ALFY interact to facilitate the formation of p62 bodies/ALIS and their degradation by autophagy. Autophagy (2010) 1.93
Cbl-dependent ubiquitination is required for progression of EGF receptors into clathrin-coated pits. Mol Biol Cell (2004) 1.82
Endocytosis and signaling. Curr Opin Cell Biol (2011) 1.78
A phosphatidylinositol 3-kinase class III sub-complex containing VPS15, VPS34, Beclin 1, UVRAG and BIF-1 regulates cytokinesis and degradative endocytic traffic. Exp Cell Res (2010) 1.75
The ESCRT-III subunit hVps24 is required for degradation but not silencing of the epidermal growth factor receptor. Mol Biol Cell (2006) 1.74
The small GTPase Rab22 interacts with EEA1 and controls endosomal membrane trafficking. J Cell Sci (2002) 1.74
Flat clathrin coats on endosomes mediate degradative protein sorting by scaffolding Hrs in dynamic microdomains. J Cell Sci (2006) 1.71
Eap45 in mammalian ESCRT-II binds ubiquitin via a phosphoinositide-interacting GLUE domain. J Biol Chem (2005) 1.68
Fab1 phosphatidylinositol 3-phosphate 5-kinase controls trafficking but not silencing of endocytosed receptors. Mol Biol Cell (2006) 1.68
Alix regulates cortical actin and the spatial distribution of endosomes. J Cell Sci (2005) 1.67
Autophagic degradation of dBruce controls DNA fragmentation in nurse cells during late Drosophila melanogaster oogenesis. J Cell Biol (2010) 1.65
Autophagy in tumour suppression and promotion. Mol Oncol (2009) 1.64
Molecular mechanisms of the membrane sculpting ESCRT pathway. Cold Spring Harb Perspect Biol (2013) 1.58
The growth-regulatory protein HCRP1/hVps37A is a subunit of mammalian ESCRT-I and mediates receptor down-regulation. Mol Biol Cell (2004) 1.58
Antibody crossreactivity between the tumour suppressor PHLPP1 and the proto-oncogene β-catenin. EMBO Rep (2012) 1.57
Actin-based motility of endosomes is linked to the polar tip growth of root hairs. Eur J Cell Biol (2005) 1.52
Early endosomal regulation of Smad-dependent signaling in endothelial cells. J Biol Chem (2002) 1.52
A dual function for Deep orange in programmed autophagy in the Drosophila melanogaster fat body. Exp Cell Res (2006) 1.50
Differential functions of Hrs and ESCRT proteins in endocytic membrane trafficking. Exp Cell Res (2007) 1.46
Multivesicular endosome biogenesis in the absence of ESCRTs. Traffic (2009) 1.44
Cell death during Drosophila melanogaster early oogenesis is mediated through autophagy. Autophagy (2009) 1.43
Comparative analysis of ESCRT-I, ESCRT-II and ESCRT-III function in Drosophila by efficient isolation of ESCRT mutants. J Cell Sci (2009) 1.42
p62 at the interface of autophagy, oxidative stress signaling, and cancer. Antioxid Redox Signal (2012) 1.42
Shaping development with ESCRTs. Nat Cell Biol (2011) 1.38
How do ESCRT proteins control autophagy? J Cell Sci (2009) 1.37
Ultrastructural characterization of giant endosomes induced by GTPase-deficient Rab5. Histochem Cell Biol (2009) 1.36
Cytokinesis and cancer. FEBS Lett (2010) 1.36
Role of Rab5 in the recruitment of hVps34/p150 to the early endosome. Traffic (2002) 1.35
Vps22/EAP30 in ESCRT-II mediates endosomal sorting of growth factor and chemokine receptors destined for lysosomal degradation. Traffic (2007) 1.35
Ubc4/5 and c-Cbl continue to ubiquitinate EGF receptor after internalization to facilitate polyubiquitination and degradation. Mol Biol Cell (2008) 1.34
Regulation of early endosomal entry by the Drosophila tumor suppressors Rabenosyn and Vps45. Mol Biol Cell (2008) 1.34
Structural basis of ubiquitin recognition by mammalian Eap45 GLUE domain. Nat Struct Mol Biol (2006) 1.27
Phosphatidylinositol 3-phosphate is found in microdomains of early endosomes. Histochem Cell Biol (2003) 1.27
RILP is required for the proper morphology and function of late endosomes. J Cell Sci (2007) 1.26
Membrane remodeling by the PX-BAR protein SNX18 promotes autophagosome formation. J Cell Biol (2013) 1.26
Analyzing phosphoinositides and their interacting proteins. Nat Methods (2006) 1.21
Hrs and endocytic sorting of ubiquitinated membrane proteins. Cell Struct Funct (2002) 1.20
Acquisition of Hrs, an essential component of phagosomal maturation, is impaired by mycobacteria. Mol Cell Biol (2004) 1.20
CISK attenuates degradation of the chemokine receptor CXCR4 via the ubiquitin ligase AIP4. EMBO J (2006) 1.20
Molecular mechanisms of ubiquitin-dependent membrane traffic. Annu Rev Biophys (2011) 1.19
Endocytosis and signaling: a relationship under development. Cell (2003) 1.19
UVRAG mutations associated with microsatellite unstable colon cancer do not affect autophagy. Autophagy (2010) 1.16
The PI 3-kinase regulator Vps15 is required for autophagic clearance of protein aggregates. Autophagy (2008) 1.14
Class III phosphatidylinositol 3-kinase and its catalytic product PtdIns3P in regulation of endocytic membrane traffic. FEBS J (2013) 1.13
ESCRT proteins and cell signalling. Traffic (2011) 1.11
An endosomally localized isoform of Eps15 interacts with Hrs to mediate degradation of epidermal growth factor receptor. J Cell Biol (2008) 1.08
ESCRT & Co. Biol Cell (2010) 1.06
Phosphatidylinositol 3-phosphate, a lipid that regulates membrane dynamics, protein sorting and cell signalling. Bioessays (2013) 1.06
Ubiquitination and phosphorylation of Beclin 1 and its binding partners: Tuning class III phosphatidylinositol 3-kinase activity and tumor suppression. FEBS Lett (2012) 1.05
Nedd4-dependent lysine-11-linked polyubiquitination of the tumour suppressor Beclin 1. Biochem J (2012) 1.04
Ubiquitylation of the gap junction protein connexin-43 signals its trafficking from early endosomes to lysosomes in a process mediated by Hrs and Tsg101. J Cell Sci (2009) 1.04
ESCRT proteins in physiology and disease. Exp Cell Res (2008) 1.04
Structure and functions of stable intercellular bridges formed by incomplete cytokinesis during development. Commun Integr Biol (2011) 1.03
Phosphorylation of Hrs downstream of the epidermal growth factor receptor. Eur J Biochem (2002) 1.02
Cindr interacts with anillin to control cytokinesis in Drosophila melanogaster. Curr Biol (2010) 1.02
Cloning and subcellular localization of a human phosphatidylinositol 3-phosphate 5-kinase, PIKfyve/Fab1. Gene (2006) 1.01
Aberrant receptor signaling and trafficking as mechanisms in oncogenesis. Crit Rev Oncog (2007) 0.99
Production of phosphatidylinositol 5-phosphate via PIKfyve and MTMR3 regulates cell migration. EMBO Rep (2012) 0.98
Phosphoinositide 3-kinases as accelerators and brakes of autophagy. FEBS J (2013) 0.98
Cell-cycle-dependent binding kinetics for the early endosomal tethering factor EEA1. EMBO Rep (2008) 0.95
Protein secretion: unconventional exit by exophagy. Curr Biol (2010) 0.95
Divide and ProsPer: the emerging role of PtdIns3P in cytokinesis. Trends Cell Biol (2010) 0.95
Disruption of Vps4 and JNK function in Drosophila causes tumour growth. PLoS One (2009) 0.94
Control of Notch-ligand endocytosis by ligand-receptor interaction. J Cell Sci (2010) 0.92
Both clathrin-positive and -negative coats are involved in endosomal sorting of the EGF receptor. Exp Cell Res (2006) 0.92
A new side to ubiquitin. Trends Biochem Sci (2006) 0.92
Cell differentiation: midbody remnants - junk or fate factors? Curr Biol (2011) 0.92
The role of ESCRT proteins in attenuation of cell signalling. Biochem Soc Trans (2009) 0.90
Dual degradation mechanisms ensure disposal of NHE6 mutant protein associated with neurological disease. Exp Cell Res (2009) 0.90
Mechanisms and functions of endocytosis. J Cell Biol (2008) 0.90
Self-eating from an ER-associated cup. J Cell Biol (2008) 0.90