Published in Nat Struct Mol Biol on March 30, 2005
Origins and Mechanisms of miRNAs and siRNAs. Cell (2009) 20.77
Sorting of small RNAs into Arabidopsis argonaute complexes is directed by the 5' terminal nucleotide. Cell (2008) 9.02
Specific association of Piwi with rasiRNAs derived from retrotransposon and heterochromatic regions in the Drosophila genome. Genes Dev (2006) 6.60
A dicer-independent miRNA biogenesis pathway that requires Ago catalysis. Nature (2010) 6.37
A three-dimensional view of the molecular machinery of RNA interference. Nature (2009) 6.31
Arabidopsis ARGONAUTE1 is an RNA Slicer that selectively recruits microRNAs and short interfering RNAs. Proc Natl Acad Sci U S A (2005) 6.09
Structure of the guide-strand-containing argonaute silencing complex. Nature (2008) 5.36
Slicer function of Drosophila Argonautes and its involvement in RISC formation. Genes Dev (2005) 5.29
Drosophila microRNAs are sorted into functionally distinct argonaute complexes after production by dicer-1. Cell (2007) 5.26
Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes. Nature (2009) 5.24
A complex system of small RNAs in the unicellular green alga Chlamydomonas reinhardtii. Genes Dev (2007) 4.95
MicroRNA function: multiple mechanisms for a tiny RNA? RNA (2005) 4.78
A human, ATP-independent, RISC assembly machine fueled by pre-miRNA. Genes Dev (2005) 4.55
The role of PACT in the RNA silencing pathway. EMBO J (2006) 4.53
Crystal structure of A. aeolicus argonaute, a site-specific DNA-guided endoribonuclease, provides insights into RISC-mediated mRNA cleavage. Mol Cell (2005) 4.11
Quantitative analysis of Argonaute protein reveals microRNA-dependent localization to stress granules. Proc Natl Acad Sci U S A (2006) 4.02
In vitro reconstitution of the human RISC-loading complex. Proc Natl Acad Sci U S A (2008) 3.43
On the origin and functions of RNA-mediated silencing: from protists to man. Curr Genet (2006) 3.05
The structure of human argonaute-2 in complex with miR-20a. Cell (2012) 2.83
The Argonaute protein family. Genome Biol (2008) 2.83
Caspase-dependent conversion of Dicer ribonuclease into a death-promoting deoxyribonuclease. Science (2010) 2.66
Combinatorial delivery of small interfering RNAs reduces RNAi efficacy by selective incorporation into RISC. Nucleic Acids Res (2007) 2.62
Six RNA viruses and forty-one hosts: viral small RNAs and modulation of small RNA repertoires in vertebrate and invertebrate systems. PLoS Pathog (2010) 2.62
Prolyl 4-hydroxylation regulates Argonaute 2 stability. Nature (2008) 2.51
Structure of yeast Argonaute with guide RNA. Nature (2012) 2.38
Regulation of MicroRNA Biogenesis: A miRiad of mechanisms. Cell Commun Signal (2009) 2.27
PhyloFacts: an online structural phylogenomic encyclopedia for protein functional and structural classification. Genome Biol (2006) 2.27
Existence of a microRNA pathway in anucleate platelets. Nat Struct Mol Biol (2009) 2.26
Stepwise analyses of metal ions in RNase H catalysis from substrate destabilization to product release. EMBO J (2006) 2.23
The kinase regulator mob1 acts as a patterning protein for stentor morphogenesis. PLoS Biol (2014) 2.23
Structural insights into RNA processing by the human RISC-loading complex. Nat Struct Mol Biol (2009) 2.19
Miwi catalysis is required for piRNA amplification-independent LINE1 transposon silencing. Nature (2011) 2.11
Argonaute divides its RNA guide into domains with distinct functions and RNA-binding properties. Cell (2012) 2.07
A genomewide screen for components of the RNAi pathway in Drosophila cultured cells. Proc Natl Acad Sci U S A (2006) 2.04
ATP-dependent human RISC assembly pathways. Nat Struct Mol Biol (2009) 2.04
Fluorescence correlation spectroscopy and fluorescence cross-correlation spectroscopy reveal the cytoplasmic origination of loaded nuclear RISC in vivo in human cells. Nucleic Acids Res (2008) 2.01
Structural determinants of miRNAs for RISC loading and slicer-independent unwinding. Nat Struct Mol Biol (2009) 2.01
Retroviral integrase superfamily: the structural perspective. EMBO Rep (2009) 1.97
Functional involvement of Tudor and dPRMT5 in the piRNA processing pathway in Drosophila germlines. EMBO J (2009) 1.94
Expanded RNA-binding activities of mammalian Argonaute 2. Nucleic Acids Res (2009) 1.94
Rice MicroRNA effector complexes and targets. Plant Cell (2009) 1.93
QIP, a putative exonuclease, interacts with the Neurospora Argonaute protein and facilitates conversion of duplex siRNA into single strands. Genes Dev (2007) 1.88
Form, function, and regulation of ARGONAUTE proteins. Plant Cell (2010) 1.87
Conversion of pre-RISC to holo-RISC by Ago2 during assembly of RNAi complexes. RNA (2006) 1.85
Distinct passenger strand and mRNA cleavage activities of human Argonaute proteins. Nat Struct Mol Biol (2009) 1.81
Precursor microRNA-programmed silencing complex assembly pathways in mammals. Mol Cell (2012) 1.81
Highly complementary target RNAs promote release of guide RNAs from human Argonaute2. Mol Cell (2013) 1.81
Structural basis for microRNA targeting. Science (2014) 1.77
MicroRNAs in gene regulation: when the smallest governs it all. J Biomed Biotechnol (2006) 1.76
RNAi factors are present and active in human cell nuclei. Cell Rep (2014) 1.73
A direct role for Hsp90 in pre-RISC formation in Drosophila. Nat Struct Mol Biol (2010) 1.69
The rough endoplasmatic reticulum is a central nucleation site of siRNA-mediated RNA silencing. EMBO J (2013) 1.68
The RNA-induced silencing complex: a versatile gene-silencing machine. J Biol Chem (2009) 1.65
Strand-specific 5'-O-methylation of siRNA duplexes controls guide strand selection and targeting specificity. RNA (2007) 1.61
Hsp90 regulates the function of argonaute 2 and its recruitment to stress granules and P-bodies. Mol Biol Cell (2009) 1.60
Argonaute protein identity and pairing geometry determine cooperativity in mammalian RNA silencing. RNA (2011) 1.59
Dephosphorylation of tyrosine 393 in argonaute 2 by protein tyrosine phosphatase 1B regulates gene silencing in oncogenic RAS-induced senescence. Mol Cell (2014) 1.58
Characterization of the miRNA-RISC loading complex and miRNA-RISC formed in the Drosophila miRNA pathway. RNA (2009) 1.55
Structure of C3PO and mechanism of human RISC activation. Nat Struct Mol Biol (2011) 1.55
Identification of microRNAs involved in pathogen-associated molecular pattern-triggered plant innate immunity. Plant Physiol (2010) 1.54
Adenovirus virus-associated RNA is processed to functional interfering RNAs involved in virus production. J Virol (2006) 1.53
ARGONAUTE4 is required for resistance to Pseudomonas syringae in Arabidopsis. Plant Cell (2007) 1.52
Functional dissection of the human TNRC6 (GW182-related) family of proteins. Mol Cell Biol (2009) 1.49
Specific residues at every third position of siRNA shape its efficient RNAi activity. Nucleic Acids Res (2007) 1.49
Emerging roles of microRNAs as molecular switches in the integrated circuit of the cancer cell. RNA (2009) 1.48
Genome-wide identification, organization and phylogenetic analysis of Dicer-like, Argonaute and RNA-dependent RNA Polymerase gene families and their expression analysis during reproductive development and stress in rice. BMC Genomics (2008) 1.46
Binding and cleavage specificities of human Argonaute2. J Biol Chem (2009) 1.45
Competition for RISC binding predicts in vitro potency of siRNA. Nucleic Acids Res (2006) 1.44
Structural biology of RNA silencing and its functional implications. Cold Spring Harb Symp Quant Biol (2006) 1.42
MicroRNA biogenesis: regulating the regulators. Crit Rev Biochem Mol Biol (2012) 1.41
miRNA Repertoires of Demosponges Stylissa carteri and Xestospongia testudinaria. PLoS One (2016) 1.38
Small interfering RNAs containing full 2'-O-methylribonucleotide-modified sense strands display Argonaute2/eIF2C2-dependent activity. RNA (2005) 1.38
RDE-1 slicer activity is required only for passenger-strand cleavage during RNAi in Caenorhabditis elegans. Nat Struct Mol Biol (2009) 1.35
Protein interactions and complexes in human microRNA biogenesis and function. Front Biosci (2008) 1.33
siRNA repositioning for guide strand selection by human Dicer complexes. Mol Cell (2011) 1.31
Overlapping functions of argonaute proteins in patterning and morphogenesis of Drosophila embryos. PLoS Genet (2006) 1.29
Dicer-1, but not Loquacious, is critical for assembly of miRNA-induced silencing complexes. RNA (2007) 1.28
Ancestral roles of small RNAs: an Ago-centric perspective. Cold Spring Harb Perspect Biol (2011) 1.27
RNA interference in schistosomes: machinery and methodology. Parasitology (2009) 1.27
How to slice: snapshots of Argonaute in action. Silence (2010) 1.26
Plant responses against invasive nucleic acids: RNA silencing and its suppression by plant viral pathogens. Semin Cell Dev Biol (2009) 1.26
Structure-based cleavage mechanism of Thermus thermophilus Argonaute DNA guide strand-mediated DNA target cleavage. Proc Natl Acad Sci U S A (2013) 1.26
The Tetrahymena argonaute-binding protein Giw1p directs a mature argonaute-siRNA complex to the nucleus. Cell (2010) 1.25
An unusual Dicer-like1 protein fuels the RNA interference pathway in Trypanosoma brucei. RNA (2006) 1.25
RNA silencing in Chlamydomonas: mechanisms and tools. Curr Genet (2005) 1.24
Reduced levels of Ago2 expression result in increased siRNA competition in mammalian cells. Nucleic Acids Res (2007) 1.23
Two molecular features contribute to the Argonaute specificity for the microRNA and RNAi pathways in C. elegans. RNA (2008) 1.22
Argonautes confront new small RNAs. Curr Opin Chem Biol (2007) 1.20
Structural and functional modules in RNA interference. Curr Opin Struct Biol (2009) 1.19
RISC-target interaction: cleavage and translational suppression. Biochim Biophys Acta (2008) 1.18
The role of Dicer protein partners in the processing of microRNA precursors. PLoS One (2011) 1.15
The making of a slicer: activation of human Argonaute-1. Cell Rep (2013) 1.15
Argonaute2 expression is post-transcriptionally coupled to microRNA abundance. RNA (2013) 1.15
Alternative RISC assembly: binding and repression of microRNA-mRNA duplexes by human Ago proteins. RNA (2012) 1.13
A potential protein-RNA recognition event along the RISC-loading pathway from the structure of A. aeolicus Argonaute with externally bound siRNA. Structure (2006) 1.12
Mechanism of microRNA-target interaction: molecular dynamics simulations and thermodynamics analysis. PLoS Comput Biol (2010) 1.12
Functional insight into Maelstrom in the germline piRNA pathway: a unique domain homologous to the DnaQ-H 3'-5' exonuclease, its lineage-specific expansion/loss and evolutionarily active site switch. Biol Direct (2008) 1.11
A role for human Dicer in pre-RISC loading of siRNAs. Nucleic Acids Res (2010) 1.11
Overcoming nonviral gene delivery barriers: perspective and future. Mol Pharm (2013) 1.10
Analysis of acyclic nucleoside modifications in siRNAs finds sensitivity at position 1 that is restored by 5'-terminal phosphorylation both in vitro and in vivo. Nucleic Acids Res (2009) 1.10
A microRNA polycistron as a potential human oncogene. Nature (2005) 40.21
MicroRNAs: small RNAs with a big role in gene regulation. Nat Rev Genet (2004) 37.83
Argonaute2 is the catalytic engine of mammalian RNAi. Science (2004) 22.86
Genome-wide in situ exon capture for selective resequencing. Nat Genet (2007) 19.97
A microRNA component of the p53 tumour suppressor network. Nature (2007) 19.25
Discrete small RNA-generating loci as master regulators of transposon activity in Drosophila. Cell (2007) 18.35
Dicer is essential for mouse development. Nat Genet (2003) 15.87
Control of translation and mRNA degradation by miRNAs and siRNAs. Genes Dev (2006) 15.20
Processing of primary microRNAs by the Microprocessor complex. Nature (2004) 14.59
Polycomb proteins targeted by a short repeat RNA to the mouse X chromosome. Science (2008) 13.79
Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach. Cell (2006) 12.72
Crystal structure of Argonaute and its implications for RISC slicer activity. Science (2004) 12.48
MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies. Nat Cell Biol (2005) 12.12
Discovery of functional elements in 12 Drosophila genomes using evolutionary signatures. Nature (2007) 11.66
Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence. Cell (2003) 11.40
Pseudogene-derived small interfering RNAs regulate gene expression in mouse oocytes. Nature (2008) 10.71
Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells. Genes Dev (2002) 10.71
A germline-specific class of small RNAs binds mammalian Piwi proteins. Nature (2006) 9.88
The Piwi-piRNA pathway provides an adaptive defense in the transposon arms race. Science (2007) 9.36
Sorting of small RNAs into Arabidopsis argonaute complexes is directed by the 5' terminal nucleotide. Cell (2008) 9.02
Probing tumor phenotypes using stable and regulated synthetic microRNA precursors. Nat Genet (2005) 8.99
Small RNAs as guardians of the genome. Cell (2009) 8.88
Characterization of Dicer-deficient murine embryonic stem cells. Proc Natl Acad Sci U S A (2005) 8.35
Second-generation shRNA libraries covering the mouse and human genomes. Nat Genet (2005) 8.23
An endogenous small interfering RNA pathway in Drosophila. Nature (2008) 7.88
Developmentally regulated piRNA clusters implicate MILI in transposon control. Science (2007) 7.68
MIWI2 is essential for spermatogenesis and repression of transposons in the mouse male germline. Dev Cell (2007) 7.66
The Argonaute family: tentacles that reach into RNAi, developmental control, stem cell maintenance, and tumorigenesis. Genes Dev (2002) 7.61
A role for the P-body component GW182 in microRNA function. Nat Cell Biol (2005) 7.54
Analysis of the C. elegans Argonaute family reveals that distinct Argonautes act sequentially during RNAi. Cell (2006) 7.14
The crystal structure of the Argonaute2 PAZ domain reveals an RNA binding motif in RNAi effector complexes. Nat Struct Biol (2003) 6.90
Fragile X-related protein and VIG associate with the RNA interference machinery. Genes Dev (2002) 6.43
Specialized piRNA pathways act in germline and somatic tissues of the Drosophila ovary. Cell (2009) 6.39
A dicer-independent miRNA biogenesis pathway that requires Ago catalysis. Nature (2010) 6.37
A resource for large-scale RNA-interference-based screens in mammals. Nature (2004) 6.36
A piRNA pathway primed by individual transposons is linked to de novo DNA methylation in mice. Mol Cell (2008) 6.35
A role for Piwi and piRNAs in germ cell maintenance and transposon silencing in Zebrafish. Cell (2007) 6.31
A novel miRNA processing pathway independent of Dicer requires Argonaute2 catalytic activity. Science (2010) 5.84
An epi-allelic series of p53 hypomorphs created by stable RNAi produces distinct tumor phenotypes in vivo. Nat Genet (2003) 5.82
Genome analysis of the platypus reveals unique signatures of evolution. Nature (2008) 5.74
Alta-Cyclic: a self-optimizing base caller for next-generation sequencing. Nat Methods (2008) 5.70
A genetic screen for candidate tumor suppressors identifies REST. Cell (2005) 5.61
An oncogenomics-based in vivo RNAi screen identifies tumor suppressors in liver cancer. Cell (2008) 5.47
Cancer proliferation gene discovery through functional genomics. Science (2008) 5.41
microRNAs join the p53 network--another piece in the tumour-suppression puzzle. Nat Rev Cancer (2007) 5.38
RNA interference in adult mice. Nature (2002) 5.33
A lentiviral microRNA-based system for single-copy polymerase II-regulated RNA interference in mammalian cells. Proc Natl Acad Sci U S A (2005) 5.29
A biochemical approach to identifying microRNA targets. Proc Natl Acad Sci U S A (2007) 5.16
Stable suppression of gene expression by RNAi in mammalian cells. Proc Natl Acad Sci U S A (2002) 5.05
An epigenetic role for maternally inherited piRNAs in transposon silencing. Science (2008) 5.05
miR-19 is a key oncogenic component of mir-17-92. Genes Dev (2009) 4.95
A complex system of small RNAs in the unicellular green alga Chlamydomonas reinhardtii. Genes Dev (2007) 4.95
Mechanism of DNA translocation in a replicative hexameric helicase. Nature (2006) 4.91
Silencing of microRNA families by seed-targeting tiny LNAs. Nat Genet (2011) 4.81
Distinct catalytic and non-catalytic roles of ARGONAUTE4 in RNA-directed DNA methylation. Nature (2006) 4.68
The CRISPR system: small RNA-guided defense in bacteria and archaea. Mol Cell (2010) 4.60
Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation. Mol Cell (2009) 4.57
Profiling essential genes in human mammary cells by multiplex RNAi screening. Science (2008) 4.51
Hybrid selection of discrete genomic intervals on custom-designed microarrays for massively parallel sequencing. Nat Protoc (2009) 4.45
Systematic discovery and characterization of fly microRNAs using 12 Drosophila genomes. Genome Res (2007) 4.28
Small RNA sorting: matchmaking for Argonautes. Nat Rev Genet (2010) 4.27
A genome-scale shRNA resource for transgenic RNAi in Drosophila. Nat Methods (2011) 4.24
Critical roles for Dicer in the female germline. Genes Dev (2007) 4.23
Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities. Nature (2007) 4.14
RNase III enzymes and the initiation of gene silencing. Nat Struct Mol Biol (2004) 4.01
Targeted deletion of Dicer in the heart leads to dilated cardiomyopathy and heart failure. Proc Natl Acad Sci U S A (2008) 4.00
Slicer and the argonautes. Nat Chem Biol (2007) 3.99
Biochemical specialization within Arabidopsis RNA silencing pathways. Mol Cell (2005) 3.92
miRNAs on the move: miRNA biogenesis and the RNAi machinery. Curr Opin Cell Biol (2004) 3.82
Structural basis for the EBA-175 erythrocyte invasion pathway of the malaria parasite Plasmodium falciparum. Cell (2005) 3.79
A rapid and scalable system for studying gene function in mice using conditional RNA interference. Cell (2011) 3.69
A micrococcal nuclease homologue in RNAi effector complexes. Nature (2003) 3.67
Synthetic shRNAs as potent RNAi triggers. Nat Biotechnol (2004) 3.67
The miRNA-processing enzyme dicer is essential for the morphogenesis and maintenance of hair follicles. Curr Biol (2006) 3.64
Suppression of tumorigenesis by the p53 target PUMA. Proc Natl Acad Sci U S A (2004) 3.42
Sperm methylation profiles reveal features of epigenetic inheritance and evolution in primates. Cell (2011) 3.39
Toolkit for evaluating genes required for proliferation and survival using tetracycline-regulated RNAi. Nat Biotechnol (2010) 3.33
Hierarchical rules for Argonaute loading in Drosophila. Mol Cell (2009) 3.20
High definition profiling of mammalian DNA methylation by array capture and single molecule bisulfite sequencing. Genome Res (2009) 3.08
Structure of the Cand1-Cul1-Roc1 complex reveals regulatory mechanisms for the assembly of the multisubunit cullin-dependent ubiquitin ligases. Cell (2004) 3.07
DNA Sudoku--harnessing high-throughput sequencing for multiplexed specimen analysis. Genome Res (2009) 3.05
RNAi: an ever-growing puzzle. Trends Biochem Sci (2003) 3.01
Production of complex nucleic acid libraries using highly parallel in situ oligonucleotide synthesis. Nat Methods (2004) 3.01
Proteomic analysis of murine Piwi proteins reveals a role for arginine methylation in specifying interaction with Tudor family members. Genes Dev (2009) 2.95
The guardian's little helper: microRNAs in the p53 tumor suppressor network. Cancer Res (2007) 2.92
Exome sequencing and disease-network analysis of a single family implicate a mutation in KIF1A in hereditary spastic paraparesis. Genome Res (2011) 2.89
Evolutionary flux of canonical microRNAs and mirtrons in Drosophila. Nat Genet (2010) 2.84
The structure of human argonaute-2 in complex with miR-20a. Cell (2012) 2.83
RNAi and expression of retrotransposons MuERV-L and IAP in preimplantation mouse embryos. Dev Biol (2004) 2.82
Functional identification of optimized RNAi triggers using a massively parallel sensor assay. Mol Cell (2011) 2.82
Lessons from Nature: microRNA-based shRNA libraries. Nat Methods (2006) 2.80