Published in BMJ on March 30, 2010
SPIRIT 2013 explanation and elaboration: guidance for protocols of clinical trials. BMJ (2013) 9.01
Screening for prostate cancer: systematic review and meta-analysis of randomised controlled trials. BMJ (2010) 7.15
Assessing and reporting heterogeneity in treatment effects in clinical trials: a proposal. Trials (2010) 3.45
Epidural steroid injections are associated with less improvement in patients with lumbar spinal stenosis: a subgroup analysis of the Spine Patient Outcomes Research Trial. Spine (Phila Pa 1976) (2013) 3.37
Influence of sex on outcomes of stenting versus endarterectomy: a subgroup analysis of the Carotid Revascularization Endarterectomy versus Stenting Trial (CREST). Lancet Neurol (2011) 2.15
Examining the evidence: a systematic review of the inclusion and analysis of older adults in randomized controlled trials. J Gen Intern Med (2011) 1.92
Prognosis research strategy (PROGRESS) 4: stratified medicine research. BMJ (2013) 1.71
Somatostatin-based radiopeptide therapy with [177Lu-DOTA]-TOC versus [90Y-DOTA]-TOC in neuroendocrine tumours. Eur J Nucl Med Mol Imaging (2013) 1.54
Azithromycin may antagonize inhaled tobramycin when targeting Pseudomonas aeruginosa in cystic fibrosis. Ann Am Thorac Soc (2014) 1.43
Sex based subgroup differences in randomized controlled trials: empirical evidence from Cochrane meta-analyses. BMJ (2016) 1.41
Three simple rules to ensure reasonably credible subgroup analyses. BMJ (2015) 1.40
Effect of supplementation with zinc and other micronutrients on malaria in Tanzanian children: a randomised trial. PLoS Med (2011) 1.36
Estimating treatment effects for individual patients based on the results of randomised clinical trials. BMJ (2011) 1.32
Meta-analysis of BRAF mutation as a predictive biomarker of benefit from anti-EGFR monoclonal antibody therapy for RAS wild-type metastatic colorectal cancer. Br J Cancer (2015) 1.28
Dabigatran, Rivaroxaban, or Apixaban versus Warfarin in Patients with Nonvalvular Atrial Fibrillation: A Systematic Review and Meta-Analysis of Subgroups. Thrombosis (2013) 1.20
Intervention effects on physical activity: the HEIA study - a cluster randomized controlled trial. Int J Behav Nutr Phys Act (2013) 1.19
Random treatment assignment using mathematical equipoise for comparative effectiveness trials. Clin Transl Sci (2011) 1.14
Clinical disease severity of respiratory viral co-infection versus single viral infection: a systematic review and meta-analysis. PLoS One (2014) 1.13
Pre-referral rectal artesunate in severe malaria: flawed trial. Trials (2011) 1.10
Learning from failure--rationale and design for a study about discontinuation of randomized trials (DISCO study). BMC Med Res Methodol (2012) 1.10
Effect of tranexamic acid on mortality in patients with traumatic bleeding: prespecified analysis of data from randomised controlled trial. BMJ (2012) 1.07
Informing evidence-based decision-making for patients with comorbidity: availability of necessary information in clinical trials for chronic diseases. PLoS One (2012) 1.05
Health equity: evidence synthesis and knowledge translation methods. Syst Rev (2013) 1.05
Subgroup analyses in randomised controlled trials: cohort study on trial protocols and journal publications. BMJ (2014) 1.03
Systematic review of percutaneous closure versus medical therapy in patients with cryptogenic stroke and patent foramen ovale. BMJ Open (2014) 1.02
Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data. BMJ (2017) 1.02
Gene expression profiling for guiding adjuvant chemotherapy decisions in women with early breast cancer: an evidence-based and economic analysis. Ont Health Technol Assess Ser (2010) 1.01
Direct-acting antiviral therapies for hepatitis C genotype 1 infection: a multiple treatment comparison meta-analysis. QJM (2012) 0.97
Fruits and vegetables intake and risk of bladder cancer: a PRISMA-compliant systematic review and dose-response meta-analysis of prospective cohort studies. Medicine (Baltimore) (2015) 0.97
Strengths and weaknesses of immunotherapy for advanced non-small-cell lung cancer: a meta-analysis of 12 randomized controlled trials. PLoS One (2012) 0.95
A framework for the analysis of heterogeneity of treatment effect in patient-centered outcomes research. J Clin Epidemiol (2013) 0.94
Efficacy of vitamin D supplementation in depression in adults: a systematic review. J Clin Endocrinol Metab (2013) 0.93
Zinc for the treatment of the common cold: a systematic review and meta-analysis of randomized controlled trials. CMAJ (2012) 0.92
Basing information on comprehensive, critically appraised, and up-to-date syntheses of the scientific evidence: a quality dimension of the International Patient Decision Aid Standards. BMC Med Inform Decis Mak (2013) 0.91
Aggregating and disaggregating patients in clinical trials and their subgroup analyses. Ann Intern Med (2010) 0.90
High prevalence of potential biases threatens the interpretation of trials in patients with chronic disease. BMC Med (2011) 0.90
Cognitive behavioral therapy age effects in child and adolescent anxiety: an individual patient data metaanalysis. Depress Anxiety (2013) 0.88
Oral contraceptive formulation and risk of breast cancer. Contraception (2011) 0.85
Factors explaining the heterogeneity of effects of patient decision aids on knowledge of outcome probabilities: a systematic review sub-analysis. Syst Rev (2013) 0.84
The value of heterogeneity for cost-effectiveness subgroup analysis: conceptual framework and application. Med Decis Making (2014) 0.84
Minimally important difference estimates and methods: a protocol. BMJ Open (2015) 0.83
Probiotics for antibiotic-associated diarrhea: do we have a verdict? World J Gastroenterol (2014) 0.83
Systematic reviews need to consider applicability to disadvantaged populations: inter-rater agreement for a health equity plausibility algorithm. BMC Med Res Methodol (2012) 0.82
Effects of an intervention aimed at reducing the intake of sugar-sweetened beverages in primary school children: a controlled trial. Int J Behav Nutr Phys Act (2014) 0.82
Population-based childhood overweight prevention: outcomes of the 'Be active, eat right' study. PLoS One (2013) 0.82
Do MRI findings identify patients with low back pain or sciatica who respond better to particular interventions? A systematic review. Eur Spine J (2015) 0.81
The long-term impact of the MEMA kwa Vijana adolescent sexual and reproductive health intervention: effect of dose and time since intervention exposure. PLoS One (2011) 0.81
Reflections on physical activity intervention research in young people - dos, don'ts, and critical thoughts. Int J Behav Nutr Phys Act (2016) 0.80
Reply: Comment on 'Meta-analysis of BRAF mutation as a predictive biomarker of benefit from anti-EGFR monoclonal-antibody therapy for RAS wild-type metastatic colorectal cancer'. Br J Cancer (2015) 0.80
Minimally invasive versus open surgery for cervical and lumbar discectomy: a systematic review and meta-analysis. CMAJ Open (2014) 0.80
Exploring equity in primary-care-based physical activity interventions using PROGRESS-Plus: a systematic review and evidence synthesis. Int J Behav Nutr Phys Act (2016) 0.78
Predicting a clinically important outcome in patients with low back pain following McKenzie therapy or spinal manipulation: a stratified analysis in a randomized controlled trial. BMC Musculoskelet Disord (2015) 0.78
CLOCK gene variation is associated with incidence of type-2 diabetes and cardiovascular diseases in type-2 diabetic subjects: dietary modulation in the PREDIMED randomized trial. Cardiovasc Diabetol (2016) 0.78
Cochrane in CORR (®): Platelet-rich Therapies for Musculoskeletal Soft Tissue Injuries (Review). Clin Orthop Relat Res (2015) 0.78
Associations of the MCM6-rs3754686 proxy for milk intake in Mediterranean and American populations with cardiovascular biomarkers, disease and mortality: Mendelian randomization. Sci Rep (2016) 0.78
Systematic review and meta-analysis: Multi-strain probiotics as adjunct therapy for Helicobacter pylori eradication and prevention of adverse events. United European Gastroenterol J (2015) 0.77
Opioids for chronic non-cancer pain: a protocol for a systematic review of randomized controlled trials. Syst Rev (2013) 0.77
Fracture prevention in patients with cognitive impairment presenting with a hip fracture: secondary analysis of data from the HORIZON Recurrent Fracture Trial. Osteoporos Int (2013) 0.77
Identifying Treatment Effect Modifiers in the STarT Back Trial: A Secondary Analysis. J Pain (2016) 0.77
Evaluation of systematic assessment of asthma-like symptoms and tobacco smoke exposure in early childhood by well-child professionals: a randomised trial. PLoS One (2014) 0.76
Pharmacogenomic substudies of randomized controlled trials: consideration of safety outcomes. Ther Adv Drug Saf (2014) 0.76
Subgroup analyses in confirmatory clinical trials: time to be specific about their purposes. BMC Med Res Methodol (2016) 0.76
Extending the PRISMA statement to equity-focused systematic reviews (PRISMA-E 2012): explanation and elaboration. Int J Equity Health (2015) 0.76
Can we predict response to the McKenzie method in patients with acute low back pain? A secondary analysis of a randomized controlled trial. Eur Spine J (2011) 0.76
Markers of Differential Response to Inhaled Corticosteroid Treatment Among Children with Mild Persistent Asthma. J Allergy Clin Immunol Pract (2015) 0.76
Recombinant factor VIIa for variceal bleeding in liver cirrhosis: still only a hope. Arch Med Sci (2017) 0.75
Anti-angiogenic therapy in advanced non-small cell lung carcinoma (NSCLC): is there a role in subsequent lines of therapy? J Thorac Dis (2015) 0.75
An approach to addressing subpopulation considerations in systematic reviews: the experience of reviewers supporting the U.S. Preventive Services Task Force. Syst Rev (2017) 0.75
Do MRI findings identify patients with chronic low back pain and Modic changes who respond best to rest or exercise: a subgroup analysis of a randomised controlled trial. Chiropr Man Therap (2015) 0.75
Multivariable fractional polynomial interaction to investigate continuous effect modifiers in a meta-analysis on higher versus lower PEEP for patients with ARDS. BMJ Open (2016) 0.75
Gabapentin in procedure-specific postoperative pain management - preplanned subgroup analyses from a systematic review with meta-analyses and trial sequential analyses. BMC Anesthesiol (2017) 0.75
Perioperative stroke. Can J Anaesth (2015) 0.75
Current-oasis: a potential mirage of numbers. Can J Hosp Pharm (2011) 0.75
Light therapy for non-seasonal depression: systematic review and meta-analysis. BJPsych Open (2016) 0.75
Targeted Temperature Management After Cardiac Arrest Due to Drowning: "Frequentist" and "Bayesian" Decision Making. Pediatr Crit Care Med (2016) 0.75
Outcome Reporting Bias in Government-Sponsored Policy Evaluations: A Qualitative Content Analysis of 13 Studies. PLoS One (2016) 0.75
Two years of school-based intervention program could improve the physical fitness among Ecuadorian adolescents at health risk: subgroups analysis from a cluster-randomized trial. BMC Pediatr (2016) 0.75
Helping people make well-informed decisions about health care: old and new challenges to achieving the aim of the Cochrane Collaboration. Syst Rev (2013) 0.75
Subgroup analyses of randomized clinical trials in heart failure: facts and numbers. ESC Heart Fail (2016) 0.75
Idraparinux or idrabiotaparinux for long-term venous thromboembolism treatment: a systematic review and meta-analysis of randomized controlled trials. PLoS One (2013) 0.75
Promotion of a healthy lifestyle among 5-year-old overweight children: health behavior outcomes of the 'Be active, eat right' study. BMC Public Health (2014) 0.75
Efficacy of Electrical Stimulators for Bone Healing: A Meta-Analysis of Randomized Sham-Controlled Trials. Sci Rep (2016) 0.75
Association between cannabis use and treatment outcomes in patients receiving methadone maintenance treatment: a systematic review protocol. Syst Rev (2016) 0.75
A Perspective on the Application of Pro-/Synbiotics in Clinical Practice. Front Microbiol (2017) 0.75
Equity effects of children's physical activity interventions: a systematic scoping review. Int J Behav Nutr Phys Act (2017) 0.75
Corticosteroids for treatment of sore throat: systematic review and meta-analysis of randomised trials. BMJ (2017) 0.75
Cochrane in CORR (®): Industry Sponsorship and Research Outcome. Clin Orthop Relat Res (2017) 0.75
Grading quality of evidence and strength of recommendations. BMJ (2004) 26.08
Adherence to antiretroviral therapy in sub-Saharan Africa and North America: a meta-analysis. JAMA (2006) 11.71
GRADE guidelines: 3. Rating the quality of evidence. J Clin Epidemiol (2011) 10.02
Human papillomavirus DNA versus Papanicolaou screening tests for cervical cancer. N Engl J Med (2007) 9.53
Randomized trials stopped early for benefit: a systematic review. JAMA (2005) 8.43
Surgical mask vs N95 respirator for preventing influenza among health care workers: a randomized trial. JAMA (2009) 7.61
Systems for grading the quality of evidence and the strength of recommendations I: critical appraisal of existing approaches The GRADE Working Group. BMC Health Serv Res (2004) 7.20
High-frequency oscillation in early acute respiratory distress syndrome. N Engl J Med (2013) 6.56
Optimal search strategies for retrieving scientifically strong studies of treatment from Medline: analytical survey. BMJ (2005) 6.08
Driving pressure and survival in the acute respiratory distress syndrome. N Engl J Med (2015) 6.06
Stopping randomized trials early for benefit and estimation of treatment effects: systematic review and meta-regression analysis. JAMA (2010) 5.90
Probiotics for the prevention of Clostridium difficile-associated diarrhea: a systematic review and meta-analysis. Ann Intern Med (2012) 5.67
Comparison of mortality between private for-profit and private not-for-profit hemodialysis centers: a systematic review and meta-analysis. JAMA (2002) 5.57
A Trial of Wound Irrigation in the Initial Management of Open Fracture Wounds. N Engl J Med (2015) 5.28
Grading quality of evidence and strength of recommendations for diagnostic tests and strategies. BMJ (2008) 5.16
Bariatric surgery versus non-surgical treatment for obesity: a systematic review and meta-analysis of randomised controlled trials. BMJ (2013) 5.08
A systematic review and meta-analysis of studies comparing mortality rates of private for-profit and private not-for-profit hospitals. CMAJ (2002) 4.84
Internet versus mailed questionnaires: a randomized comparison (2). J Med Internet Res (2004) 4.45
The diabetes mellitus medication choice decision aid: a randomized trial. Arch Intern Med (2009) 4.41
Mortality in randomized controlled trials comparing drug-eluting vs. bare metal stents in coronary artery disease: a meta-analysis. Eur Heart J (2006) 4.38
Need for expertise based randomised controlled trials. BMJ (2005) 4.34
Short-term vs conventional glucocorticoid therapy in acute exacerbations of chronic obstructive pulmonary disease: the REDUCE randomized clinical trial. JAMA (2013) 4.33
An observational study of orthopaedic abstracts and subsequent full-text publications. J Bone Joint Surg Am (2002) 4.25
Effect of influenza vaccination of children on infection rates in Hutterite communities: a randomized trial. JAMA (2010) 4.21
Effects of low-carbohydrate vs low-fat diets on weight loss and cardiovascular risk factors: a meta-analysis of randomized controlled trials. Arch Intern Med (2006) 4.19
Fluid resuscitation in sepsis: a systematic review and network meta-analysis. Ann Intern Med (2014) 3.96
Effect of a clinical pathway to reduce hospitalizations in nursing home residents with pneumonia: a randomized controlled trial. JAMA (2006) 3.83
Combined corticosteroid and antiviral treatment for Bell palsy: a systematic review and meta-analysis. JAMA (2009) 3.81
A new 'mechanistic-practical" framework for designing and interpreting randomized trials. J Clin Epidemiol (2008) 3.75
The reporting of methodological factors in randomized controlled trials and the association with a journal policy to promote adherence to the Consolidated Standards of Reporting Trials (CONSORT) checklist. Control Clin Trials (2002) 3.62
Physicians' and patients' choices in evidence based practice. BMJ (2002) 3.57
Prognosis for gross motor function in cerebral palsy: creation of motor development curves. JAMA (2002) 3.51
Adverse effects of biologics: a network meta-analysis and Cochrane overview. Cochrane Database Syst Rev (2011) 3.44
Barriers to full-text publication following presentation of abstracts at annual orthopaedic meetings. J Bone Joint Surg Am (2003) 3.36
Can we individualize the 'number needed to treat'? An empirical study of summary effect measures in meta-analyses. Int J Epidemiol (2002) 3.36
Validity of composite end points in clinical trials. BMJ (2005) 3.26
Quality of care in for-profit and not-for-profit nursing homes: systematic review and meta-analysis. BMJ (2009) 3.22
Internal fixation compared with arthroplasty for displaced fractures of the femoral neck. A meta-analysis. J Bone Joint Surg Am (2003) 3.14
Effect of early surgery after hip fracture on mortality and complications: systematic review and meta-analysis. CMAJ (2010) 3.13
Problems with use of composite end points in cardiovascular trials: systematic review of randomised controlled trials. BMJ (2007) 3.06
Randomized trial of reamed and unreamed intramedullary nailing of tibial shaft fractures. J Bone Joint Surg Am (2008) 3.01
Procalcitonin algorithms for antibiotic therapy decisions: a systematic review of randomized controlled trials and recommendations for clinical algorithms. Arch Intern Med (2011) 2.97
Corticosteroid Therapy for Patients Hospitalized With Community-Acquired Pneumonia: A Systematic Review and Meta-analysis. Ann Intern Med (2015) 2.95
Does ratification of human-rights treaties have effects on population health? Lancet (2009) 2.93
Telecare for patients with type 1 diabetes and inadequate glycemic control: a randomized controlled trial and meta-analysis. Diabetes Care (2004) 2.93
Systems for grading the quality of evidence and the strength of recommendations II: pilot study of a new system. BMC Health Serv Res (2005) 2.91
Oral direct Factor Xa inhibitors versus low-molecular-weight heparin to prevent venous thromboembolism in patients undergoing total hip or knee replacement: a systematic review and meta-analysis. Ann Intern Med (2012) 2.91
The health and well-being of caregivers of children with cerebral palsy. Pediatrics (2005) 2.88
Helping patients with type 2 diabetes mellitus make treatment decisions: statin choice randomized trial. Arch Intern Med (2007) 2.82
Progress in evidence-based medicine. JAMA (2008) 2.77
Payments for care at private for-profit and private not-for-profit hospitals: a systematic review and meta-analysis. CMAJ (2004) 2.76
Response, survival, and long-term toxicity after therapy with the radiolabeled somatostatin analogue [90Y-DOTA]-TOC in metastasized neuroendocrine cancers. J Clin Oncol (2011) 2.72
Specific instructions for estimating unclearly reported blinding status in randomized trials were reliable and valid. J Clin Epidemiol (2011) 2.69
Credibility of claims of subgroup effects in randomised controlled trials: systematic review. BMJ (2012) 2.69
A systematic review and meta-analysis of studies comparing readmission rates and mortality rates in patients with heart failure. Arch Intern Med (2004) 2.68
Operative management of displaced femoral neck fractures in elderly patients. An international survey. J Bone Joint Surg Am (2005) 2.68
Internet versus mailed questionnaires: a controlled comparison (2). J Med Internet Res (2004) 2.59
Clinical expertise in the era of evidence-based medicine and patient choice. ACP J Club (2002) 2.58
Probiotics for the prevention of Clostridium difficile-associated diarrhea in adults and children. Cochrane Database Syst Rev (2013) 2.58
An observational study found that authors of randomized controlled trials frequently use concealment of randomization and blinding, despite the failure to report these methods. J Clin Epidemiol (2004) 2.58
Users' guide to detecting misleading claims in clinical research reports. BMJ (2004) 2.55
The minimal detectable change cannot reliably replace the minimal important difference. J Clin Epidemiol (2009) 2.55
Effect of different antilipidemic agents and diets on mortality: a systematic review. Arch Intern Med (2005) 2.55
Risk prediction models for mortality in ambulatory patients with heart failure: a systematic review. Circ Heart Fail (2013) 2.50
Diagnosis of DVT: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest (2012) 2.50
Three day versus five day treatment with amoxicillin for non-severe pneumonia in young children: a multicentre randomised controlled trial. BMJ (2004) 2.41
Procalcitonin to initiate or discontinue antibiotics in acute respiratory tract infections. Cochrane Database Syst Rev (2012) 2.31
Mortality predictions in the intensive care unit: comparing physicians with scoring systems. Crit Care Med (2006) 2.29
How to use an article reporting a multiple treatment comparison meta-analysis. JAMA (2012) 2.28
A systematic review of studies comparing health outcomes in Canada and the United States. Open Med (2007) 2.26
Ethical issues in stopping randomized trials early because of apparent benefit. Ann Intern Med (2007) 2.21
Systematic reviewers neglect bias that results from trials stopped early for benefit. J Clin Epidemiol (2007) 2.20
Early stopping of randomized clinical trials for overt efficacy is problematic. J Clin Epidemiol (2008) 2.18
Failure of anticoagulant thromboprophylaxis: risk factors in medical-surgical critically ill patients*. Crit Care Med (2015) 2.16
Low intensity pulsed ultrasonography for fractures: systematic review of randomised controlled trials. BMJ (2009) 2.15
Integrating mortality and morbidity outcomes: using quality-adjusted life years in critical care trials. Am J Respir Crit Care Med (2012) 2.15
Use of GRADE grid to reach decisions on clinical practice guidelines when consensus is elusive. BMJ (2008) 2.15
Measurement properties and interpretability of the Chronic respiratory disease questionnaire (CRQ). COPD (2005) 2.12