Published in Cell on January 24, 2003
Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation. Cell (2008) 6.07
Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers. Nature (2007) 5.65
The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation. Proc Natl Acad Sci U S A (2004) 5.37
FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors. J Exp Med (2007) 4.59
Diversity of degradation signals in the ubiquitin-proteasome system. Nat Rev Mol Cell Biol (2008) 4.42
Multimodal activation of the ubiquitin ligase SCF by Nedd8 conjugation. Mol Cell (2008) 4.09
The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia. J Exp Med (2007) 4.04
Sequence and structural analysis of BTB domain proteins. Genome Biol (2005) 3.88
SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase. Genes Dev (2003) 3.35
Keap1 recruits Neh2 through binding to ETGE and DLG motifs: characterization of the two-site molecular recognition model. Mol Cell Biol (2006) 3.27
Cullin-based ubiquitin ligases: Cul3-BTB complexes join the family. EMBO J (2004) 3.07
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Svp1p defines a family of phosphatidylinositol 3,5-bisphosphate effectors. EMBO J (2004) 2.73
Structure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signaling. EMBO J (2006) 2.67
Structure of RCC1 chromatin factor bound to the nucleosome core particle. Nature (2010) 2.61
Mechanistic insight into the allosteric activation of a ubiquitin-conjugating enzyme by RING-type ubiquitin ligases. Proc Natl Acad Sci U S A (2005) 2.60
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Plk1 regulates activation of the anaphase promoting complex by phosphorylating and triggering SCFbetaTrCP-dependent destruction of the APC Inhibitor Emi1. Mol Biol Cell (2004) 2.48
Rapid E2-E3 assembly and disassembly enable processive ubiquitylation of cullin-RING ubiquitin ligase substrates. Cell (2009) 2.40
Different electrostatic potentials define ETGE and DLG motifs as hinge and latch in oxidative stress response. Mol Cell Biol (2007) 2.38
Structure/function implications in a dynamic complex of the intrinsically disordered Sic1 with the Cdc4 subunit of an SCF ubiquitin ligase. Structure (2010) 2.33
The crystal structure of the human polo-like kinase-1 polo box domain and its phospho-peptide complex. EMBO J (2003) 2.31
The hippo tumor pathway promotes TAZ degradation by phosphorylating a phosphodegron and recruiting the SCF{beta}-TrCP E3 ligase. J Biol Chem (2010) 2.27
Detection of sequential polyubiquitylation on a millisecond timescale. Nature (2009) 2.25
The Mdm2 RING domain C-terminus is required for supramolecular assembly and ubiquitin ligase activity. EMBO J (2006) 2.21
Control of hematopoietic stem cell quiescence by the E3 ubiquitin ligase Fbw7. J Exp Med (2008) 2.19
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Prolyl isomerase Pin1 as a molecular switch to determine the fate of phosphoproteins. Trends Biochem Sci (2011) 1.98
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Essential role for ubiquitin-ubiquitin-conjugating enzyme interaction in ubiquitin discharge from Cdc34 to substrate. Mol Cell (2011) 1.92
FWD1-mediated degradation of FREQUENCY in Neurospora establishes a conserved mechanism for circadian clock regulation. EMBO J (2003) 1.89
Structural regulation of cullin-RING ubiquitin ligase complexes. Curr Opin Struct Biol (2011) 1.89
An allosteric inhibitor of substrate recognition by the SCF(Cdc4) ubiquitin ligase. Nat Biotechnol (2010) 1.88
Cranioectodermal Dysplasia, Sensenbrenner syndrome, is a ciliopathy caused by mutations in the IFT122 gene. Am J Hum Genet (2010) 1.86
Getting into position: the catalytic mechanisms of protein ubiquitylation. Biochem J (2004) 1.83
Multisite protein kinase A and glycogen synthase kinase 3beta phosphorylation leads to Gli3 ubiquitination by SCFbetaTrCP. Mol Cell Biol (2006) 1.82
The SCF-Fbw7 ubiquitin ligase degrades MED13 and MED13L and regulates CDK8 module association with Mediator. Genes Dev (2013) 1.79
SCFCdc4 acts antagonistically to the PGC-1alpha transcriptional coactivator by targeting it for ubiquitin-mediated proteolysis. Genes Dev (2008) 1.78
The Hedgehog-inducible ubiquitin ligase subunit WSB-1 modulates thyroid hormone activation and PTHrP secretion in the developing growth plate. Nat Cell Biol (2005) 1.78
PhosphoGRID: a database of experimentally verified in vivo protein phosphorylation sites from the budding yeast Saccharomyces cerevisiae. Database (Oxford) (2010) 1.78
Phosphodependent recruitment of Bub1 and Bub3 to Spc7/KNL1 by Mph1 kinase maintains the spindle checkpoint. Curr Biol (2012) 1.77
Ubiquitylation and proteasomal degradation of the p21(Cip1), p27(Kip1) and p57(Kip2) CDK inhibitors. Cell Cycle (2010) 1.74
SF3B1 mutations correlated to cytogenetics and mutations in NOTCH1, FBXW7, MYD88, XPO1 and TP53 in 1160 untreated CLL patients. Leukemia (2013) 1.66
Polyelectrostatic interactions of disordered ligands suggest a physical basis for ultrasensitivity. Proc Natl Acad Sci U S A (2007) 1.65
Fbw7/hCDC4 dimerization regulates its substrate interactions. Cell Div (2007) 1.64
A TRAIL receptor-dependent synthetic lethal relationship between MYC activation and GSK3beta/FBW7 loss of function. Proc Natl Acad Sci U S A (2005) 1.64
Different HECT domain ubiquitin ligases employ distinct mechanisms of polyubiquitin chain synthesis. EMBO J (2005) 1.56
Mutations in a BTB-Kelch protein, KLHL7, cause autosomal-dominant retinitis pigmentosa. Am J Hum Genet (2009) 1.52
Bub3 reads phosphorylated MELT repeats to promote spindle assembly checkpoint signaling. Elife (2013) 1.52
Tumor suppression by the Fbw7 ubiquitin ligase: mechanisms and opportunities. Cancer Cell (2014) 1.51
Roles of F-box proteins in cancer. Nat Rev Cancer (2014) 1.51
WD40 repeat propellers define a ubiquitin-binding domain that regulates turnover of F box proteins. Mol Cell (2010) 1.50
A dual E3 mechanism for Rub1 ligation to Cdc53. Mol Cell (2010) 1.49
The Fbw7/human CDC4 tumor suppressor targets proproliferative factor KLF5 for ubiquitination and degradation through multiple phosphodegron motifs. J Biol Chem (2010) 1.48
Deciphering the retinoblastoma protein phosphorylation code. Trends Biochem Sci (2012) 1.46
Model of the brain tumor-Pumilio translation repressor complex. Genes Dev (2003) 1.46
Interaction of G-protein βγ complex with chromatin modulates GPCR-dependent gene regulation. PLoS One (2013) 1.43
Structures of inactive retinoblastoma protein reveal multiple mechanisms for cell cycle control. Genes Dev (2012) 1.37
Pin1 has opposite effects on wild-type and P301L tau stability and tauopathy. J Clin Invest (2008) 1.37
Structural analysis of Bub3 interactions in the mitotic spindle checkpoint. Proc Natl Acad Sci U S A (2007) 1.35
Regulation and recognition of SCFGrr1 targets in the glucose and amino acid signaling pathways. Mol Cell Biol (2004) 1.34
The structure of cyclin E1/CDK2: implications for CDK2 activation and CDK2-independent roles. EMBO J (2005) 1.31
The e3 ubiquitin ligase gene family in plants: regulation by degradation. Curr Genomics (2006) 1.29
Inducible dissociation of SCF(Met30) ubiquitin ligase mediates a rapid transcriptional response to cadmium. EMBO J (2005) 1.29
SH2 domains recognize contextual peptide sequence information to determine selectivity. Mol Cell Proteomics (2010) 1.29
Degradation of postsynaptic scaffold GKAP and regulation of dendritic spine morphology by the TRIM3 ubiquitin ligase in rat hippocampal neurons. PLoS One (2010) 1.28
Poxvirus ankyrin repeat proteins are a unique class of F-box proteins that associate with cellular SCF1 ubiquitin ligase complexes. Proc Natl Acad Sci U S A (2008) 1.26
Cyclin E phosphorylation regulates cell proliferation in hematopoietic and epithelial lineages in vivo. Genes Dev (2008) 1.25
Multisite phosphorylation networks as signal processors for Cdk1. Nat Struct Mol Biol (2013) 1.19
Cooperativity within proximal phosphorylation sites is revealed from large-scale proteomics data. Biol Direct (2010) 1.19
The structure of Ski8p, a protein regulating mRNA degradation: Implications for WD protein structure. Protein Sci (2004) 1.18
The stimulus-induced tyrosine phosphorylation of Munc18c facilitates vesicle exocytosis. J Biol Chem (2006) 1.18
Lysine-targeting specificity in ubiquitin and ubiquitin-like modification pathways. Nat Struct Mol Biol (2014) 1.16
Composite low affinity interactions dictate recognition of the cyclin-dependent kinase inhibitor Sic1 by the SCFCdc4 ubiquitin ligase. Proc Natl Acad Sci U S A (2012) 1.15
The Fbw7 and betaTRCP E3 ubiquitin ligases and their roles in tumorigenesis. Front Biosci (Landmark Ed) (2012) 1.12
Structural basis for the selection of glycosylated substrates by SCF(Fbs1) ubiquitin ligase. Proc Natl Acad Sci U S A (2007) 1.12
Nucleus-specific and cell cycle-regulated degradation of mitogen-activated protein kinase scaffold protein Ste5 contributes to the control of signaling competence. Mol Cell Biol (2008) 1.10
Identification and characterization of a novel human PP1 phosphatase complex. J Biol Chem (2010) 1.09
Proteomic screen reveals Fbw7 as a modulator of the NF-κB pathway. Nat Commun (2012) 1.07
Assembly and regulation of the yeast vacuolar H+-ATPase. J Bioenerg Biomembr (2003) 1.07
Multisite light-induced phosphorylation of the transcription factor PIF3 is necessary for both its rapid degradation and concomitant negative feedback modulation of photoreceptor phyB levels in Arabidopsis. Plant Cell (2013) 1.07
HIV-1 Vif-mediated ubiquitination/degradation of APOBEC3G involves four critical lysine residues in its C-terminal domain. Proc Natl Acad Sci U S A (2009) 1.06
Role for the SCFCDC4 ubiquitin ligase in Candida albicans morphogenesis. Mol Biol Cell (2005) 1.06
Molecular basis for lysine specificity in the yeast ubiquitin-conjugating enzyme Cdc34. Mol Cell Biol (2010) 1.05
Structure of a glomulin-RBX1-CUL1 complex: inhibition of a RING E3 ligase through masking of its E2-binding surface. Mol Cell (2012) 1.05
RCC1 uses a conformationally diverse loop region to interact with the nucleosome: a model for the RCC1-nucleosome complex. J Mol Biol (2010) 1.05
The mechanism of ubiquitination in the cullin-RING E3 ligase machinery: conformational control of substrate orientation. PLoS Comput Biol (2009) 1.05
Fbw7 dimerization determines the specificity and robustness of substrate degradation. Genes Dev (2013) 1.05
Cdc34 C-terminal tail phosphorylation regulates Skp1/cullin/F-box (SCF)-mediated ubiquitination and cell cycle progression. Biochem J (2007) 1.04
Phosphorylation of the Sic1 inhibitor of B-type cyclins in Saccharomyces cerevisiae is not essential but contributes to cell cycle robustness. Genetics (2007) 1.04
Identifying the hotspots on the top faces of WD40-repeat proteins from their primary sequences by β-bulges and DHSW tetrads. PLoS One (2012) 1.03
Fbxw7 acts as an E3 ubiquitin ligase that targets c-Myb for nemo-like kinase (NLK)-induced degradation. J Biol Chem (2008) 1.03
Nonessential sites improve phosphorylation switch. Biophys J (2010) 1.02
Inactivation of FBXW7/hCDC4-β expression by promoter hypermethylation is associated with favorable prognosis in primary breast cancer. Breast Cancer Res (2010) 1.01
A computational method for the analysis and prediction of protein:phosphopeptide-binding sites. Protein Sci (2004) 1.00
Saccharomyces cerevisiae Ime2 phosphorylates Sic1 at multiple PXS/T sites but is insufficient to trigger Sic1 degradation. Biochem J (2006) 1.00
Characterizing ubiquitination sites by peptide-based immunoaffinity enrichment. Mol Cell Proteomics (2012) 1.00
A network of assembly factors is involved in remodeling rRNA elements during preribosome maturation. J Cell Biol (2014) 1.00
Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature (2002) 37.66
BioGRID: a general repository for interaction datasets. Nucleic Acids Res (2006) 22.41
The BioGRID Interaction Database: 2008 update. Nucleic Acids Res (2007) 11.83
The chemical genomic portrait of yeast: uncovering a phenotype for all genes. Science (2008) 8.52
The BioGRID Interaction Database: 2011 update. Nucleic Acids Res (2010) 8.46
The minimum information required for reporting a molecular interaction experiment (MIMIx). Nat Biotechnol (2007) 8.24
Broadening the horizon--level 2.5 of the HUPO-PSI format for molecular interactions. BMC Biol (2007) 8.03
Global analysis of protein phosphorylation in yeast. Nature (2005) 7.46
Systematic identification of pathways that couple cell growth and division in yeast. Science (2002) 6.95
Osprey: a network visualization system. Genome Biol (2003) 6.23
The BioGRID interaction database: 2013 update. Nucleic Acids Res (2012) 6.09
A global protein kinase and phosphatase interaction network in yeast. Science (2010) 5.95
A dimerization-dependent mechanism drives RAF catalytic activation. Nature (2009) 5.39
A dynamic transcriptional network communicates growth potential to ribosome synthesis and critical cell size. Genes Dev (2004) 5.08
PSICQUIC and PSISCORE: accessing and scoring molecular interactions. Nat Methods (2011) 5.01
How cells coordinate growth and division. Curr Biol (2004) 4.81
Structure of the dual enzyme Ire1 reveals the basis for catalysis and regulation in nonconventional RNA splicing. Cell (2008) 4.59
A hitchhiker's guide to the cullin ubiquitin ligases: SCF and its kin. Biochim Biophys Acta (2004) 4.53
Higher-order substrate recognition of eIF2alpha by the RNA-dependent protein kinase PKR. Cell (2005) 4.41
A mechanism for cell-cycle regulation of MAP kinase signaling in a yeast differentiation pathway. Cell (2007) 4.21
The BTB protein MEL-26 is a substrate-specific adaptor of the CUL-3 ubiquitin-ligase. Nature (2003) 4.18
The GRID: the General Repository for Interaction Datasets. Genome Biol (2003) 4.09
CDK activity antagonizes Whi5, an inhibitor of G1/S transcription in yeast. Cell (2004) 4.04
Molecular profiling of non-small cell lung cancer and correlation with disease-free survival. Cancer Res (2002) 3.68
SAINT: probabilistic scoring of affinity purification-mass spectrometry data. Nat Methods (2010) 3.50
Stratus not altocumulus: a new view of the yeast protein interaction network. PLoS Biol (2006) 3.44
Mechanistic link between PKR dimerization, autophosphorylation, and eIF2alpha substrate recognition. Cell (2005) 3.38
Protein interaction data curation: the International Molecular Exchange (IMEx) consortium. Nat Methods (2012) 3.17
Cullin-based ubiquitin ligases: Cul3-BTB complexes join the family. EMBO J (2004) 3.07
The Protein-Protein Interaction tasks of BioCreative III: classification/ranking of articles and linking bio-ontology concepts to full text. BMC Bioinformatics (2011) 3.03
Chemical genetics reveals a complex functional ground state of neural stem cells. Nat Chem Biol (2007) 2.88
Flavonol activation defines an unanticipated ligand-binding site in the kinase-RNase domain of IRE1. Mol Cell (2010) 2.74
Suprafacial orientation of the SCFCdc4 dimer accommodates multiple geometries for substrate ubiquitination. Cell (2007) 2.69
Formin leaky cap allows elongation in the presence of tight capping proteins. Curr Biol (2003) 2.69
53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark. Nature (2013) 2.64
A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein. Mol Cell Proteomics (2008) 2.56
The size of the nucleus increases as yeast cells grow. Mol Biol Cell (2007) 2.55
Autoinhibition of the HECT-type ubiquitin ligase Smurf2 through its C2 domain. Cell (2007) 2.53
Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1. Nature (2010) 2.47
Functional genomics and proteomics: charting a multidimensional map of the yeast cell. Trends Cell Biol (2003) 2.46
An allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme. Cell (2011) 2.35
Bone recognition mechanism of porcine osteocalcin from crystal structure. Nature (2003) 2.35
Evolutionary and physiological importance of hub proteins. PLoS Comput Biol (2006) 2.34
Structure/function implications in a dynamic complex of the intrinsically disordered Sic1 with the Cdc4 subunit of an SCF ubiquitin ligase. Structure (2010) 2.33
Regulation of Smurf2 ubiquitin ligase activity by anchoring the E2 to the HECT domain. Mol Cell (2005) 2.29
The RNA-binding SAM domain of Smaug defines a new family of post-transcriptional regulators. Nat Struct Biol (2003) 2.29
ProHits: integrated software for mass spectrometry-based interaction proteomics. Nat Biotechnol (2010) 2.22
Dynamic equilibrium engagement of a polyvalent ligand with a single-site receptor. Proc Natl Acad Sci U S A (2008) 2.00
An allosteric inhibitor of substrate recognition by the SCF(Cdc4) ubiquitin ligase. Nat Biotechnol (2010) 1.88
Combinations of antibiotics and nonantibiotic drugs enhance antimicrobial efficacy. Nat Chem Biol (2011) 1.84
Still stratus not altocumulus: further evidence against the date/party hub distinction. PLoS Biol (2007) 1.84
Structural basis and sequence rules for substrate recognition by Tankyrase explain the basis for cherubism disease. Cell (2011) 1.83
The rate of cell growth is governed by cell cycle stage. Genes Dev (2009) 1.82
Dcn1 functions as a scaffold-type E3 ligase for cullin neddylation. Mol Cell (2008) 1.78
High-resolution genetic mapping with ordered arrays of Saccharomyces cerevisiae deletion mutants. Genetics (2002) 1.78
PhosphoGRID: a database of experimentally verified in vivo protein phosphorylation sites from the budding yeast Saccharomyces cerevisiae. Database (Oxford) (2010) 1.78
The Sak polo-box comprises a structural domain sufficient for mitotic subcellular localization. Nat Struct Biol (2002) 1.76
The linear ubiquitin-specific deubiquitinase gumby regulates angiogenesis. Nature (2013) 1.70
Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. Sci Signal (2013) 1.69
Structure of the Shigella T3SS effector IpaH defines a new class of E3 ubiquitin ligases. Nat Struct Mol Biol (2008) 1.65
Polyelectrostatic interactions of disordered ligands suggest a physical basis for ultrasensitivity. Proc Natl Acad Sci U S A (2007) 1.65
OTUB1 co-opts Lys48-linked ubiquitin recognition to suppress E2 enzyme function. Mol Cell (2012) 1.58
Potent and selective inhibitors of the inositol-requiring enzyme 1 endoribonuclease. J Biol Chem (2011) 1.58
Cross-species discovery of syncretic drug combinations that potentiate the antifungal fluconazole. Mol Syst Biol (2011) 1.51
Atomic structure of the KEOPS complex: an ancient protein kinase-containing molecular machine. Mol Cell (2008) 1.51
The dual-specificity phosphatase CDC14B bundles and stabilizes microtubules. Mol Cell Biol (2005) 1.49
ALDH2 mediates 5-nitrofuran activity in multiple species. Chem Biol (2012) 1.48
Problems with co-funding in Canada. Science (2005) 1.48
From large networks to small molecules. Curr Opin Chem Biol (2004) 1.45
Sequence-specific recognition of RNA hairpins by the SAM domain of Vts1p. Nat Struct Mol Biol (2006) 1.45
Recurated protein interaction datasets. Nat Methods (2009) 1.43
A strategy for modulation of enzymes in the ubiquitin system. Science (2013) 1.43
A predictive model for drug bioaccumulation and bioactivity in Caenorhabditis elegans. Nat Chem Biol (2010) 1.41
Sch9 regulates ribosome biogenesis via Stb3, Dot6 and Tod6 and the histone deacetylase complex RPD3L. EMBO J (2011) 1.40
CIF-1, a shared subunit of the COP9/signalosome and eukaryotic initiation factor 3 complexes, regulates MEL-26 levels in the Caenorhabditis elegans embryo. Mol Cell Biol (2007) 1.38
Off-target effects of psychoactive drugs revealed by genome-wide assays in yeast. PLoS Genet (2008) 1.37
The F-box protein Dia2 overcomes replication impedance to promote genome stability in Saccharomyces cerevisiae. Genetics (2006) 1.33
Non-canonical interaction of phosphoinositides with pleckstrin homology domains of Tiam1 and ArhGAP9. J Biol Chem (2007) 1.32
Dual regulation of the met4 transcription factor by ubiquitin-dependent degradation and inhibition of promoter recruitment. Mol Cell (2002) 1.32
Morphogenetic surfactants and their role in the formation of aerial hyphae in Streptomyces coelicolor. Mol Microbiol (2006) 1.30
A change in conformational dynamics underlies the activation of Eph receptor tyrosine kinases. EMBO J (2006) 1.30
Inducible dissociation of SCF(Met30) ubiquitin ligase mediates a rapid transcriptional response to cadmium. EMBO J (2005) 1.29
Structure-function analysis of core STRIPAK Proteins: a signaling complex implicated in Golgi polarization. J Biol Chem (2011) 1.26
The human Dcn1-like protein DCNL3 promotes Cul3 neddylation at membranes. Proc Natl Acad Sci U S A (2009) 1.24
An interaction network of the mammalian COP9 signalosome identifies Dda1 as a core subunit of multiple Cul4-based E3 ligases. J Cell Sci (2009) 1.23