Altered natural killer (NK) cell frequency and phenotype in latent autoimmune diabetes in adults (LADA) prior to insulin deficiency.

PubWeight™: 0.82‹?›

🔗 View Article (PMC 2940148)

Published in Clin Exp Immunol on April 09, 2010

Authors

C Akesson1, K Uvebrant, C Oderup, K Lynch, R A Harris, A Lernmark, C-D Agardh, C M Cilio

Author Affiliations

1: Cellular Autoimmunity Unit, Department of Clinical Sciences, Malmö University Hospital, Malmö, Sweden.

Articles cited by this

CD4+CD25high regulatory cells in human peripheral blood. J Immunol (2001) 11.25

Functions of natural killer cells. Nat Immunol (2008) 9.88

MHC class I molecules and KIRs in human history, health and survival. Nat Rev Immunol (2005) 6.98

Regulation of immune responses through inhibitory receptors. Annu Rev Immunol (1999) 4.06

The Bw4 public epitope of HLA-B molecules confers reactivity with natural killer cell clones that express NKB1, a putative HLA receptor. J Exp Med (1995) 3.43

Immune functions encoded by the natural killer gene complex. Nat Rev Immunol (2003) 3.21

CD4+CD25+ regulatory T cells inhibit natural killer cell functions in a transforming growth factor-beta-dependent manner. J Exp Med (2005) 2.93

NKB1: a natural killer cell receptor involved in the recognition of polymorphic HLA-B molecules. J Exp Med (1994) 2.59

Impairment of NK cell function by NKG2D modulation in NOD mice. Immunity (2003) 2.57

UKPDS 25: autoantibodies to islet-cell cytoplasm and glutamic acid decarboxylase for prediction of insulin requirement in type 2 diabetes. UK Prospective Diabetes Study Group. Lancet (1997) 2.47

Clinical and genetic characteristics of type 2 diabetes with and without GAD antibodies. Diabetes (1999) 2.36

What does it take to make a natural killer? Nat Rev Immunol (2003) 2.30

Antibodies to glutamic acid decarboxylase reveal latent autoimmune diabetes mellitus in adults with a non-insulin-dependent onset of disease. Diabetes (1993) 2.15

CD4+CD25+ T regulatory cells suppress NK cell-mediated immunotherapy of cancer. J Immunol (2006) 2.10

A novel radioligand binding assay to determine diagnostic accuracy of isoform-specific glutamic acid decarboxylase antibodies in childhood IDDM. Diabetologia (1994) 2.03

CD4+CD25+ T regulatory cells inhibit cytotoxic activity of T CD8+ and NK lymphocytes in the direct cell-to-cell interaction. Clin Immunol (2004) 1.60

The enigma of the natural killer cell. Nature (1995) 1.59

Suppression of natural killer cell-mediated bone marrow cell rejection by CD4+CD25+ regulatory T cells. Proc Natl Acad Sci U S A (2006) 1.47

Activation of human NK cells by plasmacytoid dendritic cells and its modulation by CD4+ T helper cells and CD4+ CD25hi T regulatory cells. Eur J Immunol (2005) 1.42

Triple-label hybridization assay for type-1 diabetes-related HLA alleles. Biotechniques (1995) 1.41

Latent autoimmune diabetes mellitus in adults (LADA): the role of antibodies to glutamic acid decarboxylase in diagnosis and prediction of insulin dependency. Diabet Med (1994) 1.36

Altered natural killer cells in type 1 diabetic patients. Diabetes (2007) 1.26

Islet cell antibodies identify latent type I diabetes in patients aged 35-75 years at diagnosis. Diabetes (1986) 1.26

NK cells lyse T regulatory cells that expand in response to an intracellular pathogen. J Immunol (2008) 1.26

Accelerated chemically induced tumor development mediated by CD4+CD25+ regulatory T cells in wild-type hosts. Proc Natl Acad Sci U S A (2005) 1.24

The role of NK cells in autoimmune disease. Autoimmunity (2002) 1.24

Regulatory T cells control dendritic cell/NK cell cross-talk in lymph nodes at the steady state by inhibiting CD4+ self-reactive T cells. J Immunol (2008) 1.22

NK cells: elusive players in autoimmunity. Trends Immunol (2005) 1.17

The NKG2D receptor: sensing stressed cells. Trends Mol Med (2008) 1.17

Rapid HLA-DQB1 genotyping for four alleles in the assessment of risk for IDDM in the Finnish population. The Childhood Diabetes in Finland (DiMe) Study Group. Diabetes Care (1996) 1.16

Insulin and glucagon secretion in patients with slowly progressing autoimmune diabetes (LADA). J Clin Endocrinol Metab (2000) 1.15

The immunoregulatory effects of NK cells: the role of TGF-beta and implications for autoimmunity. Immunol Today (1997) 1.15

Clinical and pathogenic significance of pancreatic-islet-cell antibodies in diabetics treated with oral hypoglycaemic agents. Lancet (1977) 1.14

GAD antibodies in NIDDM. Ten-year follow-up from the diagnosis. Diabetes Care (1995) 1.09

Quantitative assay using recombinant human islet glutamic acid decarboxylase (GAD65) shows that 64K autoantibody positivity at onset predicts diabetes type. J Clin Invest (1993) 1.07

NK cells and Treg cells: a fascinating dance cheek to cheek. Eur J Immunol (2008) 1.04

The regulatory effect of natural killer cells: do "NK-reg cells" exist? Cell Mol Immunol (2006) 0.98

Alterations in lymphocyte subpopulations in type 1 (insulin-dependent) diabetes mellitus: exploration of possible mechanisms and relationships to autoimmune phenomena. Diabetologia (1984) 0.98

T regulatory cells control numbers of NK cells and CD8alpha+ immature dendritic cells in the lymph node paracortex. J Immunol (2007) 0.97

Activating and inhibitory NK cell receptors. Adv Exp Med Biol (1998) 0.96

Natural killer cells prevent CD28-mediated Foxp3 transcription in CD4+CD25- T lymphocytes. Exp Hematol (2007) 0.94

Regulation of adaptive immunity by natural killer cells. Immunol Res (1998) 0.93

Validation of allele-specific polymerase chain reaction for DNA typing of HLA-B27. Clin Chem (1995) 0.91

Autoimmune diabetes mellitus--much progress, but many challenges. Adv Immunol (2008) 0.86

A simple and rapid microSepharose assay for GAD65 and ICA512 autoantibodies in diabetes. Diabetes Incidence Study in Sweden (DISS). J Immunol Methods (1998) 0.86

Natural killer cell and islet killer cell activities in type 1 (insulin-dependent) diabetes. Diabetologia (1986) 0.85

Immunoregulatory dysfunctions in type I diabetes: natural and antibody-dependent cellular cytotoxic activities. J Clin Immunol (1986) 0.82

Natural killer cells in insulin dependent diabetes mellitus. Br Med J (Clin Res Ed) (1986) 0.82

Evidence that the reduced number of natural killer cells in type 1 (insulin-dependent) diabetes may be genetically determined. Diabetologia (1987) 0.82

Immune responses to insulin and lymphocyte subclasses at diagnosis of insulin-dependent diabetes and one year later. Immunobiology (1990) 0.82

Cytotoxic activity in children with insulin-dependent diabetes mellitus. Diabetes Res Clin Pract (1994) 0.80

Articles by these authors

(truncated to the top 100)

Sites of alcohol and volatile anaesthetic action on GABA(A) and glycine receptors. Nature (1997) 7.49

Modelling cost-effectiveness of Helicobacter pylori screening to prevent gastric cancer: a mandate for clinical trials. Lancet (1996) 5.03

Evidence for existence of tissue-specific regulation of the mammalian pyruvate dehydrogenase complex. Biochem J (1998) 3.36

Depressed bronchoalveolar urokinase activity in patients with adult respiratory distress syndrome. N Engl J Med (1990) 3.04

RAGE is the major receptor for the proinflammatory activity of HMGB1 in rodent macrophages. Scand J Immunol (2005) 2.96

Islet autoantibodies in cord blood from children who developed type I (insulin-dependent) diabetes mellitus before 15 years of age. Diabetologia (1999) 2.81

Course of tic severity in Tourette syndrome: the first two decades. Pediatrics (1998) 2.75

The preparation of, and studies on, free cell suspensions from mouse pancreatic islets. Diabetologia (1974) 2.69

Autoantibodies in newly diagnosed diabetic children immunoprecipitate human pancreatic islet cell proteins. Nature (1982) 2.58

The role of coronary angiography and coronary revascularization before noncardiac vascular surgery. JAMA (1995) 2.38

Autoimmune type 1 diabetes: resolved and unresolved issues. J Clin Invest (2001) 2.35

Specific binding sites for alcohols and anesthetics on ligand-gated ion channels. Proc Natl Acad Sci U S A (2000) 2.24

Starvation and diabetes increase the amount of pyruvate dehydrogenase kinase isoenzyme 4 in rat heart. Biochem J (1998) 2.11

A genetic linkage map of the laboratory rat, Rattus norvegicus. Nat Genet (1995) 2.10

A confidential study of deaths after emergency medical admission: issues relating to quality of care. Clin Med (2003) 2.10

A molecular model of human branched-chain amino acid metabolism. Am J Clin Nutr (1998) 2.09

Conformational basis of energy transformations in membrane systems. 3. Configurational changes in the mitochondrial inner membrane induced by changes in functional states. Arch Biochem Biophys (1968) 2.04

A novel radioligand binding assay to determine diagnostic accuracy of isoform-specific glutamic acid decarboxylase antibodies in childhood IDDM. Diabetologia (1994) 2.03

Anesthetics and ion channels: molecular models and sites of action. Annu Rev Pharmacol Toxicol (2001) 2.01

Comparing health inequality in men and women: prospective study of mortality 1986-96. BMJ (2000) 2.00

HLA-D region beta-chain DNA endonuclease fragments differ between HLA-DR identical healthy and insulin-dependent diabetic individuals. Nature (1983) 1.99

Mechanism responsible for inactivation of skeletal muscle pyruvate dehydrogenase complex in starvation and diabetes. Diabetes (1999) 1.95

Gene expression in human alcoholism: microarray analysis of frontal cortex. Alcohol Clin Exp Res (2000) 1.93

G-protein-coupled inwardly rectifying potassium channels are targets of alcohol action. Nat Neurosci (1999) 1.92

The conformational basis of energy conservation in membrane systems. II. Correlation between conformational change and functional states. Proc Natl Acad Sci U S A (1968) 1.91

A "SMART" design for building individualized treatment sequences. Annu Rev Clin Psychol (2011) 1.89

Relevant concentrations of inhaled anesthetics for in vitro studies of anesthetic mechanisms. Anesthesiology (2001) 1.87

Genetic dissection of autoimmune type I diabetes in the BB rat. Nat Genet (1992) 1.87

Transformation of biphasic calcium phosphate ceramics in vivo: ultrastructural and physicochemical characterization. J Biomed Mater Res (1989) 1.85

Isolation and preservation of peripheral blood mononuclear cells for analysis of islet antigen-reactive T cell responses: position statement of the T-Cell Workshop Committee of the Immunology of Diabetes Society. Clin Exp Immunol (2010) 1.82

Implications for prediction and hazard assessment from the 2004 Parkfield earthquake. Nature (2005) 1.81

Neurobiology of alcohol abuse. Trends Pharmacol Sci (1992) 1.81

Hypothesis: inhaled anesthetics produce immobility and amnesia by different mechanisms at different sites. Anesth Analg (1997) 1.80

Enhancement of glycine receptor function by ethanol is inversely correlated with molecular volume at position alpha267. J Biol Chem (1998) 1.77

Relative predispositional effects of HLA class II DRB1-DQB1 haplotypes and genotypes on type 1 diabetes: a meta-analysis. Tissue Antigens (2007) 1.77

Mutations of gamma-aminobutyric acid and glycine receptors change alcohol cutoff: evidence for an alcohol receptor? Proc Natl Acad Sci U S A (1998) 1.76

The pancreatic beta-cell recognition of insulin secretagogues. Effects of calcium and sodium on glucose metabolism and insulin release. Biochem J (1974) 1.76

Effects of growth factors on an intestinal epithelial cell line: transforming growth factor beta inhibits proliferation and stimulates differentiation. Biochem Biophys Res Commun (1987) 1.75

The World Health Organization International Collaborative Study for islet cell antibodies. Diabetologia (2000) 1.74

Studies on the inhibition of hepatic lipogenesis by N-6,O-2'-dibutyryl adenosine 3',5'-monophosphate. Arch Biochem Biophys (1975) 1.73

Enhancement of homomeric glycine receptor function by long-chain alcohols and anaesthetics. Br J Pharmacol (1996) 1.72

Family cell lines available for research. Am J Hum Genet (1990) 1.72

Isolation of rabbit liver branched chain alpha-ketoacid dehydrogenase and regulation by phosphorylation. J Biol Chem (1982) 1.71

Effects of gaseous anesthetics nitrous oxide and xenon on ligand-gated ion channels. Comparison with isoflurane and ethanol. Anesthesiology (2000) 1.70

Interferon expression in the pancreases of patients with type I diabetes. Diabetes (1995) 1.69

Genetic factors influencing alcohol dependence. Br J Pharmacol (2008) 1.64

Etiological diagnosis of primary adrenal insufficiency using an original flowchart of immune and biochemical markers. J Clin Endocrinol Metab (1998) 1.63

Islet-cell-surface antibodies in juvenile diabetes mellitus. N Engl J Med (1978) 1.59

Regulation of branched-chain alpha-ketoacid dehydrogenase kinase. Arch Biochem Biophys (1984) 1.57

Isoenzymes of pyruvate dehydrogenase phosphatase. DNA-derived amino acid sequences, expression, and regulation. J Biol Chem (1998) 1.57

Starvation increases the amount of pyruvate dehydrogenase kinase in several mammalian tissues. Arch Biochem Biophys (2000) 1.57

Mechanism of action of ethanol: initial central nervous system actions. Pharmacol Rev (1989) 1.52

Highly efficient generation of recombinant baculoviruses by enzymatically medicated site-specific in vitro recombination. Nucleic Acids Res (1992) 1.52

Radioimmunoassays for glutamic acid decarboxylase (GAD65) and GAD65 autoantibodies using 35S or 3H recombinant human ligands. J Immunol Methods (1995) 1.51

A single amino acid determines differences in ethanol actions on strychnine-sensitive glycine receptors. Mol Pharmacol (1996) 1.51

Adaptive increase in pyruvate dehydrogenase kinase 4 during starvation is mediated by peroxisome proliferator-activated receptor alpha. Biochem Biophys Res Commun (2001) 1.50

Preparation and characterization of plasma membrane-enriched fractions from rat pancreatic islets. J Cell Biol (1976) 1.50

Activity state of the branched chain alpha-ketoacid dehydrogenase complex in heart, liver, and kidney of normal, fasted, diabetic, and protein-starved rats. Biochem Biophys Res Commun (1983) 1.50

Naturally processed T cell epitopes from human glutamic acid decarboxylase identified using mice transgenic for the type 1 diabetes-associated human MHC class II allele, DRB1*0401. J Clin Invest (1996) 1.49

Combined analysis of studies of the effects of the matrix metalloproteinase inhibitor marimastat on serum tumor markers in advanced cancer: selection of a biologically active and tolerable dose for longer-term studies. Clin Cancer Res (1998) 1.48

Targeted upregulation of pyruvate dehydrogenase kinase (PDK)-4 in slow-twitch skeletal muscle underlies the stable modification of the regulatory characteristics of PDK induced by high-fat feeding. Diabetes (2000) 1.48

Prognostic factors for the course of beta cell function in autoimmune diabetes. J Clin Endocrinol Metab (2000) 1.48

The conformational basis of energy transformations in membrane systems. I. Conformational changes in mitochondria. Proc Natl Acad Sci U S A (1968) 1.46

Activation of inflammatory signaling by lipopolysaccharide produces a prolonged increase of voluntary alcohol intake in mice. Brain Behav Immun (2011) 1.46

Primary structure of pyruvate dehydrogenase kinase establishes a new family of eukaryotic protein kinases. J Biol Chem (1993) 1.45

Human cell lines from families available for diabetes research. Diabetologia (1991) 1.44

Branched-chain alpha-ketoacid dehydrogenase kinase. Molecular cloning, expression, and sequence similarity with histidine protein kinases. J Biol Chem (1992) 1.42

Haematological effects of reinfused mediastinal blood after cardiac surgery. Med J Aust (1991) 1.42

Effects of ethanol on recombinant human neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes. J Pharmacol Exp Ther (1999) 1.42

Potassium channels as targets for ethanol: studies of G-protein-coupled inwardly rectifying potassium channel 2 (GIRK2) null mutant mice. J Pharmacol Exp Ther (2001) 1.42

Cloning and characterization of PDK4 on 7q21.3 encoding a fourth pyruvate dehydrogenase kinase isoenzyme in human. J Biol Chem (1996) 1.41

A new ureteral anastomotic device: the Unilink system. A pilot study using the porcine model. Am J Obstet Gynecol (1994) 1.39

Cloned cell lines from a transplantable islet cell tumor are heterogeneous and express cholecystokinin in addition to islet hormones. J Cell Biol (1986) 1.39

Effect of pH on malonyl-CoA inhibition of carnitine palmitoyltransferase I. Biochem J (1983) 1.39

Association between HLA and islet cell antibodies in diabetic patients with a mitochondrial DNA mutation at base pair 3243. Diabetologia (1996) 1.38

Screening surgeons for HIV infection. A cost-effectiveness analysis. Ann Intern Med (1995) 1.38

Relationship of obesity to bile lithogenicity in man. Ann Surg (1979) 1.38

Auto- and alloimmune reactivity to human islet allografts transplanted into type 1 diabetic patients. Diabetes (1999) 1.38

Glutamate decarboxylase (GAD65) and tyrosine phosphatase-like protein (IA-2) autoantibodies index in a regional population is related to glucose intolerance and body mass index. Diabetologia (1999) 1.37

A pervasive mechanism for analgesia: activation of GIRK2 channels. Proc Natl Acad Sci U S A (2002) 1.37

Screening of several H-2 congenic mouse strains identified H-2(q) mice as highly susceptible to MOG-induced EAE with minimal adjuvant requirement. J Neuroimmunol (2000) 1.36

Ethanol sensitivity of the GABAA receptor expressed in Xenopus oocytes requires 8 amino acids contained in the gamma 2L subunit. Neuron (1991) 1.36

The pancreatic beta-cell recognition of insulin secretogogues. Influence of neuraminidase treatment on the release of insulin and the islet content of insulin, sialic acid, and cyclic adenosine 3':5'-monophosphate. J Biol Chem (1974) 1.35

Glutamate decarboxylase-, insulin-, and islet cell-antibodies and HLA typing to detect diabetes in a general population-based study of Swedish children. J Clin Invest (1995) 1.33

Antibodies to a Mr-64,000 islet cell protein in Swedish children with newly diagnosed type 1 (insulin-dependent) diabetes. Diabetologia (1988) 1.32

Evidence for both a regulatory mutation and a structural mutation in a family with maple syrup urine disease. J Clin Invest (1989) 1.32

Autoantibodies to a 64-kilodalton islet cell protein precede the onset of spontaneous diabetes in the BB rat. Science (1984) 1.31

Inhibition of branched chain alpha-ketoacid dehydrogenase kinase activity by alpha-chloroisocaproate. J Biol Chem (1982) 1.31

Earthquake triggering by seismic waves following the Landers and Hector Mine earthquakes. Nature (2001) 1.30

Amino acid volume and hydropathy of a transmembrane site determine glycine and anesthetic sensitivity of glycine receptors. J Biol Chem (1999) 1.30

Human class II major histocompatibility antigen beta-chains are derived from at least three loci. Nature (1983) 1.29

The metabolic effects of dichloroacetate. Metabolism (1981) 1.29

cDNA cloning of the E1 alpha subunit of the branched-chain alpha-keto acid dehydrogenase and elucidation of a molecular basis for maple syrup urine disease. Ann N Y Acad Sci (1989) 1.28

Assessment of disability caused by rheumatic diseases in general practice. Ann Rheum Dis (1987) 1.28

Potentiation of gamma-aminobutyric acid type A receptor-mediated chloride currents by novel halogenated compounds correlates with their abilities to induce general anesthesia. Mol Pharmacol (1994) 1.28

General anesthetics potentiate gamma-aminobutyric acid actions on gamma-aminobutyric acidA receptors expressed by Xenopus oocytes: lack of involvement of intracellular calcium. J Pharmacol Exp Ther (1992) 1.27

Insulin downregulates pyruvate dehydrogenase kinase (PDK) mRNA: potential mechanism contributing to increased lipid oxidation in insulin-resistant subjects. Mol Genet Metab (1998) 1.27

Mechanism responsible for 5-(tetradecyloxy)-2-furoic acid inhibition of hepatic lipogenesis. J Biol Chem (1979) 1.27

Actions of long chain alcohols on GABAA and glutamate receptors: relation to in vivo effects. Br J Pharmacol (1996) 1.27

Altered sensitivity of carnitine palmitoyltransferase to inhibition by malonyl-CoA in ketotic diabetic rats. Biochem J (1984) 1.25