Published in Nucleic Acids Res on April 26, 2010
The Prp8 RNase H-like domain inhibits Brr2-mediated U4/U6 snRNA unwinding by blocking Brr2 loading onto the U4 snRNA. Genes Dev (2012) 1.17
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The C-terminal RG dipeptide repeats of the spliceosomal Sm proteins D1 and D3 contain symmetrical dimethylarginines, which form a major B-cell epitope for anti-Sm autoantibodies. J Biol Chem (2000) 2.36
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Binding of the human Prp31 Nop domain to a composite RNA-protein platform in U4 snRNP. Science (2007) 1.64
A comprehensive interaction map of the human survival of motor neuron (SMN) complex. J Biol Chem (2006) 1.61
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Chances and pitfalls of chemical cross-linking with amine-reactive N-hydroxysuccinimide esters. Anal Bioanal Chem (2008) 1.48
A general approach for identification of RNA-protein cross-linking sites within native human spliceosomal small nuclear ribonucleoproteins (snRNPs). Analysis of RNA-protein contacts in native U1 and U4/U6.U5 snRNPs. J Biol Chem (2000) 1.45
The SMN complex is associated with snRNPs throughout their cytoplasmic assembly pathway. Mol Cell Biol (2002) 1.39
Structural and functional analysis of the E. coli NusB-S10 transcription antitermination complex. Mol Cell (2008) 1.37
SMN, the spinal muscular atrophy protein, forms a pre-import snRNP complex with snurportin1 and importin beta. Hum Mol Genet (2002) 1.36
Molecular basis for the recognition of snurportin 1 by importin beta. J Biol Chem (2008) 1.34
The assembly of a spliceosomal small nuclear ribonucleoprotein particle. Nucleic Acids Res (2008) 1.34
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The 5' end of U2 snRNA is in close proximity to U1 and functional sites of the pre-mRNA in early spliceosomal complexes. Mol Cell (2007) 1.26
Structural basis for m3G-cap-mediated nuclear import of spliceosomal UsnRNPs by snurportin1. EMBO J (2005) 1.26
The importin-beta binding domain of snurportin1 is responsible for the Ran- and energy-independent nuclear import of spliceosomal U snRNPs in vitro. J Cell Biol (2002) 1.21
Sequence-structure-function relationships of Tgs1, the yeast snRNA/snoRNA cap hypermethylase. Nucleic Acids Res (2003) 1.17
Stalling of spliceosome assembly at distinct stages by small-molecule inhibitors of protein acetylation and deacetylation. RNA (2008) 1.16
MS3D structural elucidation of the HIV-1 packaging signal. Proc Natl Acad Sci U S A (2008) 1.10
RNA structural requirements for the association of the spliceosomal hPrp31 protein with the U4 and U4atac small nuclear ribonucleoproteins. J Biol Chem (2006) 1.08
Mass spectrometric analysis of a UV-cross-linked protein-DNA complex: tryptophans 54 and 88 of E. coli SSB cross-link to DNA. Protein Sci (2001) 1.02
Structural basis for m7G-cap hypermethylation of small nuclear, small nucleolar and telomerase RNA by the dimethyltransferase TGS1. Nucleic Acids Res (2009) 1.00
Detection of protein-RNA crosslinks by NanoLC-ESI-MS/MS using precursor ion scanning and multiple reaction monitoring (MRM) experiments. J Am Soc Mass Spectrom (2007) 0.98
Complete MALDI-ToF MS analysis of cross-linked peptide-RNA oligonucleotides derived from nonlabeled UV-irradiated ribonucleoprotein particles. RNA (2005) 0.98
Direct observation of UV-crosslinked protein-nucleic acid complexes by matrix-assisted laser desorption ionization mass spectrometry. Rapid Commun Mass Spectrom (1993) 0.97
Improved identification of enriched peptide RNA cross-links from ribonucleoprotein particles (RNPs) by mass spectrometry. Nucleic Acids Res (2007) 0.95
Crystal structure of Lsm3 octamer from Saccharomyces cerevisiae: implications for Lsm ring organisation and recruitment. J Mol Biol (2008) 0.94
A novel strategy for the identification of protein-DNA contacts by photocrosslinking and mass spectrometry. Nucleic Acids Res (2004) 0.94
Structural basis for RanGTP independent entry of spliceosomal U snRNPs into the nucleus. J Mol Biol (2007) 0.93
Nucleoprotein photo-cross-linking using halopyrimidine-substituted RNAs. Methods Enzymol (2000) 0.92
Characterization of the DNA-binding site in the ferric uptake regulator protein from Escherichia coli by UV crosslinking and mass spectrometry. FEBS Lett (2005) 0.91
Purification, crystallization and preliminary crystallographic data of the m3G cap-binding domain of human snRNP import factor snurportin 1. Acta Crystallogr D Biol Crystallogr (2004) 0.82
Trimethylguanosine nucleoside inhibits cross-linking between Snurportin 1 and m3G-CAPPED U1 snRNA. Nucleosides Nucleotides Nucleic Acids (2006) 0.79
Characterization of DNA--protein cross-links induced by oxanine: cellular damage derived from nitric oxide and nitrous acid. Biochemistry (2007) 0.78
Single-stranded antisense siRNAs guide target RNA cleavage in RNAi. Cell (2002) 14.37
Molecular anatomy of a trafficking organelle. Cell (2006) 11.47
Identification of novel argonaute-associated proteins. Curr Biol (2005) 6.13
Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells. EMBO Rep (2007) 3.89
Small nuclear ribonucleoprotein remodeling during catalytic activation of the spliceosome. Science (2002) 3.59
Protein composition of human prespliceosomes isolated by a tobramycin affinity-selection method. Proc Natl Acad Sci U S A (2002) 3.14
CASK Functions as a Mg2+-independent neurexin kinase. Cell (2008) 3.10
Isolation of an active step I spliceosome and composition of its RNP core. Nature (2008) 3.10
Importin 8 is a gene silencing factor that targets argonaute proteins to distinct mRNAs. Cell (2009) 2.98
GraFix: sample preparation for single-particle electron cryomicroscopy. Nat Methods (2007) 2.71
Protein composition and electron microscopy structure of affinity-purified human spliceosomal B complexes isolated under physiological conditions. Mol Cell Biol (2006) 2.55
Crystal structure of the archaeal ammonium transporter Amt-1 from Archaeoglobus fulgidus. Proc Natl Acad Sci U S A (2005) 2.49
EF-P is essential for rapid synthesis of proteins containing consecutive proline residues. Science (2012) 2.44
Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein. EMBO J (2002) 2.39
The evolutionarily conserved core design of the catalytic activation step of the yeast spliceosome. Mol Cell (2009) 2.39
Conserved stem II of the box C/D motif is essential for nucleolar localization and is required, along with the 15.5K protein, for the hierarchical assembly of the box C/D snoRNP. Mol Cell Biol (2002) 2.37
Crystal structure of the borna disease virus nucleoprotein. Structure (2003) 2.30
Functional interaction between PML and SATB1 regulates chromatin-loop architecture and transcription of the MHC class I locus. Nat Cell Biol (2006) 2.29
A subset of human 35S U5 proteins, including Prp19, function prior to catalytic step 1 of splicing. EMBO J (2004) 2.20
Mechanism and consequences for paralog-specific sumoylation of ubiquitin-specific protease 25. Mol Cell (2008) 2.15
NES consensus redefined by structures of PKI-type and Rev-type nuclear export signals bound to CRM1. Nat Struct Mol Biol (2010) 2.12
Crystal structure of the nuclear export receptor CRM1 in complex with Snurportin1 and RanGTP. Science (2009) 2.08
Composition and three-dimensional EM structure of double affinity-purified, human prespliceosomal A complexes. EMBO J (2007) 2.07
Identification, cloning, and functional analysis of the human U6 snRNA-specific terminal uridylyl transferase. RNA (2006) 2.05
Assembly and maturation of the U3 snoRNP in the nucleoplasm in a large dynamic multiprotein complex. Mol Cell (2004) 1.89
Reconstitution of both steps of Saccharomyces cerevisiae splicing with purified spliceosomal components. Nat Struct Mol Biol (2009) 1.89
Induction of interferon-alpha by immune complexes or liposomes containing systemic lupus erythematosus autoantigen- and Sjögren's syndrome autoantigen-associated RNA. Arthritis Rheum (2006) 1.86
Exon definition complexes contain the tri-snRNP and can be directly converted into B-like precatalytic splicing complexes. Mol Cell (2010) 1.84
Protein composition of human mRNPs spliced in vitro and differential requirements for mRNP protein recruitment. RNA (2006) 1.83
Hierarchical, clustered protein interactions with U4/U6 snRNA: a biochemical role for U4/U6 proteins. EMBO J (2002) 1.82
Prdm3 and Prdm16 are H3K9me1 methyltransferases required for mammalian heterochromatin integrity. Cell (2012) 1.78
A cytoplasmic complex mediates specific mRNA recognition and localization in yeast. PLoS Biol (2011) 1.78
A reversibly photoswitchable GFP-like protein with fluorescence excitation decoupled from switching. Nat Biotechnol (2011) 1.74
U1 small nuclear ribonucleoprotein immune complexes induce type I interferon in plasmacytoid dendritic cells through TLR7. Blood (2005) 1.74
Phosphorylation of human PRP28 by SRPK2 is required for integration of the U4/U6-U5 tri-snRNP into the spliceosome. Nat Struct Mol Biol (2008) 1.73
Molecular basis for multiple sulfatase deficiency and mechanism for formylglycine generation of the human formylglycine-generating enzyme. Cell (2005) 1.71
The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome. RNA (2004) 1.67
Genomic and proteomic analysis of thirty-nine structural proteins of shrimp white spot syndrome virus. J Virol (2004) 1.65
Conservation of the protein composition and electron microscopy structure of Drosophila melanogaster and human spliceosomal complexes. Mol Cell Biol (2008) 1.64
Phosphorylation of human Argonaute proteins affects small RNA binding. Nucleic Acids Res (2010) 1.64
Syk kinase-coupled C-type lectin receptors engage protein kinase C-σ to elicit Card9 adaptor-mediated innate immunity. Immunity (2012) 1.61
The nuclear F-actin interactome of Xenopus oocytes reveals an actin-bundling kinesin that is essential for meiotic cytokinesis. EMBO J (2013) 1.58
B cell receptor-mediated antigen gathering requires ubiquitin ligase Cbl and adaptors Grb2 and Dok-3 to recruit dynein to the signaling microcluster. Immunity (2011) 1.53
Semiquantitative proteomic analysis of the human spliceosome via a novel two-dimensional gel electrophoresis method. Mol Cell Biol (2011) 1.48
Molecular architecture of the human Prp19/CDC5L complex. Mol Cell Biol (2010) 1.44
Detecting endogenous SUMO targets in mammalian cells and tissues. Nat Struct Mol Biol (2013) 1.44
Crystal structure of a bacterial class 2 histone deacetylase homologue. J Mol Biol (2005) 1.41
Characterization of the cleavage site and function of resulting cleavage fragments after limited proteolysis of Clostridium difficile toxin B (TcdB) by host cells. Microbiology (2005) 1.40
The iron-sulphur protein RNase L inhibitor functions in translation termination. EMBO Rep (2010) 1.40
MINOS1 is a conserved component of mitofilin complexes and required for mitochondrial function and cristae organization. Mol Biol Cell (2011) 1.37
Structural and functional analysis of the E. coli NusB-S10 transcription antitermination complex. Mol Cell (2008) 1.37
Localization of Prp8, Brr2, Snu114 and U4/U6 proteins in the yeast tri-snRNP by electron microscopy. Nat Struct Mol Biol (2008) 1.37
Crystal structure of the polysialic acid-degrading endosialidase of bacteriophage K1F. Nat Struct Mol Biol (2004) 1.36
Post-transcriptional spliceosomes are retained in nuclear speckles until splicing completion. Nat Commun (2012) 1.35
Tyrosine 394 is phosphorylated in Alzheimer's paired helical filament tau and in fetal tau with c-Abl as the candidate tyrosine kinase. J Neurosci (2005) 1.35
Functional organization of the Sm core in the crystal structure of human U1 snRNP. EMBO J (2010) 1.35
Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson's disease. Acta Neuropathol (2013) 1.34
Organization of core spliceosomal components U5 snRNA loop I and U4/U6 Di-snRNP within U4/U6.U5 Tri-snRNP as revealed by electron cryomicroscopy. Mol Cell (2006) 1.33
A Syd-1 homologue regulates pre- and postsynaptic maturation in Drosophila. J Cell Biol (2010) 1.33
Quantitative comparison of glutamatergic and GABAergic synaptic vesicles unveils selectivity for few proteins including MAL2, a novel synaptic vesicle protein. J Neurosci (2010) 1.32
Fragile X mental retardation protein (FMRP) binds specifically to the brain cytoplasmic RNAs BC1/BC200 via a novel RNA-binding motif. J Biol Chem (2005) 1.32
PERILIPIN-dependent control of lipid droplet structure and fat storage in Drosophila. Cell Metab (2010) 1.31
Systematic analysis of barrier-forming FG hydrogels from Xenopus nuclear pore complexes. EMBO J (2012) 1.27
Mutagenesis suggests several roles of Snu114p in pre-mRNA splicing. J Biol Chem (2003) 1.27
The 5' end of U2 snRNA is in close proximity to U1 and functional sites of the pre-mRNA in early spliceosomal complexes. Mol Cell (2007) 1.26
Structural basis for m3G-cap-mediated nuclear import of spliceosomal UsnRNPs by snurportin1. EMBO J (2005) 1.26
Three-dimensional structure of a pre-catalytic human spliceosomal complex B. Nat Struct Mol Biol (2004) 1.25
Role of cdk2 in the sequential phosphorylation/activation of C/EBPbeta during adipocyte differentiation. Proc Natl Acad Sci U S A (2007) 1.25
The importin-beta binding domain of snurportin1 is responsible for the Ran- and energy-independent nuclear import of spliceosomal U snRNPs in vitro. J Cell Biol (2002) 1.21
Crystal structure of human pFGE, the paralog of the Calpha-formylglycine-generating enzyme. J Biol Chem (2005) 1.21
RNA structure and RNA-protein interactions in purified yeast U6 snRNPs. J Mol Biol (2005) 1.20
Determination of protein stoichiometry within protein complexes using absolute quantification and multiple reaction monitoring. Anal Chem (2010) 1.20
Identification of SNAP-47, a novel Qbc-SNARE with ubiquitous expression. J Biol Chem (2006) 1.19
Dissection of the factor requirements for spliceosome disassembly and the elucidation of its dissociation products using a purified splicing system. Genes Dev (2013) 1.18
Functional analysis of seven genes encoding eight translation initiation factor 4E (eIF4E) isoforms in Drosophila. Mech Dev (2004) 1.17
The Prp8 RNase H-like domain inhibits Brr2-mediated U4/U6 snRNA unwinding by blocking Brr2 loading onto the U4 snRNA. Genes Dev (2012) 1.17
Stalling of spliceosome assembly at distinct stages by small-molecule inhibitors of protein acetylation and deacetylation. RNA (2008) 1.16
In vivo expression and purification of aptamer-tagged small RNA regulators. Nucleic Acids Res (2009) 1.15
Ubiquitin-specific protease-like 1 (USPL1) is a SUMO isopeptidase with essential, non-catalytic functions. EMBO Rep (2012) 1.15