Published in Am J Physiol Heart Circ Physiol on July 09, 2010
Impaired skeletal muscle blood flow control with advancing age in humans: attenuated ATP release and local vasodilation during erythrocyte deoxygenation. Circ Res (2012) 2.45
Endothelial nitric oxide synthase in red blood cells: key to a new erythrocrine function? Redox Biol (2014) 2.18
Pannexin channels are not gap junction hemichannels. Channels (Austin) (2011) 1.84
Pannexins in ischemia-induced neurodegeneration. Proc Natl Acad Sci U S A (2011) 1.55
Hemolysis is a primary ATP-release mechanism in human erythrocytes. Blood (2014) 1.54
A molecular signature in the pannexin1 intracellular loop confers channel activation by the α1 adrenoreceptor in smooth muscle cells. Sci Signal (2015) 1.53
Vesicular and conductive mechanisms of nucleotide release. Purinergic Signal (2012) 1.49
Intercellular Ca(2+) waves: mechanisms and function. Physiol Rev (2012) 1.32
Mechanisms of ATP release and signalling in the blood vessel wall. Cardiovasc Res (2012) 1.27
Multiscale approach to link red blood cell dynamics, shear viscosity, and ATP release. Proc Natl Acad Sci U S A (2011) 1.26
Impaired adenosine-5'-triphosphate release from red blood cells promotes their adhesion to endothelial cells: a mechanism of hypoxemia after transfusion. Crit Care Med (2011) 1.26
Pannexin: from discovery to bedside in 11±4 years? Brain Res (2012) 1.24
Erythrocytes as controllers of perfusion distribution in the microvasculature of skeletal muscle. Acta Physiol (Oxf) (2010) 1.22
Regulation of blood flow distribution in skeletal muscle: role of erythrocyte-released ATP. J Physiol (2012) 1.18
The ATP permeability of pannexin 1 channels in a heterologous system and in mammalian taste cells is dispensable. J Cell Sci (2012) 1.16
Temperature-dependent release of ATP from human erythrocytes: mechanism for the control of local tissue perfusion. Exp Physiol (2012) 1.15
Physiological mechanisms for the modulation of pannexin 1 channel activity. J Physiol (2012) 1.07
Homeostasis of extracellular ATP in human erythrocytes. J Biol Chem (2011) 1.04
The membrane protein Pannexin1 forms two open-channel conformations depending on the mode of activation. Sci Signal (2014) 1.03
Differentiating connexin hemichannels and pannexin channels in cellular ATP release. FEBS Lett (2014) 1.01
Posttranslational modifications in connexins and pannexins. J Membr Biol (2012) 1.00
Porphyromonas gingivalis-nucleoside-diphosphate-kinase inhibits ATP-induced reactive-oxygen-species via P2X7 receptor/NADPH-oxidase signalling and contributes to persistence. Cell Microbiol (2013) 1.00
Two non-vesicular ATP release pathways in the mouse erythrocyte membrane. FEBS Lett (2011) 1.00
Bacterial RTX toxins allow acute ATP release from human erythrocytes directly through the toxin pore. J Biol Chem (2014) 0.99
P2Y2 receptor activation opens pannexin-1 channels in rat carotid body type II cells: potential role in amplifying the neurotransmitter ATP. J Physiol (2012) 0.98
Prostacyclin receptor-mediated ATP release from erythrocytes requires the voltage-dependent anion channel. Am J Physiol Heart Circ Physiol (2011) 0.98
Erythrocyte-derived ATP and perfusion distribution: role of intracellular and intercellular communication. Microcirculation (2012) 0.98
A selective phosphodiesterase 3 inhibitor rescues low PO2-induced ATP release from erythrocytes of humans with type 2 diabetes: implication for vascular control. Am J Physiol Heart Circ Physiol (2011) 0.98
Toward a multiscale description of microvascular flow regulation: o(2)-dependent release of ATP from human erythrocytes and the distribution of ATP in capillary networks. Front Physiol (2012) 0.97
S-nitrosylation inhibits pannexin 1 channel function. J Biol Chem (2012) 0.96
Expression of pannexin isoforms in the systemic murine arterial network. J Vasc Res (2012) 0.95
The bizarre pharmacology of the ATP release channel pannexin1. Neuropharmacology (2013) 0.93
Alanine substitution scanning of pannexin1 reveals amino acid residues mediating ATP sensitivity. Purinergic Signal (2011) 0.93
Carbenoxolone blocks endotoxin-induced protein kinase R (PKR) activation and high mobility group box 1 (HMGB1) release. Mol Med (2013) 0.92
ATP release through pannexon channels. Philos Trans R Soc Lond B Biol Sci (2015) 0.92
Restoration of intracellular ATP production in banked red blood cells improves inducible ATP export and suppresses RBC-endothelial adhesion. Am J Physiol Heart Circ Physiol (2014) 0.89
Kinetics of extracellular ATP in mastoparan 7-activated human erythrocytes. Biochim Biophys Acta (2013) 0.88
ATP and potassium ions: a deadly combination for astrocytes. Sci Rep (2014) 0.88
Stomatin inhibits pannexin-1-mediated whole-cell currents by interacting with its carboxyl terminal. PLoS One (2012) 0.86
High affinity complexes of pannexin channels and L-type calcium channel splice-variants in human lung: Possible role in clevidipine-induced dyspnea relief in acute heart failure. EBioMedicine (2016) 0.86
Angiotensin II mobilizes intracellular calcium and activates pannexin-1 channels in rat carotid body type II cells via AT1 receptors. J Physiol (2014) 0.85
Novel Mechanisms of Herbal Therapies for Inhibiting HMGB1 Secretion or Action. Evid Based Complement Alternat Med (2015) 0.84
Expanding role of ATP as a versatile messenger at carotid and aortic body chemoreceptors. J Physiol (2012) 0.84
Amplification of human platelet activation by surface pannexin-1 channels. J Thromb Haemost (2014) 0.83
Pathways regulating the trafficking and turnover of pannexin1 protein and the role of the C-terminal domain. J Biol Chem (2011) 0.82
Emerging functions of pannexin 1 in the eye. Front Cell Neurosci (2014) 0.81
Adenine nucleotide control of coronary blood flow during exercise. Am J Physiol Heart Circ Physiol (2010) 0.81
Pannexin1 channels dominate ATP release in the cochlea ensuring endocochlear potential and auditory receptor potential generation and hearing. Sci Rep (2015) 0.80
CR1-mediated ATP release by human red blood cells promotes CR1 clustering and modulates the immune transfer process. J Biol Chem (2013) 0.80
Liberation of ATP secondary to hemolysis is not mutually exclusive of regulated export. Blood (2015) 0.80
The ectonucleotidases CD39 and CD73: Novel checkpoint inhibitor targets. Immunol Rev (2017) 0.80
Possible role of hemichannels in cancer. Front Physiol (2014) 0.78
Emerging concepts regarding pannexin 1 in the vasculature. Biochem Soc Trans (2015) 0.78
Role of erythrocyte-released ATP in the regulation of microvascular oxygen supply in skeletal muscle. Acta Physiol (Oxf) (2015) 0.77
Mechanosensitive unpaired innexin channels in C. elegans touch neurons. Am J Physiol Cell Physiol (2014) 0.77
Hypoxia is an effective stimulus for vesicular release of ATP from human umbilical vein endothelial cells. Placenta (2015) 0.76
Pannexin 1 is required for full activation of insulin-stimulated glucose uptake in adipocytes. Mol Metab (2015) 0.76
Carbenoxolone inhibits Pannexin1 channels through interactions in the first extracellular loop. J Gen Physiol (2016) 0.76
Skeletal muscle vasodilation during systemic hypoxia in humans. J Appl Physiol (1985) (2015) 0.76
Augmentation of Muscle Blood Flow by Ultrasound Cavitation Is Mediated by ATP and Purinergic Signaling. Circulation (2017) 0.75
Pannexin channel and connexin hemichannel expression in vascular function and inflammation. BMC Cell Biol (2017) 0.75
Reversible binding of hemoglobin to band 3 constitutes the molecular switch that mediates O2 regulation of erythrocyte properties. Blood (2016) 0.75
An ongoing search for potential targets and therapies for lethal sepsis. Mil Med Res (2015) 0.75
Connexins, Pannexins, and Their Channels in Fibroproliferative Diseases. J Membr Biol (2016) 0.75
Response: Hemolysis is a primary and physiologically relevant ATP release mechanism in human erythrocytes. Blood (2015) 0.75
Dynamic Regulation of Cell Volume and Extracellular ATP of Human Erythrocytes. PLoS One (2016) 0.75
CALHM1-Mediated ATP Release and Ciliary Beat Frequency Modulation in Nasal Epithelial Cells. Sci Rep (2017) 0.75
Connexin Hemichannels in Astrocytes: An Assessment of Controversies Regarding Their Functional Characteristics. Neurochem Res (2017) 0.75
Pannexin-1 mediates large pore formation and interleukin-1beta release by the ATP-gated P2X7 receptor. EMBO J (2006) 8.12
Pannexin membrane channels are mechanosensitive conduits for ATP. FEBS Lett (2004) 4.73
Connexins regulate calcium signaling by controlling ATP release. Proc Natl Acad Sci U S A (1998) 4.35
Pannexin 1 in erythrocytes: function without a gap. Proc Natl Acad Sci U S A (2006) 4.03
The role of pannexin 1 hemichannels in ATP release and cell-cell communication in mouse taste buds. Proc Natl Acad Sci U S A (2007) 4.01
Pharmacological properties of homomeric and heteromeric pannexin hemichannels expressed in Xenopus oocytes. J Neurochem (2005) 3.87
Release of ATP from human erythrocytes in response to a brief period of hypoxia and hypercapnia. Cardiovasc Res (1992) 2.86
Deformation-induced ATP release from red blood cells requires CFTR activity. Am J Physiol (1998) 2.85
Gating and regulation of connexin 43 (Cx43) hemichannels. Proc Natl Acad Sci U S A (2003) 2.79
Probenecid, a gout remedy, inhibits pannexin 1 channels. Am J Physiol Cell Physiol (2008) 2.79
Pannexin 1: the molecular substrate of astrocyte "hemichannels". J Neurosci (2009) 2.48
Erythrocytes: oxygen sensors and modulators of vascular tone. Physiology (Bethesda) (2009) 2.25
ATP: the red blood cell link to NO and local control of the pulmonary circulation. Am J Physiol (1996) 2.23
The multidrug resistance (mdr1) gene product functions as an ATP channel. Proc Natl Acad Sci U S A (1993) 2.09
Physiological role of gap-junctional hemichannels. Extracellular calcium-dependent isosmotic volume regulation. J Cell Biol (2000) 2.08
Red blood cell regulation of microvascular tone through adenosine triphosphate. Am J Physiol Heart Circ Physiol (2000) 2.00
Pannexin 1 contributes to ATP release in airway epithelia. Am J Respir Cell Mol Biol (2009) 1.89
Red blood cell-derived ATP as a regulator of skeletal muscle perfusion. Med Sci Sports Exerc (2004) 1.89
Connexin and pannexin mediated cell-cell communication. Neuron Glia Biol (2007) 1.86
The red blood cell as an oxygen sensor: what is the evidence? Acta Physiol Scand (2000) 1.64
Modulation of membrane channel currents by gap junction protein mimetic peptides: size matters. Am J Physiol Cell Physiol (2007) 1.60
Participation of cAMP in a signal-transduction pathway relating erythrocyte deformation to ATP release. Am J Physiol Cell Physiol (2001) 1.58
Pannexins, distant relatives of the connexin family with specific cellular functions? Bioessays (2009) 1.50
Voltage-dependent anion channel-1 (VDAC-1) contributes to ATP release and cell volume regulation in murine cells. J Gen Physiol (2004) 1.49
Hepatocellular ATP-binding cassette protein expression enhances ATP release and autocrine regulation of cell volume. J Biol Chem (1997) 1.47
CFTR Cl- channel and CFTR-associated ATP channel: distinct pores regulated by common gates. EMBO J (1998) 1.37
Regulation of cellular ATP release. Trans Am Clin Climatol Assoc (2007) 1.36
Heterotrimeric G protein Gi is involved in a signal transduction pathway for ATP release from erythrocytes. Am J Physiol Heart Circ Physiol (2003) 1.33
Extracellular ATP signaling in the rabbit lung: erythrocytes as determinants of vascular resistance. Am J Physiol Heart Circ Physiol (2003) 1.33
Red not dead: signaling in and from erythrocytes. Trends Endocrinol Metab (2007) 1.29
Thrombin promotes release of ATP from lung epithelial cells through coordinated activation of rho- and Ca2+-dependent signaling pathways. J Biol Chem (2009) 1.27
CFTR channels expressed in CHO cells do not have detectable ATP conductance. J Membr Biol (1996) 1.26
Phosphodiesterase 3 is present in rabbit and human erythrocytes and its inhibition potentiates iloprost-induced increases in cAMP. Am J Physiol Heart Circ Physiol (2008) 1.22
Maxi-anion channel as a candidate pathway for osmosensitive ATP release from mouse astrocytes in primary culture. Cell Res (2008) 1.20
Receptor-mediated activation of the heterotrimeric G-protein Gs results in ATP release from erythrocytes. Med Sci Monit (2001) 1.18
Purified cystic fibrosis transmembrane conductance regulator (CFTR) does not function as an ATP channel. J Biol Chem (1996) 1.18
Pharmacological "cross-inhibition" of connexin hemichannels and swelling activated anion channels. Glia (2009) 1.16
NO inhibits signal transduction pathway for ATP release from erythrocytes via its action on heterotrimeric G protein Gi. Am J Physiol Heart Circ Physiol (2004) 1.16
Generation of an erythrocyte vesicle transport system by Plasmodium falciparum malaria parasites. Blood (2003) 1.09
Prostacyclin analogs stimulate receptor-mediated cAMP synthesis and ATP release from rabbit and human erythrocytes. Microcirculation (2008) 1.09
Rabbit erythrocytes possess adenylyl cyclase type II that is activated by the heterotrimeric G proteins Gs and Gi. Pharmacol Rep (2005) 1.07
Rabbit erythrocytes release ATP and dilate skeletal muscle arterioles in the presence of reduced oxygen tension. Pharmacol Rep (2009) 1.05
Evaluation of a new thin film tonometer. Br J Anaesth (1974) 1.04
Nitric oxide inhibits ATP release from erythrocytes. J Pharmacol Exp Ther (2004) 1.03
Wide nanoscopic pore of maxi-anion channel suits its function as an ATP-conductive pathway. Biophys J (2004) 1.01
What is hidden in the pannexin treasure trove: the sneak peek and the guesswork. J Cell Mol Med (2006) 0.98
Cystic fibrosis transmembrane conductance regulator and adenosine triphosphate. Science (1997) 0.96
ATP-conducting maxi-anion channel: a new player in stress-sensory transduction. Jpn J Physiol (2004) 0.94
Extracellular osmolarity modulates G protein-coupled receptor-dependent ATP release from 1321N1 astrocytoma cells. Am J Physiol Cell Physiol (2009) 0.92
Gap junction-mimetic peptides do work, but in unexpected ways. Cell Commun Adhes (2008) 0.90
Purinergic signaling underlies CFTR control of human airway epithelial cell volume. J Cyst Fibros (2004) 0.89
Erythrocytes of humans with cystic fibrosis fail to stimulate nitric oxide synthesis in isolated rabbit lungs. Am J Physiol Heart Circ Physiol (2004) 0.85
Protein kinases A and C regulate receptor-mediated increases in cAMP in rabbit erythrocytes. Am J Physiol Heart Circ Physiol (2009) 0.85
ATP stimulates the release of prostacyclin from perfused veins isolated from the hamster hindlimb. Am J Physiol Regul Integr Comp Physiol (2003) 0.82
Erythrocytes: oxygen sensors and modulators of vascular tone. Physiology (Bethesda) (2009) 2.25
Synergistic effects of prostacyclin analogs and phosphodiesterase inhibitors on cyclic adenosine 3',5' monophosphate accumulation and adenosine 3'5' triphosphate release from human erythrocytes. Exp Biol Med (Maywood) (2013) 2.07
Defects in oxygen supply to skeletal muscle of prediabetic ZDF rats. Am J Physiol Heart Circ Physiol (2010) 1.81
Reduced expression of G(i) in erythrocytes of humans with type 2 diabetes is associated with impairment of both cAMP generation and ATP release. Diabetes (2006) 1.38
Heterotrimeric G protein Gi is involved in a signal transduction pathway for ATP release from erythrocytes. Am J Physiol Heart Circ Physiol (2003) 1.33
Extracellular ATP signaling in the rabbit lung: erythrocytes as determinants of vascular resistance. Am J Physiol Heart Circ Physiol (2003) 1.33
Red not dead: signaling in and from erythrocytes. Trends Endocrinol Metab (2007) 1.29
Phosphodiesterase 3 is present in rabbit and human erythrocytes and its inhibition potentiates iloprost-induced increases in cAMP. Am J Physiol Heart Circ Physiol (2008) 1.22
Preferential use of unobstructed lateral portals as the access route to the pore of human ATP-gated ion channels (P2X receptors). Proc Natl Acad Sci U S A (2011) 1.20
Regulation of blood flow distribution in skeletal muscle: role of erythrocyte-released ATP. J Physiol (2012) 1.18
Acidic amino acids impart enhanced Ca2+ permeability and flux in two members of the ATP-gated P2X receptor family. J Gen Physiol (2007) 1.16
Contribution of transmembrane regions to ATP-gated P2X2 channel permeability dynamics. J Biol Chem (2004) 1.16
NO inhibits signal transduction pathway for ATP release from erythrocytes via its action on heterotrimeric G protein Gi. Am J Physiol Heart Circ Physiol (2004) 1.16
Prostacyclin analogs stimulate receptor-mediated cAMP synthesis and ATP release from rabbit and human erythrocytes. Microcirculation (2008) 1.09
P2X4 receptors in activated C8-B4 cells of cerebellar microglial origin. J Gen Physiol (2010) 1.07
Native and recombinant ASIC1a receptors conduct negligible Ca2+ entry. Cell Calcium (2009) 1.06
Rabbit erythrocytes release ATP and dilate skeletal muscle arterioles in the presence of reduced oxygen tension. Pharmacol Rep (2009) 1.05
The CDK domain of p21 is a suppressor of IL-1beta-mediated inflammation in activated macrophages. Eur J Immunol (2009) 1.04
Tunable calcium current through TRPV1 receptor channels. J Biol Chem (2008) 1.03
Nitric oxide inhibits ATP release from erythrocytes. J Pharmacol Exp Ther (2004) 1.03
Gain and loss of channel function by alanine substitutions in the transmembrane segments of the rat ATP-gated P2X2 receptor. J Neurosci (2004) 1.02
Insulin inhibits low oxygen-induced ATP release from human erythrocytes: implication for vascular control. Microcirculation (2009) 1.00
Diamide decreases deformability of rabbit erythrocytes and attenuates low oxygen tension-induced ATP release. Exp Biol Med (Maywood) (2010) 0.99
Insulin inhibits human erythrocyte cAMP accumulation and ATP release: role of phosphodiesterase 3 and phosphoinositide 3-kinase. Exp Biol Med (Maywood) (2010) 0.99
Erythrocyte-derived ATP and perfusion distribution: role of intracellular and intercellular communication. Microcirculation (2012) 0.98
Prostacyclin receptor-mediated ATP release from erythrocytes requires the voltage-dependent anion channel. Am J Physiol Heart Circ Physiol (2011) 0.98
A selective phosphodiesterase 3 inhibitor rescues low PO2-induced ATP release from erythrocytes of humans with type 2 diabetes: implication for vascular control. Am J Physiol Heart Circ Physiol (2011) 0.98
On the role of the first transmembrane domain in cation permeability and flux of the ATP-gated P2X2 receptor. J Biol Chem (2007) 0.97
Toward a multiscale description of microvascular flow regulation: o(2)-dependent release of ATP from human erythrocytes and the distribution of ATP in capillary networks. Front Physiol (2012) 0.97
Functional expression of mammalian receptors and membrane channels in different cells. J Struct Biol (2007) 0.96
Cloning and characterization of two novel zebrafish P2X receptor subunits. Biochem Biophys Res Commun (2002) 0.96
Iloprost- and isoproterenol-induced increases in cAMP are regulated by different phosphodiesterases in erythrocytes of both rabbits and humans. Am J Physiol Heart Circ Physiol (2009) 0.92
Allosteric modulation of Ca2+ flux in ligand-gated cation channel (P2X4) by actions on lateral portals. J Biol Chem (2012) 0.92
Identification of cytosolic phosphodiesterases in the erythrocyte: a possible role for PDE5. Med Sci Monit (2011) 0.91
Divergent effects of low-O(2) tension and iloprost on ATP release from erythrocytes of humans with type 2 diabetes: implications for O(2) supply to skeletal muscle. Am J Physiol Heart Circ Physiol (2010) 0.90
Electrospray ionization tandem mass spectrometry of sodiated adducts of cholesteryl esters. Lipids (2011) 0.89
Regulation of cAMP by phosphodiesterases in erythrocytes. Pharmacol Rep (2010) 0.87
Erythrocytes of humans with cystic fibrosis fail to stimulate nitric oxide synthesis in isolated rabbit lungs. Am J Physiol Heart Circ Physiol (2004) 0.85
Protein kinases A and C regulate receptor-mediated increases in cAMP in rabbit erythrocytes. Am J Physiol Heart Circ Physiol (2009) 0.85
5,6-EET-induced contraction of intralobar pulmonary arteries depends on the activation of Rho-kinase. J Appl Physiol (1985) (2005) 0.84
Differential effects of 5,6-EET on segmental pulmonary vasoactivity in the rabbit. Am J Physiol Heart Circ Physiol (2003) 0.83
Lactate interferes with ATP release from red blood cells. Am J Physiol Heart Circ Physiol (2007) 0.83
Calcium-dependent decrease in the single-channel conductance of TRPV1. Pflugers Arch (2011) 0.82
Inhibition of ATP release from erythrocytes: a role for EPACs and PKC. Microcirculation (2011) 0.82
Cyclooxygenase (COX)-1 and COX-2 participate in 5,6-epoxyeicosatrienoic acid-induced contraction of rabbit intralobar pulmonary arteries. J Pharmacol Exp Ther (2007) 0.80
Synergistic effects of C-peptide and insulin on low O2-induced ATP release from human erythrocytes. Am J Physiol Regul Integr Comp Physiol (2013) 0.75