Published in Mol Cell Biol on February 12, 2007
How the fanconi anemia pathway guards the genome. Annu Rev Genet (2009) 4.94
Expanded roles of the Fanconi anemia pathway in preserving genomic stability. Genes Dev (2010) 3.33
FANCI phosphorylation functions as a molecular switch to turn on the Fanconi anemia pathway. Nat Struct Mol Biol (2008) 3.22
New insights into checkpoint kinase 1 in the DNA damage response signaling network. Clin Cancer Res (2010) 2.82
The FANC pathway and BLM collaborate during mitosis to prevent micro-nucleation and chromosome abnormalities. Nat Cell Biol (2009) 2.62
Regulators of cyclin-dependent kinases are crucial for maintaining genome integrity in S phase. J Cell Biol (2010) 2.43
Interaction between the helicases genetically linked to Fanconi anemia group J and Bloom's syndrome. EMBO J (2011) 1.95
Taking the time to make important decisions: the checkpoint effector kinases Chk1 and Chk2 and the DNA damage response. DNA Repair (Amst) (2009) 1.89
Cellular and molecular consequences of defective Fanconi anemia proteins in replication-coupled DNA repair: mechanistic insights. Mutat Res (2009) 1.80
DDB1 targets Chk1 to the Cul4 E3 ligase complex in normal cycling cells and in cells experiencing replication stress. Cancer Res (2009) 1.60
Advances in understanding the complex mechanisms of DNA interstrand cross-link repair. Cold Spring Harb Perspect Biol (2013) 1.45
CHK1 inhibition as a strategy for targeting Fanconi Anemia (FA) DNA repair pathway deficient tumors. Mol Cancer (2009) 1.42
UBE2T, the Fanconi anemia core complex, and FANCD2 are recruited independently to chromatin: a basis for the regulation of FANCD2 monoubiquitination. Mol Cell Biol (2007) 1.40
Roles of Chk1 in cell biology and cancer therapy. Int J Cancer (2013) 1.37
Cisplatin-induced DNA damage activates replication checkpoint signaling components that differentially affect tumor cell survival. Mol Pharmacol (2009) 1.33
Fanconi anemia proteins stabilize replication forks. DNA Repair (Amst) (2008) 1.23
Functional interaction between the Fanconi Anemia D2 protein and proliferating cell nuclear antigen (PCNA) via a conserved putative PCNA interaction motif. J Biol Chem (2009) 1.22
Ubiquitylation and the Fanconi anemia pathway. FEBS Lett (2011) 1.21
A ubiquitin-binding protein, FAAP20, links RNF8-mediated ubiquitination to the Fanconi anemia DNA repair network. Mol Cell (2012) 1.19
ATR-dependent phosphorylation of FANCA on serine 1449 after DNA damage is important for FA pathway function. Blood (2008) 1.19
Expanded roles for Chk1 in genome maintenance. J Biol Chem (2008) 1.15
Emerging links between the biological clock and the DNA damage response. Chromosoma (2007) 1.12
Fanconi anemia proteins and endogenous stresses. Mutat Res (2009) 1.11
Preclinical models for neuroblastoma: establishing a baseline for treatment. PLoS One (2011) 1.09
Inhibition of the Nedd8 system sensitizes cells to DNA interstrand cross-linking agents. Mol Cancer Res (2012) 1.08
Non-specific chemical inhibition of the Fanconi anemia pathway sensitizes cancer cells to cisplatin. Mol Cancer (2012) 1.04
Rescue of replication failure by Fanconi anaemia proteins. Chromosoma (2011) 1.02
FANCJ helicase operates in the Fanconi Anemia DNA repair pathway and the response to replicational stress. Curr Mol Med (2009) 1.00
The Fanconi anemia protein FANCM is controlled by FANCD2 and the ATR/ATM pathways. J Biol Chem (2009) 0.99
Stress and DNA repair biology of the Fanconi anemia pathway. Blood (2014) 0.99
Functional and physical interaction between the mismatch repair and FA-BRCA pathways. Hum Mol Genet (2011) 0.97
The BLM dissolvasome in DNA replication and repair. Cell Mol Life Sci (2013) 0.97
Abundance of the Fanconi anaemia core complex is regulated by the RuvBL1 and RuvBL2 AAA+ ATPases. Nucleic Acids Res (2014) 0.96
Checkpoint kinase 1 in DNA damage response and cell cycle regulation. Cell Mol Life Sci (2013) 0.95
Opportunities and challenges of radiotherapy for treating cancer. Nat Rev Clin Oncol (2015) 0.95
Significance of the Fanconi anemia FANCD2 protein in sporadic and metastatic human breast cancer. Am J Pathol (2010) 0.94
FANCI Regulates Recruitment of the FA Core Complex at Sites of DNA Damage Independently of FANCD2. PLoS Genet (2015) 0.91
The Fanconi anemia pathway and ICL repair: implications for cancer therapy. Crit Rev Biochem Mol Biol (2010) 0.90
Biomarkers and mechanisms of FANCD2 function. J Biomed Biotechnol (2008) 0.89
USP1 deubiquitinase maintains phosphorylated CHK1 by limiting its DDB1-dependent degradation. Hum Mol Genet (2011) 0.89
BRCA1, FANCD2 and Chk1 are potential molecular targets for the modulation of a radiation-induced DNA damage response in bystander cells. Cancer Lett (2014) 0.89
Regulation of the activation of the Fanconi anemia pathway by the p21 cyclin-dependent kinase inhibitor. Oncogene (2011) 0.87
FANC pathway promotes UV-induced stalled replication forks recovery by acting both upstream and downstream Polη and Rev1. PLoS One (2013) 0.87
Fanconi anemia and the cell cycle: new perspectives on aneuploidy. F1000Prime Rep (2014) 0.86
Trial Watch: Targeting ATM-CHK2 and ATR-CHK1 pathways for anticancer therapy. Mol Cell Oncol (2015) 0.86
The carboxyl terminus of FANCE recruits FANCD2 to the Fanconi Anemia (FA) E3 ligase complex to promote the FA DNA repair pathway. J Biol Chem (2014) 0.84
Fanconi anemia proteins and their interacting partners: a molecular puzzle. Anemia (2012) 0.82
The FANC pathway is activated by adenovirus infection and promotes viral replication-dependent recombination. Nucleic Acids Res (2011) 0.81
Exploiting the Fanconi Anemia Pathway for Targeted Anti-Cancer Therapy. Mol Cells (2015) 0.80
Cellular response to DNA interstrand crosslinks: the Fanconi anemia pathway. Cell Mol Life Sci (2016) 0.79
High levels of RAD51 perturb DNA replication elongation and cause unscheduled origin firing due to impaired CHK1 activation. Cell Cycle (2015) 0.78
Replication Protein A (RPA) deficiency activates the Fanconi anemia DNA repair pathway. Cell Cycle (2016) 0.77
Aurora A kinase is required for activation of the Fanconi anemia/BRCA pathway upon DNA damage. FEBS Open Bio (2016) 0.77
Screening for large genomic rearrangements of the BRIP1 and CHK1 genes in Finnish breast cancer families. Fam Cancer (2010) 0.77
Fanconi anemia cells with unrepaired DNA damage activate components of the checkpoint recovery process. Theor Biol Med Model (2015) 0.76
Ataxin-3 promotes genome integrity by stabilizing Chk1. Nucleic Acids Res (2017) 0.75
DNA damage response and cancer therapeutics through the lens of the Fanconi Anemia DNA repair pathway. Cell Commun Signal (2017) 0.75
Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway. Mol Cell (2001) 8.99
A stable human-derived packaging cell line for production of high titer retrovirus/vesicular stomatitis virus G pseudotypes. Proc Natl Acad Sci U S A (1996) 8.53
Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25. Science (1997) 8.24
ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1. Mol Cell Biol (2001) 7.26
A novel ubiquitin ligase is deficient in Fanconi anemia. Nat Genet (2003) 4.79
Rapid destruction of human Cdc25A in response to DNA damage. Science (2000) 4.74
The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair. Nat Cell Biol (2005) 4.62
A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M. Nat Genet (2005) 4.57
Involvement of Brca1 in S-phase and G(2)-phase checkpoints after ionizing irradiation. Mol Cell Biol (2001) 4.35
S-phase-specific interaction of the Fanconi anemia protein, FANCD2, with BRCA1 and RAD51. Blood (2002) 4.27
The emerging genetic and molecular basis of Fanconi anaemia. Nat Rev Genet (2001) 4.07
The Fanconi Anemia/BRCA pathway: new faces in the crowd. Genes Dev (2005) 3.90
Epithelial cancer in Fanconi anemia complementation group D2 (Fancd2) knockout mice. Genes Dev (2003) 3.58
MAPKAP kinase-2 is a cell cycle checkpoint kinase that regulates the G2/M transition and S phase progression in response to UV irradiation. Mol Cell (2005) 3.48
ATR couples FANCD2 monoubiquitination to the DNA-damage response. Genes Dev (2004) 3.44
SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase. Genes Dev (2003) 3.35
Functional interaction of monoubiquitinated FANCD2 and BRCA2/FANCD1 in chromatin. Mol Cell Biol (2004) 3.20
BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage. Nat Genet (2002) 3.11
Fanconi anemia (cross)linked to DNA repair. Cell (2005) 2.78
The vertebrate Hef ortholog is a component of the Fanconi anemia tumor-suppressor pathway. Nat Struct Mol Biol (2005) 2.55
UBE2T is the E2 in the Fanconi anemia pathway and undergoes negative autoregulation. Mol Cell (2006) 2.51
Fanconi anemia diagnosis and the diepoxybutane (DEB) test. Exp Hematol (1993) 2.16
A FancD2-monoubiquitin fusion reveals hidden functions of Fanconi anemia core complex in DNA repair. Mol Cell (2005) 2.15
Determination of substrate motifs for human Chk1 and hCds1/Chk2 by the oriented peptide library approach. J Biol Chem (2002) 2.06
The protein kinase C inhibitor Gö6976 is a potent inhibitor of DNA damage-induced S and G2 cell cycle checkpoints. Cancer Res (2003) 1.70
Phosphorylation of FANCD2 on two novel sites is required for mitomycin C resistance. Mol Cell Biol (2006) 1.65
Human Claspin works with BRCA1 to both positively and negatively regulate cell proliferation. Proc Natl Acad Sci U S A (2004) 1.62
Isolation of a cDNA representing the Fanconi anemia complementation group E gene. Am J Hum Genet (2000) 1.51
14-3-3gamma binds to MDMX that is phosphorylated by UV-activated Chk1, resulting in p53 activation. EMBO J (2006) 1.40
The Fanconi anemia protein, FANCE, promotes the nuclear accumulation of FANCC. Blood (2002) 1.24
Activation of the Fanconi anemia/BRCA pathway and recombination repair in the cellular response to solar ultraviolet light. Cancer Res (2006) 1.07
Cell cycle-dependent potentiation of cisplatin by UCN-01 in non-small-cell lung carcinoma. Cancer Chemother Pharmacol (2003) 0.83
Biallelic inactivation of BRCA2 in Fanconi anemia. Science (2002) 9.31
Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair. Cell (2007) 6.68
How the fanconi anemia pathway guards the genome. Annu Rev Genet (2009) 4.94
Regulation of monoubiquitinated PCNA by DUB autocleavage. Nat Cell Biol (2006) 4.67
The deubiquitinating enzyme USP1 regulates the Fanconi anemia pathway. Mol Cell (2005) 4.40
S-phase-specific interaction of the Fanconi anemia protein, FANCD2, with BRCA1 and RAD51. Blood (2002) 4.27
Disruption of the Fanconi anemia-BRCA pathway in cisplatin-sensitive ovarian tumors. Nat Med (2003) 4.04
Human Fanconi anemia monoubiquitination pathway promotes homologous DNA repair. Proc Natl Acad Sci U S A (2005) 3.93
The Fanconi Anemia/BRCA pathway: new faces in the crowd. Genes Dev (2005) 3.90
Molecular pathogenesis of Fanconi anemia: recent progress. Blood (2006) 3.76
Convergence of the fanconi anemia and ataxia telangiectasia signaling pathways. Cell (2002) 3.71
ATR couples FANCD2 monoubiquitination to the DNA-damage response. Genes Dev (2004) 3.44
Regulation of DNA cross-link repair by the Fanconi anemia/BRCA pathway. Genes Dev (2012) 3.42
Expanded roles of the Fanconi anemia pathway in preserving genomic stability. Genes Dev (2010) 3.33
A UAF1-containing multisubunit protein complex regulates the Fanconi anemia pathway. Mol Cell (2007) 3.27
Single-molecule kinetics of lambda exonuclease reveal base dependence and dynamic disorder. Science (2003) 3.22
Functional interaction of monoubiquitinated FANCD2 and BRCA2/FANCD1 in chromatin. Mol Cell Biol (2004) 3.20
Structural basis for the recognition between HIV-1 integrase and transcriptional coactivator p75. Proc Natl Acad Sci U S A (2005) 3.18
Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, Bcl-2, and caspase-3. Cell (2008) 3.15
Human DNA ligase I completely encircles and partially unwinds nicked DNA. Nature (2004) 2.85
Cell cycle-dependent chromatin loading of the Fanconi anemia core complex by FANCM/FAAP24. Blood (2008) 2.83
Regulation of DNA repair by ubiquitylation. Nat Rev Mol Cell Biol (2006) 2.73
Inhibition of homologous recombination by the PCNA-interacting protein PARI. Mol Cell (2011) 2.61
DNA ligases: structure, reaction mechanism, and function. Chem Rev (2006) 2.57
UBE2T is the E2 in the Fanconi anemia pathway and undergoes negative autoregulation. Mol Cell (2006) 2.51
BRCA1 functions as a differential modulator of chemotherapy-induced apoptosis. Cancer Res (2003) 2.51
DNA repair pathways in clinical practice: lessons from pediatric cancer susceptibility syndromes. J Clin Oncol (2006) 2.49
Structural basis for the dual coding potential of 8-oxoguanosine by a high-fidelity DNA polymerase. EMBO J (2004) 2.43
Compromised CDK1 activity sensitizes BRCA-proficient cancers to PARP inhibition. Nat Med (2011) 2.35
Bone marrow failure in Fanconi anemia is triggered by an exacerbated p53/p21 DNA damage response that impairs hematopoietic stem and progenitor cells. Cell Stem Cell (2012) 2.26
The Fanconi anemia pathway is required for the DNA replication stress response and for the regulation of common fragile site stability. Hum Mol Genet (2005) 2.23
A flexible interface between DNA ligase and PCNA supports conformational switching and efficient ligation of DNA. Mol Cell (2006) 2.23
Chromatin remodeling at DNA double-strand breaks. Cell (2013) 2.18
UAF1 is a subunit of multiple deubiquitinating enzyme complexes. J Biol Chem (2008) 2.17
RNA expression analysis from formalin fixed paraffin embedded tissues. Histochem Cell Biol (2008) 2.13
Inactivation of murine Usp1 results in genomic instability and a Fanconi anemia phenotype. Dev Cell (2009) 2.12
Regulated interaction of the Fanconi anemia protein, FANCD2, with chromatin. Blood (2004) 2.08
A DNA repair pathway-focused score for prediction of outcomes in ovarian cancer treated with platinum-based chemotherapy. J Natl Cancer Inst (2012) 2.07
A structural basis for allosteric control of DNA recombination by lambda integrase. Nature (2005) 2.05
The crystal structure of the bifunctional primase-helicase of bacteriophage T7. Mol Cell (2003) 1.99
Interaction of FANCD2 and NBS1 in the DNA damage response. Nat Cell Biol (2002) 1.96
Chemosensitization to cisplatin by inhibitors of the Fanconi anemia/BRCA pathway. Mol Cancer Ther (2006) 1.88
Dissecting the broad substrate specificity of human 3-methyladenine-DNA glycosylase. J Biol Chem (2003) 1.82
Fanconi anemia pathway-deficient tumor cells are hypersensitive to inhibition of ataxia telangiectasia mutated. J Clin Invest (2007) 1.80
Molecular pathogenesis and clinical management of Fanconi anemia. J Clin Invest (2012) 1.79
Menin associates with FANCD2, a protein involved in repair of DNA damage. Cancer Res (2003) 1.78
A lysine residue in the fingers subdomain of T7 DNA polymerase modulates the miscoding potential of 8-oxo-7,8-dihydroguanosine. Structure (2005) 1.76
The Fanconi anemia core complex is required for efficient point mutagenesis and Rev1 foci assembly. DNA Repair (Amst) (2008) 1.74
Srs2 disassembles Rad51 filaments by a protein-protein interaction triggering ATP turnover and dissociation of Rad51 from DNA. Mol Cell (2009) 1.73
Regulation of Rev1 by the Fanconi anemia core complex. Nat Struct Mol Biol (2012) 1.72
Structure of the coiled-coil dimerization motif of Sir4 and its interaction with Sir3. Structure (2003) 1.71
Axial ligand tuning of a nonheme iron(IV)-oxo unit for hydrogen atom abstraction. Proc Natl Acad Sci U S A (2007) 1.70
Potentiation of inflammatory CXCL8 signalling sustains cell survival in PTEN-deficient prostate carcinoma. Eur Urol (2012) 1.69
Identification and validation of an anthracycline/cyclophosphamide-based chemotherapy response assay in breast cancer. J Natl Cancer Inst (2014) 1.66
Domain-swapped dimerization of the HIV-1 capsid C-terminal domain. Proc Natl Acad Sci U S A (2007) 1.66
Phosphorylation of FANCD2 on two novel sites is required for mitomycin C resistance. Mol Cell Biol (2006) 1.65
Modular architecture of the bacteriophage T7 primase couples RNA primer synthesis to DNA synthesis. Mol Cell (2003) 1.61
Hematopoietic stem cell defects in mice with deficiency of Fancd2 or Usp1. Stem Cells (2010) 1.60
A novel diagnostic screen for defects in the Fanconi anemia pathway. Blood (2002) 1.54
Crystal structure and DNA binding functions of ERCC1, a subunit of the DNA structure-specific endonuclease XPF-ERCC1. Proc Natl Acad Sci U S A (2005) 1.54
XPF-ERCC1 participates in the Fanconi anemia pathway of cross-link repair. Mol Cell Biol (2009) 1.50
Association of biallelic BRCA2/FANCD1 mutations with spontaneous chromosomal instability and solid tumors of childhood. Blood (2003) 1.49
DNA polymerase POLN participates in cross-link repair and homologous recombination. Mol Cell Biol (2009) 1.47
Human ELG1 regulates the level of ubiquitinated proliferating cell nuclear antigen (PCNA) through Its interactions with PCNA and USP1. J Biol Chem (2010) 1.43
A nonhistone protein-protein interaction required for assembly of the SIR complex and silent chromatin. Mol Cell Biol (2005) 1.42
Case records of the Massachusetts General Hospital. Case 13-2006. A 50-year-old man with a painful bone mass and lesions in the liver. N Engl J Med (2006) 1.42
CHK1 inhibition as a strategy for targeting Fanconi Anemia (FA) DNA repair pathway deficient tumors. Mol Cancer (2009) 1.42
Human alkyladenine DNA glycosylase uses acid-base catalysis for selective excision of damaged purines. Biochemistry (2003) 1.42
Structure-based drug design and optimization of mannoside bacterial FimH antagonists. J Med Chem (2010) 1.40
Nucleotide insertion opposite a cis-syn thymine dimer by a replicative DNA polymerase from bacteriophage T7. Nat Struct Mol Biol (2004) 1.40
The Escherichia coli 3-methyladenine DNA glycosylase AlkA has a remarkably versatile active site. J Biol Chem (2004) 1.39
Knockdown of zebrafish Fancd2 causes developmental abnormalities via p53-dependent apoptosis. Dev Cell (2003) 1.38
Cytokinesis failure occurs in Fanconi anemia pathway-deficient murine and human bone marrow hematopoietic cells. J Clin Invest (2010) 1.38
Rational design of human DNA ligase inhibitors that target cellular DNA replication and repair. Cancer Res (2008) 1.36
The FANCM/FAAP24 complex is required for the DNA interstrand crosslink-induced checkpoint response. Mol Cell (2010) 1.35
Identification of a peptide fragment of DSCR1 that competitively inhibits calcineurin activity in vitro and in vivo. Proc Natl Acad Sci U S A (2005) 1.33
Direct DNA binding activity of the Fanconi anemia D2 protein. J Biol Chem (2005) 1.33
DNA damage responses and their many interactions with the replication fork. Carcinogenesis (2006) 1.32
Human DNA ligase III recognizes DNA ends by dynamic switching between two DNA-bound states. Biochemistry (2010) 1.32
Structural dynamics in DNA damage signaling and repair. Curr Opin Struct Biol (2010) 1.31
The USP1/UAF1 complex promotes double-strand break repair through homologous recombination. Mol Cell Biol (2011) 1.31
Two DNA-binding and nick recognition modules in human DNA ligase III. J Biol Chem (2008) 1.30
Functional evidence for a small and rigid active site in a high fidelity DNA polymerase: probing T7 DNA polymerase with variably sized base pairs. J Biol Chem (2005) 1.29
Multiple interactions with the Rad51 recombinase govern the homologous recombination function of Rad54. J Biol Chem (2004) 1.28
Regulation of the Fanconi anemia pathway by a SUMO-like delivery network. Genes Dev (2011) 1.28
Cdk1 participates in BRCA1-dependent S phase checkpoint control in response to DNA damage. Mol Cell (2009) 1.27
Dedicated to the core: understanding the Fanconi anemia complex. DNA Repair (Amst) (2006) 1.27
Regulated degradation of FANCM in the Fanconi anemia pathway during mitosis. Genes Dev (2009) 1.25
Structural determinants for inhibitor specificity and selectivity in PDE2A using the wheat germ in vitro translation system. Biochemistry (2005) 1.24
The Fanconi anemia/BRCA pathway: a coordinator of cross-link repair. Exp Cell Res (2006) 1.24
Antigen processing by nardilysin and thimet oligopeptidase generates cytotoxic T cell epitopes. Nat Immunol (2010) 1.24
The Fanconi anemia protein, FANCE, promotes the nuclear accumulation of FANCC. Blood (2002) 1.24
Structural basis for the recruitment of ERCC1-XPF to nucleotide excision repair complexes by XPA. EMBO J (2007) 1.23
Genetic reversion in an acute myelogenous leukemia cell line from a Fanconi anemia patient with biallelic mutations in BRCA2. Cancer Res (2003) 1.23
Synthetic lethality between CCNE1 amplification and loss of BRCA1. Proc Natl Acad Sci U S A (2013) 1.22
Crystal structures of 2-acetylaminofluorene and 2-aminofluorene in complex with T7 DNA polymerase reveal mechanisms of mutagenesis. Proc Natl Acad Sci U S A (2004) 1.21
WDR20 regulates activity of the USP12 x UAF1 deubiquitinating enzyme complex. J Biol Chem (2010) 1.20
Chromatin recruitment of DNA repair proteins: lessons from the fanconi anemia and double-strand break repair pathways. Mol Cell (2008) 1.19