Kruppel-like factor-4 transcriptionally regulates VE-cadherin expression and endothelial barrier function.

PubWeight™: 1.29‹?› | Rank: Top 10%

🔗 View Article (PMC 3018700)

Published in Circ Res on August 19, 2010

Authors

Colleen E Cowan1, Erin E Kohler, Tracey A Dugan, M Kamran Mirza, Asrar B Malik, Kishore K Wary

Author Affiliations

1: Department of Pharmacology, University of Illinois, 835 S Wolcott, Room E403, Mail code 868, Chicago, IL 60612, USA.

Articles citing this

Conversion of human fibroblasts to functional endothelial cells by defined factors. Arterioscler Thromb Vasc Biol (2013) 1.61

Cellular and molecular regulation of vascular permeability. Thromb Haemost (2013) 1.13

NANOG induction of fetal liver kinase-1 (FLK1) transcription regulates endothelial cell proliferation and angiogenesis. Blood (2010) 1.04

Inhibition of AMP-activated protein kinase accentuates lipopolysaccharide-induced lung endothelial barrier dysfunction and lung injury in vivo. Am J Pathol (2013) 1.01

Update in acute lung injury and critical care 2010. Am J Respir Crit Care Med (2011) 0.98

Cross talk between focal adhesion kinase and cadherins: role in regulating endothelial barrier function. Microvasc Res (2011) 0.96

Flk1+ and VE-cadherin+ endothelial cells derived from iPSCs recapitulates vascular development during differentiation and display similar angiogenic potential as ESC-derived cells. PLoS One (2013) 0.95

Suicide gene reveals the myocardial neovascularization role of mesenchymal stem cells overexpressing CXCR4 (MSC(CXCR4)). PLoS One (2012) 0.95

Endothelial permeability and VE-cadherin: a wacky comradeship. Cell Adh Migr (2014) 0.93

Endothelial Kruppel-like factor 4 regulates angiogenesis and the Notch signaling pathway. J Biol Chem (2014) 0.91

KLF4 is a key determinant in the development and progression of cerebral cavernous malformations. EMBO Mol Med (2015) 0.89

Deletion of Krüppel-like factor 4 in endothelial and hematopoietic cells enhances neointimal formation following vascular injury. J Am Heart Assoc (2014) 0.89

Integrative assessment of chlorine-induced acute lung injury in mice. Am J Respir Cell Mol Biol (2012) 0.89

Brain pericytes serve as microglia-generating multipotent vascular stem cells following ischemic stroke. J Neuroinflammation (2016) 0.87

Kruppel-like factor 4 protein regulates isoproterenol-induced cardiac hypertrophy by modulating myocardin expression and activity. J Biol Chem (2014) 0.86

Endostar, a modified recombinant human endostatin, suppresses angiogenesis through inhibition of Wnt/β-catenin signaling pathway. PLoS One (2014) 0.85

Kruppel-like factors and vascular inflammation: implications for atherosclerosis. Curr Atheroscler Rep (2012) 0.84

Lipid phosphate phosphatase-3 regulates tumor growth via β-catenin and CYCLIN-D1 signaling. Mol Cancer (2011) 0.83

MicroRNA MiR-199a-5p regulates smooth muscle cell proliferation and morphology by targeting WNT2 signaling pathway. J Biol Chem (2015) 0.82

Localization and pneumococcal alteration of junction proteins in the human alveolar-capillary compartment. Histochem Cell Biol (2017) 0.80

Endothelial permeability and VE-cadherin: a wacky comradeship. Cell Adh Migr (2013) 0.80

Low-dose 6-bromoindirubin-3'-oxime induces partial dedifferentiation of endothelial cells to promote increased neovascularization. Stem Cells (2014) 0.80

Association of Kruppel-like factor 4 expression with the prognosis of esophageal squamous cell carcinoma patients. Int J Clin Exp Pathol (2014) 0.79

Endothelial Plasticity: Shifting Phenotypes through Force Feedback. Stem Cells Int (2016) 0.79

c-Kit+ progenitors generate vascular cells for tissue-engineered grafts through modulation of the Wnt/Klf4 pathway. Biomaterials (2015) 0.78

Endothelium-Derived 5-Methoxytryptophan Protects Endothelial Barrier Function by Blocking p38 MAPK Activation. PLoS One (2016) 0.78

Endothelial lipid phosphate phosphatase-3 deficiency that disrupts the endothelial barrier function is a modifier of cardiovascular development. Cardiovasc Res (2016) 0.77

Endothelial Transdifferentiation of Tumor Cells Triggered by the Twist1-Jagged1-KLF4 Axis: Relationship between Cancer Stemness and Angiogenesis. Stem Cells Int (2015) 0.77

MicroRNA-7 Deficiency Ameliorates the Pathologies of Acute Lung Injury through Elevating KLF4. Front Immunol (2016) 0.76

Endothelial Dicer promotes atherosclerosis and vascular inflammation by miRNA-103-mediated suppression of KLF4. Nat Commun (2016) 0.76

KLF2 and KLF4 control endothelial identity and vascular integrity. JCI Insight (2017) 0.75

PTP1B in Calpain-dependent Feedback Regulation of VEGFR2 in Endothelial Cells: Implication in VEGF-dependent Angiogenesis and Diabetic Wound Healing. J Biol Chem (2016) 0.75

Inhibition of MiR-92a May Protect Endothelial Cells After Acute Myocardial Infarction in Rats: Role of KLF2/4. Med Sci Monit (2016) 0.75

Type 3 muscarinic acetylcholine receptor stimulation is a determinant of endothelial barrier function and adherens junctions integrity: role of protein-tyrosine phosphatase 1B. BMB Rep (2014) 0.75

Krüppel-like factor 4 (KLF4): What we currently know. Gene (2017) 0.75

Articles cited by this

Signaling mechanisms regulating endothelial permeability. Physiol Rev (2006) 7.63

Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis. Cell (1999) 7.33

Klf4 is a transcription factor required for establishing the barrier function of the skin. Nat Genet (1999) 5.91

The zinc-finger transcription factor Klf4 is required for terminal differentiation of goblet cells in the colon. Development (2002) 5.09

Krüppel-like factors: three fingers in many pies. J Biol Chem (2001) 5.05

Epidermal barrier formation and recovery in skin disorders. J Clin Invest (2006) 4.14

KLF4, p21 and context-dependent opposing forces in cancer. Nat Rev Cancer (2006) 4.14

The control of vascular integrity by endothelial cell junctions: molecular basis and pathological implications. Dev Cell (2009) 3.87

The biology of the mammalian Krüppel-like family of transcription factors. Int J Biochem Cell Biol (2001) 3.31

A gene for a novel zinc-finger protein expressed in differentiated epithelial cells and transiently in certain mesenchymal cells. J Biol Chem (1996) 3.30

Kruppel-like factor 4 regulates endothelial inflammation. J Biol Chem (2007) 3.06

Role of Krüppel-like transcription factors in endothelial biology. Circ Res (2007) 2.87

Mammalian Krüppel-like transcription factors: more than just a pretty finger. Trends Biochem Sci (1999) 2.70

Kruppel-like factor 4 is a mediator of proinflammatory signaling in macrophages. J Biol Chem (2005) 2.62

Oxidized phospholipids induce phenotypic switching of vascular smooth muscle cells in vivo and in vitro. Circ Res (2007) 2.55

Positive- and negative-acting Kruppel-like transcription factors bind a transforming growth factor beta control element required for expression of the smooth muscle cell differentiation marker SM22alpha in vivo. J Biol Chem (2000) 2.54

The Kruppel-like factor KLF4 is a critical regulator of monocyte differentiation. EMBO J (2007) 2.34

Conditional deletion of Krüppel-like factor 4 delays downregulation of smooth muscle cell differentiation markers but accelerates neointimal formation following vascular injury. Circ Res (2008) 2.30

Human EZF, a Krüppel-like zinc finger protein, is expressed in vascular endothelial cells and contains transcriptional activation and repression domains. J Biol Chem (1998) 2.15

Mechanisms of transendothelial migration of leukocytes. Circ Res (2009) 2.14

Transcriptional profiling of Krüppel-like factor 4 reveals a function in cell cycle regulation and epithelial differentiation. J Mol Biol (2003) 2.11

Monoclonal antibodies directed to different regions of vascular endothelial cadherin extracellular domain affect adhesion and clustering of the protein and modulate endothelial permeability. Blood (2001) 2.00

Novel cross talk of Kruppel-like factor 4 and beta-catenin regulates normal intestinal homeostasis and tumor repression. Mol Cell Biol (2006) 1.96

Hemizygous deficiency of Krüppel-like factor 2 augments experimental atherosclerosis. Circ Res (2008) 1.94

Requirement of Krüppel-like factor 4 in preventing entry into mitosis following DNA damage. J Biol Chem (2003) 1.76

Role of protein tyrosine phosphatase 1B in vascular endothelial growth factor signaling and cell-cell adhesions in endothelial cells. Circ Res (2008) 1.71

Haploinsufficiency of Krüppel-like factor 4 promotes adenomatous polyposis coli dependent intestinal tumorigenesis. Cancer Res (2007) 1.71

ADAM10 regulates endothelial permeability and T-Cell transmigration by proteolysis of vascular endothelial cadherin. Circ Res (2008) 1.66

Conditional deletion of the mouse Klf4 gene results in corneal epithelial fragility, stromal edema, and loss of conjunctival goblet cells. Mol Cell Biol (2006) 1.63

Cultured endothelial cells display endogenous activation of the canonical Wnt signaling pathway and express multiple ligands, receptors, and secreted modulators of Wnt signaling. Dev Dyn (2006) 1.54

Kruppel-like factor 4, Elk-1, and histone deacetylases cooperatively suppress smooth muscle cell differentiation markers in response to oxidized phospholipids. Am J Physiol Cell Physiol (2008) 1.46

KLF4 interacts with beta-catenin/TCF4 and blocks p300/CBP recruitment by beta-catenin. Mol Cell Biol (2009) 1.44

Klf4 and corticosteroids activate an overlapping set of transcriptional targets to accelerate in utero epidermal barrier acquisition. Proc Natl Acad Sci U S A (2006) 1.35

Sp1-dependent activation of KLF4 is required for PDGF-BB-induced phenotypic modulation of smooth muscle. Am J Physiol Heart Circ Physiol (2009) 1.32

Oxidized phospholipids induce type VIII collagen expression and vascular smooth muscle cell migration. Circ Res (2009) 1.23

HIF-2alpha specifically activates the VE-cadherin promoter independently of hypoxia and in synergy with Ets-1 through two essential ETS-binding sites. Oncogene (2007) 1.22

Vascular bed origin dictates flow pattern regulation of endothelial adhesion molecule expression. Am J Physiol Heart Circ Physiol (2007) 1.18

ETS1 lowers capillary endothelial cell density at confluence and induces the expression of VE-cadherin. Oncogene (2000) 1.11

Identification of candidate Klf4 target genes reveals the molecular basis of the diverse regulatory roles of Klf4 in the mouse cornea. Invest Ophthalmol Vis Sci (2008) 1.08

Early genetic mechanisms underlying the inhibitory effects of endostatin and fumagillin on human endothelial cells. Genome Res (2004) 0.92

Conditional deletion of Cited2 results in defective corneal epithelial morphogenesis and maintenance. Dev Biol (2009) 0.85

Articles by these authors

Signaling mechanisms regulating endothelial permeability. Physiol Rev (2006) 7.63

Regulation of endothelial junctional permeability. Ann N Y Acad Sci (2008) 3.39

NF-kappa B activation as a pathological mechanism of septic shock and inflammation. Am J Physiol Lung Cell Mol Physiol (2006) 3.15

Impairment of store-operated Ca2+ entry in TRPC4(-/-) mice interferes with increase in lung microvascular permeability. Circ Res (2002) 3.05

Regulation of endothelial permeability via paracellular and transcellular transport pathways. Annu Rev Physiol (2010) 2.86

Reactive oxygen species in inflammation and tissue injury. Antioxid Redox Signal (2013) 2.59

NADPH oxidase-dependent signaling in endothelial cells: role in physiology and pathophysiology. Antioxid Redox Signal (2009) 2.29

Role of TRPM2 channel in mediating H2O2-induced Ca2+ entry and endothelial hyperpermeability. Circ Res (2007) 2.24

Fyn binds to and phosphorylates the kidney slit diaphragm component Nephrin. J Biol Chem (2003) 2.23

Caveolin regulation of endothelial function. Am J Physiol Lung Cell Mol Physiol (2003) 2.22

TLR4 signaling induces TLR2 expression in endothelial cells via neutrophil NADPH oxidase. J Clin Invest (2003) 2.16

Toll-like receptor-4 (TLR4) signaling augments chemokine-induced neutrophil migration by modulating cell surface expression of chemokine receptors. Nat Med (2003) 2.14

Persistent eNOS activation secondary to caveolin-1 deficiency induces pulmonary hypertension in mice and humans through PKG nitration. J Clin Invest (2009) 2.02

RhoGDI-1 modulation of the activity of monomeric RhoGTPase RhoA regulates endothelial barrier function in mouse lungs. Circ Res (2007) 1.99

Neutrophil caveolin-1 expression contributes to mechanism of lung inflammation and injury. Am J Physiol Lung Cell Mol Physiol (2007) 1.97

Role of Src-induced dynamin-2 phosphorylation in caveolae-mediated endocytosis in endothelial cells. J Biol Chem (2004) 1.94

Novel mechanism of endothelial nitric oxide synthase activation mediated by caveolae internalization in endothelial cells. Circ Res (2006) 1.92

Caveolin-1 regulates store-operated Ca2+ influx by binding of its scaffolding domain to transient receptor potential channel-1 in endothelial cells. Mol Pharmacol (2006) 1.92

Toll-like receptor 4 mediates neutrophil sequestration and lung injury induced by endotoxin and hyperinflation. Crit Care Med (2010) 1.87

Caveolin-1 regulates NF-kappaB activation and lung inflammatory response to sepsis induced by lipopolysaccharide. J Immunol (2006) 1.86

Activation of sphingosine kinase-1 reverses the increase in lung vascular permeability through sphingosine-1-phosphate receptor signaling in endothelial cells. Circ Res (2008) 1.85

Protease-activated receptor-3 (PAR3) regulates PAR1 signaling by receptor dimerization. Proc Natl Acad Sci U S A (2007) 1.81

Quantitative analysis of albumin uptake and transport in the rat microvessel endothelial monolayer. Am J Physiol Lung Cell Mol Physiol (2003) 1.81

Caveolin-1 scaffold domain interacts with TRPC1 and IP3R3 to regulate Ca2+ store release-induced Ca2+ entry in endothelial cells. Am J Physiol Cell Physiol (2008) 1.80

Homocysteine inhibits arterial endothelial cell growth through transcriptional downregulation of fibroblast growth factor-2 involving G protein and DNA methylation. Circ Res (2008) 1.78

Suppression of RhoA activity by focal adhesion kinase-induced activation of p190RhoGAP: role in regulation of endothelial permeability. J Biol Chem (2005) 1.74

Protein kinase C-delta (PKC-delta ) is activated by type I interferons and mediates phosphorylation of Stat1 on serine 727. J Biol Chem (2002) 1.72

Endothelial cell-restricted disruption of FoxM1 impairs endothelial repair following LPS-induced vascular injury. J Clin Invest (2006) 1.71

Ca2+ signaling, TRP channels, and endothelial permeability. Microcirculation (2006) 1.70

Lipopolysaccharide stimulates platelet secretion and potentiates platelet aggregation via TLR4/MyD88 and the cGMP-dependent protein kinase pathway. J Immunol (2009) 1.70

Role of Ca2+ signaling in the regulation of endothelial permeability. Vascul Pharmacol (2002) 1.69

Dual regulation of endothelial junctional permeability. Sci STKE (2007) 1.67

Two waves of platelet secretion induced by thromboxane A2 receptor and a critical role for phosphoinositide 3-kinases. J Biol Chem (2003) 1.63

Intercellular adhesion molecule-1-dependent neutrophil adhesion to endothelial cells induces caveolae-mediated pulmonary vascular hyperpermeability. Circ Res (2008) 1.63

Role of NADPH oxidase in the mechanism of lung neutrophil sequestration and microvessel injury induced by Gram-negative sepsis: studies in p47phox-/- and gp91phox-/- mice. J Immunol (2002) 1.60

RhoA/Rho-associated kinase pathway selectively regulates thrombin-induced intercellular adhesion molecule-1 expression in endothelial cells via activation of I kappa B kinase beta and phosphorylation of RelA/p65. J Immunol (2004) 1.56

Increased pulmonary vascular resistance and defective pulmonary artery filling in caveolin-1-/- mice. Am J Physiol Lung Cell Mol Physiol (2008) 1.56

The redox-sensitive cation channel TRPM2 modulates phagocyte ROS production and inflammation. Nat Immunol (2011) 1.55

Constitutive eNOS-derived nitric oxide is a determinant of endothelial junctional integrity. Am J Physiol Lung Cell Mol Physiol (2005) 1.54

Protein kinase Calpha phosphorylates the TRPC1 channel and regulates store-operated Ca2+ entry in endothelial cells. J Biol Chem (2004) 1.53

Molecular determinants of endothelial transcytosis and their role in endothelial permeability. Am J Physiol Lung Cell Mol Physiol (2007) 1.53

Sphingosine 1-phosphate-induced mobilization of intracellular Ca2+ mediates rac activation and adherens junction assembly in endothelial cells. J Biol Chem (2005) 1.52

Nonmuscle myosin light-chain kinase mediates neutrophil transmigration in sepsis-induced lung inflammation by activating beta2 integrins. Nat Immunol (2008) 1.51

Protein kinase Calpha-induced p115RhoGEF phosphorylation signals endothelial cytoskeletal rearrangement. J Biol Chem (2003) 1.50

Phosphatidylinositol 3-kinase gamma signaling through protein kinase Czeta induces NADPH oxidase-mediated oxidant generation and NF-kappaB activation in endothelial cells. J Biol Chem (2006) 1.49

siRNA-induced caveolin-1 knockdown in mice increases lung vascular permeability via the junctional pathway. Am J Physiol Lung Cell Mol Physiol (2005) 1.48

PKCzeta regulates TNF-alpha-induced activation of NADPH oxidase in endothelial cells. Circ Res (2002) 1.46

Angiopoietin-1 opposes VEGF-induced increase in endothelial permeability by inhibiting TRPC1-dependent Ca2 influx. Circ Res (2005) 1.44

Galphaq-TRPC6-mediated Ca2+ entry induces RhoA activation and resultant endothelial cell shape change in response to thrombin. J Biol Chem (2006) 1.44

Tumor necrosis factor-alpha induces early-onset endothelial adhesivity by protein kinase Czeta-dependent activation of intercellular adhesion molecule-1. Circ Res (2003) 1.44

RhoA interaction with inositol 1,4,5-trisphosphate receptor and transient receptor potential channel-1 regulates Ca2+ entry. Role in signaling increased endothelial permeability. J Biol Chem (2003) 1.43

Bidirectional regulation of neutrophil migration by mitogen-activated protein kinases. Nat Immunol (2012) 1.43

Tumor necrosis factor-alpha-induced TRPC1 expression amplifies store-operated Ca2+ influx and endothelial permeability. Am J Physiol Lung Cell Mol Physiol (2004) 1.41

RNA interference targeting transforming growth factor-beta type II receptor suppresses ocular inflammation and fibrosis. Mol Vis (2004) 1.36

Galpha(q) and Gbetagamma regulate PAR-1 signaling of thrombin-induced NF-kappaB activation and ICAM-1 transcription in endothelial cells. Circ Res (2002) 1.36

Size and dynamics of caveolae studied using nanoparticles in living endothelial cells. ACS Nano (2009) 1.33

Cdc42 regulates the restoration of endothelial barrier function. Circ Res (2003) 1.31

Gbetagamma activation of Src induces caveolae-mediated endocytosis in endothelial cells. J Biol Chem (2004) 1.31

Vesicle formation and trafficking in endothelial cells and regulation of endothelial barrier function. Histochem Cell Biol (2002) 1.28

Role of neutrophil NADPH oxidase in the mechanism of tumor necrosis factor-alpha -induced NF-kappa B activation and intercellular adhesion molecule-1 expression in endothelial cells. J Biol Chem (2001) 1.27

A streptococcal collagen-like protein interacts with the alpha2beta1 integrin and induces intracellular signaling. J Biol Chem (2005) 1.27

Protease-activated receptor-1 activation of endothelial cells induces protein kinase Calpha-dependent phosphorylation of syntaxin 4 and Munc18c: role in signaling p-selectin expression. J Biol Chem (2004) 1.25

Role of NF-kappaB-dependent caveolin-1 expression in the mechanism of increased endothelial permeability induced by lipopolysaccharide. J Biol Chem (2007) 1.25

Activation of NLRP3 inflammasome in alveolar macrophages contributes to mechanical stretch-induced lung inflammation and injury. J Immunol (2013) 1.24

TLR4 activation of TRPC6-dependent calcium signaling mediates endotoxin-induced lung vascular permeability and inflammation. J Exp Med (2012) 1.24

E3 ubiquitin ligase Cblb regulates the acute inflammatory response underlying lung injury. Nat Med (2007) 1.22

Requisite role of the cholinergic alpha7 nicotinic acetylcholine receptor pathway in suppressing Gram-negative sepsis-induced acute lung inflammatory injury. J Immunol (2009) 1.21

Albumin mediates the transcytosis of myeloperoxidase by means of caveolae in endothelial cells. Proc Natl Acad Sci U S A (2004) 1.20

Integrated control of lung fluid balance. Am J Physiol Lung Cell Mol Physiol (2004) 1.20

Bone marrow progenitor cells induce endothelial adherens junction integrity by sphingosine-1-phosphate-mediated Rac1 and Cdc42 signaling. Circ Res (2009) 1.19

Protein kinase C modifications of VE-cadherin, p120, and beta-catenin contribute to endothelial barrier dysregulation induced by thrombin. Am J Physiol Lung Cell Mol Physiol (2003) 1.19

Myocardium defects and ventricular hypoplasia in mice homozygous null for the Forkhead Box M1 transcription factor. Dev Dyn (2007) 1.18

Protein transport across the lung epithelial barrier. Am J Physiol Lung Cell Mol Physiol (2003) 1.18

Regulation of cell-cell interactions by phosphatidic acid phosphatase 2b/VCIP. EMBO J (2003) 1.17

ICAM-1-activated Src and eNOS signaling increase endothelial cell surface PECAM-1 adhesivity and neutrophil transmigration. Blood (2012) 1.17

FoxM1 regulates re-annealing of endothelial adherens junctions through transcriptional control of beta-catenin expression. J Exp Med (2010) 1.17

Nitric oxide-dependent Src activation and resultant caveolin-1 phosphorylation promote eNOS/caveolin-1 binding and eNOS inhibition. Mol Biol Cell (2012) 1.16

A novel binding site in collagen type III for integrins alpha1beta1 and alpha2beta1. J Biol Chem (2005) 1.15

Ca2+ influx induced by protease-activated receptor-1 activates a feed-forward mechanism of TRPC1 expression via nuclear factor-kappaB activation in endothelial cells. J Biol Chem (2006) 1.15

Cdc42 regulates adherens junction stability and endothelial permeability by inducing alpha-catenin interaction with the vascular endothelial cadherin complex. Circ Res (2005) 1.15

Cholesterol-dependent syntaxin-4 and SNAP-23 clustering regulates caveolar fusion with the endothelial plasma membrane. J Biol Chem (2005) 1.15

Augmented inducible nitric oxide synthase expression and increased NO production reduce sepsis-induced lung injury and mortality in myeloperoxidase-null mice. Am J Physiol Lung Cell Mol Physiol (2008) 1.14

LPS activation of Toll-like receptor 4 signals CD11b/CD18 expression in neutrophils. Am J Physiol Lung Cell Mol Physiol (2004) 1.14

Tumor necrosis factor-alpha induces nuclear factor-kappaB-dependent TRPC1 expression in endothelial cells. J Biol Chem (2003) 1.14

FoxM1 mediates the progenitor function of type II epithelial cells in repairing alveolar injury induced by Pseudomonas aeruginosa. J Exp Med (2011) 1.14

Functional role of TRPC channels in the regulation of endothelial permeability. Pflugers Arch (2005) 1.13

Modulatory role of focal adhesion kinase in regulating human pulmonary arterial endothelial barrier function. J Physiol (2002) 1.13

Caveolin-1-eNOS signaling promotes p190RhoGAP-A nitration and endothelial permeability. J Cell Biol (2011) 1.10

Intersectin regulates fission and internalization of caveolae in endothelial cells. Mol Biol Cell (2003) 1.10

Transforming growth factor beta regulates cell-cell adhesion through extracellular matrix remodeling and activation of focal adhesion kinase in human colon carcinoma Moser cells. Oncogene (2004) 1.09

Thrombin receptors activate G(o) proteins in endothelial cells to regulate intracellular calcium and cell shape changes. J Biol Chem (2002) 1.08

GDI-1 phosphorylation switch at serine 96 induces RhoA activation and increased endothelial permeability. Mol Cell Biol (2007) 1.08

Intersectin-1s regulates the mitochondrial apoptotic pathway in endothelial cells. J Biol Chem (2007) 1.08

Ca2+ entry via TRPC channels is necessary for thrombin-induced NF-kappaB activation in endothelial cells through AMP-activated protein kinase and protein kinase Cdelta. J Biol Chem (2008) 1.07

Delivery of nanoparticle: complexed drugs across the vascular endothelial barrier via caveolae. IUBMB Life (2011) 1.05

Caveolin-1 deficiency dampens Toll-like receptor 4 signaling through eNOS activation. Am J Pathol (2010) 1.04

Role of H(2)O(2)-activated TRPM2 calcium channel in oxidant-induced endothelial injury. Thromb Haemost (2009) 1.04

NANOG induction of fetal liver kinase-1 (FLK1) transcription regulates endothelial cell proliferation and angiogenesis. Blood (2010) 1.04