Published in Science on August 27, 2010
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Regulation of gene expression through a transcriptional repressor that senses acyl-chain length in membrane phospholipids. Dev Cell (2014) 1.50
A conserved endoplasmic reticulum membrane protein complex (EMC) facilitates phospholipid transfer from the ER to mitochondria. PLoS Biol (2014) 1.27
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Multivalent adhesion molecule 7 clusters act as signaling platform for host cellular GTPase activation and facilitate epithelial barrier dysfunction. PLoS Pathog (2014) 0.91
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Yeast adaptation to weak acids prevents futile energy expenditure. Front Microbiol (2013) 0.87
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Lipin 2 binds phosphatidic acid by the electrostatic hydrogen bond switch mechanism independent of phosphorylation. J Biol Chem (2014) 0.79
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Dual function of a bacterial protein as an adhesin and extracellular effector of host GTPase signaling. Small GTPases (2015) 0.78
Regulation of lipid metabolism: a tale of two yeasts. Curr Opin Cell Biol (2012) 0.78
Inositol depletion restores vesicle transport in yeast phospholipid flippase mutants. PLoS One (2015) 0.78
Cooperation between the Hepatitis C Virus p7 and NS5B Proteins Enhances Virion Infectivity. J Virol (2015) 0.78
Lipids as conductors in the orchestra of life. F1000 Biol Rep (2012) 0.78
BTN1, the Saccharomyces cerevisiae homolog to the human Batten disease gene, is involved in phospholipid distribution. Dis Model Mech (2011) 0.76
Phospholipase C and D regulation of Src, calcium release and membrane fusion during Xenopus laevis development. Dev Biol (2015) 0.76
A quantitative fluorometric approach for measuring the interaction of RhoGDI with membranes and Rho GTPases. Methods Mol Biol (2012) 0.75
Comparative characterization of phosphatidic acid sensors and their localization during frustrated phagocytosis. J Biol Chem (2017) 0.75
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The Role of Phospholipase D in Regulated Exocytosis. J Biol Chem (2015) 0.75
Crz1p regulates pH homeostasis in Candida glabrata by altering membrane lipid composition. Appl Environ Microbiol (2016) 0.75
Ist2 in the yeast cortical endoplasmic reticulum promotes trafficking of the amino acid transporter Bap2 to the plasma membrane. PLoS One (2014) 0.75
Tracking Diacylglycerol and Phosphatidic Acid Pools in Budding Yeast. Lipid Insights (2016) 0.75
Extracellular Proton Concentrations Impacts LN229 Glioblastoma Tumor Cell Fate via Differential Modulation of Surface Lipids. Front Oncol (2017) 0.75
Systematic identification of genes involved in metabolic acid stress resistance in yeast and their potential as cancer targets. Dis Model Mech (2016) 0.75
Saccharomyces cerevisiae Is Dependent on Vesicular Traffic between the Golgi Apparatus and the Vacuole When Inositolphosphorylceramide Synthase Aur1 Is Inactivated. Eukaryot Cell (2015) 0.75
Med15B regulates acid stress response and tolerance in Candida glabrata. Appl Environ Microbiol (2017) 0.75
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Recruitment and regulation of phosphatidylinositol phosphate kinase type 1 gamma by the FERM domain of talin. Nature (2002) 4.03
A class of dynamin-like GTPases involved in the generation of the tubular ER network. Cell (2009) 3.88
Amphiphysin 2 (Bin1) and T-tubule biogenesis in muscle. Science (2002) 3.68
Membrane proteins of the endoplasmic reticulum induce high-curvature tubules. Science (2008) 3.60
Dual role of 3-methyladenine in modulation of autophagy via different temporal patterns of inhibition on class I and III phosphoinositide 3-kinase. J Biol Chem (2010) 3.45
Mechanisms determining the morphology of the peripheral ER. Cell (2010) 3.35
Structural mechanism for sterol sensing and transport by OSBP-related proteins. Nature (2005) 3.22
The reticulon and DP1/Yop1p proteins form immobile oligomers in the tubular endoplasmic reticulum. J Biol Chem (2008) 3.13
An enzymatic cascade of Rab5 effectors regulates phosphoinositide turnover in the endocytic pathway. J Cell Biol (2005) 2.97
Biosynthetic labeling of RNA with uracil phosphoribosyltransferase allows cell-specific microarray analysis of mRNA synthesis and decay. Nat Biotechnol (2005) 2.92
Fld1p, a functional homologue of human seipin, regulates the size of lipid droplets in yeast. J Cell Biol (2008) 2.85
Cryo-EM visualization of a viral internal ribosome entry site bound to human ribosomes: the IRES functions as an RNA-based translation factor. Cell (2004) 2.84
Impaired PtdIns(4,5)P2 synthesis in nerve terminals produces defects in synaptic vesicle trafficking. Nature (2004) 2.81
The eEF2 kinase confers resistance to nutrient deprivation by blocking translation elongation. Cell (2013) 2.74
Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice. J Clin Invest (2011) 2.68
Retroviruses human immunodeficiency virus and murine leukemia virus are enriched in phosphoinositides. J Virol (2008) 2.43
Membrane expansion alleviates endoplasmic reticulum stress independently of the unfolded protein response. J Cell Biol (2009) 2.35
Decreased synaptic vesicle recycling efficiency and cognitive deficits in amphiphysin 1 knockout mice. Neuron (2002) 2.21
Chondroitin fragments are odorants that trigger fear behavior in fish. Curr Biol (2012) 2.20
ARF6 stimulates clathrin/AP-2 recruitment to synaptic membranes by activating phosphatidylinositol phosphate kinase type Igamma. J Cell Biol (2003) 2.19
Functional interactions between sphingolipids and sterols in biological membranes regulating cell physiology. Mol Biol Cell (2009) 2.17
Salmonella modulates vesicular traffic by altering phosphoinositide metabolism. Science (2004) 2.06
Nonvesicular sterol movement from plasma membrane to ER requires oxysterol-binding protein-related proteins and phosphoinositides. J Cell Biol (2006) 2.04
Inhibitory effect of dietary lipids on chaperone-mediated autophagy. Proc Natl Acad Sci U S A (2012) 1.97
The transcription factor STAT-1 couples macrophage synthesis of 25-hydroxycholesterol to the interferon antiviral response. Immunity (2012) 1.96
Lipid-regulated sterol transfer between closely apposed membranes by oxysterol-binding protein homologues. J Cell Biol (2009) 1.88
Regulation of synaptojanin 1 by cyclin-dependent kinase 5 at synapses. Proc Natl Acad Sci U S A (2004) 1.84
In vivo measurement of cytosolic and mitochondrial pH using a pH-sensitive GFP derivative in Saccharomyces cerevisiae reveals a relation between intracellular pH and growth. Microbiology (2009) 1.80
Lipid transfer and signaling at organelle contact sites: the tip of the iceberg. Curr Opin Cell Biol (2011) 1.73
A role for phosphatidic acid in the formation of "supersized" lipid droplets. PLoS Genet (2011) 1.69
The budding yeast nuclear envelope adjacent to the nucleolus serves as a membrane sink during mitotic delay. Curr Biol (2012) 1.65
An upstream open reading frame regulates translation of GADD34 during cellular stresses that induce eIF2alpha phosphorylation. J Biol Chem (2009) 1.65
Mitochondrial cardiolipin involved in outer-membrane protein biogenesis: implications for Barth syndrome. Curr Biol (2009) 1.62
Structure of a lipid-bound extended synaptotagmin indicates a role in lipid transfer. Nature (2014) 1.60
Host defense against viral infection involves interferon mediated down-regulation of sterol biosynthesis. PLoS Biol (2011) 1.56
The phospholipase D1 pathway modulates macroautophagy. Nat Commun (2010) 1.56
Synaptojanin 1-linked phosphoinositide dyshomeostasis and cognitive deficits in mouse models of Down's syndrome. Proc Natl Acad Sci U S A (2008) 1.54
Weaving the web of ER tubules. Cell (2011) 1.53
Comparative lipidomic analysis of mouse and human brain with Alzheimer disease. J Biol Chem (2011) 1.51
Caenorhabditis elegans ortholog of a diabetes susceptibility locus: oga-1 (O-GlcNAcase) knockout impacts O-GlcNAc cycling, metabolism, and dauer. Proc Natl Acad Sci U S A (2006) 1.51
Phospholipase d2 ablation ameliorates Alzheimer's disease-linked synaptic dysfunction and cognitive deficits. J Neurosci (2010) 1.49
A role for oxysterol-binding protein-related protein 5 in endosomal cholesterol trafficking. J Cell Biol (2011) 1.48
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A conserved membrane-binding domain targets proteins to organelle contact sites. J Cell Sci (2012) 1.47
Development of the pacemaker tissues of the heart. Circ Res (2010) 1.46
Lipid interaction of the C terminus and association of the transmembrane segments facilitate atlastin-mediated homotypic endoplasmic reticulum fusion. Proc Natl Acad Sci U S A (2012) 1.46
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Arabidopsis lipins mediate eukaryotic pathway of lipid metabolism and cope critically with phosphate starvation. Proc Natl Acad Sci U S A (2009) 1.44
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Intracellular pH is a tightly controlled signal in yeast. Biochim Biophys Acta (2011) 1.42
PtdIns4P synthesis by PI4KIIIα at the plasma membrane and its impact on plasma membrane identity. J Cell Biol (2012) 1.41
The dynamin-like GTPase Sey1p mediates homotypic ER fusion in S. cerevisiae. J Cell Biol (2012) 1.38
The translocator maintenance protein Tam41 is required for mitochondrial cardiolipin biosynthesis. J Cell Biol (2008) 1.32
Mass spectrometry-based profiling of phospholipids and sphingolipids in extracts from Saccharomyces cerevisiae. Yeast (2006) 1.30
Tissue-autonomous function of Drosophila seipin in preventing ectopic lipid droplet formation. PLoS Genet (2011) 1.30
Arabidopsis ABCG transporters, which are required for export of diverse cuticular lipids, dimerize in different combinations. Plant Cell (2010) 1.30
Phosphatidylinositol 4-kinase type IIalpha is responsible for the phosphatidylinositol 4-kinase activity associated with synaptic vesicles. Proc Natl Acad Sci U S A (2003) 1.28
Toward one step analysis of cellular lipidomes using liquid chromatography coupled with mass spectrometry: application to Saccharomyces cerevisiae and Schizosaccharomyces pombe lipidomics. Mol Biosyst (2010) 1.28
Triacylglycerol utilization is required for regrowth of in vitro hypoxic nonreplicating Mycobacterium bovis bacillus Calmette-Guerin. J Bacteriol (2009) 1.25
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Measuring enzyme activities under standardized in vivo-like conditions for systems biology. FEBS J (2010) 1.21
Induction of autophagy by palmitic acid via protein kinase C-mediated signaling pathway independent of mTOR (mammalian target of rapamycin). J Biol Chem (2012) 1.19
Meibum lipid composition in Asians with dry eye disease. PLoS One (2011) 1.16
A small molecule fusion inhibitor of dengue virus. Antiviral Res (2009) 1.16
Direct imaging reveals stable, micrometer-scale lipid domains that segregate proteins in live cells. J Cell Biol (2013) 1.15
Molecular characterization of seipin and its mutants: implications for seipin in triacylglycerol synthesis. J Lipid Res (2011) 1.14
Sterol transport in yeast and the oxysterol binding protein homologue (OSH) family. Biochim Biophys Acta (2007) 1.14
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Comparative plasma lipidome between human and cynomolgus monkey: are plasma polar lipids good biomarkers for diabetic monkeys? PLoS One (2011) 1.14
Nonvesicular phospholipid transfer between peroxisomes and the endoplasmic reticulum. Proc Natl Acad Sci U S A (2008) 1.14
Non-targeted profiling of lipids during kainate-induced neuronal injury. FASEB J (2006) 1.13
Yeast lipid analysis and quantification by mass spectrometry. Methods Enzymol (2010) 1.13
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ER-shaping proteins facilitate lipid exchange between the ER and mitochondria in S. cerevisiae. J Cell Sci (2012) 1.12
Genome-wide analysis of yeast stress survival and tolerance acquisition to analyze the central trade-off between growth rate and cellular robustness. Mol Biol Cell (2011) 1.11
Plasma membrane--endoplasmic reticulum contact sites regulate phosphatidylcholine synthesis. EMBO Rep (2013) 1.11
Trans-Golgi network and endosome dynamics connect ceramide homeostasis with regulation of the unfolded protein response and TOR signaling in yeast. Mol Biol Cell (2008) 1.10
Caveolae regulate the nanoscale organization of the plasma membrane to remotely control Ras signaling. J Cell Biol (2014) 1.10
Towards ontology-driven navigation of the lipid bibliosphere. BMC Bioinformatics (2008) 1.10
Genome-wide analysis of intracellular pH reveals quantitative control of cell division rate by pH(c) in Saccharomyces cerevisiae. Genome Biol (2012) 1.09
Activity-based proteome profiling of potential cellular targets of Orlistat--an FDA-approved drug with anti-tumor activities. J Am Chem Soc (2010) 1.09
Host and viral translational mechanisms during cricket paralysis virus infection. J Virol (2009) 1.09
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A mechanistic paradigm for broad-spectrum antivirals that target virus-cell fusion. PLoS Pathog (2013) 1.05
mTOR signaling regulates the processing of pre-rRNA in human cells. Nucleic Acids Res (2011) 1.05
Putting the pH into phosphatidic acid signaling. BMC Biol (2011) 1.05
Fenretinide prevents lipid-induced insulin resistance by blocking ceramide biosynthesis. J Biol Chem (2012) 1.05
U18666A, an intra-cellular cholesterol transport inhibitor, inhibits dengue virus entry and replication. Antiviral Res (2011) 1.04
Alternative reading frame selection mediated by a tRNA-like domain of an internal ribosome entry site. Proc Natl Acad Sci U S A (2012) 1.03