Published in Proc Natl Acad Sci U S A on November 05, 2010
The Phosphatidylinositol (3,4,5)-Trisphosphate-dependent Rac Exchanger 1·Ras-related C3 Botulinum Toxin Substrate 1 (P-Rex1·Rac1) Complex Reveals the Basis of Rac1 Activation in Breast Cancer Cells. J Biol Chem (2015) 0.95
Significant reduction in errors associated with nonbonded contacts in protein crystal structures: automated all-atom refinement with PrimeX. Acta Crystallogr D Biol Crystallogr (2012) 0.95
The GRP1 PH domain, like the AKT1 PH domain, possesses a sentry glutamate residue essential for specific targeting to plasma membrane PI(3,4,5)P(3). Biochemistry (2011) 0.93
A novel assay reveals preferential binding between Rabs, kinesins, and specific endosomal subpopulations. J Cell Biol (2015) 0.92
SsaA, a member of a novel class of transcriptional regulators, controls sansanmycin production in Streptomyces sp. strain SS through a feedback mechanism. J Bacteriol (2013) 0.87
Structure of the cytoplasmic domain of Yersinia pestis YscD, an essential component of the type III secretion system. Acta Crystallogr D Biol Crystallogr (2012) 0.81
Structure and interactions of the cytoplasmic domain of the Yersinia type III secretion protein YscD. J Bacteriol (2012) 0.80
Dbf4: the whole is greater than the sum of its parts. Cell Cycle (2013) 0.80
Membrane and Protein Interactions of the Pleckstrin Homology Domain Superfamily. Membranes (Basel) (2015) 0.79
A novel non-canonical forkhead-associated (FHA) domain-binding interface mediates the interaction between Rad53 and Dbf4 proteins. J Biol Chem (2013) 0.77
Role of Host Type IA Phosphoinositide 3-Kinase Pathway Components in Invasin-Mediated Internalization of Yersinia enterocolitica. Infect Immun (2016) 0.76
Cytoskeleton Molecular Motors: Structures and Their Functions in Neuron. Int J Biol Sci (2016) 0.75
Structural Correlation of the Neck Coil with the Coiled-coil (CC1)-Forkhead-associated (FHA) Tandem for Active Kinesin-3 KIF13A. J Biol Chem (2015) 0.75
Regulators and Effectors of Arf GTPases in Neutrophils. J Immunol Res (2015) 0.75
Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate. Science (1997) 8.81
Membrane recognition by phospholipid-binding domains. Nat Rev Mol Cell Biol (2008) 7.43
Hippocampal neuronal polarity specified by spatially localized mPar3/mPar6 and PI 3-kinase activity. Cell (2003) 4.84
Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination. Proc Natl Acad Sci U S A (2006) 4.45
The molecular basis of FHA domain:phosphopeptide binding specificity and implications for phospho-dependent signaling mechanisms. Mol Cell (2000) 3.64
Signalling through phosphoinositide 3-kinases: the lipids take centre stage. Curr Opin Cell Biol (1999) 3.47
Neuronal polarity: from extracellular signals to intracellular mechanisms. Nat Rev Neurosci (2007) 3.31
The FHA domain. FEBS Lett (2002) 3.03
Identification and analysis of PH domain-containing targets of phosphatidylinositol 3-kinase using a novel in vivo assay in yeast. EMBO J (1998) 2.75
Role of phosphatidylinositol(4,5)bisphosphate organization in membrane transport by the Unc104 kinesin motor. Cell (2002) 2.73
A novel motor, KIF13A, transports mannose-6-phosphate receptor to plasma membrane through direct interaction with AP-1 complex. Cell (2000) 2.56
Phosphoinositides in constitutive membrane traffic. Physiol Rev (2004) 2.45
Conversion of Unc104/KIF1A kinesin into a processive motor after dimerization. Science (2002) 2.19
Understanding PTEN regulation: PIP2, polarity and protein stability. Oncogene (2008) 2.07
PIP3 is involved in neuronal polarization and axon formation. J Neurochem (2004) 1.97
Walking the walk: how kinesin and dynein coordinate their steps. Curr Opin Cell Biol (2009) 1.94
15 A resolution model of the monomeric kinesin motor, KIF1A. Cell (2000) 1.76
Membrane and juxtamembrane targeting by PH and PTB domains. Biochim Biophys Acta (2006) 1.74
SNIP1 is a candidate modifier of the transcriptional activity of c-Myc on E box-dependent target genes. Mol Cell (2006) 1.73
Phosphoinositides and signal transduction. Cell Mol Life Sci (2002) 1.52
Structure and function of the phosphothreonine-specific FHA domain. Sci Signal (2008) 1.43
Transport of PIP3 by GAKIN, a kinesin-3 family protein, regulates neuronal cell polarity. J Cell Biol (2006) 1.40
Screening for ligands using a generic and high-throughput light-scattering-based assay. J Biomol Screen (2006) 1.31
To step or not to step? How biochemistry and mechanics influence processivity in Kinesin and Eg5. Curr Opin Cell Biol (2006) 1.31
Structural model for strain-dependent microtubule activation of Mg-ADP release from kinesin. Nat Struct Mol Biol (2008) 1.29
Identification and cloning of centaurin-alpha. A novel phosphatidylinositol 3,4,5-trisphosphate-binding protein from rat brain. J Biol Chem (1996) 1.28
The type Ialpha inositol polyphosphate 4-phosphatase generates and terminates phosphoinositide 3-kinase signals on endosomes and the plasma membrane. Mol Biol Cell (2005) 1.26
The mechanisms of kinesin motor motility: lessons from the monomeric motor KIF1A. Nat Rev Mol Cell Biol (2009) 1.16
Capturing protein tails by CAP-Gly domains. Trends Biochem Sci (2008) 1.15
Mechanistic insights into phosphoprotein-binding FHA domains. Acc Chem Res (2008) 1.15
The effector domain of human Dlg tumor suppressor acts as a switch that relieves autoinhibition of kinesin-3 motor GAKIN/KIF13B. Biochemistry (2007) 1.10
Centaurin-alpha1 interacts directly with kinesin motor protein KIF13B. J Cell Sci (2005) 1.07
FHA domains as phospho-threonine binding modules in cell signaling. IUBMB Life (2003) 1.04
Centaurin-alpha1 is an in vivo phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein for ARF6 that is involved in actin cytoskeleton organization. J Biol Chem (2003) 1.03
Detection of novel intracellular agonist responsive pools of phosphatidylinositol 3,4-bisphosphate using the TAPP1 pleckstrin homology domain in immunoelectron microscopy. Biochem J (2004) 1.02
A target of phosphatidylinositol 3,4,5-trisphosphate with a zinc finger motif similar to that of the ADP-ribosylation-factor GTPase-activating protein and two pleckstrin homology domains. Eur J Biochem (1997) 0.98
The ATPase cycle of the mitotic motor CENP-E. J Biol Chem (2009) 0.95
NMR structure of the forkhead-associated domain from the Arabidopsis receptor kinase-associated protein phosphatase. Proc Natl Acad Sci U S A (2003) 0.91
Specific detection of phosphatidylinositol 3,4,5-trisphosphate binding proteins by the PIP3 analogue beads: an application for rapid purification of the PIP3 binding proteins. Biochim Biophys Acta (1998) 0.88
II. Structure and specificity of the interaction between the FHA2 domain of Rad53 and phosphotyrosyl peptides. J Mol Biol (2000) 0.86
Identification of the human KIF13A gene homologous to Drosophila kinesin-73 and candidate for schizophrenia. Genomics (2001) 0.84
Altered expression of protein p42IP4/centaurin-alpha 1 in Alzheimer's disease brains and possible interaction of p42IP4 with nucleolin. Neuroreport (2004) 0.82
Expression and subcellular localization of p42IP4/centaurin-alpha, a brain-specific, high-affinity receptor for inositol 1,3,4,5-tetrakisphosphate and phosphatidylinositol 3,4,5-trisphosphate in rat brain. Eur J Neurosci (1997) 0.82
Substrate specificity and acute regulation of the tumour suppressor phosphatase, PTEN. Biochem Soc Symp (2007) 0.78
Oligomerization controls in tissue-specific manner ligand binding of native, affinity-purified p42(IP4)/centaurin alpha1 and cytohesins-proteins with high affinity for the messengers D-inositol 1,3,4,5-tetrakisphosphate/phosphatidylinositol 3,4,5-trisphosphate. Biochim Biophys Acta (2003) 0.77
Evolutionary and biomedical insights from the rhesus macaque genome. Science (2007) 16.21
The genome of the mesopolyploid crop species Brassica rapa. Nat Genet (2011) 8.23
Clinical epidemiology of the global expansion of Klebsiella pneumoniae carbapenemases. Lancet Infect Dis (2013) 6.60
Nova regulates brain-specific splicing to shape the synapse. Nat Genet (2005) 6.58
Tissue-specific expression and regulation of sexually dimorphic genes in mice. Genome Res (2006) 6.45
A test of enhancing model accuracy in high-throughput crystallography. J Struct Funct Genomics (2005) 5.96
Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells. Cancer Cell (2009) 5.81
Discovery of tissue-specific exons using comprehensive human exon microarrays. Genome Biol (2007) 5.53
Unusual intron conservation near tissue-regulated exons found by splicing microarrays. PLoS Comput Biol (2006) 4.63
Pten in stromal fibroblasts suppresses mammary epithelial tumours. Nature (2009) 4.21
A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells. Nat Chem Biol (2011) 3.60
Genetic and genomic analysis of a fat mass trait with complex inheritance reveals marked sex specificity. PLoS Genet (2006) 3.51
Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens. Nat Neurosci (2010) 3.41
Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis. Nat Chem Biol (2012) 3.40
Human genomic deletions mediated by recombination between Alu elements. Am J Hum Genet (2006) 3.15
In situ proteolysis for protein crystallization and structure determination. Nat Methods (2007) 3.05
Targeting cancer stem cells through L1CAM suppresses glioma growth. Cancer Res (2008) 2.97
Genome-wide RNAi screen reveals a specific sensitivity of IRES-containing RNA viruses to host translation inhibition. Genes Dev (2005) 2.83
A new family of potent AB(5) cytotoxins produced by Shiga toxigenic Escherichia coli. J Exp Med (2004) 2.81
Heritability of alternative splicing in the human genome. Genome Res (2007) 2.76
Changing trends in antimicrobial resistance and serotypes of Streptococcus pneumoniae isolates in Asian countries: an Asian Network for Surveillance of Resistant Pathogens (ANSORP) study. Antimicrob Agents Chemother (2012) 2.65
Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling. Cell (2012) 2.54
A Drosophila resource of transgenic RNAi lines for neurogenetics. Genetics (2009) 2.45
Cell-specific aptamer probes for membrane protein elucidation in cancer cells. J Proteome Res (2008) 2.44
Increased CCR5 affinity and reduced CCR5/CD4 dependence of a neurovirulent primary human immunodeficiency virus type 1 isolate. J Virol (2002) 2.43
c-Myc is required for maintenance of glioma cancer stem cells. PLoS One (2008) 2.41
Genome-scale protein expression and structural biology of Plasmodium falciparum and related Apicomplexan organisms. Mol Biochem Parasitol (2006) 2.39
In vitro anti-cancer activity and structure-activity relationships of natural products isolated from fruits of Panax ginseng. Cancer Chemother Pharmacol (2006) 2.33
Agricultural origins and the isotopic identity of domestication in northern China. Proc Natl Acad Sci U S A (2009) 2.32
Spread of methicillin-resistant Staphylococcus aureus between the community and the hospitals in Asian countries: an ANSORP study. J Antimicrob Chemother (2011) 2.30
Aberrant light directly impairs mood and learning through melanopsin-expressing neurons. Nature (2012) 2.26
The Drosophila melanogaster transcriptome by paired-end RNA sequencing. Genome Res (2010) 2.25
Novel rank-based statistical methods reveal microRNAs with differential expression in multiple cancer types. PLoS One (2009) 2.21
L3MBTL1 recognition of mono- and dimethylated histones. Nat Struct Mol Biol (2007) 2.12
Gaussian Bare-Bones Differential Evolution. IEEE Trans Cybern (2013) 2.08
Identification of pathways for atherosclerosis in mice: integration of quantitative trait locus analysis and global gene expression data. Circ Res (2007) 2.07
Coagulation facilitates tumor cell spreading in the pulmonary vasculature during early metastatic colony formation. Cancer Res (2004) 2.07
High prevalence of macrolide resistance in Mycoplasma pneumoniae isolates from adult and adolescent patients with respiratory tract infection in China. Clin Infect Dis (2010) 2.02
Solution state characterization of amyloid beta-derived diffusible ligands. Biochemistry (2006) 1.96
Binding of different histone marks differentially regulates the activity and specificity of polycomb repressive complex 2 (PRC2). Proc Natl Acad Sci U S A (2010) 1.96
Mutations in NMNAT1 cause Leber congenital amaurosis and identify a new disease pathway for retinal degeneration. Nat Genet (2012) 1.96
COPI activity coupled with fatty acid biosynthesis is required for viral replication. PLoS Pathog (2006) 1.95
Selective anesthesia-induced neuroinflammation in developing mouse brain and cognitive impairment. Anesthesiology (2013) 1.93
MDM2 is a negative regulator of p21WAF1/CIP1, independent of p53. J Biol Chem (2004) 1.93
Molecular evidence for spread of two major methicillin-resistant Staphylococcus aureus clones with a unique geographic distribution in Chinese hospitals. Antimicrob Agents Chemother (2008) 1.91
Structures of apicomplexan calcium-dependent protein kinases reveal mechanism of activation by calcium. Nat Struct Mol Biol (2010) 1.91
Meta-analysis of vitamin D, calcium and the prevention of breast cancer. Breast Cancer Res Treat (2009) 1.90
Structural and chemical profiling of the human cytosolic sulfotransferases. PLoS Biol (2007) 1.90
ANOSVA: a statistical method for detecting splice variation from expression data. Bioinformatics (2005) 1.88
Antisense therapy targeting MDM2 oncogene in prostate cancer: Effects on proliferation, apoptosis, multiple gene expression, and chemotherapy. Proc Natl Acad Sci U S A (2003) 1.87
Genetic variants in fibroblast growth factor receptor 2 (FGFR2) contribute to susceptibility of breast cancer in Chinese women. Carcinogenesis (2008) 1.87
Novel roles of Akt and mTOR in suppressing TGF-beta/ALK5-mediated Smad3 activation. EMBO J (2005) 1.85
MDM2 and human malignancies: expression, clinical pathology, prognostic markers, and implications for chemotherapy. Curr Cancer Drug Targets (2005) 1.83
High prevalence of multidrug-resistant nonfermenters in hospital-acquired pneumonia in Asia. Am J Respir Crit Care Med (2011) 1.80
Role for CD47-SIRPalpha signaling in xenograft rejection by macrophages. Proc Natl Acad Sci U S A (2007) 1.80
Band 3 is a host receptor binding merozoite surface protein 1 during the Plasmodium falciparum invasion of erythrocytes. Proc Natl Acad Sci U S A (2003) 1.79
Association of UHRF1 with methylated H3K9 directs the maintenance of DNA methylation. Nat Struct Mol Biol (2012) 1.77
Anesthetics isoflurane and desflurane differently affect mitochondrial function, learning, and memory. Ann Neurol (2012) 1.76
Tet3 CXXC domain and dioxygenase activity cooperatively regulate key genes for Xenopus eye and neural development. Cell (2012) 1.76
Measuring microRNAs: comparisons of microarray and quantitative PCR measurements, and of different total RNA prep methods. BMC Biotechnol (2008) 1.75
CCR2 signaling contributes to ischemia-reperfusion injury in kidney. J Am Soc Nephrol (2003) 1.73
Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain. Nat Chem Biol (2013) 1.72
Wnt/beta-catenin signaling pathway as a novel cancer drug target. Curr Cancer Drug Targets (2004) 1.72
A large multicenter correlation study of thyroid nodule cytopathology and histopathology. Thyroid (2010) 1.68
MicroRNA-199a targets CD44 to suppress the tumorigenicity and multidrug resistance of ovarian cancer-initiating cells. FEBS J (2012) 1.67
Structural basis of human CYP51 inhibition by antifungal azoles. J Mol Biol (2010) 1.67
Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors. Nat Commun (2012) 1.67
Emergence of primate genes by retrotransposon-mediated sequence transduction. Proc Natl Acad Sci U S A (2006) 1.66
Experimental studies on anisotropic thermoelectric properties and structures of n-type Bi2Te2.7Se0.3. Nano Lett (2010) 1.63
Validation of the simplified criteria for diagnosis of autoimmune hepatitis in Chinese patients. J Hepatol (2010) 1.63
Next generation sequencing-based molecular diagnosis of retinitis pigmentosa: identification of a novel genotype-phenotype correlation and clinical refinements. Hum Genet (2013) 1.63
Superresolution imaging of targeted proteins in fixed and living cells using photoactivatable organic fluorophores. J Am Chem Soc (2010) 1.61
Binding of Rac1, Rnd1, and RhoD to a novel Rho GTPase interaction motif destabilizes dimerization of the plexin-B1 effector domain. J Biol Chem (2007) 1.61
Crystal structures of Trypanosoma brucei sterol 14alpha-demethylase and implications for selective treatment of human infections. J Biol Chem (2009) 1.60
Curcumin, a dietary component, has anticancer, chemosensitization, and radiosensitization effects by down-regulating the MDM2 oncogene through the PI3K/mTOR/ETS2 pathway. Cancer Res (2007) 1.60
Evaluation of the coverage and depth of transcriptome by RNA-Seq in chickens. BMC Bioinformatics (2011) 1.60
Recombinant probiotics for treatment and prevention of enterotoxigenic Escherichia coli diarrhea. Gastroenterology (2005) 1.58
Molecular classification of thyroid nodules using high-dimensionality genomic data. J Clin Endocrinol Metab (2010) 1.57
Population health impact and cost-effectiveness of monitoring inactive chronic hepatitis B and treating eligible patients in Shanghai, China. Hepatology (2014) 1.56
Serology of severe acute respiratory syndrome: implications for surveillance and outcome. J Infect Dis (2004) 1.55
Dual-modality optical and positron emission tomography imaging of vascular endothelial growth factor receptor on tumor vasculature using quantum dots. Eur J Nucl Med Mol Imaging (2008) 1.55
Prevalence and risk factors associated with chronic kidney disease in an adult population from southern China. Nephrol Dial Transplant (2008) 1.55
The cyclin dependent kinase inhibitor (R)-roscovitine prevents alloreactive T cell clonal expansion and protects against acute GvHD. Cell Cycle (2009) 1.52
Backward genotype-trait association (BGTA)-based dissection of complex traits in case-control designs. Hum Hered (2006) 1.52
Sgf29 binds histone H3K4me2/3 and is required for SAGA complex recruitment and histone H3 acetylation. EMBO J (2011) 1.52
Restaging of locally advanced rectal cancer with magnetic resonance imaging and endoluminal ultrasound after preoperative chemoradiotherapy: a systemic review and meta-analysis. Dis Colon Rectum (2014) 1.52
Substitutional alloy of Bi and Te at high pressure. Phys Rev Lett (2011) 1.51
Stabilization of E2F1 protein by MDM2 through the E2F1 ubiquitination pathway. Oncogene (2005) 1.51
Rotation of the stalk/neck and one head in a new crystal structure of the kinesin motor protein, Ncd. EMBO J (2003) 1.50
Novel polysaccharide adjuvant from the roots of Actinidia eriantha with dual Th1 and Th2 potentiating activity. Vaccine (2009) 1.49
Rapid change of methicillin-resistant Staphylococcus aureus clones in a Chinese tertiary care hospital over a 15-year period. Antimicrob Agents Chemother (2010) 1.48
AgBase: supporting functional modeling in agricultural organisms. Nucleic Acids Res (2010) 1.48
Geminivirus AL2 and L2 proteins interact with and inactivate SNF1 kinase. Plant Cell (2003) 1.47
Comprehensive molecular diagnosis of 179 Leber congenital amaurosis and juvenile retinitis pigmentosa patients by targeted next generation sequencing. J Med Genet (2013) 1.47