Published in EMBO J on December 16, 2009
MDM2, MDMX and p53 in oncogenesis and cancer therapy. Nat Rev Cancer (2013) 3.60
The p53 orchestra: Mdm2 and Mdmx set the tone. Trends Cell Biol (2010) 3.08
The Mdm2-p53 relationship evolves: Mdm2 swings both ways as an oncogene and a tumor suppressor. Genes Dev (2010) 2.27
Epigenetic and genetic features of 24 colon cancer cell lines. Oncogenesis (2013) 2.02
ATM phosphorylation of Mdm2 Ser394 regulates the amplitude and duration of the DNA damage response in mice. Cancer Cell (2012) 1.70
The phenotype of MDM2 auto-degradation after DNA damage is due to epitope masking by phosphorylation. Cell Cycle (2011) 1.62
Roles of COP9 signalosome in cancer. Cell Cycle (2011) 1.37
Smac mimetics activate the E3 ligase activity of cIAP1 protein by promoting RING domain dimerization. J Biol Chem (2011) 1.25
Regulation of p53: a collaboration between Mdm2 and Mdmx. Oncotarget (2012) 1.24
Spliced MDM2 isoforms promote mutant p53 accumulation and gain-of-function in tumorigenesis. Nat Commun (2013) 1.19
A p53-independent role for the MDM2 antagonist Nutlin-3 in DNA damage response initiation. BMC Cancer (2011) 1.15
Hypoxia inactivates the VHL tumor suppressor through PIASy-mediated SUMO modification. PLoS One (2010) 1.12
FOXO3 signalling links ATM to the p53 apoptotic pathway following DNA damage. Nat Commun (2012) 1.12
Mechanism of p53 stabilization by ATM after DNA damage. Cell Cycle (2010) 1.09
Multitasking with ubiquitin through multivalent interactions. Trends Biochem Sci (2010) 1.07
The Regulation of Multiple p53 Stress Responses is Mediated through MDM2. Genes Cancer (2012) 1.06
Patterns and functional implications of rare germline variants across 12 cancer types. Nat Commun (2015) 1.02
Scission of the p53-MDM2 Loop by Ribosomal Proteins. Genes Cancer (2012) 1.00
Regulation of MDM2 E3 ligase activity by phosphorylation after DNA damage. Mol Cell Biol (2011) 1.00
p53 promotes repair of heterochromatin DNA by regulating JMJD2b and SUV39H1 expression. Oncogene (2013) 1.00
Inhibition of p53 DNA binding function by the MDM2 protein acidic domain. J Biol Chem (2011) 0.99
The regulation of MDM2 oncogene and its impact on human cancers. Acta Biochim Biophys Sin (Shanghai) (2014) 0.97
Casein kinase 1α regulates an MDMX intramolecular interaction to stimulate p53 binding. Mol Cell Biol (2012) 0.94
Controlling the Mdm2-Mdmx-p53 Circuit. Pharmaceuticals (Basel) (2010) 0.92
Mdm2 links genotoxic stress and metabolism to p53. Protein Cell (2011) 0.92
Enigma negatively regulates p53 through MDM2 and promotes tumor cell survival in mice. J Clin Invest (2010) 0.91
Abnormal MDMX degradation in tumor cells due to ARF deficiency. Oncogene (2011) 0.90
The Many Faces of MDM2 Binding Partners. Genes Cancer (2012) 0.90
DNA damage-induced activation of ATM promotes β-TRCP-mediated Mdm2 ubiquitination and destruction. Oncotarget (2012) 0.88
Posttranslational modification of mammalian AP endonuclease (APE1). Cell Mol Life Sci (2010) 0.87
c-Abl phosphorylation of Mdm2 facilitates Mdm2-Mdmx complex formation. J Biol Chem (2010) 0.87
Role of p53 in neurodegenerative diseases. Neurodegener Dis (2011) 0.86
Mdm2's dilemma: to degrade or to translate p53? Cancer Cell (2012) 0.84
Regulation of Mutant p53 Protein Expression. Front Oncol (2015) 0.84
Phosphorylation of Daxx by ATM contributes to DNA damage-induced p53 activation. PLoS One (2013) 0.83
F-box protein FBXO31 directs degradation of MDM2 to facilitate p53-mediated growth arrest following genotoxic stress. Proc Natl Acad Sci U S A (2015) 0.83
It Takes 15 to Tango: Making Sense of the Many Ubiquitin Ligases of p53. Genes Cancer (2012) 0.83
Autoactivation of the MDM2 E3 ligase by intramolecular interaction. Mol Cell Biol (2014) 0.83
The MDM2 RING domain and central acidic domain play distinct roles in MDM2 protein homodimerization and MDM2-MDMX protein heterodimerization. J Biol Chem (2015) 0.83
Ubiquitination of human AP-endonuclease 1 (APE1) enhanced by T233E substitution and by CDK5. Nucleic Acids Res (2011) 0.82
Functional analysis and consequences of Mdm2 E3 ligase inhibition in human tumor cells. Oncogene (2012) 0.82
The Roles of MDM2 and MDMX Phosphorylation in Stress Signaling to p53. Genes Cancer (2012) 0.81
Murine Double-Minute 2 Homolog Single Nucleotide Polymorphisms 285 and 309 in Cervical Carcinogenesis. Mol Diagn Ther (2015) 0.80
Protecting the genome from mdm2 and mdmx. Genes Cancer (2012) 0.79
Requirement for human Mps1/TTK in oxidative DNA damage repair and cell survival through MDM2 phosphorylation. Nucleic Acids Res (2015) 0.79
Ribosomal protein S27-like is a physiological regulator of p53 that suppresses genomic instability and tumorigenesis. Elife (2014) 0.77
Dystonia, facial dysmorphism, intellectual disability and breast cancer associated with a chromosome 13q34 duplication and overexpression of TFDP1: case report. BMC Med Genet (2013) 0.77
Probing the mechanisms underlying human diseases in making ribosomes. Biochem Soc Trans (2016) 0.76
MDM2 oligomers: antagonizers of the guardian of the genome. Oncogene (2016) 0.76
Regulation of the Mdm2-p53 signaling axis in the DNA damage response and tumorigenesis. Transl Cancer Res (2016) 0.76
Characterization of cancer-associated missense mutations in MDM2. Mol Cell Oncol (2015) 0.75
Mdm2 Phosphorylation Regulates Its Stability and Has Contrasting Effects on Oncogene and Radiation-Induced Tumorigenesis. Cell Rep (2016) 0.75
Is p53 Involved in Tissue-Specific Insulin Resistance Formation? Oxid Med Cell Longev (2017) 0.75
SMG7 is a critical regulator of p53 stability and function in DNA damage stress response. Cell Discov (2016) 0.75
Systematic identification of phosphorylation-mediated protein interaction switches. PLoS Comput Biol (2017) 0.75
Structural basis of how stress-induced MDMX phosphorylation activates p53. Oncogene (2015) 0.75
Enhanced phosphorylation of p53 by ATM in response to DNA damage. Science (1998) 10.89
DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2. Cell (1997) 10.52
Recognition of the polyubiquitin proteolytic signal. EMBO J (2000) 10.12
The p53 pathway: positive and negative feedback loops. Oncogene (2005) 9.75
Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM. Cancer Res (2004) 9.70
The p53 pathway. J Pathol (1999) 6.79
Substrate specificities and identification of putative substrates of ATM kinase family members. J Biol Chem (1999) 6.14
Disruption of p53 in human cancer cells alters the responses to therapeutic agents. J Clin Invest (1999) 6.13
Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53. Genes Dev (2000) 5.90
The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites. Genes Dev (2000) 5.72
Mapping of the p53 and mdm-2 interaction domains. Mol Cell Biol (1993) 5.31
MDMX: a novel p53-binding protein with some functional properties of MDM2. EMBO J (1996) 4.13
ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage. Genes Dev (2001) 4.06
A UbcH5/ubiquitin noncovalent complex is required for processive BRCA1-directed ubiquitination. Mol Cell (2006) 3.30
Regulation of p53 function and stability by phosphorylation. Mol Cell Biol (1999) 3.24
Accelerated MDM2 auto-degradation induced by DNA-damage kinases is required for p53 activation. EMBO J (2004) 3.10
Serine15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2. EMBO J (1999) 3.00
Critical role for Daxx in regulating Mdm2. Nat Cell Biol (2006) 2.96
Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage. Proc Natl Acad Sci U S A (1999) 2.87
Targeting of substrates to the 26S proteasome. FASEB J (1997) 2.70
Suprafacial orientation of the SCFCdc4 dimer accommodates multiple geometries for substrate ubiquitination. Cell (2007) 2.69
Monoubiquitylation promotes mitochondrial p53 translocation. EMBO J (2007) 2.62
E4F1 is an atypical ubiquitin ligase that modulates p53 effector functions independently of degradation. Cell (2006) 2.50
MDM2 promotes ubiquitination and degradation of MDMX. Mol Cell Biol (2003) 2.45
ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage. EMBO J (2005) 2.29
Mdmx stabilizes p53 and Mdm2 via two distinct mechanisms. EMBO Rep (2001) 2.27
The Mdm2 RING domain C-terminus is required for supramolecular assembly and ubiquitin ligase activity. EMBO J (2006) 2.21
Mdm4 and Mdm2 cooperate to inhibit p53 activity in proliferating and quiescent cells in vivo. Proc Natl Acad Sci U S A (2006) 2.20
Ser18 and 23 phosphorylation is required for p53-dependent apoptosis and tumor suppression. EMBO J (2006) 2.12
Control of p53 ubiquitination and nuclear export by MDM2 and ARF. Cell Growth Differ (2001) 2.05
Cell type- and promoter-specific roles of Ser18 phosphorylation in regulating p53 responses. J Biol Chem (2003) 2.02
Comparative study of the p53-mdm2 and p53-MDMX interfaces. Oncogene (1999) 1.98
DNA damage induced p53 stabilization: no indication for an involvement of p53 phosphorylation. Oncogene (1999) 1.96
Mdm-2 phosphorylation by DNA-dependent protein kinase prevents interaction with p53. Cancer Res (1997) 1.88
Mutations in Fbx4 inhibit dimerization of the SCF(Fbx4) ligase and contribute to cyclin D1 overexpression in human cancer. Cancer Cell (2008) 1.78
Regulation of Mdm2-directed degradation by the C terminus of p53. Mol Cell Biol (1998) 1.69
A mouse p53 mutant lacking the proline-rich domain rescues Mdm4 deficiency and provides insight into the Mdm2-Mdm4-p53 regulatory network. Cancer Cell (2006) 1.64
Control of biochemical reactions through supramolecular RING domain self-assembly. Proc Natl Acad Sci U S A (2002) 1.63
Defective apoptosis and B-cell lymphomas in mice with p53 point mutation at Ser 23. EMBO J (2004) 1.63
DNA damage induces MDMX nuclear translocation by p53-dependent and -independent mechanisms. Mol Cell Biol (2002) 1.53
Oligomerization is required for p53 to be efficiently ubiquitinated by MDM2. J Biol Chem (1999) 1.33
Functional role of Mdm2 phosphorylation by ATR in attenuation of p53 nuclear export. Oncogene (2003) 1.21
Proteolytic cleavage of the mdm2 oncoprotein during apoptosis. J Biol Chem (1997) 1.20
c-Abl regulates p53 levels under normal and stress conditions by preventing its nuclear export and ubiquitination. Mol Cell Biol (2001) 1.19
SOAPdenovo2: an empirically improved memory-efficient short-read de novo assembler. Gigascience (2012) 20.89
Assemblathon 1: a competitive assessment of de novo short read assembly methods. Genome Res (2011) 8.38
The genome of the mesopolyploid crop species Brassica rapa. Nat Genet (2011) 8.23
Insulin-stimulated phosphorylation of a Rab GTPase-activating protein regulates GLUT4 translocation. J Biol Chem (2003) 5.86
Acetylation of the p53 DNA-binding domain regulates apoptosis induction. Mol Cell (2006) 5.40
ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation. Mol Cell (2006) 5.01
Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans. Mol Cell Biol (2004) 4.31
Transcriptional repression of the anti-apoptotic survivin gene by wild type p53. J Biol Chem (2001) 4.21
Assemblathon 2: evaluating de novo methods of genome assembly in three vertebrate species. Gigascience (2013) 4.11
HDAC6 modulates cell motility by altering the acetylation level of cortactin. Mol Cell (2007) 3.99
Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. Cell (2011) 3.95
Ordered phosphorylation governs oscillation of a three-protein circadian clock. Science (2007) 3.78
Convergence of the fanconi anemia and ataxia telangiectasia signaling pathways. Cell (2002) 3.71
Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery. Nucleic Acids Res (2005) 3.56
A method to identify serine kinase substrates. Akt phosphorylates a novel adipocyte protein with a Rab GTPase-activating protein (GAP) domain. J Biol Chem (2002) 3.33
HnRNP L stimulates splicing of the eNOS gene by binding to variable-length CA repeats. Nat Struct Biol (2003) 3.22
VFDB 2008 release: an enhanced web-based resource for comparative pathogenomics. Nucleic Acids Res (2007) 3.07
A human protein complex homologous to the Drosophila MSL complex is responsible for the majority of histone H4 acetylation at lysine 16. Mol Cell Biol (2005) 3.04
Muscle-specific PPARgamma-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones. J Clin Invest (2003) 2.87
Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage. Nat Cell Biol (2006) 2.85
A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes. Proc Natl Acad Sci U S A (2002) 2.78
AS160, the Akt substrate regulating GLUT4 translocation, has a functional Rab GTPase-activating protein domain. Biochem J (2005) 2.76
Biomolecular characterization and protein sequences of the Campanian hadrosaur B. canadensis. Science (2009) 2.48
SIRT1 sumoylation regulates its deacetylase activity and cellular response to genotoxic stress. Nat Cell Biol (2007) 2.47
MDM2 promotes ubiquitination and degradation of MDMX. Mol Cell Biol (2003) 2.45
SIRT1 regulates the function of the Nijmegen breakage syndrome protein. Mol Cell (2007) 2.42
Bacterial glycosidases for the production of universal red blood cells. Nat Biotechnol (2007) 2.41
Yeast enhancer of polycomb defines global Esa1-dependent acetylation of chromatin. Genes Dev (2003) 2.30
ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage. EMBO J (2005) 2.29
Biphasic roles for soluble guanylyl cyclase (sGC) in platelet activation. Blood (2011) 2.27
MDMX overexpression prevents p53 activation by the MDM2 inhibitor Nutlin. J Biol Chem (2006) 2.20
Histone sumoylation is a negative regulator in Saccharomyces cerevisiae and shows dynamic interplay with positive-acting histone modifications. Genes Dev (2006) 2.15
The c-MYC oncoprotein is a substrate of the acetyltransferases hGCN5/PCAF and TIP60. Mol Cell Biol (2004) 2.13
Aurora-A abrogation of p53 DNA binding and transactivation activity by phosphorylation of serine 215. J Biol Chem (2004) 2.11
Comprehensive proteomic analysis of interphase and mitotic 14-3-3-binding proteins. J Biol Chem (2004) 2.05
pIRS: Profile-based Illumina pair-end reads simulator. Bioinformatics (2012) 2.00
System-wide investigation of ErbB4 reveals 19 sites of Tyr phosphorylation that are unusually selective in their recruitment properties. Chem Biol (2008) 1.97
TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia. Genes Dev (2010) 1.95
Acetylation of poly(ADP-ribose) polymerase-1 by p300/CREB-binding protein regulates coactivation of NF-kappaB-dependent transcription. J Biol Chem (2005) 1.93
MDM2 interaction with nuclear corepressor KAP1 contributes to p53 inactivation. EMBO J (2005) 1.85
Cathepsin L in secretory vesicles functions as a prohormone-processing enzyme for production of the enkephalin peptide neurotransmitter. Proc Natl Acad Sci U S A (2003) 1.83
COPE: an accurate k-mer-based pair-end reads connection tool to facilitate genome assembly. Bioinformatics (2012) 1.83
Isolation of human NURF: a regulator of Engrailed gene expression. EMBO J (2003) 1.80
Direct identification of PTEN phosphorylation sites. FEBS Lett (2002) 1.80
MDMX regulation of p53 response to ribosomal stress. EMBO J (2006) 1.77
An inner centromere protein that stimulates the microtubule depolymerizing activity of a KinI kinesin. Dev Cell (2003) 1.76
Analysis of phosphorylation of human heat shock factor 1 in cells experiencing a stress. BMC Biochem (2005) 1.76
Efficient p53 activation and apoptosis by simultaneous disruption of binding to MDM2 and MDMX. Cancer Res (2007) 1.76
Human Elongator facilitates RNA polymerase II transcription through chromatin. Proc Natl Acad Sci U S A (2002) 1.75
Design, synthesis, and evaluation of an alpha-helix mimetic library targeting protein-protein interactions. J Am Chem Soc (2009) 1.72
Lipopolysaccharide stimulates platelet secretion and potentiates platelet aggregation via TLR4/MyD88 and the cGMP-dependent protein kinase pathway. J Immunol (2009) 1.70
Inhibition of GLUT4 translocation by Tbc1d1, a Rab GTPase-activating protein abundant in skeletal muscle, is partially relieved by AMP-activated protein kinase activation. J Biol Chem (2008) 1.68
Regulation of MDMX nuclear import and degradation by Chk2 and 14-3-3. EMBO J (2006) 1.67
A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes. J Biol Chem (2002) 1.67
Synthesis and anti-HIV activity evaluation of 2-(4-(naphthalen-2-yl)-1,2,3-thiadiazol-5-ylthio)-N-acetamides as novel non-nucleoside HIV-1 reverse transcriptase inhibitors. Eur J Med Chem (2009) 1.64
Phosphorylation regulates targeting of cytoplasmic dynein to kinetochores during mitosis. J Cell Biol (2008) 1.64
MDM2 acts downstream of p53 as an E3 ligase to promote FOXO ubiquitination and degradation. J Biol Chem (2009) 1.63
The phenotype of MDM2 auto-degradation after DNA damage is due to epitope masking by phosphorylation. Cell Cycle (2011) 1.62
Somatic acquisition and signaling of TGFBR1*6A in cancer. JAMA (2005) 1.59
Peroxisome proliferator-activated receptor-α is renoprotective in doxorubicin-induced glomerular injury. Kidney Int (2011) 1.59
Functional analysis of the subunits of the chromatin assembly factor RSF. Mol Cell Biol (2003) 1.56
Complete genome sequence of Shigella flexneri 5b and comparison with Shigella flexneri 2a. BMC Genomics (2006) 1.54
Revisiting the molecular evolutionary history of Shigella spp. J Mol Evol (2006) 1.54
The Association of Biomolecular Resource Facilities Proteomics Research Group 2006 study: relative protein quantitation. Mol Cell Proteomics (2007) 1.53
DNA damage induces MDMX nuclear translocation by p53-dependent and -independent mechanisms. Mol Cell Biol (2002) 1.53
Functional characterization of core promoter elements: DPE-specific transcription requires the protein kinase CK2 and the PC4 coactivator. Mol Cell (2005) 1.52
p53 acetylation is crucial for its transcription-independent proapoptotic functions. J Biol Chem (2009) 1.48
Two distinct roles of mitogen-activated protein kinases in platelets and a novel Rac1-MAPK-dependent integrin outside-in retractile signaling pathway. Blood (2008) 1.47
Antihypertensive effects of selective prostaglandin E2 receptor subtype 1 targeting. J Clin Invest (2007) 1.45
Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase. Proc Natl Acad Sci U S A (2002) 1.43
PPARgamma agonists prevent TGFbeta1/Smad3-signaling in human hepatic stellate cells. Biochem Biophys Res Commun (2006) 1.42
Regulation of p53-MDMX interaction by casein kinase 1 alpha. Mol Cell Biol (2005) 1.41
Recurrent gain-of-function mutation in PRKG1 causes thoracic aortic aneurysms and acute aortic dissections. Am J Hum Genet (2013) 1.40
SIRT1 deacetylates the DNA methyltransferase 1 (DNMT1) protein and alters its activities. Mol Cell Biol (2011) 1.35
Critical roles for the COOH-terminal NITY and RGT sequences of the integrin beta3 cytoplasmic domain in inside-out and outside-in signaling. J Cell Biol (2003) 1.34
SirT1 is an inhibitor of proliferation and tumor formation in colon cancer. J Biol Chem (2009) 1.33
Functional relevance of novel p300-mediated lysine 314 and 315 acetylation of RelA/p65. Nucleic Acids Res (2008) 1.32
Regulation of Bax activation and apoptotic response to microtubule-damaging agents by p53 transcription-dependent and -independent pathways. J Biol Chem (2004) 1.32
Regulation of E2F1 function by the nuclear corepressor KAP1. J Biol Chem (2007) 1.31
ShiBASE: an integrated database for comparative genomics of Shigella. Nucleic Acids Res (2006) 1.31
Structure-based design of high affinity peptides inhibiting the interaction of p53 with MDM2 and MDMX. J Biol Chem (2009) 1.31
Inhibition of SUV39H1 methyltransferase activity by DBC1. J Biol Chem (2009) 1.31
Two roles for the Drosophila IKK complex in the activation of Relish and the induction of antimicrobial peptide genes. Proc Natl Acad Sci U S A (2009) 1.30
Overexpressed pituitary tumor-transforming gene causes aneuploidy in live human cells. Endocrinology (2003) 1.29
MDM2-ARF complex regulates p53 sumoylation. Oncogene (2003) 1.29
Characterization and cloning of T24, a Taenia solium antigen diagnostic for cysticercosis. Mol Biochem Parasitol (2006) 1.28
Insulin-stimulated phosphorylation of the Rab GTPase-activating protein TBC1D1 regulates GLUT4 translocation. J Biol Chem (2009) 1.27
Leaves and fruits of Bauhinia (Leguminosae, Caesalpinioideae, Cercideae) from the Oligocene Ningming Formation of Guangxi, South China and their biogeographic implications. BMC Evol Biol (2014) 1.24