miRNAs control insulin content in pancreatic β-cells via downregulation of transcriptional repressors.

PubWeight™: 1.75‹?› | Rank: Top 3%

🔗 View Article (PMC 3049206)

Published in EMBO J on February 01, 2011

Authors

Tal Melkman-Zehavi1, Roni Oren, Sharon Kredo-Russo, Tirosh Shapira, Amitai D Mandelbaum, Natalia Rivkin, Tomer Nir, Kim A Lennox, Mark A Behlke, Yuval Dor, Eran Hornstein

Author Affiliations

1: Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.

Articles citing this

How to make a functional β-cell. Development (2013) 1.58

A miR-19 regulon that controls NF-κB signaling. Nucleic Acids Res (2012) 1.43

MicroRNAs in metabolic disease. Arterioscler Thromb Vasc Biol (2013) 1.33

Thioredoxin-interacting protein regulates insulin transcription through microRNA-204. Nat Med (2013) 1.25

The miRNA profile of human pancreatic islets and beta-cells and relationship to type 2 diabetes pathogenesis. PLoS One (2013) 1.25

MicroRNA-30d induces insulin transcription factor MafA and insulin production by targeting mitogen-activated protein 4 kinase 4 (MAP4K4) in pancreatic β-cells. J Biol Chem (2012) 1.19

MicroRNA-7a regulates pancreatic β cell function. J Clin Invest (2014) 1.18

The circular RNA Cdr1as, via miR-7 and its targets, regulates insulin transcription and secretion in islet cells. Sci Rep (2015) 1.14

MicroRNA-7 regulates the mTOR pathway and proliferation in adult pancreatic β-cells. Diabetes (2012) 1.08

MicroRNA expression in alpha and beta cells of human pancreatic islets. PLoS One (2013) 1.08

Beta-cell specific deletion of Dicer1 leads to defective insulin secretion and diabetes mellitus. PLoS One (2011) 1.04

Simultaneous miRNA and mRNA transcriptome profiling of human myoblasts reveals a novel set of myogenic differentiation-associated miRNAs and their target genes. BMC Genomics (2013) 1.04

MicroRNAs as Haematopoiesis Regulators. Adv Hematol (2013) 1.03

MicroRNA-24/MODY gene regulatory pathway mediates pancreatic β-cell dysfunction. Diabetes (2013) 1.03

Stem cell approaches for diabetes: towards beta cell replacement. Genome Med (2011) 1.02

MicroRNA, nutrition, and cancer prevention. Adv Nutr (2011) 1.02

Epigenetics: the missing link to understanding β-cell dysfunction in the pathogenesis of type 2 diabetes. Epigenetics (2012) 1.01

MicroRNAs -the next generation therapeutic targets in human diseases. Theranostics (2013) 0.97

MicroRNAs in metabolism. Acta Physiol (Oxf) (2016) 0.97

miR-24 limits aortic vascular inflammation and murine abdominal aneurysm development. Nat Commun (2014) 0.95

Argonaute2 regulates the pancreatic β-cell secretome. Mol Cell Proteomics (2013) 0.95

MiR-103 controls milk fat accumulation in goat (Capra hircus) mammary gland during lactation. PLoS One (2013) 0.93

Matched miRNA and mRNA signatures from an hESC-based in vitro model of pancreatic differentiation reveal novel regulatory interactions. J Cell Sci (2013) 0.92

Dysregulation of Dicer1 in beta cells impairs islet architecture and glucose metabolism. Exp Diabetes Res (2012) 0.88

MicroRNAs as pharmacological targets in diabetes. Pharmacol Res (2013) 0.88

Post-transcriptional regulation in metabolic diseases. RNA Biol (2012) 0.88

Postnatal β-cell maturation is associated with islet-specific microRNA changes induced by nutrient shifts at weaning. Nat Commun (2015) 0.85

Regulation of Pancreatic Beta Cell Stimulus-Secretion Coupling by microRNAs. Genes (Basel) (2014) 0.85

β-Cell MicroRNAs: Small but Powerful. Diabetes (2015) 0.84

MiR-375 promotes redifferentiation of adult human β cells expanded in vitro. PLoS One (2015) 0.84

Addressing Bias in Small RNA Library Preparation for Sequencing: A New Protocol Recovers MicroRNAs that Evade Capture by Current Methods. Front Genet (2015) 0.83

The microRNA-29 Family Dictates the Balance Between Homeostatic and Pathological Glucose Handling in Diabetes and Obesity. Diabetes (2016) 0.83

DICER Inactivation Identifies Pancreatic β-Cell "Disallowed" Genes Targeted by MicroRNAs. Mol Endocrinol (2015) 0.83

Dicer1 is required to repress neuronal fate during endocrine cell maturation. Diabetes (2013) 0.82

miR-25 and miR-92a regulate insulin I biosynthesis in rats. RNA Biol (2013) 0.82

Analysis of differential miRNA expression in the duodenum of Escherichia coli F18-sensitive and -resistant weaned piglets. PLoS One (2012) 0.82

MicroRNAs: new insights into chronic childhood diseases. Biomed Res Int (2013) 0.81

Role of regulatory micro RNAs in type 2 diabetes mellitus-related inflammation. Nucleic Acid Ther (2012) 0.81

Update on the protective molecular pathways improving pancreatic beta-cell dysfunction. Mediators Inflamm (2013) 0.81

Pancreas-enriched miRNAs are altered in the circulation of subjects with diabetes: a pilot cross-sectional study. Sci Rep (2016) 0.80

Menin is required for optimal processing of the microRNA let-7a. J Biol Chem (2014) 0.80

Epigenetics and Cellular Metabolism. Genet Epigenet (2016) 0.80

Minireview: microRNA function in pancreatic β cells. Mol Endocrinol (2014) 0.80

Transcriptional mechanisms controlling miR-375 gene expression in the pancreas. Exp Diabetes Res (2012) 0.80

A comparative analysis of high-throughput platforms for validation of a circulating microRNA signature in diabetic retinopathy. Sci Rep (2015) 0.78

Targeting noncoding RNAs in disease. J Clin Invest (2017) 0.78

Inhibition of ZEB1 expression induces redifferentiation of adult human β cells expanded in vitro. Sci Rep (2015) 0.77

Multiple microRNAs within the 14q32 cluster target the mRNAs of major type 1 diabetes autoantigens IA-2, IA-2β, and GAD65. FASEB J (2015) 0.77

Comparative microRNA expression profiles of cynomolgus monkeys, rat, and human reveal that mir-182 is involved in T2D pathogenic processes. J Diabetes Res (2014) 0.77

Organogenesis and functional genomics of the endocrine pancreas. Cell Mol Life Sci (2012) 0.77

Re-dicing the pancreatic β-cell: do microRNAs define cellular identity? EMBO J (2011) 0.77

Endothelial Dicer promotes atherosclerosis and vascular inflammation by miRNA-103-mediated suppression of KLF4. Nat Commun (2016) 0.76

miR-24 in diabetes. Oncotarget (2015) 0.76

Arsenic Exposure and Type 2 Diabetes: MicroRNAs as Mechanistic Links? Curr Diab Rep (2017) 0.75

Type 1 Diabetes Candidate Genes Linked to Pancreatic Islet Cell Inflammation and Beta-Cell Apoptosis. Genes (Basel) (2017) 0.75

Regulatory Roles of MicroRNAs in Diabetes. Int J Mol Sci (2016) 0.75

Making sense in antisense: therapeutic potential of noncoding RNAs in diabetes-induced vascular dysfunction. J Diabetes Res (2013) 0.75

The Biochemical Cascades of the Human Pancreatic β-Cells: The Role of MicroRNAs. J Bioanal Biomed (2015) 0.75

Functional Transcriptomics in Diverse Intestinal Epithelial Cell Types Reveals Robust microRNA Sensitivity in Intestinal Stem Cells to Microbial Status. J Biol Chem (2017) 0.75

Role of miRNAs in the pathogenesis and susceptibility of diabetes mellitus. J Hum Genet (2016) 0.75

A Systematic Comparison of Purification and Normalization Protocols for Quantitative MicroRNA Expressional Profiling in Insulin-Producing Cells. Int J Mol Sci (2016) 0.75

Noncoding RNAs in β cell biology. Curr Opin Endocrinol Diabetes Obes (2015) 0.75

MiRNAs in β-Cell Development, Identity, and Disease. Front Genet (2017) 0.75

Let-7 and MicroRNA-148 Regulate Parathyroid Hormone Levels in Secondary Hyperparathyroidism. J Am Soc Nephrol (2017) 0.75

Beyond the Protein-Coding Sequence: Noncoding RNAs in the Pathogenesis of Type 2 Diabetes. Rev Diabet Stud (2016) 0.75

MicroRNAs as stress regulators in pancreatic beta cells and diabetes. Mol Metab (2017) 0.75

MiR-30a targets IL-1α and regulates islet functions as an inflammation buffer and response factor. Sci Rep (2017) 0.75

Articles cited by this

MicroRNAs: target recognition and regulatory functions. Cell (2009) 92.17

Combinatorial microRNA target predictions. Nat Genet (2005) 50.48

Role for a bidentate ribonuclease in the initiation step of RNA interference. Nature (2001) 38.75

The nuclear RNase III Drosha initiates microRNA processing. Nature (2003) 35.49

The role of site accessibility in microRNA target recognition. Nat Genet (2007) 18.52

Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation. Nature (2004) 16.56

A pancreatic islet-specific microRNA regulates insulin secretion. Nature (2004) 15.02

Z/EG, a double reporter mouse line that expresses enhanced green fluorescent protein upon Cre-mediated excision. Genesis (2001) 12.85

Method for the isolation of intact islets of Langerhans from the rat pancreas. Diabetes (1967) 11.63

The RNaseIII enzyme Dicer is required for morphogenesis but not patterning of the vertebrate limb. Proc Natl Acad Sci U S A (2005) 8.33

Control of endodermal endocrine development by Hes-1. Nat Genet (2000) 7.71

A dicer-independent miRNA biogenesis pathway that requires Ago catalysis. Nature (2010) 6.37

Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells. Development (1998) 4.08

Tissue-specific regulation of the insulin gene by a novel basic helix-loop-helix transcription factor. Genes Dev (1995) 4.07

miR-375 maintains normal pancreatic alpha- and beta-cell mass. Proc Natl Acad Sci U S A (2009) 3.89

Genetic analysis reveals that PAX6 is required for normal transcription of pancreatic hormone genes and islet development. Genes Dev (1997) 3.75

MicroRNA expression is required for pancreatic islet cell genesis in the mouse. Diabetes (2007) 2.80

Activated Notch1 prevents differentiation of pancreatic acinar cells and attenuate endocrine development. Dev Biol (2003) 2.41

MicroRNA-9 controls the expression of Granuphilin/Slp4 and the secretory response of insulin-producing cells. J Biol Chem (2006) 2.29

miR-375 targets 3'-phosphoinositide-dependent protein kinase-1 and regulates glucose-induced biological responses in pancreatic beta-cells. Diabetes (2008) 2.23

MicroRNA-124a regulates Foxa2 expression and intracellular signaling in pancreatic beta-cell lines. J Biol Chem (2007) 2.15

IA1 is NGN3-dependent and essential for differentiation of the endocrine pancreas. EMBO J (2006) 2.02

Molecular medicine of microRNAs: structure, function and implications for diabetes. Expert Rev Mol Med (2008) 1.99

Identification of glucose-regulated miRNAs from pancreatic {beta} cells reveals a role for miR-30d in insulin transcription. RNA (2008) 1.95

The Nkx6.1 homeodomain transcription factor suppresses glucagon expression and regulates glucose-stimulated insulin secretion in islet beta cells. Proc Natl Acad Sci U S A (2005) 1.88

Regulation of the expression of components of the exocytotic machinery of insulin-secreting cells by microRNAs. Biol Chem (2008) 1.85

The zinc-finger factor Insm1 (IA-1) is essential for the development of pancreatic beta cells and intestinal endocrine cells. Genes Dev (2006) 1.81

The islet beta cell-enriched MafA activator is a key regulator of insulin gene transcription. J Biol Chem (2005) 1.73

The human glucokinase gene beta-cell-type promoter: an essential role of insulin promoter factor 1/PDX-1 in its activation in HIT-T15 cells. Diabetes (1996) 1.72

Insulin gene transcription is mediated by interactions between the p300 coactivator and PDX-1, BETA2, and E47. Mol Cell Biol (2002) 1.61

Transcriptional regulation of the human insulin gene is dependent on the homeodomain protein STF1/IPF1 acting through the CT boxes. Proc Natl Acad Sci U S A (1994) 1.56

Glucose regulation of insulin gene expression in pancreatic beta-cells. Biochem J (2008) 1.50

microRNAs and the regulation of glucose and lipid metabolism. Diabetes Obes Metab (2007) 1.49

HES-1 is involved in adaptation of adult human beta-cells to proliferation in vitro. Diabetes (2008) 1.28

Transcription factors regulating beta-cell function. Eur J Endocrinol (2006) 1.27

PDX-1 and MafA play a crucial role in pancreatic beta-cell differentiation and maintenance of mature beta-cell function. Endocr J (2007) 1.20

New pancreas from old: microregulators of pancreas regeneration. Trends Endocrinol Metab (2007) 1.20

SOX6 attenuates glucose-stimulated insulin secretion by repressing PDX1 transcriptional activity and is down-regulated in hyperinsulinemic obese mice. J Biol Chem (2005) 1.14

BETA3, a novel helix-loop-helix protein, can act as a negative regulator of BETA2 and MyoD-responsive genes. Mol Cell Biol (1996) 1.12

INSM1 functions as a transcriptional repressor of the neuroD/beta2 gene through the recruitment of cyclin D1 and histone deacetylases. Biochem J (2006) 1.12

Structure, expression, and biological function of INSM1 transcription factor in neuroendocrine differentiation. FASEB J (2009) 1.10

Syntaxin-3 and syntaxin-1A inhibit L-type calcium channel activity, insulin biosynthesis and exocytosis in beta-cell lines. Diabetologia (2002) 0.97

BETA2 activates transcription from the upstream glucokinase gene promoter in islet beta-cells and gut endocrine cells. Diabetes (2003) 0.96

Identification of an INSM1-binding site in the insulin promoter: negative regulation of the insulin gene transcription. J Endocrinol (2008) 0.95

Identification of microRNAs with a role in glucose stimulated insulin secretion by expression profiling of MIN6 cells. Biochem Biophys Res Commun (2010) 0.95

Transcriptional repressors are increased in pancreatic islets of type 2 diabetic rats. Biochem Biophys Res Commun (1998) 0.91

Articles by these authors

VEGF-induced adult neovascularization: recruitment, retention, and role of accessory cells. Cell (2006) 9.32

The RNaseIII enzyme Dicer is required for morphogenesis but not patterning of the vertebrate limb. Proc Natl Acad Sci U S A (2005) 8.33

Determinants of targeting by endogenous and exogenous microRNAs and siRNAs. RNA (2007) 6.44

Synthetic dsRNA Dicer substrates enhance RNAi potency and efficacy. Nat Biotechnol (2004) 5.40

The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha. Cell (2010) 5.11

Loss of HIF-2alpha and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice. Nat Med (2002) 5.10

Ribosomal protein S6 phosphorylation is a determinant of cell size and glucose homeostasis. Genes Dev (2005) 4.41

Recovery from diabetes in mice by beta cell regeneration. J Clin Invest (2007) 4.32

A structural basis for discriminating between self and nonself double-stranded RNAs in mammalian cells. Nat Biotechnol (2006) 3.46

In vivo lineage tracing defines the role of acinar-to-ductal transdifferentiation in inflammatory ductal metaplasia. Gastroenterology (2007) 3.41

Control of pancreatic β cell regeneration by glucose metabolism. Cell Metab (2011) 3.35

Pten constrains centroacinar cell expansion and malignant transformation in the pancreas. Cancer Cell (2005) 3.15

Effects of sodium ions on DNA duplex oligomers: improved predictions of melting temperatures. Biochemistry (2004) 3.00

Functional polarity is introduced by Dicer processing of short substrate RNAs. Nucleic Acids Res (2005) 2.83

Hedgehog signaling is required for effective regeneration of exocrine pancreas. Gastroenterology (2008) 2.71

Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand. Cell (2012) 2.45

Analysis of microRNA turnover in mammalian cells following Dicer1 ablation. Nucleic Acids Res (2011) 2.39

Beta-catenin is essential for pancreatic acinar but not islet development. Development (2005) 2.38

Human embryonic stem cells and their differentiated derivatives are less susceptible to immune rejection than adult cells. Stem Cells (2005) 2.24

Small nucleolar RNAs U32a, U33, and U35a are critical mediators of metabolic stress. Cell Metab (2011) 2.16

Sustained Neurog3 expression in hormone-expressing islet cells is required for endocrine maturation and function. Proc Natl Acad Sci U S A (2009) 2.09

Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms. Mol Cell Biol (2008) 1.96

Transduction of growth or mitogenic signals into translational activation of TOP mRNAs is fully reliant on the phosphatidylinositol 3-kinase-mediated pathway but requires neither S6K1 nor rpS6 phosphorylation. Mol Cell Biol (2002) 1.90

Hybridization kinetics and thermodynamics of molecular beacons. Nucleic Acids Res (2003) 1.88

miRNA malfunction causes spinal motor neuron disease. Proc Natl Acad Sci U S A (2010) 1.83

Mononuclear phagocyte miRNome analysis identifies miR-142 as critical regulator of murine dendritic cell homeostasis. Blood (2012) 1.82

Lineage tracing evidence for in vitro dedifferentiation but rare proliferation of mouse pancreatic beta-cells. Diabetes (2007) 1.78

Rational design and in vitro and in vivo delivery of Dicer substrate siRNA. Nat Protoc (2006) 1.74

A transgenic mouse marking live replicating cells reveals in vivo transcriptional program of proliferation. Dev Cell (2012) 1.72

LKB1 regulates pancreatic beta cell size, polarity, and function. Cell Metab (2009) 1.70

MicroRNAs are essential for development and function of inner ear hair cells in vertebrates. Proc Natl Acad Sci U S A (2009) 1.67

Epithelial microRNAs regulate gut mucosal immunity via epithelium-T cell crosstalk. Nat Immunol (2011) 1.67

Predicting stability of DNA duplexes in solutions containing magnesium and monovalent cations. Biochemistry (2008) 1.63

A biological solution to a fundamental distributed computing problem. Science (2011) 1.62

Progress toward in vivo use of siRNAs-II. Mol Ther (2011) 1.60

Rapid identification of cell-specific, internalizing RNA aptamers with bioinformatics analyses of a cell-based aptamer selection. PLoS One (2012) 1.60

Design of LNA probes that improve mismatch discrimination. Nucleic Acids Res (2006) 1.59

Myt1 and Ngn3 form a feed-forward expression loop to promote endocrine islet cell differentiation. Dev Biol (2008) 1.55

Respiratory syncytial virus nonstructural protein 2 specifically inhibits type I interferon signal transduction. Virology (2005) 1.54

The activating receptor NKp46 is essential for the development of type 1 diabetes. Nat Immunol (2009) 1.54

Structure-function relationships of shared-stem and conventional molecular beacons. Nucleic Acids Res (2002) 1.51

MicroRNA as repressors of stress-induced anxiety: the case of amygdalar miR-34. J Neurosci (2011) 1.47

Chitosan/siRNA nanoparticle-mediated TNF-alpha knockdown in peritoneal macrophages for anti-inflammatory treatment in a murine arthritis model. Mol Ther (2008) 1.47

Effects of fluorescent dyes, quenchers, and dangling ends on DNA duplex stability. Biochem Biophys Res Commun (2005) 1.44

Stable expression of shRNAs in human CD34+ progenitor cells can avoid induction of interferon responses to siRNAs in vitro. Nat Biotechnol (2006) 1.44

A miR-19 regulon that controls NF-κB signaling. Nucleic Acids Res (2012) 1.43

Activated pp60c-Src leads to elevated hypoxia-inducible factor (HIF)-1alpha expression under normoxia. J Biol Chem (2002) 1.42

Beta cell transdifferentiation does not contribute to preneoplastic/metaplastic ductal lesions of the pancreas by genetic lineage tracing in vivo. Proc Natl Acad Sci U S A (2007) 1.39

Blood vessels restrain pancreas branching, differentiation and growth. Development (2011) 1.35

A potential role for RNA interference in controlling the activity of the human LINE-1 retrotransposon. Nucleic Acids Res (2005) 1.34

Gene silencing by synthetic U1 adaptors. Nat Biotechnol (2009) 1.29

Four-dimensional realistic modeling of pancreatic organogenesis. Proc Natl Acad Sci U S A (2008) 1.29

Hybridization of 2'-O-methyl and 2'-deoxy molecular beacons to RNA and DNA targets. Nucleic Acids Res (2002) 1.26

A role for the Dicer helicase domain in the processing of thermodynamically unstable hairpin RNAs. Nucleic Acids Res (2008) 1.25

TLR7 is involved in sequence-specific sensing of single-stranded RNAs in human macrophages. J Immunol (2008) 1.25

Advances in molecular and cellular therapies for hearing loss. Mol Ther (2007) 1.25

The promoter of the pri-miR-375 gene directs expression selectively to the endocrine pancreas. PLoS One (2009) 1.25

Spectroscopic features of dual fluorescence/luminescence resonance energy-transfer molecular beacons. Anal Chem (2003) 1.24

A direct comparison of anti-microRNA oligonucleotide potency. Pharm Res (2010) 1.22

miRNA-based mechanism for the commitment of multipotent progenitors to a single cellular fate. Proc Natl Acad Sci U S A (2010) 1.19

Glucose and aging control the quiescence period that follows pancreatic beta cell replication. Development (2010) 1.19

Systemic regulation of the age-related decline of pancreatic β-cell replication. Diabetes (2013) 1.19

MicroRNA regulation of the paired-box transcription factor Pax3 confers robustness to developmental timing of myogenesis. Proc Natl Acad Sci U S A (2011) 1.17

Chemical modification patterns compatible with high potency dicer-substrate small interfering RNAs. Oligonucleotides (2008) 1.17

Efficient cytosolic delivery of molecular beacon conjugates and flow cytometric analysis of target RNA. Nucleic Acids Res (2008) 1.16

The catalytic histidine dyad of high density lipoprotein-associated serum paraoxonase-1 (PON1) is essential for PON1-mediated inhibition of low density lipoprotein oxidation and stimulation of macrophage cholesterol efflux. J Biol Chem (2006) 1.15

Nucleotide bias observed with a short SELEX RNA aptamer library. Nucleic Acid Ther (2011) 1.15

MiRNA expression in psoriatic skin: reciprocal regulation of hsa-miR-99a and IGF-1R. PLoS One (2011) 1.15

Role of the ductal transcription factors HNF6 and Sox9 in pancreatic acinar-to-ductal metaplasia. Gut (2012) 1.14

Alternative RISC assembly: binding and repression of microRNA-mRNA duplexes by human Ago proteins. RNA (2012) 1.13

Active Src elevates the expression of beta-catenin by enhancement of cap-dependent translation. Mol Cell Biol (2005) 1.12

Avoiding false-positive signals with nuclease-vulnerable molecular beacons in single living cells. Nucleic Acids Res (2007) 1.12

The plastic pancreas. Dev Cell (2013) 1.12

A role for human Dicer in pre-RISC loading of siRNAs. Nucleic Acids Res (2010) 1.11

Ngn3(+) endocrine progenitor cells control the fate and morphogenesis of pancreatic ductal epithelium. Dev Biol (2011) 1.11

Glucose regulates cyclin D2 expression in quiescent and replicating pancreatic β-cells through glycolysis and calcium channels. Endocrinology (2011) 1.11

Improved Performance of Anti-miRNA Oligonucleotides Using a Novel Non-Nucleotide Modifier. Mol Ther Nucleic Acids (2013) 1.10

Design of active small interfering RNAs. Curr Opin Mol Ther (2007) 1.10

Pancreatic beta cells in very old mice retain capacity for compensatory proliferation. J Biol Chem (2012) 1.09

Growth-limiting role of endothelial cells in endoderm development. Dev Biol (2011) 1.08

Characterization of modified antisense oligonucleotides in Xenopus laevis embryos. Oligonucleotides (2006) 1.08

FGF-2 expands murine hematopoietic stem and progenitor cells via proliferation of stromal cells, c-Kit activation, and CXCL12 down-regulation. Blood (2012) 1.08

A microRNA network regulates expression and biosynthesis of wild-type and DeltaF508 mutant cystic fibrosis transmembrane conductance regulator. Proc Natl Acad Sci U S A (2012) 1.07

Right- and left-loop short shRNAs have distinct and unusual mechanisms of gene silencing. Nucleic Acids Res (2012) 1.07

An evolutionary perspective of animal microRNAs and their targets. J Biomed Biotechnol (2009) 1.06

Estimating cell depth from somatic mutations. PLoS Comput Biol (2008) 1.06

Determinants of cytokine induction by small interfering RNA in human peripheral blood mononuclear cells. J Interferon Cytokine Res (2008) 1.03

Phosphorylation of ribosomal protein S6 attenuates DNA damage and tumor suppression during development of pancreatic cancer. Cancer Res (2013) 1.02

Effects of chemical modification on the potency, serum stability, and immunostimulatory properties of short shRNAs. RNA (2009) 1.02

Dissecting the cellular origins of pancreatic cancer. Cell Cycle (2006) 1.02

Rational design of immunostimulatory siRNAs. Mol Ther (2010) 1.02

Vascular instruction of pancreas development. Development (2012) 1.01

Synthesis and characterization of mannosylated pegylated polyethylenimine as a carrier for siRNA. Int J Pharm (2011) 1.01