Published in Science on December 31, 2009
A map of human genome variation from population-scale sequencing. Nature (2010) 121.13
De novo assembly and genotyping of variants using colored de Bruijn graphs. Nat Genet (2012) 5.61
Fine-scale recombination rate differences between sexes, populations and individuals. Nature (2010) 4.74
Genome-wide single-cell analysis of recombination activity and de novo mutation rates in human sperm. Cell (2012) 3.52
PRDM9 variation strongly influences recombination hot-spot activity and meiotic instability in humans. Nat Genet (2010) 3.33
Phased whole-genome genetic risk in a family quartet using a major allele reference sequence. PLoS Genet (2011) 3.20
The landscape of recombination in African Americans. Nature (2011) 3.06
A fine-scale chimpanzee genetic map from population sequencing. Science (2012) 2.83
Genome-wide patterns of genetic variation in worldwide Arabidopsis thaliana accessions from the RegMap panel. Nat Genet (2012) 2.78
Mechanisms for recurrent and complex human genomic rearrangements. Curr Opin Genet Dev (2012) 2.67
Genome-wide analysis reveals novel molecular features of mouse recombination hotspots. Nature (2011) 2.61
Mammalian recombination hot spots: properties, control and evolution. Nat Rev Genet (2010) 2.54
Genetic recombination is directed away from functional genomic elements in mice. Nature (2012) 2.46
Genomic variation in natural populations of Drosophila melanogaster. Genetics (2012) 2.33
Fine-scale heterogeneity in crossover rate in the garnet-scalloped region of the Drosophila melanogaster X chromosome. Genetics (2013) 2.17
Meiotic recombination in mammals: localization and regulation. Nat Rev Genet (2013) 2.00
Variants of the protein PRDM9 differentially regulate a set of human meiotic recombination hotspots highly active in African populations. Proc Natl Acad Sci U S A (2011) 1.90
Health and population effects of rare gene knockouts in adult humans with related parents. Science (2016) 1.90
Sequence-specific regulator Prdm14 safeguards mouse ESCs from entering extraembryonic endoderm fates. Nat Struct Mol Biol (2010) 1.88
Recombination modulates how selection affects linked sites in Drosophila. PLoS Biol (2012) 1.77
Genome destabilization by homologous recombination in the germ line. Nat Rev Mol Cell Biol (2010) 1.76
Genome-wide association studies in mice. Nat Rev Genet (2012) 1.75
Mouse PRDM9 DNA-binding specificity determines sites of histone H3 lysine 4 trimethylation for initiation of meiotic recombination. PLoS Biol (2011) 1.73
Death of PRDM9 coincides with stabilization of the recombination landscape in the dog genome. Genome Res (2011) 1.62
Re-engineering the zinc fingers of PRDM9 reverses hybrid sterility in mice. Nature (2016) 1.58
Mouse tetrad analysis provides insights into recombination mechanisms and hotspot evolutionary dynamics. Nat Genet (2014) 1.57
Identification of uncommon recurrent Potocki-Lupski syndrome-associated duplications and the distribution of rearrangement types and mechanisms in PTLS. Am J Hum Genet (2010) 1.49
Coevolution of retroelements and tandem zinc finger genes. Genome Res (2011) 1.46
Recombination rate variation and speciation: theoretical predictions and empirical results from rabbits and mice. Philos Trans R Soc Lond B Biol Sci (2012) 1.44
Frequency of nonallelic homologous recombination is correlated with length of homology: evidence that ectopic synapsis precedes ectopic crossing-over. Am J Hum Genet (2011) 1.43
Variation in human recombination rates and its genetic determinants. PLoS One (2011) 1.39
The common marmoset genome provides insight into primate biology and evolution. Nat Genet (2014) 1.38
Rapid sequence and expression divergence suggest selection for novel function in primate-specific KRAB-ZNF genes. Mol Biol Evol (2010) 1.38
RNF212 is a dosage-sensitive regulator of crossing-over during mammalian meiosis. Nat Genet (2013) 1.38
Observation and prediction of recurrent human translocations mediated by NAHR between nonhomologous chromosomes. Genome Res (2011) 1.37
Ongoing GC-biased evolution is widespread in the human genome and enriched near recombination hot spots. Genome Biol Evol (2011) 1.36
Stable recombination hotspots in birds. Science (2015) 1.36
Genetic recombination is targeted towards gene promoter regions in dogs. PLoS Genet (2013) 1.35
Genomic hypomethylation in the human germline associates with selective structural mutability in the human genome. PLoS Genet (2012) 1.35
Arabidopsis meiotic crossover hot spots overlap with H2A.Z nucleosomes at gene promoters. Nat Genet (2013) 1.29
De novo prediction of DNA-binding specificities for Cys2His2 zinc finger proteins. Nucleic Acids Res (2013) 1.28
Genome-wide fine-scale recombination rate variation in Drosophila melanogaster. PLoS Genet (2012) 1.28
High recombination rates and hotspots in a Plasmodium falciparum genetic cross. Genome Biol (2011) 1.27
Copy number gain at Xp22.31 includes complex duplication rearrangements and recurrent triplications. Hum Mol Genet (2011) 1.25
Nonparadoxical evolutionary stability of the recombination initiation landscape in yeast. Science (2015) 1.22
Recombination is associated with the evolution of genome structure and worker behavior in honey bees. Proc Natl Acad Sci U S A (2012) 1.22
Genome rearrangements and pervasive meiotic drive cause hybrid infertility in fission yeast. Elife (2014) 1.19
The impressionistic landscape of meiotic recombination. Cell (2011) 1.18
Meiosis: making a break for it. Curr Opin Cell Biol (2010) 1.16
Genetic variants in REC8, RNF212, and PRDM9 influence male recombination in cattle. PLoS Genet (2012) 1.16
Recombination rate variation in closely related species. Heredity (Edinb) (2011) 1.16
The case of the fickle fingers: how the PRDM9 zinc finger protein specifies meiotic recombination hotspots in humans. PLoS Biol (2011) 1.15
Genetic and evolutionary correlates of fine-scale recombination rate variation in Drosophila persimilis. J Mol Evol (2010) 1.15
Prdm9, a major determinant of meiotic recombination hotspots, is not functional in dogs and their wild relatives, wolves and coyotes. PLoS One (2011) 1.14
Mechanism and regulation of meiotic recombination initiation. Cold Spring Harb Perspect Biol (2014) 1.13
xnd-1 regulates the global recombination landscape in Caenorhabditis elegans. Nature (2010) 1.12
PRDM9 binding organizes hotspot nucleosomes and limits Holliday junction migration. Genome Res (2014) 1.12
Genetic analysis of genome-scale recombination rate evolution in house mice. PLoS Genet (2011) 1.12
Epigenetic remodeling of meiotic crossover frequency in Arabidopsis thaliana DNA methyltransferase mutants. PLoS Genet (2012) 1.11
A high-density linkage map enables a second-generation collared flycatcher genome assembly and reveals the patterns of avian recombination rate variation and chromosomal evolution. Mol Ecol (2014) 1.11
Self-organization of meiotic recombination initiation: general principles and molecular pathways. Annu Rev Genet (2014) 1.10
Rare allelic forms of PRDM9 associated with childhood leukemogenesis. Genome Res (2012) 1.09
Extensive recombination rate variation in the house mouse species complex inferred from genetic linkage maps. Genome Res (2010) 1.09
Gain, loss and divergence in primate zinc-finger genes: a rich resource for evolution of gene regulatory differences between species. PLoS One (2011) 1.08
Discrete DNA sites regulate global distribution of meiotic recombination. Trends Genet (2010) 1.08
DNA binding specificities of the long zinc-finger recombination protein PRDM9. Genome Biol (2013) 1.08
Human-specific histone methylation signatures at transcription start sites in prefrontal neurons. PLoS Biol (2012) 1.08
Histone H3 lysine 4 methyltransferases and demethylases in self-renewal and differentiation of stem cells. Cell Biosci (2013) 1.07
Novel origins of copy number variation in the dog genome. Genome Biol (2012) 1.06
SPR-5 is a histone H3K4 demethylase with a role in meiotic double-strand break repair. Proc Natl Acad Sci U S A (2011) 1.03
Scale matters: the spatial correlation of yeast meiotic DNA breaks with histone H3 trimethylation is driven largely by independent colocalization at promoters. Cell Cycle (2012) 1.02
PRDM9 drives evolutionary erosion of hotspots in Mus musculus through haplotype-specific initiation of meiotic recombination. PLoS Genet (2015) 1.02
Recombination regulator PRDM9 influences the instability of its own coding sequence in humans. Proc Natl Acad Sci U S A (2012) 1.02
An improved predictive recognition model for Cys(2)-His(2) zinc finger proteins. Nucleic Acids Res (2014) 1.02
Cattle Sex-Specific Recombination and Genetic Control from a Large Pedigree Analysis. PLoS Genet (2015) 1.02
A Whole-Chromosome Analysis of Meiotic Recombination in Drosophila melanogaster. G3 (Bethesda) (2012) 1.01
Genetics. Genetic control of hotspots. Science (2010) 1.01
Genomic tools for evolution and conservation in the chimpanzee: Pan troglodytes ellioti is a genetically distinct population. PLoS Genet (2012) 1.00
Crossovers are associated with mutation and biased gene conversion at recombination hotspots. Proc Natl Acad Sci U S A (2015) 1.00
Histone chaperone Spt6 is required for class switch recombination but not somatic hypermutation. Proc Natl Acad Sci U S A (2011) 0.99
PRDM9 marks the spot. Nat Genet (2010) 0.98
High diversity at PRDM9 in chimpanzees and bonobos. PLoS One (2012) 0.98
High-resolution sex-specific linkage maps of the mouse reveal polarized distribution of crossovers in male germline. Genetics (2014) 0.97
Acetylated Histone H3K9 is associated with meiotic recombination hotspots, and plays a role in recombination redundantly with other factors including the H3K4 methylase Set1 in fission yeast. Nucleic Acids Res (2013) 0.96
Patterns of recombination activity on mouse chromosome 11 revealed by high resolution mapping. PLoS One (2010) 0.96
Transmission distortion affecting human noncrossover but not crossover recombination: a hidden source of meiotic drive. PLoS Genet (2014) 0.96
Diversity of Prdm9 zinc finger array in wild mice unravels new facets of the evolutionary turnover of this coding minisatellite. PLoS One (2014) 0.95
Contrasting methods of quantifying fine structure of human recombination. Annu Rev Genomics Hum Genet (2010) 0.95
The (r)evolution of SINE versus LINE distributions in primate genomes: sex chromosomes are important. Genome Res (2010) 0.95
GC-biased gene conversion in yeast is specifically associated with crossovers: molecular mechanisms and evolutionary significance. Mol Biol Evol (2013) 0.95
PRDM9 points the zinc finger at meiotic recombination hotspots. Genome Biol (2010) 0.94
Important characteristics of sequence-specific recombination hotspots in Schizosaccharomyces pombe. Genetics (2010) 0.94
Primate evolution of the recombination regulator PRDM9. Nat Commun (2014) 0.94
Prdm9 polymorphism unveils mouse evolutionary tracks. DNA Res (2014) 0.93
Fine characterisation of a recombination hotspot at the DPY19L2 locus and resolution of the paradoxical excess of duplications over deletions in the general population. PLoS Genet (2013) 0.92
The Drosophila zinc finger protein trade embargo is required for double strand break formation in meiosis. PLoS Genet (2011) 0.92
Detecting sequence polymorphisms associated with meiotic recombination hotspots in the human genome. Genome Biol (2010) 0.92
Scrambling eggs: meiotic drive and the evolution of female recombination rates. Genetics (2011) 0.92
A systematic survey of the Cys2His2 zinc finger DNA-binding landscape. Nucleic Acids Res (2015) 0.92
Recombination rates and genomic shuffling in human and chimpanzee--a new twist in the chromosomal speciation theory. Mol Biol Evol (2012) 0.91
The fine-scale structure of recombination rate variation in the human genome. Science (2004) 17.05
Evolutionary and biomedical insights from the rhesus macaque genome. Science (2007) 16.21
A common sequence motif associated with recombination hot spots and genome instability in humans. Nat Genet (2008) 8.64
Comparison of fine-scale recombination rates in humans and chimpanzees. Science (2005) 7.86
An initiation site for meiotic gene conversion in the yeast Saccharomyces cerevisiae. Nature (1989) 5.99
Global mapping of meiotic recombination hotspots and coldspots in the yeast Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (2000) 5.57
A mouse speciation gene encodes a meiotic histone H3 methyltransferase. Science (2008) 5.35
Rapid evolution of male reproductive genes in the descent of man. Nature (2000) 5.33
Fine-scale recombination patterns differ between chimpanzees and humans. Nat Genet (2005) 5.00
A histone H3 methyltransferase controls epigenetic events required for meiotic prophase. Nature (2005) 4.70
Reciprocal crossover asymmetry and meiotic drive in a human recombination hot spot. Nat Genet (2002) 4.07
Accelerated evolution of the Prdm9 speciation gene across diverse metazoan taxa. PLoS Genet (2009) 3.60
Distinct histone modifications define initiation and repair of meiotic recombination in the mouse. EMBO J (2009) 3.47
Histone H3 lysine 4 trimethylation marks meiotic recombination initiation sites. EMBO J (2008) 3.40
Condensins regulate meiotic DNA break distribution, thus crossover frequency, by controlling chromosome structure. Cell (2009) 3.07
The recombinational anatomy of a mouse chromosome. PLoS Genet (2008) 2.66
Trans-regulation of mouse meiotic recombination hotspots by Rcr1. PLoS Biol (2009) 2.66
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Genome-wide control of the distribution of meiotic recombination. PLoS Biol (2009) 2.31
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Live hot, die young: transmission distortion in recombination hotspots. PLoS Genet (2007) 1.80
Predicting DNA recognition by Cys2His2 zinc finger proteins. Bioinformatics (2008) 1.74
Sperm cross-over activity in regions of the human genome showing extreme breakdown of marker association. Proc Natl Acad Sci U S A (2008) 1.70
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Segregation distortion of mouse t haplotypes the molecular basis emerges. Trends Genet (2000) 1.29
A second generation human haplotype map of over 3.1 million SNPs. Nature (2007) 85.39
A new multipoint method for genome-wide association studies by imputation of genotypes. Nat Genet (2007) 52.68
Integrating common and rare genetic variation in diverse human populations. Nature (2010) 32.30
A flexible and accurate genotype imputation method for the next generation of genome-wide association studies. PLoS Genet (2009) 30.09
A fine-scale map of recombination rates and hotspots across the human genome. Science (2005) 26.82
A comparison of bayesian methods for haplotype reconstruction from population genotype data. Am J Hum Genet (2003) 26.59
Genome-wide detection and characterization of positive selection in human populations. Nature (2007) 17.27
The fine-scale structure of recombination rate variation in the human genome. Science (2004) 17.05
Replicating genotype-phenotype associations. Nature (2007) 16.11
A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHC. Nat Genet (2006) 15.63
The effects of human population structure on large genetic association studies. Nat Genet (2004) 14.88
Genome-wide strategies for detecting multiple loci that influence complex diseases. Nat Genet (2005) 14.88
New models of collaboration in genome-wide association studies: the Genetic Association Information Network. Nat Genet (2007) 13.76
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature (2011) 13.23
Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nat Genet (2007) 12.62
Mapping copy number variation by population-scale genome sequencing. Nature (2011) 12.55
A comparison of phasing algorithms for trios and unrelated individuals. Am J Hum Genet (2006) 12.45
Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. Nature (2010) 12.27
Transcriptome and genome sequencing uncovers functional variation in humans. Nature (2013) 8.89
A common sequence motif associated with recombination hot spots and genome instability in humans. Nat Genet (2008) 8.64
A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1. Nat Genet (2010) 8.48
Intra- and interspecific variation in primate gene expression patterns. Science (2002) 7.92
Comparison of fine-scale recombination rates in humans and chimpanzees. Science (2005) 7.86
Genome-wide association analysis identifies 13 new risk loci for schizophrenia. Nat Genet (2013) 7.44
Whole-genome sequencing to delineate Mycobacterium tuberculosis outbreaks: a retrospective observational study. Lancet Infect Dis (2012) 7.18
Designing genome-wide association studies: sample size, power, imputation, and the choice of genotyping chip. PLoS Genet (2009) 6.61
Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas. Nat Genet (2012) 6.25
De novo assembly and genotyping of variants using colored de Bruijn graphs. Nat Genet (2012) 5.61
Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility. Nat Genet (2011) 5.56
Differential confounding of rare and common variants in spatially structured populations. Nat Genet (2012) 5.28
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A statistical method for predicting classical HLA alleles from SNP data. Am J Hum Genet (2008) 4.65
Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis. Nat Genet (2013) 4.62
Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region. Nat Genet (2009) 4.61
Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes. Nat Genet (2010) 4.42
Genome-wide and fine-resolution association analysis of malaria in West Africa. Nat Genet (2009) 4.30
Multilocus sequence typing of Clostridium difficile. J Clin Microbiol (2009) 4.16
The influence of recombination on human genetic diversity. PLoS Genet (2006) 4.04
A pilot study of rapid benchtop sequencing of Staphylococcus aureus and Clostridium difficile for outbreak detection and surveillance. BMJ Open (2012) 3.93
Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke. Nat Genet (2012) 3.40
Dissection of the genetics of Parkinson's disease identifies an additional association 5' of SNCA and multiple associated haplotypes at 17q21. Hum Mol Genet (2010) 3.34
Human recombination hot spots hidden in regions of strong marker association. Nat Genet (2005) 3.33
Bayesian refinement of association signals for 14 loci in 3 common diseases. Nat Genet (2012) 3.31
Evolutionary dynamics of Staphylococcus aureus during progression from carriage to disease. Proc Natl Acad Sci U S A (2012) 3.29
Human genome sequence variation and the influence of gene history, mutation and recombination. Nat Genet (2002) 3.24
Whole-genome sequencing shows that patient-to-patient transmission rarely accounts for acquisition of Staphylococcus aureus in an intensive care unit. Clin Infect Dis (2013) 3.05
Great ape genetic diversity and population history. Nature (2013) 2.95
Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci. Nat Genet (2013) 2.87
A fine-scale chimpanzee genetic map from population sequencing. Science (2012) 2.83
Mosaic PPM1D mutations are associated with predisposition to breast and ovarian cancer. Nature (2012) 2.66
HAPGEN2: simulation of multiple disease SNPs. Bioinformatics (2011) 2.58
Unparalleled complexity of the MHC class I region in rhesus macaques. Proc Natl Acad Sci U S A (2005) 2.41
Multiple instances of ancient balancing selection shared between humans and chimpanzees. Science (2013) 2.32
HLA*IMP--an integrated framework for imputing classical HLA alleles from SNP genotypes. Bioinformatics (2011) 2.21
Microevolutionary analysis of Clostridium difficile genomes to investigate transmission. Genome Biol (2012) 2.04
Genome-wide association mapping in bacteria? Trends Microbiol (2006) 1.93
The origin, evolution, and functional impact of short insertion-deletion variants identified in 179 human genomes. Genome Res (2013) 1.83
Recombination rate estimation in the presence of hotspots. Genome Res (2007) 1.83
A genome-wide metabolic QTL analysis in Europeans implicates two loci shaped by recent positive selection. PLoS Genet (2011) 1.83
Microsatellite typing of the rhesus macaque MHC region. Immunogenetics (2005) 1.69
Within-host evolution of Staphylococcus aureus during asymptomatic carriage. PLoS One (2013) 1.67
Is mate choice in humans MHC-dependent? PLoS Genet (2008) 1.66
Including known covariates can reduce power to detect genetic effects in case-control studies. Nat Genet (2012) 1.66
MHC class I A region diversity and polymorphism in macaque species. Immunogenetics (2007) 1.63
Recombination and population structure in Salmonella enterica. PLoS Genet (2011) 1.61
Human metabolic profiles are stably controlled by genetic and environmental variation. Mol Syst Biol (2011) 1.60
Application of coalescent methods to reveal fine-scale rate variation and recombination hotspots. Genetics (2004) 1.59
People of the British Isles: preliminary analysis of genotypes and surnames in a UK-control population. Eur J Hum Genet (2011) 1.58
Gang membership, violence, and psychiatric morbidity. Am J Psychiatry (2013) 1.54