Published in Expert Opin Drug Discov on August 01, 2010
High content evaluation of shear dependent platelet function in a microfluidic flow assay. Ann Biomed Eng (2012) 1.00
High Content Imaging (HCI) on Miniaturized Three-Dimensional (3D) Cell Cultures. Biosensors (Basel) (2015) 0.77
Monolithic microfabricated valves and pumps by multilayer soft lithography. Science (2000) 14.37
Soft lithography in biology and biochemistry. Annu Rev Biomed Eng (2001) 11.36
Cells on chips. Nature (2006) 8.40
Physics and applications of microfluidics in biology. Annu Rev Biomed Eng (2002) 5.90
High throughput gene expression measurement with real time PCR in a microfluidic dynamic array. PLoS One (2008) 3.34
Droplet-based microfluidic platforms for the encapsulation and screening of Mammalian cells and multicellular organisms. Chem Biol (2008) 3.00
Microfluidic platforms for lab-on-a-chip applications. Lab Chip (2007) 2.56
Cellular imaging in drug discovery. Nat Rev Drug Discov (2006) 2.52
Comment on "Oscillations in NF-kappaB signaling control the dynamics of gene expression". Science (2005) 1.79
Static microdroplet arrays: a microfluidic device for droplet trapping, incubation and release for enzymatic and cell-based assays. Lab Chip (2008) 1.59
High-throughput microfluidics: improved sample treatment and washing over standard wells. Lab Chip (2007) 1.40
High content cell screening in a microfluidic device. Mol Cell Proteomics (2008) 1.29
Microfluidic cartridges preloaded with nanoliter plugs of reagents: an alternative to 96-well plates for screening. Curr Opin Chem Biol (2006) 1.28
Cell-based high-content screening of small-molecule libraries. Curr Opin Chem Biol (2007) 1.27
Comparison of on-chip and off-chip microfluidic kinase assay formats. Assay Drug Dev Technol (2004) 1.22
Challenges and solutions to ultra-high-throughput screening assay miniaturization: submicroliter fluid handling. Drug Discov Today (2000) 1.14
High-content screening moves to the front of the line. Drug Discov Today (2006) 1.05
Biochemical analysis with microfluidic systems. Anal Bioanal Chem (2003) 0.99
Fully integrated microfluidic separations systems for biochemical analysis. J Chromatogr A (2007) 0.94
High-content analysis in preclinical drug discovery. Comb Chem High Throughput Screen (2008) 0.91
Using a microfluidic device for high-content analysis of cell signaling. Sci Signal (2009) 0.88
Multiplexed enzyme assays in capillary electrophoretic single-use microfluidic devices. Electrophoresis (2001) 0.84
High-content screening for the discovery of pharmacological compounds: advantages, challenges and potential benefits of recent technological developments. Expert Opin Drug Discov (2010) 0.78
The IkappaB-NF-kappaB signaling module: temporal control and selective gene activation. Science (2002) 13.86
MAPK-mediated bimodal gene expression and adaptive gradient sensing in yeast. Nature (2007) 3.23
Information transduction capacity of noisy biochemical signaling networks. Science (2011) 2.95
A microfluidic chemostat for experiments with bacterial and yeast cells. Nat Methods (2005) 2.91
Dynamic properties of network motifs contribute to biological network organization. PLoS Biol (2005) 2.58
Nanoscale cues regulate the structure and function of macroscopic cardiac tissue constructs. Proc Natl Acad Sci U S A (2009) 2.25
Matrix nanotopography as a regulator of cell function. J Cell Biol (2012) 2.20
A homeostatic model of IkappaB metabolism to control constitutive NF-kappaB activity. Mol Syst Biol (2007) 2.13
Transient IkappaB kinase activity mediates temporal NF-kappaB dynamics in response to a wide range of tumor necrosis factor-alpha doses. J Biol Chem (2005) 2.08
Microengineered platforms for cell mechanobiology. Annu Rev Biomed Eng (2009) 2.02
Comment on "Oscillations in NF-kappaB signaling control the dynamics of gene expression". Science (2005) 1.79
Understanding NF-kappaB signaling via mathematical modeling. Mol Syst Biol (2008) 1.79
Hypoxia-inducible factor-dependent breast cancer-mesenchymal stem cell bidirectional signaling promotes metastasis. J Clin Invest (2012) 1.71
Modeling the cell's guidance system. Sci STKE (2002) 1.68
Mechanosensitivity of fibroblast cell shape and movement to anisotropic substratum topography gradients. Biomaterials (2009) 1.53
Cellerator: extending a computer algebra system to include biochemical arrows for signal transduction simulations. Bioinformatics (2003) 1.53
Self-organization in high-density bacterial colonies: efficient crowd control. PLoS Biol (2007) 1.52
Use of MR cell tracking to evaluate targeting of glial precursor cells to inflammatory tissue by exploiting the very late antigen-4 docking receptor. Radiology (2012) 1.51
Chaperone-mediated autophagy targets hypoxia-inducible factor-1α (HIF-1α) for lysosomal degradation. J Biol Chem (2013) 1.48
A microfluidics-based turning assay reveals complex growth cone responses to integrated gradients of substrate-bound ECM molecules and diffusible guidance cues. Lab Chip (2008) 1.46
GSK-3 kinases enhance calcineurin signaling by phosphorylation of RCNs. Genes Dev (2003) 1.46
Synergistic effect of HIF-1alpha gene therapy and HIF-1-activated bone marrow-derived angiogenic cells in a mouse model of limb ischemia. Proc Natl Acad Sci U S A (2009) 1.43
Human cerebrospinal fluid regulates proliferation and migration of stem cells through insulin-like growth factor-1. Stem Cells Dev (2015) 1.42
Diverse sensitivity thresholds in dynamic signaling responses by social amoebae. Sci Signal (2012) 1.41
Guided Cell Migration on Microtextured Substrates with Variable Local Density and Anisotropy. Adv Funct Mater (2009) 1.39
Signaling diversity of PKA achieved via a Ca2+-cAMP-PKA oscillatory circuit. Nat Chem Biol (2010) 1.35
A 3D Monte Carlo analysis of the role of dyadic space geometry in spark generation. Biophys J (2005) 1.34
Multiple signaling pathways regulate yeast cell death during the response to mating pheromones. Mol Biol Cell (2006) 1.29
High content cell screening in a microfluidic device. Mol Cell Proteomics (2008) 1.29
Regulation of brain tumor dispersal by NKCC1 through a novel role in focal adhesion regulation. PLoS Biol (2012) 1.29
Oscillatory phosphorylation of yeast Fus3 MAP kinase controls periodic gene expression and morphogenesis. Curr Biol (2008) 1.27
Negative autoregulation by FAS mediates robust fetal erythropoiesis. PLoS Biol (2007) 1.25
Fine temporal control of the medium gas content and acidity and on-chip generation of series of oxygen concentrations for cell cultures. Lab Chip (2009) 1.25
Engineering neuronal growth cones to promote axon regeneration over inhibitory molecules. Proc Natl Acad Sci U S A (2011) 1.24
Visualization of JNK activity dynamics with a genetically encoded fluorescent biosensor. Proc Natl Acad Sci U S A (2010) 1.20
Lab-on-a-chip devices as an emerging platform for stem cell biology. Lab Chip (2010) 1.20
Synergistically enhanced osteogenic differentiation of human mesenchymal stem cells by culture on nanostructured surfaces with induction media. Biomacromolecules (2010) 1.18
Subcellular-resolution delivery of a cytokine through precisely manipulated nanowires. Nat Nanotechnol (2010) 1.18
A nontranscriptional role for HIF-1α as a direct inhibitor of DNA replication. Sci Signal (2013) 1.17
Cell motility of neural stem cells is reduced after SPIO-labeling, which is mitigated after exocytosis. Magn Reson Med (2012) 1.16
Enhanced sensitivity to IGF-II signaling links loss of imprinting of IGF2 to increased cell proliferation and tumor risk. Proc Natl Acad Sci U S A (2007) 1.15
Synthetic spatially graded Rac activation drives cell polarization and movement. Proc Natl Acad Sci U S A (2012) 1.14
Robust and sensitive control of a quorum-sensing circuit by two interlocked feedback loops. Mol Syst Biol (2008) 1.14
The systems biology of glycosylation. Chembiochem (2004) 1.09
Nanopatterned cardiac cell patches promote stem cell niche formation and myocardial regeneration. Integr Biol (Camb) (2012) 1.08
Matrix rigidity controls endothelial differentiation and morphogenesis of cardiac precursors. Sci Signal (2012) 1.08
Systems biology. How information theory handles cell signaling and uncertainty. Science (2012) 1.08
Biomimetic nanopatterns as enabling tools for analysis and control of live cells. Adv Mater (2010) 1.07
Control of stem cell fate and function by engineering physical microenvironments. Integr Biol (Camb) (2012) 1.04
Modelling cell polarization driven by synthetic spatially graded Rac activation. PLoS Comput Biol (2012) 1.03
Analysis of pairwise cell interactions using an integrated dielectrophoretic-microfluidic system. Mol Syst Biol (2008) 0.98
Micro- and nanoengineering for stem cell biology: the promise with a caution. Trends Biotechnol (2011) 0.97
Marginal zone B cells regulate antigen-specific T cell responses during infection. J Immunol (2012) 0.94
Mesenchymal stem cells from human fat engineered to secrete BMP4 are nononcogenic, suppress brain cancer, and prolong survival. Clin Cancer Res (2014) 0.93
Oscillatory signaling processes: the how, the why and the where. Curr Opin Genet Dev (2010) 0.92
A cell-based model for quorum sensing in heterogeneous bacterial colonies. PLoS Comput Biol (2010) 0.92
Physical transfer of membrane and cytoplasmic components as a general mechanism of cell-cell communication. J Cell Sci (2009) 0.91
The application of information theory to biochemical signaling systems. Phys Biol (2012) 0.90
Using a microfluidic device for high-content analysis of cell signaling. Sci Signal (2009) 0.88
Computational model and microfluidic platform for the investigation of paracrine and autocrine signaling in mouse embryonic stem cells. Mol Biosyst (2009) 0.88
Scp160-dependent mRNA trafficking mediates pheromone gradient sensing and chemotropism in yeast. Cell Rep (2012) 0.87
A new link between epigenetic progenitor lesions in cancer and the dynamics of signal transduction. Cell Cycle (2009) 0.87
Superimposed topographic and chemical cues synergistically guide neurite outgrowth. Lab Chip (2013) 0.86
Integration of genotypic and phenotypic screening reveals molecular mediators of melanoma-stromal interaction. Cancer Res (2011) 0.84
Quantitative analysis of the combined effect of substrate rigidity and topographic guidance on cell morphology. IEEE Trans Nanobioscience (2011) 0.84
Wires in the soup: quantitative models of cell signaling. Trends Cell Biol (2008) 0.83
Pulsing cells: how fast is too fast? HFSP J (2008) 0.83
An integrated micro-electro-fluidic and protein arraying system for parallel analysis of cell responses to controlled microenvironments. Integr Biol (Camb) (2010) 0.83
Simple haptotactic gradient generation within a triangular microfluidic channel. Lab Chip (2010) 0.82
Models at the single cell level. Wiley Interdiscip Rev Syst Biol Med (2010) 0.81
Adaptive molecular networks controlling chemotactic migration: dynamic inputs and selection of the network architecture. Philos Trans R Soc Lond B Biol Sci (2013) 0.80
Microfluidic technologies for studying synthetic circuits. Curr Opin Chem Biol (2012) 0.80
Proteomics takes stem cell analyses to another level. Nat Biotechnol (2005) 0.80
A method for probabilistic mapping between protein structure and function taxonomies through cross training. BMC Struct Biol (2008) 0.79
Concise review: Mechanotransduction via p190RhoGAP regulates a switch between cardiomyogenic and endothelial lineages in adult cardiac progenitors. Stem Cells (2014) 0.79
Microfluidics technology for systems biology research. Methods Mol Biol (2009) 0.79
Notch signaling mediates melanoma-endothelial cell communication and melanoma cell migration. Pigment Cell Melanoma Res (2013) 0.78
Control of the interface between heterotypic cell populations reveals the mechanism of intercellular transfer of signaling proteins. Integr Biol (Camb) (2015) 0.77
217 YAP Is Ready to Rac and Rho: Elucidation of a Novel YAP-Driven Network That Potentiates Brain Cancer Cell Dispersal and Confers Poor Survival in Patients. Neurosurgery (2016) 0.77
Principles of model building: an experimentation-aided approach to development of models for signaling networks. Methods Cell Biol (2012) 0.76
A scalable and integrative system for pathway bioinformatics and systems biology. Adv Exp Med Biol (2010) 0.75
Modeling intercellular transfer of biomolecules through tunneling nanotubes. Bull Math Biol (2013) 0.75
Role of spatial averaging in multicellular gradient sensing. Phys Biol (2016) 0.75
Stem cell differentiation as a renewal-reward process: predictions and validation in the colonic crypt. Adv Exp Med Biol (2012) 0.75