Published in Nucleic Acids Res on November 18, 2011
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Prediction of therapeutic microRNA based on the human metabolic network. Bioinformatics (2014) 0.76
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Profiling essential genes in human mammary cells by multiplex RNAi screening. Science (2008) 4.51
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High-throughput mapping of a dynamic signaling network in mammalian cells. Science (2005) 5.21
Scoring diverse cellular morphologies in image-based screens with iterative feedback and machine learning. Proc Natl Acad Sci U S A (2009) 5.15
Exploring the mode-of-action of bioactive compounds by chemical-genetic profiling in yeast. Cell (2006) 4.03
Large-scale essential gene identification in Candida albicans and applications to antifungal drug discovery. Mol Microbiol (2003) 2.84
Inhibition of mitochondrial translation as a therapeutic strategy for human acute myeloid leukemia. Cancer Cell (2011) 2.68
MBNL proteins repress ES-cell-specific alternative splicing and reprogramming. Nature (2013) 2.49
Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol (2012) 2.40
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Developmentally programmed nuclear destruction during yeast gametogenesis. Dev Cell (2012) 1.69
Regulation of epidermal growth factor receptor trafficking by lysine deacetylase HDAC6. Sci Signal (2009) 1.54
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A lentiviral functional proteomics approach identifies chromatin remodeling complexes important for the induction of pluripotency. Mol Cell Proteomics (2010) 1.41
A role for the TGFbeta-Par6 polarity pathway in breast cancer progression. Proc Natl Acad Sci U S A (2009) 1.29
Regulation of CD133 by HDAC6 promotes β-catenin signaling to suppress cancer cell differentiation. Cell Rep (2012) 1.24
The ubiquitin-activating enzyme E1 as a therapeutic target for the treatment of leukemia and multiple myeloma. Blood (2010) 1.24
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A comprehensive platform for highly multiplexed mammalian functional genetic screens. BMC Genomics (2011) 1.12
SATB2 augments ΔNp63α in head and neck squamous cell carcinoma. EMBO Rep (2010) 1.11
CD133 protein N-glycosylation processing contributes to cell surface recognition of the primitive cell marker AC133 epitope. J Biol Chem (2011) 1.08
A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. Mol Syst Biol (2013) 1.03
Selective inhibition of histone deacetylases sensitizes malignant cells to death receptor ligands. Mol Cancer Ther (2010) 1.03
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Control of the RNA polymerase II phosphorylation state in promoter regions by CTD interaction domain-containing proteins RPRD1A and RPRD1B. Transcription (2012) 0.99
Selective targeting of neuroblastoma tumour-initiating cells by compounds identified in stem cell-based small molecule screens. EMBO Mol Med (2010) 0.98
shRNA kinome screen identifies TBK1 as a therapeutic target for HER2+ breast cancer. Cancer Res (2014) 0.98
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System-level analysis of neuroblastoma tumor-initiating cells implicates AURKB as a novel drug target for neuroblastoma. Clin Cancer Res (2010) 0.97
The global transcriptional activator of Saccharomyces cerevisiae, Gcr1p, mediates the response to glucose by stimulating protein synthesis and CLN-dependent cell cycle progression. Genetics (2003) 0.93
The mixed lineage leukemia (MLL) fusion-associated gene AF4 promotes CD133 transcription. Cancer Res (2012) 0.90
SnapShot: High-throughput sequencing applications. Cell (2011) 0.87
Analysis of early C2C12 myogenesis identifies stably and differentially expressed transcriptional regulators whose knock-down inhibits myoblast differentiation. Physiol Genomics (2011) 0.86
Inhibition of SREBP1 sensitizes cells to death ligands. Oncotarget (2011) 0.86
Pooled lentiviral shRNA screening for functional genomics in mammalian cells. Methods Mol Biol (2011) 0.82
Integrated genomic, transcriptomic, and RNA-interference analysis of genes in somatic copy number gains in pancreatic ductal adenocarcinoma. Pancreas (2013) 0.81
Scaling up the systematic hunt for mammalian genetic interactions. Nat Methods (2013) 0.81
A genome wide shRNA screen identifies α/β hydrolase domain containing 4 (ABHD4) as a novel regulator of anoikis resistance. Apoptosis (2012) 0.81
Suppression of cancer progression by MGAT1 shRNA knockdown. PLoS One (2012) 0.81
Targeting HER2+ breast cancer cells: lysosomal accumulation of anti-HER2 antibodies is influenced by antibody binding site and conjugation to polymeric nanoparticles. J Control Release (2013) 0.79
Resveratrol has anti-leukemic activity associated with decreased O-GlcNAcylated proteins. Exp Hematol (2013) 0.78
Miniature short hairpin RNA screens to characterize antiproliferative drugs. G3 (Bethesda) (2013) 0.77
Menin links the stress response to genome stability in Drosophila melanogaster. PLoS One (2010) 0.77
Differential regulation of FGFR3 by PTPN1 and PTPN2. Proteomics (2014) 0.76
A phosphoproteomics approach to identify candidate kinase inhibitor pathway targets in lymphoma-like primary cell lines. Curr Drug Discov Technol (2013) 0.75
A biochemical genomics screen for substrates of Ste20p kinase enables the in silico prediction of novel substrates. PLoS One (2009) 0.75
A versatile lentiviral expression system to identify mammalian protein-protein interactions. Methods (2012) 0.75
RNA interference screens to uncover membrane protein biology. Brief Funct Genomics (2013) 0.75
Corrigendum: Genome-wide CRISPR screens reveal a Wnt-FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors. Nat Med (2017) 0.75
Early-stage comparative effectiveness: randomized controlled trial with histamine inverse agonist MK-7288 in excessive daytime sleepiness patients. J Clin Pharmacol (2013) 0.75