Published in Chemistry on November 30, 2011
Click nucleic acid ligation: applications in biology and nanotechnology. Acc Chem Res (2012) 0.92
Transcription of click-linked DNA in human cells. Angew Chem Int Ed Engl (2014) 0.90
Assessing the biocompatibility of click-linked DNA in Escherichia coli. Nucleic Acids Res (2012) 0.89
ClickSeq: Fragmentation-Free Next-Generation Sequencing via Click Ligation of Adaptors to Stochastically Terminated 3'-Azido cDNAs. J Mol Biol (2015) 0.77
Synthesis of triazole-linked morpholino oligonucleotides via Cu(I) catalysed cycloaddition. Org Biomol Chem (2016) 0.75
Recognition dynamics up to microseconds revealed from an RDC-derived ubiquitin ensemble in solution. Science (2008) 8.04
IL-22 is required for Th17 cell-mediated pathology in a mouse model of psoriasis-like skin inflammation. J Clin Invest (2008) 4.12
Release of long-range tertiary interactions potentiates aggregation of natively unstructured alpha-synuclein. Proc Natl Acad Sci U S A (2005) 3.48
Structure of the human voltage-dependent anion channel. Proc Natl Acad Sci U S A (2008) 2.69
Click chemistry with DNA. Chem Soc Rev (2010) 2.10
Pre-fibrillar alpha-synuclein variants with impaired beta-structure increase neurotoxicity in Parkinson's disease models. EMBO J (2009) 2.09
Atomic model of the type III secretion system needle. Nature (2012) 2.02
Single-ascending-dose pharmacokinetics and safety of the novel broad-spectrum antifungal triazole BAL4815 after intravenous infusions (50, 100, and 200 milligrams) and oral administrations (100, 200, and 400 milligrams) of its prodrug, BAL8557, in healthy volunteers. Antimicrob Agents Chemother (2006) 2.00
Defining long-range order and local disorder in native alpha-synuclein using residual dipolar couplings. J Am Chem Soc (2005) 1.75
Model-free analysis of protein backbone motion from residual dipolar couplings. J Am Chem Soc (2002) 1.65
A ligand-induced switch in the periplasmic domain of sensor histidine kinase CitA. J Mol Biol (2008) 1.61
Structural polymorphism of 441-residue tau at single residue resolution. PLoS Biol (2009) 1.61
High throughput measurement of duplex, triplex and quadruplex melting curves using molecular beacons and a LightCycler. Nucleic Acids Res (2002) 1.56
Sites of tau important for aggregation populate {beta}-structure and bind to microtubules and polyanions. J Biol Chem (2005) 1.54
Multiple-dose pharmacokinetics and safety of the new antifungal triazole BAL4815 after intravenous infusion and oral administration of its prodrug, BAL8557, in healthy volunteers. Antimicrob Agents Chemother (2006) 1.53
PD-1/PD-L1, but not PD-1/PD-L2, interactions regulate the severity of experimental autoimmune encephalomyelitis. J Neuroimmunol (2006) 1.52
Structural characterization of copper(II) binding to alpha-synuclein: Insights into the bioinorganic chemistry of Parkinson's disease. Proc Natl Acad Sci U S A (2005) 1.50
Highly populated turn conformations in natively unfolded tau protein identified from residual dipolar couplings and molecular simulation. J Am Chem Soc (2007) 1.49
The NMR structure of the sensory domain of the membranous two-component fumarate sensor (histidine protein kinase) DcuS of Escherichia coli. J Biol Chem (2003) 1.48
Weak long-range correlated motions in a surface patch of ubiquitin involved in molecular recognition. J Am Chem Soc (2011) 1.45
NMR of alpha-synuclein-polyamine complexes elucidates the mechanism and kinetics of induced aggregation. EMBO J (2004) 1.41
Template-directed oligonucleotide strand ligation, covalent intramolecular DNA circularization and catenation using click chemistry. J Am Chem Soc (2007) 1.38
Protein conformational flexibility from structure-free analysis of NMR dipolar couplings: quantitative and absolute determination of backbone motion in ubiquitin. Angew Chem Int Ed Engl (2009) 1.38
Four base recognition by triplex-forming oligonucleotides at physiological pH. Nucleic Acids Res (2005) 1.37
Protein refolding is required for assembly of the type three secretion needle. Nat Struct Mol Biol (2010) 1.36
A thorough dynamic interpretation of residual dipolar couplings in ubiquitin. J Biomol NMR (2006) 1.34
Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson's disease. Acta Neuropathol (2013) 1.34
Self-consistent residual dipolar coupling based model-free analysis for the robust determination of nanosecond to microsecond protein dynamics. J Biomol NMR (2008) 1.33
Quantitative determination of the conformational properties of partially folded and intrinsically disordered proteins using NMR dipolar couplings. Structure (2009) 1.33
Familial mutants of alpha-synuclein with increased neurotoxicity have a destabilized conformation. J Biol Chem (2005) 1.30
Intramolecular DNA quadruplexes with different arrangements of short and long loops. Nucleic Acids Res (2007) 1.30
Genomic sequence correction by single-stranded DNA oligonucleotides: role of DNA synthesis and chemical modifications of the oligonucleotide ends. J Gene Med (2005) 1.29
Interaction of alpha-synuclein with divalent metal ions reveals key differences: a link between structure, binding specificity and fibrillation enhancement. J Am Chem Soc (2006) 1.28
A correspondence between solution-state dynamics of an individual protein and the sequence and conformational diversity of its family. PLoS Comput Biol (2009) 1.27
The "jaws" of the tau-microtubule interaction. J Biol Chem (2007) 1.25
Fluorescence based strategies for genetic analysis. Chem Commun (Camb) (2005) 1.23
Novel techniques for weak alignment of proteins in solution using chemical tags coordinating lanthanide ions. J Biomol NMR (2004) 1.22
Efficient RNA synthesis by in vitro transcription of a triazole-modified DNA template. Chem Commun (Camb) (2011) 1.22
Structural characterization of the intrinsically unfolded protein beta-synuclein, a natural negative regulator of alpha-synuclein aggregation. J Mol Biol (2007) 1.21
Synthesis and polymerase chain reaction amplification of DNA strands containing an unnatural triazole linkage. J Am Chem Soc (2009) 1.19
Plasticity of the PAS domain and a potential role for signal transduction in the histidine kinase DcuS. Nat Struct Mol Biol (2008) 1.17
Similarity of SABRE field dependence in chemically different substrates. J Magn Reson (2011) 1.17
Effect of G-tract length on the topology and stability of intramolecular DNA quadruplexes. Biochemistry (2007) 1.16
Structure of the NCoA-1/SRC-1 PAS-B domain bound to the LXXLL motif of the STAT6 transactivation domain. J Mol Biol (2004) 1.16
Characterization of Alzheimer's-like paired helical filaments from the core domain of tau protein using solid-state NMR spectroscopy. J Am Chem Soc (2008) 1.15
Site-specific interactions of Cu(II) with alpha and beta-synuclein: bridging the molecular gap between metal binding and aggregation. J Am Chem Soc (2008) 1.15
Ultrafast dynamics in DNA: "fraying" at the end of the helix. J Am Chem Soc (2006) 1.14
Structural basis of the activity of the microtubule-stabilizing agent epothilone a studied by NMR spectroscopy in solution. Angew Chem Int Ed Engl (2007) 1.13
Tension induces a base-paired overstretched DNA conformation. Proc Natl Acad Sci U S A (2012) 1.13
Structural insights into how 5-hydroxymethylation influences transcription factor binding. Chem Commun (Camb) (2013) 1.13
Functional dynamics in the voltage-dependent anion channel. Proc Natl Acad Sci U S A (2010) 1.13
Characterization and use of an unprecedentedly bright and structurally non-perturbing fluorescent DNA base analogue. Nucleic Acids Res (2007) 1.13
New strategy for the synthesis of chemically modified RNA constructs exemplified by hairpin and hammerhead ribozymes. Proc Natl Acad Sci U S A (2010) 1.12
Conformational changes specific for pseudophosphorylation at serine 262 selectively impair binding of tau to microtubules. Biochemistry (2009) 1.12
A glutathione-dependent formaldehyde-activating enzyme (Gfa) from Paracoccus denitrificans detected and purified via two-dimensional proton exchange NMR spectroscopy. J Biol Chem (2001) 1.11
Bilayer in small bicelles revealed by lipid-protein interactions using NMR spectroscopy. J Am Chem Soc (2008) 1.11
DNA adopts normal B-form upon incorporation of highly fluorescent DNA base analogue tC: NMR structure and UV-Vis spectroscopy characterization. Nucleic Acids Res (2004) 1.11
Sequence effects of single base loops in intramolecular quadruplex DNA. FEBS Lett (2007) 1.11
Rapid and efficient DNA strand cross-linking by click chemistry. Chembiochem (2008) 1.10
Fluorescent properties of DNA base analogue tC upon incorporation into DNA--negligible influence of neighbouring bases on fluorescence quantum yield. Nucleic Acids Res (2005) 1.10
The high-resolution solution structure of epothilone A bound to tubulin: an understanding of the structure-activity relationships for a powerful class of antitumor agents. Angew Chem Int Ed Engl (2003) 1.09
Side-chain orientation and hydrogen-bonding imprint supra-Tau(c) motion on the protein backbone of ubiquitin. Angew Chem Int Ed Engl (2005) 1.09
Modular architecture of Munc13/calmodulin complexes: dual regulation by Ca2+ and possible function in short-term synaptic plasticity. EMBO J (2009) 1.09
Nucleic acid base analog FRET-pair facilitating detailed structural measurements in nucleic acid containing systems. J Am Chem Soc (2009) 1.09
Kinetics of conformational sampling in ubiquitin. Angew Chem Int Ed Engl (2011) 1.07
Thermodynamic and kinetic stability of intermolecular triple helices containing different proportions of C+*GC and T*AT triplets. Nucleic Acids Res (2003) 1.06
The native conformation of the human VDAC1 N terminus. Angew Chem Int Ed Engl (2010) 1.05
The INPHARMA method: protein-mediated interligand NOEs for pharmacophore mapping. Angew Chem Int Ed Engl (2005) 1.04
β-Barrel mobility underlies closure of the voltage-dependent anion channel. Structure (2012) 1.04
β-Sheet core of tau paired helical filaments revealed by solid-state NMR. J Am Chem Soc (2012) 1.03
An extra dimension in nucleic acid sequence recognition. Q Rev Biophys (2006) 1.03
Antimalarial drug quinacrine binds to C-terminal helix of cellular prion protein. J Med Chem (2003) 1.03
Biocompatible artificial DNA linker that is read through by DNA polymerases and is functional in Escherichia coli. Proc Natl Acad Sci U S A (2011) 1.02
Field dependent dynamic nuclear polarization with radicals in aqueous solution. J Am Chem Soc (2008) 1.01
Self-consistency analysis of dipolar couplings in multiple alignments of ubiquitin. J Am Chem Soc (2003) 1.01
The nature of the stimulus and of the fumarate binding site of the fumarate sensor DcuS of Escherichia coli. J Biol Chem (2005) 1.00
Triplex addressability as a basis for functional DNA nanostructures. Nano Lett (2007) 1.00
Structural characterization of Ca(2+)-ATPase-bound phospholamban in lipid bilayers by solid-state nuclear magnetic resonance (NMR) spectroscopy. Biochemistry (2008) 1.00
The uronium/guanidinium Peptide coupling reagents: finally the true uronium salts. Angew Chem Int Ed Engl (2002) 1.00
TREM-1 expression is increased in the synovium of rheumatoid arthritis patients and induces the expression of pro-inflammatory cytokines. Rheumatology (Oxford) (2009) 1.00
Structural and mechanistic basis behind the inhibitory interaction of PcTS on alpha-synuclein amyloid fibril formation. Proc Natl Acad Sci U S A (2009) 0.99
The solution structure of a DNA*RNA duplex containing 5-propynyl U and C; comparison with 5-Me modifications. Nucleic Acids Res (2003) 0.99
Power-law solvation dynamics in DNA over six decades in time. J Am Chem Soc (2005) 0.99
Functionalized nanostructures: redox-active porphyrin anchors for supramolecular DNA assemblies. ACS Nano (2010) 0.98
Paramagnetic tagging of diamagnetic proteins for solution NMR. Magn Reson Chem (2006) 0.98
Indirect DNA readout by an H-NS related protein: structure of the DNA complex of the C-terminal domain of Ler. PLoS Pathog (2011) 0.97
A very stable cyclic DNA miniduplex with just two base pairs. Chembiochem (2008) 0.96
Prion protein helix1 promotes aggregation but is not converted into beta-sheet. J Biol Chem (2006) 0.96
A structural model of the complex formed by phospholamban and the calcium pump of sarcoplasmic reticulum obtained by molecular mechanics. Chembiochem (2002) 0.96
Orientational and dynamical heterogeneity of rhodamine 6G terminally attached to a DNA helix revealed by NMR and single-molecule fluorescence spectroscopy. J Am Chem Soc (2007) 0.95
Hydroxylation of methylated CpG dinucleotides reverses stabilisation of DNA duplexes by cytosine 5-methylation. Chem Commun (Camb) (2011) 0.95
Shuttle DNP spectrometer with a two-center magnet. Phys Chem Chem Phys (2010) 0.95
Stable DNA triple helix formation using oligonucleotides containing 2'-aminoethoxy,5-propargylamino-U. Biochemistry (2002) 0.94
(1)H and (13)C dynamic nuclear polarization in aqueous solution with a two-field (0.35 T/14 T) shuttle DNP spectrometer. J Am Chem Soc (2009) 0.94