PubRank

Christian Griesinger

Author PubWeight™ 153.34‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Recognition dynamics up to microseconds revealed from an RDC-derived ubiquitin ensemble in solution. Science 2008 8.04
2 Release of long-range tertiary interactions potentiates aggregation of natively unstructured alpha-synuclein. Proc Natl Acad Sci U S A 2005 3.48
3 Structure of the human voltage-dependent anion channel. Proc Natl Acad Sci U S A 2008 2.69
4 Pre-fibrillar alpha-synuclein variants with impaired beta-structure increase neurotoxicity in Parkinson's disease models. EMBO J 2009 2.09
5 Atomic model of the type III secretion system needle. Nature 2012 2.02
6 Defining long-range order and local disorder in native alpha-synuclein using residual dipolar couplings. J Am Chem Soc 2005 1.75
7 Model-free analysis of protein backbone motion from residual dipolar couplings. J Am Chem Soc 2002 1.65
8 A ligand-induced switch in the periplasmic domain of sensor histidine kinase CitA. J Mol Biol 2008 1.61
9 Structural polymorphism of 441-residue tau at single residue resolution. PLoS Biol 2009 1.61
10 Sites of tau important for aggregation populate {beta}-structure and bind to microtubules and polyanions. J Biol Chem 2005 1.54
11 Structural characterization of copper(II) binding to alpha-synuclein: Insights into the bioinorganic chemistry of Parkinson's disease. Proc Natl Acad Sci U S A 2005 1.50
12 Highly populated turn conformations in natively unfolded tau protein identified from residual dipolar couplings and molecular simulation. J Am Chem Soc 2007 1.49
13 The NMR structure of the sensory domain of the membranous two-component fumarate sensor (histidine protein kinase) DcuS of Escherichia coli. J Biol Chem 2003 1.48
14 Weak long-range correlated motions in a surface patch of ubiquitin involved in molecular recognition. J Am Chem Soc 2011 1.45
15 NMR of alpha-synuclein-polyamine complexes elucidates the mechanism and kinetics of induced aggregation. EMBO J 2004 1.41
16 Protein conformational flexibility from structure-free analysis of NMR dipolar couplings: quantitative and absolute determination of backbone motion in ubiquitin. Angew Chem Int Ed Engl 2009 1.38
17 Protein refolding is required for assembly of the type three secretion needle. Nat Struct Mol Biol 2010 1.36
18 A thorough dynamic interpretation of residual dipolar couplings in ubiquitin. J Biomol NMR 2006 1.34
19 Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson's disease. Acta Neuropathol 2013 1.34
20 Self-consistent residual dipolar coupling based model-free analysis for the robust determination of nanosecond to microsecond protein dynamics. J Biomol NMR 2008 1.33
21 Quantitative determination of the conformational properties of partially folded and intrinsically disordered proteins using NMR dipolar couplings. Structure 2009 1.33
22 Familial mutants of alpha-synuclein with increased neurotoxicity have a destabilized conformation. J Biol Chem 2005 1.30
23 Interaction of alpha-synuclein with divalent metal ions reveals key differences: a link between structure, binding specificity and fibrillation enhancement. J Am Chem Soc 2006 1.28
24 A correspondence between solution-state dynamics of an individual protein and the sequence and conformational diversity of its family. PLoS Comput Biol 2009 1.27
25 The "jaws" of the tau-microtubule interaction. J Biol Chem 2007 1.25
26 Novel techniques for weak alignment of proteins in solution using chemical tags coordinating lanthanide ions. J Biomol NMR 2004 1.22
27 Structural characterization of the intrinsically unfolded protein beta-synuclein, a natural negative regulator of alpha-synuclein aggregation. J Mol Biol 2007 1.21
28 Plasticity of the PAS domain and a potential role for signal transduction in the histidine kinase DcuS. Nat Struct Mol Biol 2008 1.17
29 Similarity of SABRE field dependence in chemically different substrates. J Magn Reson 2011 1.17
30 Structure of the NCoA-1/SRC-1 PAS-B domain bound to the LXXLL motif of the STAT6 transactivation domain. J Mol Biol 2004 1.16
31 Characterization of Alzheimer's-like paired helical filaments from the core domain of tau protein using solid-state NMR spectroscopy. J Am Chem Soc 2008 1.15
32 Site-specific interactions of Cu(II) with alpha and beta-synuclein: bridging the molecular gap between metal binding and aggregation. J Am Chem Soc 2008 1.15
33 Structural basis of the activity of the microtubule-stabilizing agent epothilone a studied by NMR spectroscopy in solution. Angew Chem Int Ed Engl 2007 1.13
34 Functional dynamics in the voltage-dependent anion channel. Proc Natl Acad Sci U S A 2010 1.13
35 Conformational changes specific for pseudophosphorylation at serine 262 selectively impair binding of tau to microtubules. Biochemistry 2009 1.12
36 A glutathione-dependent formaldehyde-activating enzyme (Gfa) from Paracoccus denitrificans detected and purified via two-dimensional proton exchange NMR spectroscopy. J Biol Chem 2001 1.11
37 Bilayer in small bicelles revealed by lipid-protein interactions using NMR spectroscopy. J Am Chem Soc 2008 1.11
38 The high-resolution solution structure of epothilone A bound to tubulin: an understanding of the structure-activity relationships for a powerful class of antitumor agents. Angew Chem Int Ed Engl 2003 1.09
39 Side-chain orientation and hydrogen-bonding imprint supra-Tau(c) motion on the protein backbone of ubiquitin. Angew Chem Int Ed Engl 2005 1.09
40 Modular architecture of Munc13/calmodulin complexes: dual regulation by Ca2+ and possible function in short-term synaptic plasticity. EMBO J 2009 1.09
41 Kinetics of conformational sampling in ubiquitin. Angew Chem Int Ed Engl 2011 1.07
42 The native conformation of the human VDAC1 N terminus. Angew Chem Int Ed Engl 2010 1.05
43 The INPHARMA method: protein-mediated interligand NOEs for pharmacophore mapping. Angew Chem Int Ed Engl 2005 1.04
44 β-Barrel mobility underlies closure of the voltage-dependent anion channel. Structure 2012 1.04
45 β-Sheet core of tau paired helical filaments revealed by solid-state NMR. J Am Chem Soc 2012 1.03
46 Antimalarial drug quinacrine binds to C-terminal helix of cellular prion protein. J Med Chem 2003 1.03
47 Field dependent dynamic nuclear polarization with radicals in aqueous solution. J Am Chem Soc 2008 1.01
48 Self-consistency analysis of dipolar couplings in multiple alignments of ubiquitin. J Am Chem Soc 2003 1.01
49 Structural characterization of Ca(2+)-ATPase-bound phospholamban in lipid bilayers by solid-state nuclear magnetic resonance (NMR) spectroscopy. Biochemistry 2008 1.00
50 The nature of the stimulus and of the fumarate binding site of the fumarate sensor DcuS of Escherichia coli. J Biol Chem 2005 1.00
51 Structural and mechanistic basis behind the inhibitory interaction of PcTS on alpha-synuclein amyloid fibril formation. Proc Natl Acad Sci U S A 2009 0.99
52 Paramagnetic tagging of diamagnetic proteins for solution NMR. Magn Reson Chem 2006 0.98
53 Indirect DNA readout by an H-NS related protein: structure of the DNA complex of the C-terminal domain of Ler. PLoS Pathog 2011 0.97
54 Prion protein helix1 promotes aggregation but is not converted into beta-sheet. J Biol Chem 2006 0.96
55 A structural model of the complex formed by phospholamban and the calcium pump of sarcoplasmic reticulum obtained by molecular mechanics. Chembiochem 2002 0.96
56 Orientational and dynamical heterogeneity of rhodamine 6G terminally attached to a DNA helix revealed by NMR and single-molecule fluorescence spectroscopy. J Am Chem Soc 2007 0.95
57 Shuttle DNP spectrometer with a two-center magnet. Phys Chem Chem Phys 2010 0.95
58 Structural insights into the calmodulin-Munc13 interaction obtained by cross-linking and mass spectrometry. Biochemistry 2009 0.94
59 (1)H and (13)C dynamic nuclear polarization in aqueous solution with a two-field (0.35 T/14 T) shuttle DNP spectrometer. J Am Chem Soc 2009 0.94
60 Derivation of dihedral angles from CH-CH dipolar-dipolar cross-correlated relaxation rates: a C-C torsion involving a quaternary carbon atom in epothilone A bound to tubulin. Angew Chem Int Ed Engl 2003 0.93
61 A designed conformational shift to control protein binding specificity. Angew Chem Int Ed Engl 2014 0.93
62 The dynamic structure of filamentous tau. Angew Chem Int Ed Engl 2011 0.92
63 Population shuffling of protein conformations. Angew Chem Int Ed Engl 2014 0.91
64 Toward a predictive understanding of slow methyl group dynamics in proteins. Biophys J 2011 0.91
65 Two new chiral EDTA-based metal chelates for weak alignment of proteins in solution. Org Lett 2006 0.91
66 Accessing ns-micros side chain dynamics in ubiquitin with methyl RDCs. J Biomol NMR 2009 0.91
67 Dipolar couplings in multiple alignments suggest alpha helical motion in ubiquitin. J Am Chem Soc 2003 0.90
68 2-Aminopurine incorporation perturbs the dynamics and structure of DNA. Angew Chem Int Ed Engl 2010 0.90
69 Residual dipolar couplings as a tool to study molecular recognition of ubiquitin. Biochem Soc Trans 2008 0.90
70 Sensing by the membrane-bound sensor kinase DcuS: exogenous versus endogenous sensing of C(4)-dicarboxylates in bacteria. Future Microbiol 2010 0.89
71 Bioinorganic chemistry of Parkinson's disease: structural determinants for the copper-mediated amyloid formation of alpha-synuclein. Inorg Chem 2010 0.89
72 Structural and microtubule binding properties of tau mutants of frontotemporal dementias. Biochemistry 2007 0.88
73 RDC-enhanced NMR spectroscopy in structure elucidation of sucro-neolambertellin. Angew Chem Int Ed Engl 2008 0.88
74 Stable expression of soluble therapeutic peptides in eukaryotic cells by multimerisation: application to the HIV-1 fusion inhibitory peptide C46. ChemMedChem 2006 0.88
75 Interaction of epothilone B (patupilone) with microtubules as detected by two-dimensional solid-state NMR spectroscopy. Angew Chem Int Ed Engl 2010 0.88
76 The INPHARMA technique for pharmacophore mapping: A theoretical guide to the method. J Magn Reson 2009 0.87
77 Structure and dynamics of triazole-linked DNA: biocompatibility explained. Chemistry 2011 0.87
78 The cofactor of the iron-sulfur cluster free hydrogenase hmd: structure of the light-inactivation product. Angew Chem Int Ed Engl 2004 0.87
79 Exceeding the limit of dynamics studies on biomolecules using high spin-lock field strengths with a cryogenically cooled probehead. J Magn Reson 2012 0.87
80 P160/SRC/NCoA coactivators form complexes via specific interaction of their PAS-B domain with the CID/AD1 domain. Nucleic Acids Res 2008 0.87
81 Convenient synthesis of multifunctional EDTA-based chiral metal chelates substituted with an S-mesylcysteine. Chemistry 2005 0.87
82 Correlating calcium binding, Förster resonance energy transfer, and conformational change in the biosensor TN-XXL. Biophys J 2012 0.87
83 Interdomain dynamics explored by paramagnetic NMR. J Am Chem Soc 2013 0.86
84 Structural studies on a twin-arginine signal sequence. FEBS Lett 2003 0.86
85 Nucleotide interactions of the human voltage-dependent anion channel. J Biol Chem 2014 0.85
86 NMR spectroscopic determination of the solution structure of a branched nucleic acid from residual dipolar couplings by using isotopically labeled nucleotides. Angew Chem Int Ed Engl 2004 0.85
87 A dynamic zinc redox switch. J Biol Chem 2004 0.85
88 NMR solution structure and dynamics of the peptidyl-prolyl cis-trans isomerase domain of the trigger factor from Mycoplasma genitalium compared to FK506-binding protein. J Mol Biol 2002 0.84
89 Crystallography-independent determination of ligand binding modes. Angew Chem Int Ed Engl 2008 0.84
90 Dynamics in the p38alpha MAP kinase-SB203580 complex observed by liquid-state NMR spectroscopy. Angew Chem Int Ed Engl 2008 0.84
91 Hyperpolarized binding pocket nuclear Overhauser effect for determination of competitive ligand binding. Angew Chem Int Ed Engl 2012 0.84
92 Synthesis and structural model of an alpha(2,6)-sialyl-t glycosylated MUC1 eicosapeptide under physiological conditions. Chemistry 2006 0.84
93 Electron paramagnetic resonance spectroscopy measures the distance between the external β-strands of folded α-synuclein in amyloid fibrils. Biophys J 2011 0.83
94 Determining the absolute configuration of (+)-mefloquine HCl, the side-effect-reducing enantiomer of the antimalaria drug Lariam. J Am Chem Soc 2012 0.83
95 Exploring the structural details of Cu(I) binding to α-synuclein by NMR spectroscopy. J Am Chem Soc 2010 0.83
96 Structure and potential C-terminal dimerization of a recombinant mutant of surfactant-associated protein C in chloroform/methanol. Eur J Biochem 2004 0.83
97 Bijvoet in solution reveals unexpected stereoselectivity in a Michael addition. Chemistry 2011 0.83
98 Drug design for G-protein-coupled receptors by a ligand-based NMR method. Angew Chem Int Ed Engl 2010 0.83
99 Structural characterization of binding of Cu(II) to tau protein. Biochemistry 2008 0.83
100 Measurement of long range H,C couplings in natural products in orienting media: a tool for structure elucidation of natural products. J Magn Reson 2003 0.83
101 Stereochemistry of sagittamide A from residual dipolar coupling enhanced NMR. J Am Chem Soc 2007 0.83
102 The oligomer modulator anle138b inhibits disease progression in a Parkinson mouse model even with treatment started after disease onset. Acta Neuropathol 2014 0.83
103 Standard tensorial analysis of local ordering in proteins from residual dipolar couplings. J Phys Chem B 2012 0.82
104 Solid-state NMR, electrophysiology and molecular dynamics characterization of human VDAC2. J Biomol NMR 2014 0.82
105 Long-range correlated dynamics in intrinsically disordered proteins. J Am Chem Soc 2014 0.82
106 Studying molecular 3D structure and dynamics by high-resolution solid-state NMR: Application to L-tyrosine-ethylester. J Phys Chem A 2005 0.82
107 Toward the discovery of effective polycyclic inhibitors of alpha-synuclein amyloid assembly. J Biol Chem 2011 0.82
108 Thermal coefficients of the methyl groups within ubiquitin. Protein Sci 2012 0.82
109 The cytoplasmic PASC domain of the sensor kinase DcuS of Escherichia coli: role in signal transduction, dimer formation, and DctA interaction. Microbiologyopen 2013 0.81
110 Pre-fibrillar α-synuclein mutants cause Parkinson's disease-like non-motor symptoms in Drosophila. PLoS One 2011 0.81
111 ShereKhan--calculating exchange parameters in relaxation dispersion data from CPMG experiments. Bioinformatics 2013 0.81
112 Inhibition of tau filament formation by conformational modulation. J Am Chem Soc 2013 0.81
113 Measuring the chi 1 torsion angle in protein by CH-CH cross-correlated relaxation: a new resolution-optimised experiment. J Biomol NMR 2003 0.81
114 Measuring dynamic and kinetic information in the previously inaccessible supra-τ(c) window of nanoseconds to microseconds by solution NMR spectroscopy. Molecules 2013 0.81
115 Conformative coupling of two conformational molecular switches. Angew Chem Int Ed Engl 2003 0.81
116 The structure of hormaomycin and one of its all-peptide aza-analogues in solution: syntheses and biological activities of new hormaomycin analogues. Chemistry 2005 0.81
117 Dynamics of the glycosidic bond: conformational space of lactose. Chemistry 2011 0.80
118 Resolution enhancement in spectra of natural products dissolved in weakly orienting media with the help of 1H homonuclear dipolar decoupling during acquisition: application to 1H-13C dipolar couplings measurements. J Magn Reson 2006 0.80
119 A DMSO-compatible orienting medium: towards the investigation of the stereochemistry of natural products. Angew Chem Int Ed Engl 2005 0.80
120 Challenge of large-scale motion for residual dipolar coupling based analysis of configuration: the case of fibrosterol sulfate A. J Am Chem Soc 2011 0.80
121 Structural basis behind the interaction of Zn²⁺ with the protein α-synuclein and the Aβ peptide: a comparative analysis. J Inorg Biochem 2012 0.79
122 Chromophore/DNA interactions: femto- to nanosecond spectroscopy, NMR structure, and electron transfer theory. J Phys Chem B 2007 0.79
123 Cation control in functional helical programming: structures of a D,L-peptide ion channel. Angew Chem Int Ed Engl 2002 0.79
124 Peptide mimotopes selected with HIV-1-blocking monoclonal antibodies against CCR5 represent motifs specific for HIV-1 entry. Immunol Cell Biol 2007 0.79
125 ORIUM: optimized RDC-based Iterative and Unified Model-free analysis. J Biomol NMR 2013 0.79
126 Enhanced accuracy of kinetic information from CT-CPMG experiments by transverse rotating-frame spectroscopy. J Biomol NMR 2013 0.78
127 Synergistic TRAIL sensitizers from Barleria alluaudii and Diospyros maritima. J Nat Prod 2012 0.78
128 Cutting edge: feed-forward activation of phospholipase Cγ2 via C2 domain-mediated binding to SLP65. J Immunol 2013 0.78
129 Detection and identification of protein-phosphorylation sites in histidines through HNP correlation patterns. Angew Chem Int Ed Engl 2010 0.78
130 The absolute configuration of (+)- and (-)-erythro-mefloquine. Angew Chem Int Ed Engl 2013 0.78
131 Measurement and ab initio calculation of CSA/dipole-dipole cross-correlated relaxation provide insight into the mechanism of a H2-forming dehydrogenase. J Am Chem Soc 2003 0.78
132 Residual dipolar coupling enhanced NMR spectroscopy and chiroptics: a powerful combination for the complete elucidation of symmetrical small molecules. Chemistry 2011 0.78
133 1H, 13C and 15N resonance assignments of the Calmodulin-Munc13-1 peptide complex. Biomol NMR Assign 2009 0.78
134 Relative and absolute configuration of vatiparol (1 mg): a novel anti-inflammatory polyphenol. Chemistry 2012 0.78
135 An asymmetric ion channel derived from gramicidin A. Synthesis, function and NMR structure. FEBS J 2005 0.77
136 Cys-Ph-TAHA: a lanthanide binding tag for RDC and PCS enhanced protein NMR. J Biomol NMR 2011 0.77
137 Site-specific copper-catalyzed oxidation of α-synuclein: tightening the link between metal binding and protein oxidative damage in Parkinson's disease. Inorg Chem 2014 0.77
138 Trapped in misbelief for almost 40 years: selective synthesis of the four stereoisomers of mefloquine. Chemistry 2013 0.77
139 Quantitative Real-Time Quaking-Induced Conversion Allows Monitoring of Disease-Modifying Therapy in the Urine of Prion-Infected Mice. J Neuropathol Exp Neurol 2015 0.77
140 A pre-structured helix in the intrinsically disordered 4EBP1. Mol Biosyst 2014 0.77
141 Inferential NMR/X-ray-based structure determination of a dibenzo[a,d]cycloheptenone inhibitor-p38α MAP kinase complex in solution. Angew Chem Int Ed Engl 2012 0.77
142 Peptide ligands selected with CD4-induced epitopes on native dualtropic HIV-1 envelope proteins mimic extracellular coreceptor domains and bind to HIV-1 gp120 independently of coreceptor usage. J Virol 2010 0.77
143 Mass spectrometric sequencing of individual peptides from combinatorial libraries via specific generation of chain-terminated sequences. J Comb Chem 2002 0.77
144 The Tubulin Binding Mode of MT Stabilizing and Destabilizing Agents Studied by NMR. Top Curr Chem 2009 0.77
145 Residual chemical shift anisotropy (RCSA): a tool for the analysis of the configuration of small molecules. Angew Chem Int Ed Engl 2011 0.77
146 Paramagnetic lanthanide tagging for NMR conformational analyses of N-linked oligosaccharides. Chemistry 2011 0.76
147 An NMR-based scoring function improves the accuracy of binding pose predictions by docking by two orders of magnitude. J Biomol NMR 2011 0.76
148 Determinants of interaction specificity of the Bacillus subtilis GlcT antitermination protein: functionality and phosphorylation specificity depend on the arrangement of the regulatory domains. J Biol Chem 2012 0.76
149 In vitro generation of cytolytic T cells against human melanoma cells overexpressing HDM2. Anticancer Res 2004 0.75
150 Helical structure of tercyclopropanedimethanol in solution. J Org Chem 2006 0.75
151 Effect of the solvent on the conformation of a depsipeptide: NMR-derived solution structure of hormaomycin in DMSO from residual dipolar couplings in a novel DMSO-compatible alignment medium. Chembiochem 2006 0.75
152 Specific methyl group protonation for the measurement of pharmacophore-specific interligand NOE interactions. Chemistry 2008 0.75
153 Fibrous networks with incorporated macrocycles: a chiral stimuli-responsive supramolecular supergelator and its application to biocatalysis in organic media. Chemistry 2013 0.75
154 Graphene oxide liquid crystals as a versatile and tunable alignment medium for the measurement of residual dipolar couplings in organic solvents. J Am Chem Soc 2014 0.75
155 Is enantiomer assignment possible by NMR spectroscopy using residual dipolar couplings from chiral nonracemic alignment media?--A critical assessment. Angew Chem Int Ed Engl 2012 0.75
156 Chiral discrimination of amines by anisotropic NMR parameters using chiral polyacrylamide-based gels. Magn Reson Chem 2012 0.75