Published in Trends Cell Biol on December 09, 2011
MDM2, MDMX and p53 in oncogenesis and cancer therapy. Nat Rev Cancer (2013) 3.60
Unravelling mechanisms of p53-mediated tumour suppression. Nat Rev Cancer (2014) 3.37
A polymorphic p53 response element in KIT ligand influences cancer risk and has undergone natural selection. Cell (2013) 2.60
Ferroptosis as a p53-mediated activity during tumour suppression. Nature (2015) 2.06
Global genomic profiling reveals an extensive p53-regulated autophagy program contributing to key p53 responses. Genes Dev (2013) 1.88
Molecular pathogenesis of chronic lymphocytic leukemia. J Clin Invest (2012) 1.64
Mitochondrial dysfunction in cancer. Front Oncol (2013) 1.57
p53 induces transcriptional and translational programs to suppress cell proliferation and growth. Genome Biol (2013) 1.33
The CRM1 nuclear export protein in normal development and disease. Int J Biochem Mol Biol (2012) 1.14
7SL RNA represses p53 translation by competing with HuR. Nucleic Acids Res (2014) 1.06
CAG expansion induces nucleolar stress in polyglutamine diseases. Proc Natl Acad Sci U S A (2012) 1.05
A tumor suppressor role of the Bub3 spindle checkpoint protein after apoptosis inhibition. J Cell Biol (2013) 1.02
The importance of p53 pathway genetics in inherited and somatic cancer genomes. Nat Rev Cancer (2016) 0.98
Lessons learned about human stem cell responses to ionizing radiation exposures: a long road still ahead of us. Int J Mol Sci (2013) 0.96
Caught in the cross fire: p53 in inflammation. Carcinogenesis (2014) 0.95
A small-molecule inhibitor of UBE2N induces neuroblastoma cell death via activation of p53 and JNK pathways. Cell Death Dis (2014) 0.95
TIGAR, TIGAR, burning bright. Cancer Metab (2014) 0.91
DDX3 regulates DNA damage-induced apoptosis and p53 stabilization. Biochim Biophys Acta (2013) 0.89
The HPV E2-Host Protein-Protein Interactions: A Complex Hijacking of the Cellular Network. Open Virol J (2012) 0.86
Synergistic interaction of Rnf8 and p53 in the protection against genomic instability and tumorigenesis. PLoS Genet (2013) 0.85
Metabolite and transcriptome analysis during fasting suggest a role for the p53-Ddit4 axis in major metabolic tissues. BMC Genomics (2013) 0.85
Ninjurin1, a target of p53, regulates p53 expression and p53-dependent cell survival, senescence, and radiation-induced mortality. Proc Natl Acad Sci U S A (2013) 0.82
Subtelomeric p53 binding prevents accumulation of DNA damage at human telomeres. EMBO J (2015) 0.81
Anticancer drug FL118 is more than a survivin inhibitor: where is the Achilles' heel of cancer? Am J Cancer Res (2014) 0.81
PAX3 in neuroblastoma: oncogenic potential, chemosensitivity and signalling pathways. J Cell Mol Med (2013) 0.80
Lymphocytes of patients with Alzheimer's disease display different DNA damage repair kinetics and expression profiles of DNA repair and stress response genes. Int J Mol Sci (2013) 0.79
A nanobody modulates the p53 transcriptional program without perturbing its functional architecture. Nucleic Acids Res (2014) 0.79
Coordination between p21 and DDB2 in the cellular response to UV radiation. PLoS One (2013) 0.78
A 2-methoxyestradiol bis-sulphamoylated derivative induces apoptosis in breast cell lines. Cell Biosci (2015) 0.78
Mitochondrial matrix P53 sensitizes cells to oxidative stress. Mitochondrion (2013) 0.78
Ash2L enables P53-dependent apoptosis by favoring stable transcription pre-initiation complex formation on its pro-apoptotic target promoters. Oncogene (2014) 0.78
Mechanisms of environmental chemicals that enable the cancer hallmark of evasion of growth suppression. Carcinogenesis (2015) 0.77
A PTCH1 homolog transcriptionally activated by p53 suppresses Hedgehog signaling. J Biol Chem (2014) 0.77
Prima-1 induces apoptosis in bladder cancer cell lines by activating p53. Clinics (Sao Paulo) (2013) 0.77
Mechanisms of p53 Functional De-Regulation: Role of the IκB-α/p53 Complex. Int J Mol Sci (2016) 0.77
A single mutant, A276S of p53, turns the switch to apoptosis. Mol Pharm (2013) 0.77
Long Term Aggresome Accumulation Leads to DNA Damage, p53-dependent Cell Cycle Arrest, and Steric Interference in Mitosis. J Biol Chem (2015) 0.77
RECQL: a new breast cancer susceptibility gene. Cell Cycle (2015) 0.77
Proteomic analyses uncover a new function and mode of action for mouse homolog of Diaphanous 2 (mDia2). Mol Cell Proteomics (2015) 0.76
Conditional inactivation of PDCD2 induces p53 activation and cell cycle arrest. Biol Open (2014) 0.76
p53 directly regulates the glycosidase FUCA1 to promote chemotherapy-induced cell death. Cell Cycle (2016) 0.76
Phosphorylation Regulates the Bound Structure of an Intrinsically Disordered Protein: The p53-TAZ2 Case. PLoS One (2016) 0.76
The downregulation of the RNA-binding protein Staufen2 in response to DNA damage promotes apoptosis. Nucleic Acids Res (2016) 0.75
Transglutaminase 2 contributes to a TP53-induced autophagy program to prevent oncogenic transformation. Elife (2016) 0.75
Changes in O-Linked N-Acetylglucosamine (O-GlcNAc) Homeostasis Activate the p53 Pathway in Ovarian Cancer Cells. J Biol Chem (2016) 0.75
Comparison of effects of p53 null and gain-of-function mutations on salivary tumors in MMTV-Hras transgenic mice. PLoS One (2015) 0.75
Bioinformatics and Gene Network Analyses of the Swine Mammary Gland Transcriptome during Late Gestation. Bioinform Biol Insights (2013) 0.75
Genome-wide association study identified PLCE1- rs2797992 and EGFR- rs6950826 were associated with TP53 expression in the HBV-related hepatocellular carcinoma of Chinese patients in Guangxi. Am J Transl Res (2016) 0.75
Meningioma recurrence. Open Med (Wars) (2016) 0.75
p53 continues to surprise: high levels of p53 can suppress apoptosis. Cell Cycle (2012) 0.75
Activation of PTHrP-cAMP-CREB1 signaling following p53 loss is essential for osteosarcoma initiation and maintenance. Elife (2016) 0.75
Regulation of p53 under hypoxic and inflammatory conditions in periodontium. Clin Oral Investig (2015) 0.75
Reviving the guardian of the genome: Small molecule activators of p53. Pharmacol Ther (2017) 0.75
WAF1, a potential mediator of p53 tumor suppression. Cell (1993) 38.72
The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell (1993) 33.20
Blinded by the Light: The Growing Complexity of p53. Cell (2009) 17.75
Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis. Nature (2005) 15.83
Cell-cycle checkpoints and cancer. Nature (2004) 13.19
Restoration of p53 function leads to tumour regression in vivo. Nature (2007) 12.62
Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control. Cell (1995) 12.39
An oncogene-induced DNA damage model for cancer development. Science (2008) 11.60
Transcriptional control of human p53-regulated genes. Nat Rev Mol Cell Biol (2008) 11.05
PUMA, a novel proapoptotic gene, is induced by p53. Mol Cell (2001) 11.04
p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa. Science (2003) 9.94
Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis. Science (2000) 8.74
Radiation-induced cell cycle arrest compromised by p21 deficiency. Nature (1995) 8.53
PUMA induces the rapid apoptosis of colorectal cancer cells. Mol Cell (2001) 7.95
Puma is an essential mediator of p53-dependent and -independent apoptotic pathways. Cancer Cell (2003) 7.60
Bax-deficient mice with lymphoid hyperplasia and male germ cell death. Science (1995) 6.84
Dissecting p53 tumor suppressor functions in vivo. Cancer Cell (2002) 6.24
When mutants gain new powers: news from the mutant p53 field. Nat Rev Cancer (2009) 5.86
A new mouse model to explore the initiation, progression, and therapy of BRAFV600E-induced lung tumors. Genes Dev (2007) 5.07
PML regulates p53 acetylation and premature senescence induced by oncogenic Ras. Nature (2000) 4.90
Distinct p53 transcriptional programs dictate acute DNA-damage responses and tumor suppression. Cell (2011) 4.74
The pathological response to DNA damage does not contribute to p53-mediated tumour suppression. Nature (2006) 4.57
Modulation of mammalian life span by the short isoform of p53. Genes Dev (2004) 4.52
Role of PML in cell growth and the retinoic acid pathway. Science (1998) 3.82
p53 transcriptional activation mediated by coactivators TAFII40 and TAFII60. Science (1995) 3.74
p53-dependent apoptosis suppresses tumor growth and progression in vivo. Cell (1994) 3.69
Chromosome stability, in the absence of apoptosis, is critical for suppression of tumorigenesis in Trp53 mutant mice. Nat Genet (2003) 3.61
Suppression of tumorigenesis by the p53 target PUMA. Proc Natl Acad Sci U S A (2004) 3.42
PML is induced by oncogenic ras and promotes premature senescence. Genes Dev (2000) 3.35
Bax suppresses tumorigenesis and stimulates apoptosis in vivo. Nature (1997) 3.10
Genomic instability in Gadd45a-deficient mice. Nat Genet (1999) 3.01
The mitochondrial p53 pathway. Biochim Biophys Acta (2008) 2.98
PUMA regulates intestinal progenitor cell radiosensitivity and gastrointestinal syndrome. Cell Stem Cell (2008) 2.68
The p53QS transactivation-deficient mutant shows stress-specific apoptotic activity and induces embryonic lethality. Nat Genet (2005) 2.66
bax-deficiency promotes drug resistance and oncogenic transformation by attenuating p53-dependent apoptosis. Proc Natl Acad Sci U S A (1997) 2.59
Perp is a p63-regulated gene essential for epithelial integrity. Cell (2005) 2.58
Integral role of Noxa in p53-mediated apoptotic response. Genes Dev (2003) 2.50
CD95 promotes tumour growth. Nature (2010) 2.42
PML is a direct p53 target that modulates p53 effector functions. Mol Cell (2004) 2.40
Tumor susceptibility of p21(Waf1/Cip1)-deficient mice. Cancer Res (2001) 2.37
PERP, an apoptosis-associated target of p53, is a novel member of the PMP-22/gas3 family. Genes Dev (2000) 2.33
Noxa: at the tip of the balance between life and death. Oncogene (2008) 2.09
Murine fibroblasts lacking p21 undergo senescence and are resistant to transformation by oncogenic Ras. Oncogene (1999) 2.00
Telomere dysfunction suppresses spontaneous tumorigenesis in vivo by initiating p53-dependent cellular senescence. EMBO Rep (2007) 1.96
Bax loss impairs Myc-induced apoptosis and circumvents the selection of p53 mutations during Myc-mediated lymphomagenesis. Mol Cell Biol (2001) 1.96
p53 at a glance. J Cell Sci (2010) 1.88
Tumour biology: Policing of oncogene activity by p53. Nature (2006) 1.86
Four domains of p300 each bind tightly to a sequence spanning both transactivation subdomains of p53. Proc Natl Acad Sci U S A (2007) 1.86
Structure of the Tfb1/p53 complex: Insights into the interaction between the p62/Tfb1 subunit of TFIIH and the activation domain of p53. Mol Cell (2006) 1.82
In several cell types tumour suppressor p53 induces apoptosis largely via Puma but Noxa can contribute. Cell Death Differ (2008) 1.81
Identification of a novel p53 functional domain that is necessary for mediating apoptosis. J Biol Chem (1998) 1.80
The isoforms of the p53 protein. Cold Spring Harb Perspect Biol (2010) 1.76
Puma and to a lesser extent Noxa are suppressors of Myc-induced lymphomagenesis. Cell Death Differ (2009) 1.75
CKIα ablation highlights a critical role for p53 in invasiveness control. Nature (2011) 1.72
Selection against PUMA gene expression in Myc-driven B-cell lymphomagenesis. Mol Cell Biol (2008) 1.72
Gadd45a protects against UV irradiation-induced skin tumors, and promotes apoptosis and stress signaling via MAPK and p53. Cancer Res (2002) 1.71
Two tandem and independent sub-activation domains in the amino terminus of p53 require the adaptor complex for activity. Oncogene (1997) 1.70
PH domain-only protein PHLDA3 is a p53-regulated repressor of Akt. Cell (2009) 1.65
Role of promyelocytic leukemia (PML) protein in tumor suppression. J Exp Med (2001) 1.63
Transcriptional activation by p53, but not induction of the p21 gene, is essential for oncogene-mediated apoptosis. EMBO J (1996) 1.61
p21 is a critical CDK2 regulator essential for proliferation control in Rb-deficient cells. J Cell Biol (1998) 1.59
DR5 knockout mice are compromised in radiation-induced apoptosis. Mol Cell Biol (2005) 1.55
Ultraviolet radiation triggers apoptosis of fibroblasts and skin keratinocytes mainly via the BH3-only protein Noxa. J Cell Biol (2007) 1.53
Gadd45a suppresses Ras-driven mammary tumorigenesis by activation of c-Jun NH2-terminal kinase and p38 stress signaling resulting in apoptosis and senescence. Cancer Res (2006) 1.49
Cooperative regulation of p53 by modulation of ternary complex formation with CBP/p300 and HDM2. Proc Natl Acad Sci U S A (2009) 1.48
Role of p53 serine 46 in p53 target gene regulation. PLoS One (2011) 1.48
Bax involvement in p53-mediated neuronal cell death. J Neurosci (1998) 1.48
TRAIL-R deficiency in mice promotes susceptibility to chronic inflammation and tumorigenesis. J Clin Invest (2008) 1.41
p21 delays tumor onset by preservation of chromosomal stability. Proc Natl Acad Sci U S A (2006) 1.41
Enhanced and accelerated lymphoproliferation in Fas-null mice. Proc Natl Acad Sci U S A (1996) 1.40
Loss of oncogenic H-ras-induced cell cycle arrest and p38 mitogen-activated protein kinase activation by disruption of Gadd45a. Mol Cell Biol (2003) 1.38
Atm and Bax cooperate in ionizing radiation-induced apoptosis in the central nervous system. Proc Natl Acad Sci U S A (2000) 1.35
Definition of a p53 transactivation function-deficient mutant and characterization of two independent p53 transactivation subdomains. Oncogene (1999) 1.26
BH3-only proapoptotic Bcl-2 family members Noxa and Puma mediate neural precursor cell death. J Neurosci (2006) 1.24
Uncoupling between phenotypic senescence and cell cycle arrest in aging p21-deficient fibroblasts. Mol Cell Biol (2000) 1.24
Tumor suppression by p27Kip1 and p21Cip1 during chemically induced skin carcinogenesis. Oncogene (1999) 1.23
Heterozygosity of p21WAF1/CIP1 enhances tumor cell proliferation and cyclin D1-associated kinase activity in a murine mammary cancer model. Cell Growth Differ (1999) 1.16
Specific requirement for Bax, not Bak, in Myc-induced apoptosis and tumor suppression in vivo. J Biol Chem (2006) 1.16
Timed somatic deletion of p53 in mice reveals age-associated differences in tumor progression. PLoS One (2009) 1.15
Probing p53 biological functions through the use of genetically engineered mouse models. Mutat Res (2005) 1.14
Bax accelerates tumorigenesis in p53-deficient mice. Cancer Res (2001) 1.13
Damage-induced apoptosis in intestinal epithelia from bcl-2-null and bax-null mice: investigations of the mechanistic determinants of epithelial apoptosis in vivo. Oncogene (1999) 1.13
Gadd45a functions as a promoter or suppressor of breast cancer dependent on the oncogenic stress. Cancer Res (2010) 1.12
Perp is a mediator of p53-dependent apoptosis in diverse cell types. Curr Biol (2003) 1.11
DNA damage- and stress-induced apoptosis occurs independently of PIDD. Apoptosis (2009) 1.05
Loss of the p53/p63 regulated desmosomal protein Perp promotes tumorigenesis. PLoS Genet (2010) 1.04
p21Cip1 nullizygosity increases tumor metastasis in irradiated mice. Cancer Res (2003) 1.03
Loss of p21WAF1/CIP1 accelerates Ras oncogenesis in a transgenic/knockout mammary cancer model. Oncogene (2000) 1.02
G1 checkpoint failure and increased tumor susceptibility in mice lacking the novel p53 target Ptprv. EMBO J (2005) 0.99
Full p53 transcriptional activation potential is dispensable for tumor suppression in diverse lineages. Proc Natl Acad Sci U S A (2011) 0.95
Evidence for involvement of Bax and p53, but not caspases, in radiation-induced cell death of cultured postnatal hippocampal neurons. J Neurosci Res (1998) 0.95
Fas/CD95 deficiency in ApcMin/+ mice increases intestinal tumor burden. PLoS One (2010) 0.93
p21 loss blocks senescence following Apc loss and provokes tumourigenesis in the renal but not the intestinal epithelium. EMBO Mol Med (2010) 0.91
CD95 (Fas/APO-1) and p53 signal apoptosis independently in diverse cell types. Cancer Res (2000) 0.86
A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response. Cell (2010) 12.27
Distinct p53 transcriptional programs dictate acute DNA-damage responses and tumor suppression. Cell (2011) 4.74
The role of apoptosis in cancer development and treatment response. Nat Rev Cancer (2005) 4.19
Ribosomal mutations cause p53-mediated dark skin and pleiotropic effects. Nat Genet (2008) 4.02
The p53QS transactivation-deficient mutant shows stress-specific apoptotic activity and induces embryonic lethality. Nat Genet (2005) 2.66
Perp is a p63-regulated gene essential for epithelial integrity. Cell (2005) 2.58
Developmental context determines latency of MYC-induced tumorigenesis. PLoS Biol (2004) 2.05
Global genomic profiling reveals an extensive p53-regulated autophagy program contributing to key p53 responses. Genes Dev (2013) 1.88
p53 at a glance. J Cell Sci (2010) 1.88
The metastasis-associated gene Prl-3 is a p53 target involved in cell-cycle regulation. Mol Cell (2008) 1.88
Increased sensitivity to UV radiation in mice with a p53 point mutation at Ser389. Mol Cell Biol (2004) 1.44
Loss of the desmosomal protein perp enhances the phenotypic effects of pemphigus vulgaris autoantibodies. J Invest Dermatol (2009) 1.44
Genome-wide analysis of p53 under hypoxic conditions. Mol Cell Biol (2006) 1.37
Desmosomes: new perpetrators in tumour suppression. Nat Rev Cancer (2011) 1.33
Pathways connecting telomeres and p53 in senescence, apoptosis, and cancer. Biochem Biophys Res Commun (2005) 1.20
In vivo analysis of p53 tumor suppressor function using genetically engineered mouse models. Carcinogenesis (2010) 1.14
Multiple response elements and differential p53 binding control Perp expression during apoptosis. Mol Cancer Res (2003) 1.11
Perp is a mediator of p53-dependent apoptosis in diverse cell types. Curr Biol (2003) 1.11
Knockin mice expressing a chimeric p53 protein reveal mechanistic differences in how p53 triggers apoptosis and senescence. Proc Natl Acad Sci U S A (2008) 1.05
Loss of the p53/p63 regulated desmosomal protein Perp promotes tumorigenesis. PLoS Genet (2010) 1.04
Dominant-negative but not gain-of-function effects of a p53.R270H mutation in mouse epithelium tissue after DNA damage. Cancer Res (2007) 1.01
Full p53 transcriptional activation potential is dispensable for tumor suppression in diverse lineages. Proc Natl Acad Sci U S A (2011) 0.95
International Research Symposium on Ankyloblepharon-Ectodermal Defects-Cleft Lip/Palate (AEC) syndrome. Am J Med Genet A (2009) 0.94
Perp-etrating p53-dependent apoptosis. Cell Cycle (2004) 0.90
Deficiency of the p53/p63 target Perp alters mammary gland homeostasis and promotes cancer. Breast Cancer Res (2012) 0.90
A new Perp in the lineup: linking p63 and desmosomal adhesion. Cell Cycle (2005) 0.90
Mice lacking the p53/p63 target gene Perp are resistant to papilloma development. Cancer Res (2005) 0.90
PERP regulates enamel formation via effects on cell-cell adhesion and gene expression. J Cell Sci (2011) 0.89
p63, cell adhesion and survival. Cell Cycle (2007) 0.88
Conquering the complexity of p53. Nat Genet (2004) 0.85
Differential PERP regulation by TP63 mutants provides insight into AEC pathogenesis. Am J Med Genet A (2009) 0.84
SKP-ing TAp63: stem cell depletion, senescence, and premature aging. Cell Stem Cell (2009) 0.84
Unimpaired skin carcinogenesis in Desmoglein 3 knockout mice. PLoS One (2012) 0.82
TRP53 activates a global autophagy program to promote tumor suppression. Autophagy (2013) 0.80
Engaging the p53 metabolic brake drives senescence. Cell Res (2013) 0.80
Tumor suppression: p53 alters immune surveillance to restrain liver cancer. Curr Biol (2013) 0.80
The requirement for perp in postnatal viability and epithelial integrity reflects an intrinsic role in stratified epithelia. J Invest Dermatol (2006) 0.79
Analysis of p53 transactivation domain mutants reveals Acad11 as a metabolic target important for p53 pro-survival function. Cell Rep (2015) 0.78
Loss of the desmosomal component perp impairs wound healing in vivo. Dermatol Res Pract (2010) 0.78
p53QS: an old mutant teaches us new tricks. Cell Cycle (2005) 0.78
Guilty as CHARGED: p53's expanding role in disease. Cell Cycle (2014) 0.77
Loss of the p53/p63 target PERP is an early event in oral carcinogenesis and correlates with higher rate of local relapse. Oral Surg Oral Med Oral Pathol Oral Radiol (2013) 0.76
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