Published in Breast Cancer Res on April 20, 2012
Structure, function, and regulation of desmosomes. Prog Mol Biol Transl Sci (2013) 1.00
The Pro allele of the p53 codon 72 polymorphism is associated with decreased intratumoral expression of BAX and p21, and increased breast cancer risk. PLoS One (2012) 0.94
Caspase-1 is a novel target of p63 in tumor suppression. Cell Death Dis (2013) 0.93
Downregulation of Hlx closely related to the decreased expressions of T-bet and Runx3 in patients with gastric cancer may be associated with a pathological event leading to the imbalance of Th1/Th2. Clin Dev Immunol (2012) 0.87
Desmosomes in acquired disease. Cell Tissue Res (2015) 0.83
ErbB2-dependent downregulation of a pro-apoptotic protein Perp is required for oncogenic transformation of breast epithelial cells. Oncogene (2016) 0.78
Transmembrane protein PERP is a component of tessellate junctions and of other junctional and non-junctional plasma membrane regions in diverse epithelial and epithelium-derived cells. Cell Tissue Res (2013) 0.77
Loss of the p53/p63 target PERP is an early event in oral carcinogenesis and correlates with higher rate of local relapse. Oral Surg Oral Med Oral Pathol Oral Radiol (2013) 0.76
Transcriptomic comparison of primary bovine horn core carcinoma culture and parental tissue at early stage. Vet World (2017) 0.75
Elucidating the Role of the Desmosome Protein p53 Apoptosis Effector Related to PMP-22 (PERP) in Growth Hormone Tumors. Endocrinology (2017) 0.75
A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes. Cancer Cell (2006) 27.36
p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development. Nature (1999) 14.38
p63 is a p53 homologue required for limb and epidermal morphogenesis. Nature (1999) 13.21
Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer. Nat Genet (2001) 9.55
Modelling glandular epithelial cancers in three-dimensional cultures. Nat Rev Cancer (2005) 8.70
CD4(+) T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages. Cancer Cell (2009) 8.54
The magical touch: genome targeting in epidermal stem cells induced by tamoxifen application to mouse skin. Proc Natl Acad Sci U S A (1999) 7.67
Macrophages regulate the angiogenic switch in a mouse model of breast cancer. Cancer Res (2006) 6.52
p63 is the molecular switch for initiation of an epithelial stratification program. Genes Dev (2004) 6.40
Somatic inactivation of E-cadherin and p53 in mice leads to metastatic lobular mammary carcinoma through induction of anoikis resistance and angiogenesis. Cancer Cell (2006) 4.15
Inflammation and breast cancer. Balancing immune response: crosstalk between adaptive and innate immune cells during breast cancer progression. Breast Cancer Res (2007) 3.76
Targeted expression of stromelysin-1 in mammary gland provides evidence for a role of proteinases in branching morphogenesis and the requirement for an intact basement membrane for tissue-specific gene expression. J Cell Biol (1994) 3.68
The cadherin-catenin adhesion system in signaling and cancer. J Clin Invest (2002) 3.23
Tumor-associated macrophages in breast cancer. J Mammary Gland Biol Neoplasia (2002) 2.90
Desmosomes: new perspectives on a classic. J Invest Dermatol (2007) 2.78
Perp is a p63-regulated gene essential for epithelial integrity. Cell (2005) 2.58
PERP, an apoptosis-associated target of p53, is a novel member of the PMP-22/gas3 family. Genes Dev (2000) 2.33
High-throughput tissue microarray analysis used to evaluate biology and prognostic significance of the E-cadherin pathway in non-small-cell lung cancer. J Clin Oncol (2002) 2.33
Desmosomal adhesion regulates epithelial morphogenesis and cell positioning. Nat Cell Biol (2001) 2.10
The MAPK(ERK-1,2) pathway integrates distinct and antagonistic signals from TGFalpha and FGF7 in morphogenesis of mouse mammary epithelium. Dev Biol (2007) 1.98
Cell contacts in the mouse mammary gland. I. Normal gland in postnatal development and the secretory cycle. J Cell Biol (1973) 1.91
The estrogen-dependent c-JunER protein causes a reversible loss of mammary epithelial cell polarity involving a destabilization of adherens junctions. J Cell Biol (1996) 1.79
Beta-catenin and Tcfs in mammary development and cancer. J Mammary Gland Biol Neoplasia (2003) 1.68
Myoepithelial cells: good fences make good neighbors. Breast Cancer Res (2005) 1.66
Loss of the desmosomal protein perp enhances the phenotypic effects of pemphigus vulgaris autoantibodies. J Invest Dermatol (2009) 1.44
Monoclonal antibody mapping of keratins 8 and 17 and of vimentin in normal human mammary gland, benign tumors, dysplasias and breast cancer. Int J Cancer (1988) 1.43
A beta-catenin survival signal is required for normal lobular development in the mammary gland. J Cell Sci (2003) 1.34
Desmosomes: new perpetrators in tumour suppression. Nat Rev Cancer (2011) 1.33
Gene expression profiling of localized esophageal carcinomas: association with pathologic response to preoperative chemoradiation. J Clin Oncol (2005) 1.30
E-cadherin expression in bladder cancer using formalin-fixed, paraffin-embedded tissues: correlation with histopathological grade, tumour stage and survival. Int J Cancer (1995) 1.25
Extracellular matrix composition reveals complex and dynamic stromal-epithelial interactions in the mammary gland. J Mammary Gland Biol Neoplasia (2010) 1.23
Specific demonstration of myoepithelial cells by anti-alpha smooth muscle actin antibody. J Histochem Cytochem (1988) 1.22
Downregulation and abnormal expression of E-cadherin and beta-catenin in nasopharyngeal carcinoma: close association with advanced disease stage and lymph node metastasis. Hum Pathol (1999) 1.20
Loss of heterozygosity on the long arm of chromosome 6 in breast cancer: possibly four regions of deletion. Clin Cancer Res (1996) 1.19
E-cadherin expression in invasive non-lobular carcinoma of the breast and its prognostic significance. Histopathology (2005) 1.17
In vivo function of desmosomes. J Dermatol (2004) 1.12
Self-organization is a dynamic and lineage-intrinsic property of mammary epithelial cells. Proc Natl Acad Sci U S A (2011) 1.11
Environment, inflammation, and cancer. Curr Opin Genet Dev (2010) 1.06
Loss of the p53/p63 regulated desmosomal protein Perp promotes tumorigenesis. PLoS Genet (2010) 1.04
Desmosomes and disease: an update. Histol Histopathol (2002) 1.00
Changes in adhesive properties of epithelial cells during early morphogenesis of the mammary gland. Dev Growth Differ (2001) 0.97
Down-regulation of the desmosomal cadherin desmocollin 3 in human breast cancer. Int J Oncol (2001) 0.96
Genetic deletion of the desmosomal component desmoplakin promotes tumor microinvasion in a mouse model of pancreatic neuroendocrine carcinogenesis. PLoS Genet (2010) 0.96
Genetic manipulation of mammary epithelium by transplantation. J Mammary Gland Biol Neoplasia (1996) 0.96
Reduced p120ctn expression correlates with poor survival in patients with adenocarcinoma of the gastroesophageal junction. J Surg Oncol (2005) 0.94
Biogenesis and function of mouse mammary epithelium depends on the presence of functional alpha-catenin. Mech Dev (2004) 0.94
Molecular aspects of early stages of breast cancer progression. J Cell Biochem Suppl (1993) 0.91
Identification of THW, a putative new tumor suppressor gene. Anticancer Res (2000) 0.87
Expression of p53-induced apoptosis effector PERP in primary uveal melanomas: downregulation is associated with aggressive type. Exp Eye Res (2006) 0.87
The immunohistochemical expression of desmoplakin and its role in vivo in the progression and metastasis of breast cancer. Eur J Cancer (1999) 0.84
A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response. Cell (2010) 12.27
Three-dimensional culture models of normal and malignant breast epithelial cells. Nat Methods (2007) 7.43
Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability. Nature (2005) 7.24
Of extracellular matrix, scaffolds, and signaling: tissue architecture regulates development, homeostasis, and cancer. Annu Rev Cell Dev Biol (2006) 6.64
Isolation, immortalization, and characterization of a human breast epithelial cell line with stem cell properties. Genes Dev (2002) 6.55
The morphologies of breast cancer cell lines in three-dimensional assays correlate with their profiles of gene expression. Mol Oncol (2007) 5.81
Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin. Proc Natl Acad Sci U S A (2006) 5.78
MYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancer. Nature (2004) 5.61
beta4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium. Cancer Cell (2002) 5.56
Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery. Proc Natl Acad Sci U S A (2008) 4.97
CHD5 is a tumor suppressor at human 1p36. Cell (2007) 4.90
Mosaic analysis with double markers reveals tumor cell of origin in glioma. Cell (2011) 4.78
Distinct p53 transcriptional programs dictate acute DNA-damage responses and tumor suppression. Cell (2011) 4.74
Regulation of in situ to invasive breast carcinoma transition. Cancer Cell (2008) 4.46
Normal and tumor-derived myoepithelial cells differ in their ability to interact with luminal breast epithelial cells for polarity and basement membrane deposition. J Cell Sci (2002) 4.25
The role of apoptosis in cancer development and treatment response. Nat Rev Cancer (2005) 4.19
RECQL5/Recql5 helicase regulates homologous recombination and suppresses tumor formation via disruption of Rad51 presynaptic filaments. Genes Dev (2007) 4.16
Tissue geometry determines sites of mammary branching morphogenesis in organotypic cultures. Science (2006) 4.12
Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway. Cell (2012) 4.09
Ribosomal mutations cause p53-mediated dark skin and pleiotropic effects. Nat Genet (2008) 4.02
NFKBIA deletion in glioblastomas. N Engl J Med (2010) 3.96
Evidence for a stem cell hierarchy in the adult human breast. J Cell Biol (2007) 3.76
Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice. J Clin Invest (2010) 3.74
Modeling tissue-specific signaling and organ function in three dimensions. J Cell Sci (2003) 3.52
Phenotypic reversion or death of cancer cells by altering signaling pathways in three-dimensional contexts. J Natl Cancer Inst (2002) 3.39
The perivascular niche regulates breast tumour dormancy. Nat Cell Biol (2013) 3.36
Transcriptional profiling of aging in human muscle reveals a common aging signature. PLoS Genet (2006) 3.34
Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibition. Cancer Res (2009) 3.14
Regulation of mammary gland branching morphogenesis by the extracellular matrix and its remodeling enzymes. Breast Cancer Res (2003) 3.13
Neuronal activity promotes oligodendrogenesis and adaptive myelination in the mammalian brain. Science (2014) 3.11
Tumor reversion: correction of malignant behavior by microenvironmental cues. Int J Cancer (2003) 3.02
p63 deficiency activates a program of cellular senescence and leads to accelerated aging. Genes Dev (2005) 3.02
Polarity and proliferation are controlled by distinct signaling pathways downstream of PI3-kinase in breast epithelial tumor cells. J Cell Biol (2004) 2.93
Beta1 integrin inhibitory antibody induces apoptosis of breast cancer cells, inhibits growth, and distinguishes malignant from normal phenotype in three dimensional cultures and in vivo. Cancer Res (2006) 2.86
A network model of a cooperative genetic landscape in brain tumors. JAMA (2009) 2.86
Site-specific inductive and inhibitory activities of MMP-2 and MMP-3 orchestrate mammary gland branching morphogenesis. J Cell Biol (2003) 2.68
The p53QS transactivation-deficient mutant shows stress-specific apoptotic activity and induces embryonic lethality. Nat Genet (2005) 2.66
Imaging tumor-stroma interactions during chemotherapy reveals contributions of the microenvironment to resistance. Cancer Cell (2012) 2.61
MYC suppresses cancer metastasis by direct transcriptional silencing of αv and β3 integrin subunits. Nat Cell Biol (2012) 2.61
Perp is a p63-regulated gene essential for epithelial integrity. Cell (2005) 2.58
Functional network analysis reveals extended gliomagenesis pathway maps and three novel MYC-interacting genes in human gliomas. Cancer Res (2005) 2.54
Modeling dynamic reciprocity: engineering three-dimensional culture models of breast architecture, function, and neoplastic transformation. Semin Cancer Biol (2005) 2.53
Unraveling the microenvironmental influences on the normal mammary gland and breast cancer. Semin Cancer Biol (2008) 2.41
Mechanism of Akt1 inhibition of breast cancer cell invasion reveals a protumorigenic role for TSC2. Proc Natl Acad Sci U S A (2006) 2.41
A mutation in TGFB3 associated with a syndrome of low muscle mass, growth retardation, distal arthrogryposis and clinical features overlapping with Marfan and Loeys-Dietz syndrome. Am J Med Genet A (2013) 2.35
HER2 signaling pathway activation and response of breast cancer cells to HER2-targeting agents is dependent strongly on the 3D microenvironment. Breast Cancer Res Treat (2009) 2.34
Fibrosis and cancer: do myofibroblasts come also from epithelial cells via EMT? J Cell Biochem (2007) 2.32
Targeting TACE-dependent EGFR ligand shedding in breast cancer. J Clin Invest (2007) 2.29
Mechanisms of disease: epithelial-mesenchymal transition--does cellular plasticity fuel neoplastic progression? Nat Clin Pract Oncol (2008) 2.18
Wnt-mediated self-renewal of neural stem/progenitor cells. Proc Natl Acad Sci U S A (2008) 2.15
TAp63 induces senescence and suppresses tumorigenesis in vivo. Nat Cell Biol (2009) 2.15
Prognostic breast cancer signature identified from 3D culture model accurately predicts clinical outcome across independent datasets. PLoS One (2008) 2.12
Embryonic stem cell immunogenicity increases upon differentiation after transplantation into ischemic myocardium. Circulation (2005) 2.12
Nkx3.1; Pten mutant mice develop invasive prostate adenocarcinoma and lymph node metastases. Cancer Res (2003) 2.11
High-resolution genome-wide mapping of genetic alterations in human glial brain tumors. Cancer Res (2005) 2.10
Epithelial to mesenchymal transition in human breast cancer can provide a nonmalignant stroma. Am J Pathol (2003) 2.06
Developmental context determines latency of MYC-induced tumorigenesis. PLoS Biol (2004) 2.05
A serum glycomics approach to breast cancer biomarkers. Mol Cell Proteomics (2006) 2.03
The MAPK(ERK-1,2) pathway integrates distinct and antagonistic signals from TGFalpha and FGF7 in morphogenesis of mouse mammary epithelium. Dev Biol (2007) 1.98
Late profound muscle weakness following heart transplantation due to Danon disease. Muscle Nerve (2012) 1.97
Clinical spectrum, morbidity, and mortality in 113 pediatric patients with mitochondrial disease. Pediatrics (2004) 1.95
Tissue architecture and function: dynamic reciprocity via extra- and intra-cellular matrices. Cancer Metastasis Rev (2009) 1.93
Myoepithelial cells: their origin and function in breast morphogenesis and neoplasia. J Mammary Gland Biol Neoplasia (2005) 1.92
Siah2-dependent concerted activity of HIF and FoxA2 regulates formation of neuroendocrine phenotype and neuroendocrine prostate tumors. Cancer Cell (2010) 1.88
Global genomic profiling reveals an extensive p53-regulated autophagy program contributing to key p53 responses. Genes Dev (2013) 1.88
p53 at a glance. J Cell Sci (2010) 1.88
The metastasis-associated gene Prl-3 is a p53 target involved in cell-cycle regulation. Mol Cell (2008) 1.88
Hedgehog-responsive candidate cell of origin for diffuse intrinsic pontine glioma. Proc Natl Acad Sci U S A (2011) 1.86
Beta1 integrin inhibition dramatically enhances radiotherapy efficacy in human breast cancer xenografts. Cancer Res (2008) 1.83
Human mammary progenitor cell fate decisions are products of interactions with combinatorial microenvironments. Integr Biol (Camb) (2008) 1.82
Dosage-dependent phenotypes in models of 16p11.2 lesions found in autism. Proc Natl Acad Sci U S A (2011) 1.82
The hyaluronan receptors CD44 and Rhamm (CD168) form complexes with ERK1,2 that sustain high basal motility in breast cancer cells. J Biol Chem (2007) 1.82
p21 is a prognostic marker for renal cell carcinoma: implications for novel therapeutic approaches. J Urol (2007) 1.81
Monosomy of chromosome 10 associated with dysregulation of epidermal growth factor signaling in glioblastomas. JAMA (2009) 1.81
A human breast cell model of preinvasive to invasive transition. Cancer Res (2008) 1.79
The tumor microenvironment is a dominant force in multidrug resistance. Drug Resist Updat (2012) 1.77
ΔNp63α is an oncogene that targets chromatin remodeler Lsh to drive skin stem cell proliferation and tumorigenesis. Cell Stem Cell (2011) 1.75
Laminin and biomimetic extracellular elasticity enhance functional differentiation in mammary epithelia. EMBO J (2008) 1.74
Notch signaling inhibits hepatocellular carcinoma following inactivation of the RB pathway. J Exp Med (2011) 1.74
The dominance of the microenvironment in breast and ovarian cancer. Semin Cancer Biol (2002) 1.73
Targeting the tumor microenvironment. Front Biosci (2007) 1.72
Gene expression signature in organized and growth-arrested mammary acini predicts good outcome in breast cancer. Cancer Res (2006) 1.69
Initial characterization of a dedicated breast PET/CT scanner during human imaging. J Nucl Med (2009) 1.68
Drosophila models of neurodegenerative diseases. Annu Rev Pathol (2009) 1.67
Defective sister-chromatid cohesion, aneuploidy and cancer predisposition in a mouse model of type II Rothmund-Thomson syndrome. Hum Mol Genet (2005) 1.67
Myoepithelial cells: good fences make good neighbors. Breast Cancer Res (2005) 1.66
Novel homoplasmic mutation in the mitochondrial tRNATyr gene associated with atypical mitochondrial cytopathy presenting with focal segmental glomerulosclerosis. Am J Med Genet A (2003) 1.66
Deletion of Ku70, Ku80, or both causes early aging without substantially increased cancer. Mol Cell Biol (2007) 1.65
A role for dystroglycan in epithelial polarization: loss of function in breast tumor cells. Cancer Res (2002) 1.65
Impaired human hippocampal neurogenesis after treatment for central nervous system malignancies. Ann Neurol (2007) 1.64
Cell shape regulates global histone acetylation in human mammary epithelial cells. Exp Cell Res (2007) 1.64
High-mannose glycans are elevated during breast cancer progression. Mol Cell Proteomics (2010) 1.63
Sphingosine-1-phosphate lyase potentiates apoptosis via p53- and p38-dependent pathways and is down-regulated in colon cancer. Proc Natl Acad Sci U S A (2006) 1.63
Hematopoietic cells maintain hematopoietic fates upon entering the brain. J Exp Med (2005) 1.63
Deconstructing p53 transcriptional networks in tumor suppression. Trends Cell Biol (2011) 1.62
Cancer. Respect thy neighbor! Science (2004) 1.62
Ionizing radiation predisposes nonmalignant human mammary epithelial cells to undergo transforming growth factor beta induced epithelial to mesenchymal transition. Cancer Res (2007) 1.60
Breast cancer by proxy: can the microenvironment be both the cause and consequence? Trends Mol Med (2008) 1.60