Published in Nature on March 14, 2007
Real-time observation of transcription initiation and elongation on an endogenous yeast gene. Science (2011) 3.67
Nucleosomal fluctuations govern the transcription dynamics of RNA polymerase II. Science (2009) 3.60
High-resolution dynamic mapping of histone-DNA interactions in a nucleosome. Nat Struct Mol Biol (2009) 2.74
Genetic variability of human respiratory syncytial virus A strains circulating in Ontario: a novel genotype with a 72 nucleotide G gene duplication. PLoS One (2012) 2.21
RNA polymerase active center: the molecular engine of transcription. Annu Rev Biochem (2009) 1.94
Mechanism of sequence-specific pausing of bacterial RNA polymerase. Proc Natl Acad Sci U S A (2009) 1.92
Single-molecule studies of RNA polymerase: motoring along. Annu Rev Biochem (2008) 1.80
Revisiting the central dogma one molecule at a time. Cell (2011) 1.75
Extensive relationship between antisense transcription and alternative splicing in the human genome. Genome Res (2011) 1.69
Single-molecule tracking of the transcription cycle by sub-second RNA detection. Elife (2014) 1.67
Single-molecule tracking of mRNA exiting from RNA polymerase II. Proc Natl Acad Sci U S A (2007) 1.59
Evidence that transcript cleavage is essential for RNA polymerase II transcription and cell viability. Mol Cell (2010) 1.55
Trigger loop dynamics mediate the balance between the transcriptional fidelity and speed of RNA polymerase II. Proc Natl Acad Sci U S A (2012) 1.51
The origin of short transcriptional pauses. Biophys J (2009) 1.47
Nucleosomal elements that control the topography of the barrier to transcription. Cell (2012) 1.46
A single-molecule platform for investigation of interactions between G-quadruplexes and small-molecule ligands. Nat Chem (2011) 1.43
Synergistic action of RNA polymerases in overcoming the nucleosomal barrier. Nat Struct Mol Biol (2010) 1.43
H2A.Z nucleosomes enriched over active genes are homotypic. Nat Struct Mol Biol (2010) 1.41
Fluctuations, pauses, and backtracking in DNA transcription. Biophys J (2007) 1.34
Thermal probing of E. coli RNA polymerase off-pathway mechanisms. J Mol Biol (2008) 1.29
Transcriptional pausing without backtracking. Proc Natl Acad Sci U S A (2009) 1.27
RNA transcript 3'-proximal sequence affects translocation bias of RNA polymerase. Biochemistry (2011) 1.26
Fast transcription rates of RNA polymerase II in human cells. EMBO Rep (2011) 1.24
The RSC chromatin remodelling ATPase translocates DNA with high force and small step size. EMBO J (2011) 1.24
Optical tweezers study life under tension. Nat Photonics (2011) 1.22
Single-molecule studies of RNA polymerase: one singular sensation, every little step it takes. Mol Cell (2011) 1.21
Biological mechanisms, one molecule at a time. Genes Dev (2011) 1.19
Elongation dynamics shape bursty transcription and translation. Proc Natl Acad Sci U S A (2009) 1.16
Complete dissection of transcription elongation reveals slow translocation of RNA polymerase II in a linear ratchet mechanism. Elife (2013) 1.14
Torque modulates nucleosome stability and facilitates H2A/H2B dimer loss. Nat Commun (2013) 1.07
Nascent RNA structure modulates the transcriptional dynamics of RNA polymerases. Proc Natl Acad Sci U S A (2012) 1.06
Real-time observation of the initiation of RNA polymerase II transcription. Nature (2015) 1.04
Studying genomic processes at the single-molecule level: introducing the tools and applications. Nat Rev Genet (2012) 1.02
A unified model of transcription elongation: what have we learned from single-molecule experiments? Biophys J (2011) 1.00
Coexistence of an ILPR i-motif and a partially folded structure with comparable mechanical stability revealed at the single-molecule level. J Am Chem Soc (2010) 0.99
Crucial role of dynamic linker histone binding and divalent ions for DNA accessibility and gene regulation revealed by mesoscale modeling of oligonucleosomes. Nucleic Acids Res (2012) 0.99
Molecular mechanisms of transcription through single-molecule experiments. Chem Rev (2014) 0.98
Applied force provides insight into transcriptional pausing and its modulation by transcription factor NusA. Mol Cell (2011) 0.97
Structural and mechanical properties of individual human telomeric G-quadruplexes in molecularly crowded solutions. Nucleic Acids Res (2013) 0.96
Control and signal processing by transcriptional interference. Mol Syst Biol (2009) 0.94
Displacement-weighted velocity analysis of gliding assays reveals that Chlamydomonas axonemal dynein preferentially moves conspecific microtubules. Biophys J (2013) 0.94
Single molecule transcription elongation. Methods (2009) 0.94
G-quadruplex and i-motif are mutually exclusive in ILPR double-stranded DNA. Biophys J (2012) 0.91
Single-molecule studies of transcription: from one RNA polymerase at a time to the gene expression profile of a cell. J Mol Biol (2011) 0.91
Transcription factors IIS and IIF enhance transcription efficiency by differentially modifying RNA polymerase pausing dynamics. Proc Natl Acad Sci U S A (2014) 0.89
The effect of linker histone's nucleosome binding affinity on chromatin unfolding mechanisms. Biophys J (2011) 0.89
Transcription factors TFIIF and TFIIS promote transcript elongation by RNA polymerase II by synergistic and independent mechanisms. Proc Natl Acad Sci U S A (2014) 0.88
Coliphage HK022 Nun protein inhibits RNA polymerase translocation. Proc Natl Acad Sci U S A (2014) 0.88
DNA sequences in gal operon override transcription elongation blocks. J Mol Biol (2008) 0.88
Reversible and controllable nanolocomotion of an RNA-processing machinery. Nano Lett (2010) 0.88
DNA supercoiling: a regulatory signal for the λ repressor. Proc Natl Acad Sci U S A (2014) 0.87
A Two-Way Street: Regulatory Interplay between RNA Polymerase and Nascent RNA Structure. Trends Biochem Sci (2016) 0.86
TFIIS is required for the balanced expression of the genes encoding ribosomal components under transcriptional stress. Nucleic Acids Res (2012) 0.86
Efficient reconstitution of transcription elongation complexes for single-molecule studies of eukaryotic RNA polymerase II. Transcription (2012) 0.85
Mechanisms of backtrack recovery by RNA polymerases I and II. Proc Natl Acad Sci U S A (2016) 0.84
I. VH gene transcription creates stabilized secondary structures for coordinated mutagenesis during somatic hypermutation. Mol Immunol (2008) 0.83
Changes in RNA polymerase II progression influence somatic hypermutation of Ig-related genes by AID. J Exp Med (2013) 0.83
Interplay between DNA supercoiling and transcription elongation. Transcription (2014) 0.83
Trigger loop folding determines transcription rate of Escherichia coli's RNA polymerase. Proc Natl Acad Sci U S A (2014) 0.83
A small post-translocation energy bias aids nucleotide selection in T7 RNA polymerase transcription. Biophys J (2012) 0.82
A look-ahead model for the elongation dynamics of transcription. Biophys J (2009) 0.82
High-resolution optical tweezers for single-molecule manipulation. Yale J Biol Med (2013) 0.80
Single-molecule studies of RNAPII elongation. Biochim Biophys Acta (2012) 0.80
DNA bridging and looping by HMO1 provides a mechanism for stabilizing nucleosome-free chromatin. Nucleic Acids Res (2014) 0.80
Intramolecular folding in human ILPR fragment with three C-rich repeats. PLoS One (2012) 0.79
Single molecule microscopy reveals mechanistic insight into RNA polymerase II preinitiation complex assembly and transcriptional activity. Nucleic Acids Res (2016) 0.79
Role of forward translocation in nucleoside triphosphate phosphohydrolase I (NPH I)-mediated transcription termination of vaccinia virus early genes. J Biol Chem (2011) 0.77
A traffic flow model for bio-polymerization processes. J Math Biol (2013) 0.77
Nascent RNA transcripts facilitate the formation of G-quadruplexes. Nucleic Acids Res (2014) 0.77
PHD and TFIIS-Like domains of the Bye1 transcription factor determine its multivalent genomic distribution. PLoS One (2014) 0.77
What have single-molecule studies taught us about gene expression? Genes Dev (2016) 0.76
Eeny meeny miny moe, catch a transcript by the toe, or how to enumerate eukaryotic transcripts. Genes Dev (2012) 0.75
On the move. Elife (2013) 0.75
Single molecule studies of RNA polymerase II transcription in vitro. Transcription (2014) 0.75
Single-molecule studies of high-mobility group B architectural DNA bending proteins. Biophys Rev (2016) 0.75
Dangerous play--splitting the message may leave you empty handed. Nat Struct Mol Biol (2009) 0.75
A systems view of the protein expression process. Syst Synth Biol (2011) 0.75
Conformational selection and induced fit as a useful framework for molecular motor mechanisms. Biophys Chem (2017) 0.75
Stochastic Kinetics of Nascent RNA. Phys Rev Lett (2016) 0.75
Backtracking behavior in viral RNA-dependent RNA polymerase provides the basis for a second initiation site. Nucleic Acids Res (2015) 0.75
Nucleosome mobility and the regulation of gene expression: Insights from single-molecule studies. Protein Sci (2017) 0.75
Nucleosomal arrangement affects single-molecule transcription dynamics. Proc Natl Acad Sci U S A (2016) 0.75
Dynamics of GreB-RNA polymerase interaction allow a proofreading accessory protein to patrol for transcription complexes needing rescue. Proc Natl Acad Sci U S A (2017) 0.75
A scan for positively selected genes in the genomes of humans and chimpanzees. PLoS Biol (2005) 8.32
Genomic scans for selective sweeps using SNP data. Genome Res (2005) 6.43
Equilibrium information from nonequilibrium measurements in an experimental test of Jarzynski's equality. Science (2002) 5.76
CTCF-promoted RNA polymerase II pausing links DNA methylation to splicing. Nature (2011) 5.50
Structures of Cas9 endonucleases reveal RNA-mediated conformational activation. Science (2014) 5.13
Rapid spontaneous accessibility of nucleosomal DNA. Nat Struct Mol Biol (2004) 5.00
Recent and ongoing selection in the human genome. Nat Rev Genet (2007) 4.62
Direct observation of the three-state folding of a single protein molecule. Science (2005) 4.48
Complete subunit architecture of the proteasome regulatory particle. Nature (2012) 4.41
Following translation by single ribosomes one codon at a time. Nature (2008) 4.14
The Dam1 kinetochore ring complex moves processively on depolymerizing microtubule ends. Nature (2006) 4.06
Nucleosome remodeling induced by RNA polymerase II: loss of the H2A/H2B dimer during transcription. Mol Cell (2002) 3.91
Structural roles for human translation factor eIF3 in initiation of protein synthesis. Science (2005) 3.91
Formation of a dynamic kinetochore- microtubule interface through assembly of the Dam1 ring complex. Mol Cell (2005) 3.86
Structural transitions and elasticity from torque measurements on DNA. Nature (2003) 3.71
Direct measure of the de novo mutation rate in autism and schizophrenia cohorts. Am J Hum Genet (2010) 3.69
RNA translocation and unwinding mechanism of HCV NS3 helicase and its coordination by ATP. Nature (2006) 3.67
Nucleosomal fluctuations govern the transcription dynamics of RNA polymerase II. Science (2009) 3.60
Nucleotide-dependent bending flexibility of tubulin regulates microtubule assembly. Nature (2005) 3.54
Structure, function, and activator-induced conformations of the CRSP coactivator. Science (2002) 3.52
Microtubule structure at 8 A resolution. Structure (2002) 3.41
Identifying kinetic barriers to mechanical unfolding of the T. thermophila ribozyme. Science (2003) 3.32
Recent advances in optical tweezers. Annu Rev Biochem (2008) 3.08
The structural basis for MCM2-7 helicase activation by GINS and Cdc45. Nat Struct Mol Biol (2011) 2.93
Intersubunit coordination in a homomeric ring ATPase. Nature (2009) 2.93
The Ndc80 kinetochore complex forms oligomeric arrays along microtubules. Nature (2010) 2.90
Optical-trap force transducer that operates by direct measurement of light momentum. Methods Enzymol (2003) 2.86
Mechanism of force generation of a viral DNA packaging motor. Cell (2005) 2.81
Spindle oscillations during asymmetric cell division require a threshold number of active cortical force generators. Curr Biol (2006) 2.67
Direct binding of Cenp-C to the Mis12 complex joins the inner and outer kinetochore. Curr Biol (2011) 2.62
Nature of the nucleosomal barrier to RNA polymerase II. Mol Cell (2005) 2.55
Differential detection of dual traps improves the spatial resolution of optical tweezers. Proc Natl Acad Sci U S A (2006) 2.48
Translation of polarity cues into asymmetric spindle positioning in Caenorhabditis elegans embryos. Science (2003) 2.46
Saccharomyces cerevisiae septins: supramolecular organization of heterooligomers and the mechanism of filament assembly. Proc Natl Acad Sci U S A (2008) 2.46
Experimental test of connector rotation during DNA packaging into bacteriophage phi29 capsids. PLoS Biol (2007) 2.39
Anisotropies in cortical tension reveal the physical basis of polarizing cortical flows. Nature (2010) 2.39
Genetic architecture of aluminum tolerance in rice (Oryza sativa) determined through genome-wide association analysis and QTL mapping. PLoS Genet (2011) 2.34
Evolutionary history of GS3, a gene conferring grain length in rice. Genetics (2009) 2.33
ClpX(P) generates mechanical force to unfold and translocate its protein substrates. Cell (2011) 2.31
In vitro system capable of differentiating fast Ca2+-triggered content mixing from lipid exchange for mechanistic studies of neurotransmitter release. Proc Natl Acad Sci U S A (2011) 2.27
DNA overwinds when stretched. Nature (2006) 2.27
DNA translocation and loop formation mechanism of chromatin remodeling by SWI/SNF and RSC. Mol Cell (2006) 2.25
Sequence-directed DNA translocation by purified FtsK. Science (2005) 2.22
Transient reversal of RNA polymerase II active site closing controls fidelity of transcription elongation. Mol Cell (2008) 2.21
Structural insights into RNA processing by the human RISC-loading complex. Nat Struct Mol Biol (2009) 2.19
Chirality sensing by Escherichia coli topoisomerase IV and the mechanism of type II topoisomerases. Proc Natl Acad Sci U S A (2003) 2.15
Synaptic proteins promote calcium-triggered fast transition from point contact to full fusion. Elife (2012) 2.04
Effect of force on mononucleosomal dynamics. Proc Natl Acad Sci U S A (2006) 2.03
Human CRSP interacts with RNA polymerase II CTD and adopts a specific CTD-bound conformation. Genes Dev (2002) 2.02
Mechanism of translesion transcription by RNA polymerase II and its role in cellular resistance to DNA damage. Mol Cell (2012) 1.96
Replication of mitochondrial DNA occurs by strand displacement with alternative light-strand origins, not via a strand-coupled mechanism. Genes Dev (2005) 1.94
Mechanism of sequence-specific pausing of bacterial RNA polymerase. Proc Natl Acad Sci U S A (2009) 1.92
Structural visualization of key steps in human transcription initiation. Nature (2013) 1.91
Multiple modes of Escherichia coli DNA gyrase activity revealed by force and torque. Nat Struct Mol Biol (2007) 1.91
The effect of force on thermodynamics and kinetics of single molecule reactions. Biophys Chem (2002) 1.90
Forces driving epithelial spreading in zebrafish gastrulation. Science (2012) 1.89
Recognition of RNA polymerase II and transcription bubbles by XPG, CSB, and TFIIH: insights for transcription-coupled repair and Cockayne Syndrome. Mol Cell (2005) 1.89
Polarization of PAR proteins by advective triggering of a pattern-forming system. Science (2011) 1.88
Probing the mechanical folding kinetics of TAR RNA by hopping, force-jump, and force-ramp methods. Biophys J (2005) 1.86
Shortening of RNA:DNA hybrid in the elongation complex of RNA polymerase is a prerequisite for transcription termination. Mol Cell (2002) 1.83
Retracted The bacterial condensin MukBEF compacts DNA into a repetitive, stable structure. Science (2004) 1.83
Visualizing flexibility at molecular resolution: analysis of heterogeneity in single-particle electron microscopy reconstructions. Annu Rev Biophys Biomol Struct (2007) 1.81
Nucleotide-dependent conformational changes in the DnaA-like core of the origin recognition complex. Nat Struct Mol Biol (2006) 1.80
Architecture of the Dam1 kinetochore ring complex and implications for microtubule-driven assembly and force-coupling mechanisms. Nat Struct Mol Biol (2007) 1.78
Using mechanical force to probe the mechanism of pausing and arrest during continuous elongation by Escherichia coli RNA polymerase. Proc Natl Acad Sci U S A (2002) 1.77
The folding cooperativity of a protein is controlled by its chain topology. Nature (2010) 1.76
Architecture and flexibility of the yeast Ndc80 kinetochore complex. J Mol Biol (2008) 1.75
The ribosome uses two active mechanisms to unwind messenger RNA during translation. Nature (2011) 1.74
The structural basis for regulated assembly and function of the transcriptional activator NtrC. Genes Dev (2006) 1.74
Laminin and biomimetic extracellular elasticity enhance functional differentiation in mammary epithelia. EMBO J (2008) 1.74
Development of a panel of genome-wide ancestry informative markers to study admixture throughout the Americas. PLoS Genet (2012) 1.74
Architecture of the yeast Rrp44 exosome complex suggests routes of RNA recruitment for 3' end processing. Proc Natl Acad Sci U S A (2007) 1.71
Temperature control methods in a laser tweezers system. Biophys J (2005) 1.70
ATP ground- and transition states of bacterial enhancer binding AAA+ ATPases support complex formation with their target protein, sigma54. Structure (2007) 1.69
The orthogonal tilt reconstruction method: an approach to generating single-class volumes with no missing cone for ab initio reconstruction of asymmetric particles. J Struct Biol (2005) 1.69
A revised nomenclature for the human and rodent alpha-tubulin gene family. Genomics (2007) 1.68
Bias and error in estimates of equilibrium free-energy differences from nonequilibrium measurements. Proc Natl Acad Sci U S A (2003) 1.66
Identification of oligonucleotide sequences that direct the movement of the Escherichia coli FtsK translocase. Proc Natl Acad Sci U S A (2005) 1.66
Microtubule dynamics. J Cell Sci (2002) 1.65
Molecular architecture of human polycomb repressive complex 2. Elife (2012) 1.64
Force unfolding kinetics of RNA using optical tweezers. I. Effects of experimental variables on measured results. Biophys J (2007) 1.61
Light-powering Escherichia coli with proteorhodopsin. Proc Natl Acad Sci U S A (2007) 1.59
Proofreading dynamics of a processive DNA polymerase. EMBO J (2009) 1.58
Sequence-directed DNA export guides chromosome translocation during sporulation in Bacillus subtilis. Nat Struct Mol Biol (2008) 1.58
Counting single photoactivatable fluorescent molecules by photoactivated localization microscopy (PALM). Proc Natl Acad Sci U S A (2012) 1.56
Phosphatidylinositol-4,5-bisphosphate promotes budding yeast septin filament assembly and organization. J Mol Biol (2010) 1.53
CasA mediates Cas3-catalyzed target degradation during CRISPR RNA-guided interference. Proc Natl Acad Sci U S A (2014) 1.53
Single-molecule derivation of salt dependent base-pair free energies in DNA. Proc Natl Acad Sci U S A (2010) 1.53
The ribosome modulates nascent protein folding. Science (2011) 1.51
NS3 helicase actively separates RNA strands and senses sequence barriers ahead of the opening fork. Proc Natl Acad Sci U S A (2007) 1.50
Identification of the FtsK sequence-recognition domain. Nat Struct Mol Biol (2006) 1.49
Conformational flexibility in the chromatin remodeler RSC observed by electron microscopy and the orthogonal tilt reconstruction method. Proc Natl Acad Sci U S A (2007) 1.49
Three-dimensional architecture of the bacteriophage phi29 packaged genome and elucidation of its packaging process. Virology (2007) 1.48
Mutations in the Saccharomyces cerevisiae RPB1 gene conferring hypersensitivity to 6-azauracil. Genetics (2006) 1.47