PubRank

Alan D D'Andrea

Author PubWeight™ 173.31‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Biallelic inactivation of BRCA2 in Fanconi anemia. Science 2002 9.31
2 Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair. Cell 2007 6.68
3 How the fanconi anemia pathway guards the genome. Annu Rev Genet 2009 4.94
4 Regulation of monoubiquitinated PCNA by DUB autocleavage. Nat Cell Biol 2006 4.67
5 The deubiquitinating enzyme USP1 regulates the Fanconi anemia pathway. Mol Cell 2005 4.40
6 S-phase-specific interaction of the Fanconi anemia protein, FANCD2, with BRCA1 and RAD51. Blood 2002 4.27
7 Disruption of the Fanconi anemia-BRCA pathway in cisplatin-sensitive ovarian tumors. Nat Med 2003 4.04
8 Human Fanconi anemia monoubiquitination pathway promotes homologous DNA repair. Proc Natl Acad Sci U S A 2005 3.93
9 The Fanconi Anemia/BRCA pathway: new faces in the crowd. Genes Dev 2005 3.90
10 Molecular pathogenesis of Fanconi anemia: recent progress. Blood 2006 3.76
11 Convergence of the fanconi anemia and ataxia telangiectasia signaling pathways. Cell 2002 3.71
12 ATR couples FANCD2 monoubiquitination to the DNA-damage response. Genes Dev 2004 3.44
13 Regulation of DNA cross-link repair by the Fanconi anemia/BRCA pathway. Genes Dev 2012 3.42
14 Expanded roles of the Fanconi anemia pathway in preserving genomic stability. Genes Dev 2010 3.33
15 A UAF1-containing multisubunit protein complex regulates the Fanconi anemia pathway. Mol Cell 2007 3.27
16 Functional interaction of monoubiquitinated FANCD2 and BRCA2/FANCD1 in chromatin. Mol Cell Biol 2004 3.20
17 Cell cycle-dependent chromatin loading of the Fanconi anemia core complex by FANCM/FAAP24. Blood 2008 2.83
18 Regulation of DNA repair by ubiquitylation. Nat Rev Mol Cell Biol 2006 2.73
19 Inhibition of homologous recombination by the PCNA-interacting protein PARI. Mol Cell 2011 2.61
20 UBE2T is the E2 in the Fanconi anemia pathway and undergoes negative autoregulation. Mol Cell 2006 2.51
21 DNA repair pathways in clinical practice: lessons from pediatric cancer susceptibility syndromes. J Clin Oncol 2006 2.49
22 Compromised CDK1 activity sensitizes BRCA-proficient cancers to PARP inhibition. Nat Med 2011 2.35
23 Bone marrow failure in Fanconi anemia is triggered by an exacerbated p53/p21 DNA damage response that impairs hematopoietic stem and progenitor cells. Cell Stem Cell 2012 2.26
24 The Fanconi anemia pathway is required for the DNA replication stress response and for the regulation of common fragile site stability. Hum Mol Genet 2005 2.23
25 Chromatin remodeling at DNA double-strand breaks. Cell 2013 2.18
26 UAF1 is a subunit of multiple deubiquitinating enzyme complexes. J Biol Chem 2008 2.17
27 Inactivation of murine Usp1 results in genomic instability and a Fanconi anemia phenotype. Dev Cell 2009 2.12
28 Regulated interaction of the Fanconi anemia protein, FANCD2, with chromatin. Blood 2004 2.08
29 A DNA repair pathway-focused score for prediction of outcomes in ovarian cancer treated with platinum-based chemotherapy. J Natl Cancer Inst 2012 2.07
30 Interaction of FANCD2 and NBS1 in the DNA damage response. Nat Cell Biol 2002 1.96
31 Chemosensitization to cisplatin by inhibitors of the Fanconi anemia/BRCA pathway. Mol Cancer Ther 2006 1.88
32 Fanconi anemia pathway-deficient tumor cells are hypersensitive to inhibition of ataxia telangiectasia mutated. J Clin Invest 2007 1.80
33 Molecular pathogenesis and clinical management of Fanconi anemia. J Clin Invest 2012 1.79
34 Menin associates with FANCD2, a protein involved in repair of DNA damage. Cancer Res 2003 1.78
35 Chk1-mediated phosphorylation of FANCE is required for the Fanconi anemia/BRCA pathway. Mol Cell Biol 2007 1.77
36 The Fanconi anemia core complex is required for efficient point mutagenesis and Rev1 foci assembly. DNA Repair (Amst) 2008 1.74
37 Regulation of Rev1 by the Fanconi anemia core complex. Nat Struct Mol Biol 2012 1.72
38 Phosphorylation of FANCD2 on two novel sites is required for mitomycin C resistance. Mol Cell Biol 2006 1.65
39 A novel diagnostic screen for defects in the Fanconi anemia pathway. Blood 2002 1.54
40 Association of biallelic BRCA2/FANCD1 mutations with spontaneous chromosomal instability and solid tumors of childhood. Blood 2003 1.49
41 DNA polymerase POLN participates in cross-link repair and homologous recombination. Mol Cell Biol 2009 1.47
42 Human ELG1 regulates the level of ubiquitinated proliferating cell nuclear antigen (PCNA) through Its interactions with PCNA and USP1. J Biol Chem 2010 1.43
43 Case records of the Massachusetts General Hospital. Case 13-2006. A 50-year-old man with a painful bone mass and lesions in the liver. N Engl J Med 2006 1.42
44 Knockdown of zebrafish Fancd2 causes developmental abnormalities via p53-dependent apoptosis. Dev Cell 2003 1.38
45 Cytokinesis failure occurs in Fanconi anemia pathway-deficient murine and human bone marrow hematopoietic cells. J Clin Invest 2010 1.38
46 The FANCM/FAAP24 complex is required for the DNA interstrand crosslink-induced checkpoint response. Mol Cell 2010 1.35
47 Direct DNA binding activity of the Fanconi anemia D2 protein. J Biol Chem 2005 1.33
48 DNA damage responses and their many interactions with the replication fork. Carcinogenesis 2006 1.32
49 The USP1/UAF1 complex promotes double-strand break repair through homologous recombination. Mol Cell Biol 2011 1.31
50 Regulation of the Fanconi anemia pathway by a SUMO-like delivery network. Genes Dev 2011 1.28
51 Cdk1 participates in BRCA1-dependent S phase checkpoint control in response to DNA damage. Mol Cell 2009 1.27
52 Dedicated to the core: understanding the Fanconi anemia complex. DNA Repair (Amst) 2006 1.27
53 Regulated degradation of FANCM in the Fanconi anemia pathway during mitosis. Genes Dev 2009 1.25
54 The Fanconi anemia protein, FANCE, promotes the nuclear accumulation of FANCC. Blood 2002 1.24
55 The Fanconi anemia/BRCA pathway: a coordinator of cross-link repair. Exp Cell Res 2006 1.24
56 Genetic reversion in an acute myelogenous leukemia cell line from a Fanconi anemia patient with biallelic mutations in BRCA2. Cancer Res 2003 1.23
57 Synthetic lethality between CCNE1 amplification and loss of BRCA1. Proc Natl Acad Sci U S A 2013 1.22
58 WDR20 regulates activity of the USP12 x UAF1 deubiquitinating enzyme complex. J Biol Chem 2010 1.20
59 Chromatin recruitment of DNA repair proteins: lessons from the fanconi anemia and double-strand break repair pathways. Mol Cell 2008 1.19
60 Detection of somatic mosaicism and classification of Fanconi anemia patients by analysis of the FA/BRCA pathway. Blood 2004 1.18
61 The WD40 repeats of FANCL are required for Fanconi anemia core complex assembly. J Biol Chem 2006 1.17
62 Heterogeneous activation of the Fanconi anemia pathway by patient-derived FANCA mutants. Hum Mol Genet 2002 1.13
63 Stabilization of mutant BRCA1 protein confers PARP inhibitor and platinum resistance. Proc Natl Acad Sci U S A 2013 1.11
64 FANCD2 activates transcription of TAp63 and suppresses tumorigenesis. Mol Cell 2013 1.11
65 Inhibition of the Nedd8 system sensitizes cells to DNA interstrand cross-linking agents. Mol Cancer Res 2012 1.08
66 Regulation of the Fanconi anemia pathway by monoubiquitination. Semin Cancer Biol 2003 1.08
67 Structural basis of Rev1-mediated assembly of a quaternary vertebrate translesion polymerase complex consisting of Rev1, heterodimeric polymerase (Pol) ζ, and Pol κ. J Biol Chem 2012 1.07
68 RAD18-dependent recruitment of SNM1A to DNA repair complexes by a ubiquitin-binding zinc finger. J Biol Chem 2010 1.05
69 Non-specific chemical inhibition of the Fanconi anemia pathway sensitizes cancer cells to cisplatin. Mol Cancer 2012 1.04
70 Small-molecule inhibitors of USP1 target ID1 degradation in leukemic cells. Mol Cancer Ther 2013 0.99
71 A new nuclease member of the FAN club. Nat Struct Mol Biol 2010 0.98
72 The interplay of Fanconi anemia proteins in the DNA damage response. DNA Repair (Amst) 2004 0.98
73 Inactivation of Uaf1 causes defective homologous recombination and early embryonic lethality in mice. Mol Cell Biol 2013 0.98
74 Structural determinants of human FANCF protein that function in the assembly of a DNA damage signaling complex. J Biol Chem 2006 0.97
75 XPF expression correlates with clinical outcome in squamous cell carcinoma of the head and neck. Clin Cancer Res 2011 0.93
76 DNA repair protein biomarkers associated with time to recurrence in triple-negative breast cancer. Clin Cancer Res 2010 0.90
77 Activation of Hif1α by the prolylhydroxylase inhibitor dimethyoxalyglycine decreases radiosensitivity. PLoS One 2011 0.90
78 Proteasome inhibitors block DNA repair and radiosensitize non-small cell lung cancer. PLoS One 2013 0.88
79 Human MutS and FANCM complexes function as redundant DNA damage sensors in the Fanconi Anemia pathway. DNA Repair (Amst) 2011 0.88
80 Impaired DNA double strand break repair in cells from Nijmegen breakage syndrome patients. DNA Repair (Amst) 2005 0.88
81 To the rescue: the Fanconi anemia genome stability pathway salvages replication forks. Cancer Cell 2012 0.87
82 Upregulation of Fanconi anemia DNA repair genes in melanoma compared with non-melanoma skin cancer. J Invest Dermatol 2011 0.87
83 Biallelic inactivation of REV7 is associated with Fanconi anemia. J Clin Invest 2016 0.86
84 RNF4-mediated polyubiquitination regulates the Fanconi anemia/BRCA pathway. J Clin Invest 2015 0.86
85 FANCD2 hurdles the DNA interstrand crosslink. Cell 2009 0.86
86 The carboxyl terminus of FANCE recruits FANCD2 to the Fanconi Anemia (FA) E3 ligase complex to promote the FA DNA repair pathway. J Biol Chem 2014 0.84
87 PARI overexpression promotes genomic instability and pancreatic tumorigenesis. Cancer Res 2013 0.82
88 Subtyping of Fanconi anemia patients: implications for clinical management. Blood 2003 0.81
89 USP9X inhibition promotes radiation-induced apoptosis in non-small cell lung cancer cells expressing mid-to-high MCL1. Cancer Biol Ther 2015 0.81
90 FANCM: A landing pad for the Fanconi Anemia and Bloom's Syndrome complexes. Mol Cell 2009 0.78
91 DNA damage discrimination at stalled replication forks by the Rad5 homologs HLTF and SHPRH. Mol Cell 2011 0.78
92 Stressed out: endogenous aldehydes damage hematopoietic stem cells. Cell Stem Cell 2012 0.77
93 HAUSP hunting the FOX(O). Nat Cell Biol 2006 0.76
94 Biallelic inactivation of REV7 is associated with Fanconi anemia. J Clin Invest 2017 0.75